-
1
-
-
0038387445
-
To respond or not to respond: T cells in allergic asthma
-
C.A. Herrick, and K. Bottomly To respond or not to respond: T cells in allergic asthma Nat Rev Immunol 3 2003 405 412
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 405-412
-
-
Herrick, C.A.1
Bottomly, K.2
-
2
-
-
0346874493
-
Taking our breath away: Dendritic cells in the pathogenesis of asthma
-
B.N. Lambrecht, and H. Hammad Taking our breath away: dendritic cells in the pathogenesis of asthma Nat Rev Immunol 3 2003 994 1003
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 994-1003
-
-
Lambrecht, B.N.1
Hammad, H.2
-
3
-
-
0035177431
-
Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes
-
K.Y. Vermaelen, I. Carro-Muino, B.N. Lambrecht, and R.A. Pauwels Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes J Exp Med 193 2001 51 60
-
(2001)
J Exp Med
, vol.193
, pp. 51-60
-
-
Vermaelen, K.Y.1
Carro-Muino, I.2
Lambrecht, B.N.3
Pauwels, R.A.4
-
4
-
-
0141958256
-
Prostaglandin D2 modifies airway dendritic cell migration and function in steady state conditions by selective activation of the DP-receptor
-
H. Hammad, H.J. de Heer, T. Souillie, H.C. Hoogsteden, F. Trottein, and B.N. Lambrecht Prostaglandin D2 modifies airway dendritic cell migration and function in steady state conditions by selective activation of the DP-receptor J Immunol 171 2003 3936 3940 Prostaglandin D2, which is produced by mast cells and macrophages, can slow down the steady-state migration of epithelial DCs to the lymph nodes.
-
(2003)
J Immunol
, vol.171
, pp. 3936-3940
-
-
Hammad, H.1
De Heer, H.J.2
Souillie, T.3
Hoogsteden, H.C.4
Trottein, F.5
Lambrecht, B.N.6
-
5
-
-
0141678970
-
Most lymphoid organ dendritic cell types are phenotypically and functionally immature
-
N.S. Wilson, D. El-Sukkari, G.T. Belz, C.M. Smith, R.J. Steptoe, W.R. Heath, K. Shortman, and J.A. Villadangos Most lymphoid organ dendritic cell types are phenotypically and functionally immature Blood 102 2003 2187 2194 A detailed study of DC phenotype in different lymphoid organs in steady state. Only lymph nodes draining epithelial sites have mature, freshly arriving DCs.
-
(2003)
Blood
, vol.102
, pp. 2187-2194
-
-
Wilson, N.S.1
El-Sukkari, D.2
Belz, G.T.3
Smith, C.M.4
Steptoe, R.J.5
Heath, W.R.6
Shortman, K.7
Villadangos, J.A.8
-
6
-
-
0037963473
-
Blood monocytes consist of two principal subsets wih distinct migratory properties
-
F. Geissmann, S. Jung, and D.R. Littman Blood monocytes consist of two principal subsets wih distinct migratory properties Immunity 19 2003 71 82 A very important paper with excellent in vivo tools showing that two different monocyte subsets with different functions exist in the bloodstream of mice and humans.
-
(2003)
Immunity
, vol.19
, pp. 71-82
-
-
Geissmann, F.1
Jung, S.2
Littman, D.R.3
-
7
-
-
0042410534
-
Accelerated airway dendritic cell maturation, trafficking, and elimination in a mouse model of asthma
-
K. Vermaelen, and R. Pauwels Accelerated airway dendritic cell maturation, trafficking, and elimination in a mouse model of asthma Am J Respir Cell Mol Biol 29 2003 405 409 As in [8], the authors show increased migration of DCs to the mediastinal nodes of allergic mice, where they are short lived due to the downregulation of the anti-apoptotic effector Bcl-2.
