Release mechanism of insulin encapsulated in trehalose ester derivative microparticles delivered via inhalation

International Journal of Pharmaceutics

Volumn 254, Issue 2, 2003, Pages 211-222

  Davidson, Iain G ^a   Langner, Eric J ^a   Plowman, Steven V ^a   Blair, Julian A ^a  

^a Elan Drug Delivery   (United Kingdom)

Author keywords

Controlled release; Inhalation; Microparticle

Indexed keywords

ESTER DERIVATIVE; INSULIN; TREHALOSE;

ADSORPTION; ARTICLE; CRYSTALLIZATION; DRUG ABSORPTION; DRUG RELEASE; HUMIDITY; HYDROGEN BOND; INFRARED SPECTROSCOPY; INHALATION; MOLECULAR INTERACTION; PRIORITY JOURNAL; WATER ABSORPTION;

ADMINISTRATION, INHALATION; ALGORITHMS; ANIMALS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; DELAYED-ACTION PREPARATIONS; DRUG STABILITY; ESTERS; INSULIN; LUNG; MICROSPHERES; MOLECULAR WEIGHT; PARTICLE SIZE; RATS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TREHALOSE; WATER;

EID: 0037467167     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(03)00035-8     Document Type: Article

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