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Volumn 126, Issue 21, 2004, Pages 6784-6797

A model for describing the thermodynamics of multivalent host-guest interactions at interfaces

Author keywords

[No Author keywords available]

Indexed keywords

ADSORPTION; DENDRIMERS; MONOLAYERS; SELF ASSEMBLY; THERMODYNAMICS;

EID: 2542625099     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja049085k     Document Type: Article
Times cited : (222)

References (104)
  • 70
    • 0011066764 scopus 로고
    • (a) Kuhn, W. Kolloid-Z 1934, 68, 2-15.
    • (1934) Kolloid-Z , vol.68 , pp. 2-15
    • Kuhn, W.1
  • 78
    • 2542597208 scopus 로고    scopus 로고
    • note
    • Obviously, the host-guest terminology applied here is arbitrary, and the model can be applied as well to multivalent hosts binding to guest-functionalized SAMs, multivalent ligands binding to receptor interfaces, etc..
  • 79
    • 2542617061 scopus 로고    scopus 로고
    • note
    • Competition with a monovalent guest, to block free surface host sites, is fully symmetric, both regarding thermodynamics and kinetics, with competition with a monovalent host. This is made plausible by noting that the overall interaction is determined by monovalent interactions and that it is arbitrary which partner of such an interaction is occupied by a monovalent competitor. Therefore, the mathematics of this type of competition is not incorporated here but could be worked out analogously. The case given here, competition with a species which prevents adsorption of the multivalent analyte, is most common when data are collected based on surface coverages.
  • 84
    • 2542606357 scopus 로고    scopus 로고
    • note
    • 2.
  • 85
    • 2542578892 scopus 로고    scopus 로고
    • note
    • tot = 0.1 mM, Figure 3) and electrochemistry data obtained for 3a and 3b (see ref 66). The difference (factor 1.3) is attributed to the surface roughness of the samples.
  • 90
    • 2542557685 scopus 로고    scopus 로고
    • note
    • s and V are dictated by our SPR setup.
  • 92
    • 2542604854 scopus 로고    scopus 로고
    • note
    • SPR titrations for 2b, 3a, and 3b were performed using the same equipment and the same methodology as described for 2a (see ref 49) and earlier data (refs 48 and 59).
  • 95
    • 2542569731 scopus 로고    scopus 로고
    • note
    • -1. In principle, the same reasoning can be held for the larger dendrimers such as 3b, but its effect on both stoichiometry and binding affinity becomes negligible, since the number of dendritic arms in these cases is always larger than the number of accessible surface sites when solely judged on molecular sizes, and the change of the prefactor in eq 6 is only marginal.
  • 97
    • 2542554500 scopus 로고    scopus 로고
    • note
    • max < n, an analogous expression can be derived which contains an extra prefactor determined by statistical factors as given in eqs 5 and 6.
  • 98
    • 2542601771 scopus 로고    scopus 로고
    • note
    • l] is about 0.01 M, as it is limited by solubility.
  • 100
    • 2542581849 scopus 로고    scopus 로고
    • note
    • -1 in this case.
  • 101
    • 2542551431 scopus 로고    scopus 로고
    • note
    • max, indicating negative cooperativity.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.