-
(2003)
Am J Respir Cell Mol Biol
, vol.29
, pp. 405-409
-
-
Vermaelen, K.1
Pauwels, R.2
-
9
-
-
0037332073
-
Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection
-
K.L. Legge, and T.J. Braciale Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection Immunity 18 2003 265 277
-
(2003)
Immunity
, vol.18
, pp. 265-277
-
-
Legge, K.L.1
Braciale, T.J.2
-
10
-
-
2942593821
-
Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus
-
G.T. Belz, C.M. Smith, L. Kleinert, P. Reading, A. Brooks, K. Shortman, F.R. Carbone, and W.R. Heath Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus Proc Natl Acad Sci USA 101 2004 8670 8675 This study shows that antigen is not only presented by a specific population of migrating lung DCs but also by a resident DC population in the lymph node.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 8670-8675
-
-
Belz, G.T.1
Smith, C.M.2
Kleinert, L.3
Reading, P.4
Brooks, A.5
Shortman, K.6
Carbone, F.R.7
Heath, W.R.8
-
11
-
-
3142720367
-
Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen
-
H.J. De Heer, H. Hammad, T. Soullie, D. Hijdra, N. Vos, M.A. Willart, H.C. Hoogsteden, and B.N. Lambrecht Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen J Exp Med 200 2004 89 98 This is the first description of pDCs in the lung and the first study showing a tolerogenic role for pDCs in vivo.
-
(2004)
J Exp Med
, vol.200
, pp. 89-98
-
-
De Heer, H.J.1
Hammad, H.2
Soullie, T.3
Hijdra, D.4
Vos, N.5
Willart, M.A.6
Hoogsteden, H.C.7
Lambrecht, B.N.8
-
12
-
-
0037121946
-
Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen
-
S.C. Eisenbarth, D.A. Piggott, J.W. Huleatt, I. Visintin, C.A. Herrick, and K. Bottomly Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen J Exp Med 196 2002 1645 1651
-
(2002)
J Exp Med
, vol.196
, pp. 1645-1651
-
-
Eisenbarth, S.C.1
Piggott, D.A.2
Huleatt, J.W.3
Visintin, I.4
Herrick, C.A.5
Bottomly, K.6
-
13
-
-
0036569813
-
Toll-like receptor 4 is required for optimal development of Th2 immune responses: Role of dendritic cells
-
K. Dabbagh, M.E. Dahl, P. Stepick-Biek, and D.B. Lewis Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells J Immunol 168 2002 4524 4530
-
(2002)
J Immunol
, vol.168
, pp. 4524-4530
-
-
Dabbagh, K.1
Dahl, M.E.2
Stepick-Biek, P.3
Lewis, D.B.4
-
14
-
-
0038152841
-
Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, mormally nonimmunogenic protein
-
M.K. Brimnes, L. Bonifaz, R.M. Steinman, and T.M. Moran Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, mormally nonimmunogenic protein J Exp Med 198 2003 133 144 In the absence of any PAMP, inhalation of harmless antigen leads to tolerance. Tolerance is broken by viral infection through induction of DC maturation.
