Optimization of tether length in nonglycosidically linked bivalent ligands that target sites 2 and 1 of a Shiga-like toxin

Journal of the American Chemical Society

Volumn 125, Issue 11, 2003, Pages 3284-3294

  Kitov, Pavel I ^a   Shimizu, Hiroki ^b   Homans, Steven W ^b   Bundle, David R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CARBOHYDRATES; COMPUTER SIMULATION; CONFORMATIONS; DIMERS; NUCLEAR MAGNETIC RESONANCE; THERMODYNAMICS; TOXIC MATERIALS;

BIVALENT LIGANDS;

SYNTHESIS (CHEMICAL);

3,4 BIS[[METHYL 4 O (ALPHA DEXTRO GALACTOPYRANOSYL) BETA DEXTRO GALACTOPYRANOSID 2 YLOXY]ETHYLAMINO] 3 CYCLOBUTENE 1,2 DIONE; ANTITOXIN; DISACCHARIDE; LIGAND; METHYL 4 O [2 O [2 (3 ACETAMIDOPROPYLAMINOCARBONYL)ETHYL] 4 O (ALPHA DEXTRO GALACTOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSIDE; N,N' BIS[[METHYL 4 O (ALPHA DEXTRO GALACTOPYRANOSYL) BETA DEXTRO GALACTOPYRANOSID 2 YLOXY]ETHYL]OXYCARBONYL (4 PHENYLENEDIAMINE); N,N' BIS[[METHYL 4 O (ALPHA DEXTRO GALACTOPYRANOSYL) BETA DEXTRO GALACTOPYRANOSID 2 YLOXY]ETHYL]OXYCARBONYLETHYLENEDIAMINE; N,N' BIS[[METHYL 4 O (ALPHA DEXTRO GALACTOPYRANOSYL) BETA DEXTRO GALACTOPYRANOSID 2 YLOXY]ETHYL]OXYCARBONYLPROPYLENEDIAMINE; N,N' BIS[[METHYL 4 O [4 O (ALPHA DEXTRO GALACTOPYRANOSYL) BETA DEXTRO GALACTOPYRANOSYL] BETA DEXTRO GLUCOPYRANOSIDE] 2' YLOXYETHYL]OXYCARBONYLPROPYLENEDIAMINE; OLIGOSACCHARIDE LIGAND; SHIGA LIKE TOXIN 1 INHIBITOR; TRISACCHARIDE; UNCLASSIFIED DRUG; VEROTOXIN 1;

ARTICLE; CALCULATION; COMPUTER SIMULATION; DRUG ACTIVITY; DRUG BINDING; DRUG BINDING SITE; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; THERMODYNAMICS;

CROSS-LINKING REAGENTS; DRUG DESIGN; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLYCOSIDES; KINETICS; LIGANDS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOSACCHARIDES; SHIGA-LIKE TOXIN I; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0242417566     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0258529     Document Type: Article

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