-
(2003)
J Exp Med
, vol.198
, pp. 133-144
-
-
Brimnes, M.K.1
Bonifaz, L.2
Steinman, R.M.3
Moran, T.M.4
-
16
-
-
0034890907
-
Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
-
O. Akbari, R.H. DeKruyff, and D.T. Umetsu Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen Nat Immunol 2 2001 725 731
-
(2001)
Nat Immunol
, vol.2
, pp. 725-731
-
-
Akbari, O.1
Dekruyff, R.H.2
Umetsu, D.T.3
-
17
-
-
0036732461
-
Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity
-
O. Akbari, G.J. Freeman, E.H. Meyer, E.A. Greenfield, T.T. Chang, A.H. Sharpe, G. Berry, R.H. DeKruyff, and D.T. Umetsu Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity Nat Med 8 2002 1024 1032
-
(2002)
Nat Med
, vol.8
, pp. 1024-1032
-
-
Akbari, O.1
Freeman, G.J.2
Meyer, E.H.3
Greenfield, E.A.4
Chang, T.T.5
Sharpe, A.H.6
Berry, G.7
Dekruyff, R.H.8
Umetsu, D.T.9
-
18
-
-
0033198184
-
Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells
-
D.C. Tsitoura, R.H. Dekruyff, J.R. Lamb, and D.T. Umetsu Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells J Immunol 163 1999 2592 2600
-
(1999)
J Immunol
, vol.163
, pp. 2592-2600
-
-
Tsitoura, D.C.1
Dekruyff, R.H.2
Lamb, J.R.3
Umetsu, D.T.4
-
19
-
-
0037514382
-
Lung CD25 CD4 Regulatory T Cells Suppress Type 2 Immune Responses but Not Bronchial Hyperreactivity
-
H. Hadeiba, and R.M. Locksley Lung CD25 CD4 Regulatory T Cells Suppress Type 2 Immune Responses But Not Bronchial Hyperreactivity J Immunol 170 2003 5502 5510
-
(2003)
J Immunol
, vol.170
, pp. 5502-5510
-
-
Hadeiba, H.1
Locksley, R.M.2
-
20
-
-
1542724420
-
CD4+CD25+ T Cells Regulate Airway Eosinophilic Inflammation by Modulating the Th2 Cell Phenotype
-
Z. Jaffar, T. Sivakuru, and K. Roberts CD4+CD25+ T Cells Regulate Airway Eosinophilic Inflammation by Modulating the Th2 Cell Phenotype J Immunol 172 2004 3842 3849
-
(2004)
J Immunol
, vol.172
, pp. 3842-3849
-
-
Jaffar, Z.1
Sivakuru, T.2
Roberts, K.3
-
21
-
-
2942685507
-
Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells
-
+ Treg cells are isolated with magnetic beads.
-
(2004)
J Exp Med
, vol.199
, pp. 1567-1575
-
-
Akdis, M.1
Verhagen, J.2
Taylor, A.3
Karamloo, F.4
Karagiannidis, C.5
Crameri, R.6
Thunberg, S.7
Deniz, G.8
Valenta, R.9
Fiebig, H.10
-
23
-
-
0033855772
-
Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation
-
B.N. Lambrecht, M. De Veerman, A.J. Coyle, J.C. Gutierrez-Ramos, K. Thielemans, and R.A. Pauwels Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation J Clin Invest 106 2000 551 559
-
(2000)
J Clin Invest
, vol.106
, pp. 551-559
-
-
Lambrecht, B.N.1
De Veerman, M.2
Coyle, A.J.3
Gutierrez-Ramos, J.C.4
Thielemans, K.5
Pauwels, R.A.6
-
24
-
-
1542574200
-
Activation of peroxisome proliferator-activated receptor pathway in dendritic cells inhibits development of eosinophilic airway inflammation in a mouse model of asthma
-
H. Hammad, H.J. de Heer, T. Souillie, V. Angeli, F. Trottein, H.C. Hoogsteden, and B.N. Lambrecht Activation of peroxisome proliferator-activated receptor pathway in dendritic cells inhibits development of eosinophilic airway inflammation in a mouse model of asthma Am J Pathol 164 2004 263 271
-
(2004)
Am J Pathol
, vol.164
, pp. 263-271
-
-
Hammad, H.1
De Heer, H.J.2
Souillie, T.3
Angeli, V.4
Trottein, F.5
Hoogsteden, H.C.6
Lambrecht, B.N.7
-
25
-
-
0034654008
-
Induction of rapid T cell activation, division, and recirculation by intratracheal injection of dendritic cells in a TCR transgenic model
-
B.N. Lambrecht, R.A. Pauwels, and B. Fazekas De St Groth Induction of rapid T cell activation, division, and recirculation by intratracheal injection of dendritic cells in a TCR transgenic model J Immunol 164 2000 2937 2946
-
(2000)
J Immunol
, vol.164
, pp. 2937-2946
-
-
Lambrecht, B.N.1
Pauwels, R.A.2
Fazekas De St Groth, B.3
-
26
-
-
0037148511
-
Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: A novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis
-
P. McGuirk, C. McCann, and K.H. Mills Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis J Exp Med 195 2002 221 231
-
(2002)
J Exp Med
, vol.195
, pp. 221-231
-
-
McGuirk, P.1
McCann, C.2
Mills, K.H.3
-
27
-
-
1642343980
-
Mycobacterium vaccae induces a population of pulmonary CD11c+ cells with regulatory potential in allergic mice
-
V.C. Adams, J.R. Hunt, R. Martinelli, R. Palmer, G.A. Rook, and L.R. Brunet Mycobacterium vaccae induces a population of pulmonary CD11c+ cells with regulatory potential in allergic mice Eur J Immunol 34 2004 631 638 In a mouse model of asthma, treatment with the saprophytic Mycobacterium vaccae significantly reduces allergic inflammation by inducing IL-10, TGFβ and IFN-α in lung DCs.
-
(2004)
Eur J Immunol
, vol.34
, pp. 631-638
-
-
Adams, V.C.1
Hunt, J.R.2
Martinelli, R.3
Palmer, R.4
Rook, G.A.5
Brunet, L.R.6
-
28
-
-
0037100317
-
Characterization of a new subpopulation of mouse CD8alpha(+) B220(+) dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential
-
P. Martin, G.M. Del Hoyo, F. Anjuere, C.F. Arias, H.H. Vargas, L.A. Fernandez, V. Parrillas, and C. Ardavin Characterization of a new subpopulation of mouse CD8alpha(+) B220(+) dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential Blood 100 2002 383 390
-
(2002)
Blood
, vol.100
, pp. 383-390
-
-
Martin, P.1
Del Hoyo, G.M.2
Anjuere, F.3
Arias, C.F.4
Vargas, H.H.5
Fernandez, L.A.6
Parrillas, V.7
Ardavin, C.8
-
29
-
-
0037565371
-
Differences in circulating dendritic cell subtypes in cord blood and peripheral blood of healthy and allergic children
-
M.M. Hagendorens, D.G. Ebo, A.J. Schuerwegh, A. Huybrechs, H.P. Van Bever, C.H. Bridts, L.S. De Clerck, and W.J. Stevens Differences in circulating dendritic cell subtypes in cord blood and peripheral blood of healthy and allergic children Clin Exp Allergy 33 2003 633 639
-
(2003)
Clin Exp Allergy
, vol.33
, pp. 633-639
-
-
Hagendorens, M.M.1
Ebo, D.G.2
Schuerwegh, A.J.3
Huybrechs, A.4
Van Bever, H.P.5
Bridts, C.H.6
De Clerck, L.S.7
Stevens, W.J.8
-
30
-
-
0035901102
-
Early childhood infectious diseases and the development of asthma up to school age: A birth cohort study
-
S. Illi, E. von Mutius, S. Lau, R. Bergmann, B. Niggemann, C. Sommerfeld, and U. Wahn Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study BMJ 322 2001 390 395
-
(2001)
BMJ
, vol.322
, pp. 390-395
-
-
Illi, S.1
Von Mutius, E.2
Lau, S.3
Bergmann, R.4
Niggemann, B.5
Sommerfeld, C.6
Wahn, U.7
-
31
-
-
0033987139
-
Dendritic cells are associated with augmentation of antigen sensitization by influenza a virus infection in mice
-
N. Yamamoto, S. Suzuki, A. Shirai, M. Suzuki, M. Nakazawa, Y. Nagashima, and T. Okubo Dendritic cells are associated with augmentation of antigen sensitization by influenza A virus infection in mice Eur J Immunol 30 2000 316 326
-
(2000)
Eur J Immunol
, vol.30
, pp. 316-326
-
-
Yamamoto, N.1
Suzuki, S.2
Shirai, A.3
Suzuki, M.4
Nakazawa, M.5
Nagashima, Y.6
Okubo, T.7
-
32
-
-
1542347573
-
Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells
-
M.E. Dahl, K. Dabbagh, D. Liggitt, S. Kim, and D.B. Lewis Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells Nat Immunol 5 2004 337 343 A mechanism for the observation that children infected with respiratory viruses have increased risk of asthma. IFNγ produced at the time of viral infection enhances the Th2 priming function of DCs.
-
(2004)
Nat Immunol
, vol.5
, pp. 337-343
-
-
Dahl, M.E.1
Dabbagh, K.2
Liggitt, D.3
Kim, S.4
Lewis, D.B.5
-
33
-
-
2942655175
-
'Educated' dendritic cells act as messengers from memory to naive T helper cells
-
O. Alpan, E. Bachelder, E. Isil, H. Arnheiter, and P. Matzinger 'Educated' dendritic cells act as messengers from memory to naive T helper cells Nat Immunol 5 2004 615 622 This is a rigorous study using allophenic mice (genetic mosaics) showing that effector T cells can influence subsequent priming of T cells specific for a unrelated antigen by signalling via DCs.
-
(2004)
Nat Immunol
, vol.5
, pp. 615-622
-
-
Alpan, O.1
Bachelder, E.2
Isil, E.3
Arnheiter, H.4
Matzinger, P.5
-
35
-
-
0031775744
-
Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity
-
P.A. Stumbles, J.A. Thomas, C.L. Pimm, P.T. Lee, T.J. Venaille, S. Proksch, and P.G. Holt Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity J Exp Med 188 1998 2019 2031
-
(1998)
J Exp Med
, vol.188
, pp. 2019-2031
-
-
Stumbles, P.A.1
Thomas, J.A.2
Pimm, C.L.3
Lee, P.T.4
Venaille, T.J.5
Proksch, S.6
Holt, P.G.7
-
36
-
-
0037339779
-
Dendritic cells recruited to the lung shortly after intranasal delivery of Mycobacterium bovis BCG drive the primary immune response towards a type 1 cytokine production
-
M. Lagranderie, M.A. Nahori, A.M. Balazuc, H. Kiefer-Biasizzo, J.R. Lapa e Silva, G. Milon, G. Marchal, and B.B. Vargaftig Dendritic cells recruited to the lung shortly after intranasal delivery of Mycobacterium bovis BCG drive the primary immune response towards a type 1 cytokine production Immunology 108 2003 352 364
-
(2003)
Immunology
, vol.108
, pp. 352-364
-
-
Lagranderie, M.1
Nahori, M.A.2
Balazuc, A.M.3
Kiefer-Biasizzo, H.4
Lapa Silva, E.J.R.5
Milon, G.6
Marchal, G.7
Vargaftig, B.B.8
-
37
-
-
0037313578
-
Interleukin-12 and the regulation of innate resistance and adaptive immunity
-
G. Trinchieri Interleukin-12 and the regulation of innate resistance and adaptive immunity Nat Rev Immunol 3 2003 133 146
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 133-146
-
-
Trinchieri, G.1
-
38
-
-
2942720565
-
Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development
-
H.H. Smits, A.J. van Beelen, C. Hessle, R. Westland, E. de Jong, E. Soeteman, A. Wold, E.A. Wierenga, and M.L. Kapsenberg Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development Eur J Immunol 34 2004 1371 1380
-
(2004)
Eur J Immunol
, vol.34
, pp. 1371-1380
-
-
Smits, H.H.1
Van Beelen, A.J.2
Hessle, C.3
Westland, R.4
De Jong, E.5
Soeteman, E.6
Wold, A.7
Wierenga, E.A.8
Kapsenberg, M.L.9
-
39
-
-
7044277061
-
Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization
-
H. Kuipers, C. Heirman, D. Hijdra, F. Muskens, M. Willart, A.J. Coyle, K. Thielemans, H.C. Hoogsteden, and B.N. Lambrecht Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization J Leukoc Biol 2004 DOI:10.1189/jlb.0604325
-
(2004)
J Leukoc Biol
-
-
Kuipers, H.1
Heirman, C.2
Hijdra, D.3
Muskens, F.4
Willart, M.5
Coyle, A.J.6
Thielemans, K.7
Hoogsteden, H.C.8
Lambrecht, B.N.9
-
40
-
-
0141955102
-
Lipopolysaccharide-Induced Suppression of Airway Th2 Responses Does Not Require IL-12 Production by Dendritic Cells
-
H. Kuipers, D. Hijdra, V.C. De Vries, H. Hammad, J.B. Prins, A.J. Coyle, H.C. Hoogsteden, and B.N. Lambrecht Lipopolysaccharide-Induced Suppression of Airway Th2 Responses Does Not Require IL-12 Production by Dendritic Cells J Immunol 171 2003 3645 3654
-
(2003)
J Immunol
, vol.171
, pp. 3645-3654
-
-
Kuipers, H.1
Hijdra, D.2
De Vries, V.C.3
Hammad, H.4
Prins, J.B.5
Coyle, A.J.6
Hoogsteden, H.C.7
Lambrecht, B.N.8
-
41
-
-
1642362240
-
Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production
-
D. Voehringer, K. Shinkai, and R.M. Locksley Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production Immunity 20 2004 267 277 Using IL-4 reporter mice it is shown that eosinophils, basophils and Th2 cells are early sources of IL-4 in helminth-induced eosinophilia. Eosinophil and Th2 cell recruitment depends on Stat6 expression by a bone-marrow-derived lung-tissue-resident DCs.
-
(2004)
Immunity
, vol.20
, pp. 267-277
-
-
Voehringer, D.1
Shinkai, K.2
Locksley, R.M.3
-
42
-
-
2342496710
-
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
-
D. Amsen, J.M. Blander, G.R. Lee, K. Tanigaki, T. Honjo, and R.A. Flavell Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells Cell 117 2004 515 526 The authors provide a model for instructive Th2 development by DCs. The downstream Notch signalling molecule RBP Jκ directly induces GATA3 independently of STAT6.
-
(2004)
Cell
, vol.117
, pp. 515-526
-
-
Amsen, D.1
Blander, J.M.2
Lee, G.R.3
Tanigaki, K.4
Honjo, T.5
Flavell, R.A.6
-
43
-
-
0348135024
-
Dendritic-cell control of pathogen-driven T-cell polarization
-
M.L. Kapsenberg Dendritic-cell control of pathogen-driven T-cell polarization Nat Rev Immunol 3 2003 984 993
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 984-993
-
-
Kapsenberg, M.L.1
-
44
-
-
0038448930
-
Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma
-
J.C. Huh, D.H. Strickland, F.L. Jahnsen, D.J. Turner, J.A. Thomas, S. Napoli, I. Tobagus, P.A. Stumbles, P.D. Sly, and P.G. Holt Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma J Exp Med 198 2003 19 30 The first description that antigen presentation to memory Th2 cells occurs by DCs in the respiratory epithelium, leading to bidirectional interactions.
-
(2003)
J Exp Med
, vol.198
, pp. 19-30
-
-
Huh, J.C.1
Strickland, D.H.2
Jahnsen, F.L.3
Turner, D.J.4
Thomas, J.A.5
Napoli, S.6
Tobagus, I.7
Stumbles, P.A.8
Sly, P.D.9
Holt, P.G.10
-
45
-
-
0036280217
-
Rapid response of circulating myeloid dendritic cells to inhaled allergen in asthmatic subjects
-
J.W. Upham, J.A. Denburg, and P.M. O'Byrne Rapid response of circulating myeloid dendritic cells to inhaled allergen in asthmatic subjects Clin Exp Allergy 32 2002 818 823
-
(2002)
Clin Exp Allergy
, vol.32
, pp. 818-823
-
-
Upham, J.W.1
Denburg, J.A.2
O'Byrne, P.M.3
-
46
-
-
0034778994
-
Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge
-
F.L. Jahnsen, E.D. Moloney, T. Hogan, J.W. Upham, C.M. Burke, and P.G. Holt Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge Thorax 56 2001 823 826
-
(2001)
Thorax
, vol.56
, pp. 823-826
-
-
Jahnsen, F.L.1
Moloney, E.D.2
Hogan, T.3
Upham, J.W.4
Burke, C.M.5
Holt, P.G.6
-
47
-
-
3442892041
-
Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma
-
L.S. Van Rijt, N. Vos, M. Willart, A. Kleinjan, A.J. Coyle, H.C. Hoogsteden, and B.N. Lambrecht Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma J Allergy Clin Immunol 114 2004 166 173 DCs are sufficient to induce all the features of asthma in sensitized mice. During secondary immune responses, co-stimulation by B7 family members is not necessary.
-
(2004)
J Allergy Clin Immunol
, vol.114
, pp. 166-173
-
-
Van Rijt, L.S.1
Vos, N.2
Willart, M.3
Kleinjan, A.4
Coyle, A.J.5
Hoogsteden, H.C.6
Lambrecht, B.N.7
-
48
-
-
0038785779
-
Matrix metalloproteinse-9-mediated dendritic cell recruitment into the airways is a critical step in mouse model of asthma
-
K. Vermaelen, D. Cataldo, K.G. Tournoy, T. Maes, A. Dhulst, R. Louis, J.-M. Foidart, A. Noel, and R.A. Pauwels Matrix metalloproteinse-9-mediated dendritic cell recruitment into the airways is a critical step in mouse model of asthma J Immunol 171 2003 1016 1022 Nice paper showing the necessity for matrix metalloproteinase 9 in DC migration in the lung. Lung DCs are a predominant source of TARC.
-
(2003)
J Immunol
, vol.171
, pp. 1016-1022
-
-
Vermaelen, K.1
Cataldo, D.2
Tournoy, K.G.3
Maes, T.4
Dhulst, A.5
Louis, R.6
Foidart, J.-M.7
Noel, A.8
Pauwels, R.A.9
-
49
-
-
1642457392
-
Monocyte-derived dendritic cells exposed to der p 1 allergen enhance the recruitment of Th2 cells: Major involvement of the chemokines TARC/CCL17 and MDC/CCL22
-
H. Hammad, H.H. Smits, C. Ratajczak, A. Nithiananthan, E.A. Wierenga, G.A. Stewart, A. Jacquet, A.B. Tonnel, and J. Pestel Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC/CCL17 and MDC/CCL22 Eur Cytokine Netw 14 2003 219 228
-
(2003)
Eur Cytokine Netw
, vol.14
, pp. 219-228
-
-
Hammad, H.1
Smits, H.H.2
Ratajczak, C.3
Nithiananthan, A.4
Wierenga, E.A.5
Stewart, G.A.6
Jacquet, A.7
Tonnel, A.B.8
Pestel, J.9
-
51
-
-
0032522829
-
Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice
-
B.N. Lambrecht, B. Salomon, D. Klatzmann, and R.A. Pauwels Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice J Immunol 160 1998 4090 4097
-
(1998)
J Immunol
, vol.160
, pp. 4090-4097
-
-
Lambrecht, B.N.1
Salomon, B.2
Klatzmann, D.3
Pauwels, R.A.4
-
52
-
-
0141989811
-
Airway eosinophils accumulate in the mediastinal lymph nodes but lack antigen-presenting potential for naive T cells
-
L.S. Van Rijt, N. Vos, D. Hijdra, V.C. De Vries, H.C. Hoogsteden, and B.N. Lambrecht Airway eosinophils accumulate in the mediastinal lymph nodes but lack antigen-presenting potential for naive T cells J Immunol 171 2003 3372 3378
-
(2003)
J Immunol
, vol.171
, pp. 3372-3378
-
-
Van Rijt, L.S.1
Vos, N.2
Hijdra, D.3
De Vries, V.C.4
Hoogsteden, H.C.5
Lambrecht, B.N.6
-
53
-
-
9144240996
-
Transcript signatures in experimental asthma: Identification of STAT6-dependent and -independent pathways
-
N. Zimmermann, A. Mishra, N.E. King, P.C. Fulkerson, M.P. Doepker, N.M. Nikolaidis, L.E. Kindinger, E.A. Moulton, B.J. Aronow, and M.E. Rothenberg Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways J Immunol 172 2004 1815 1824 A transcriptomics study showing which genes depend on STAT6 transcription for induction in various models of asthma.
-
(2004)
J Immunol
, vol.172
, pp. 1815-1824
-
-
Zimmermann, N.1
Mishra, A.2
King, N.E.3
Fulkerson, P.C.4
Doepker, M.P.5
Nikolaidis, N.M.6
Kindinger, L.E.7
Moulton, E.A.8
Aronow, B.J.9
Rothenberg, M.E.10
-
54
-
-
0037265240
-
Alternative activation of macrophages
-
S. Gordon Alternative activation of macrophages Nat Rev Immunol 3 2003 23 35
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 23-35
-
-
Gordon, S.1
-
55
-
-
0042512461
-
Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells
-
S. Yamazaki, T. Iyoda, K. Tarbell, K. Olson, K. Velinzon, K. Inaba, and R.M. Steinman Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells J Exp Med 198 2003 235 247 Only mature DCs can induce the expansion of Treg cells. Expanded Treg cells have enhanced suppression function. The use of DCs to expand Tregs could be used therapeutically.
-
(2003)
J Exp Med
, vol.198
, pp. 235-247
-
-
Yamazaki, S.1
Iyoda, T.2
Tarbell, K.3
Olson, K.4
Velinzon, K.5
Inaba, K.6
Steinman, R.M.7
-
56
-
-
0037446531
-
Cutting edge: Cure of colitis by CD4+CD25+ regulatory T cells
-
C. Mottet, H.H. Uhlig, and F. Powrie Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells J Immunol 170 2003 3939 3943 First report that Tregs, effector T cells and DCs cluster within sites of chronic inflammation.
-
(2003)
J Immunol
, vol.170
, pp. 3939-3943
-
-
Mottet, C.1
Uhlig, H.H.2
Powrie, F.3
-
57
-
-
0042662863
-
OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation
-
S. Salek-Ardakani, J. Song, B.S. Halteman, A.G. Jember, H. Akiba, H. Yagita, and M. Croft OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation J Exp Med 198 2003 315 324
-
(2003)
J Exp Med
, vol.198
, pp. 315-324
-
-
Salek-Ardakani, S.1
Song, J.2
Halteman, B.S.3
Jember, A.G.4
Akiba, H.5
Yagita, H.6
Croft, M.7
-
58
-
-
0035903307
-
Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells
-
A. Iellem, M. Mariani, R. Lang, H. Recalde, P. Panina-Bordignon, F. Sinigaglia, and D. D'Ambrosio Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells J Exp Med 194 2001 847 853
-
(2001)
J Exp Med
, vol.194
, pp. 847-853
-
-
Iellem, A.1
Mariani, M.2
Lang, R.3
Recalde, H.4
Panina-Bordignon, P.5
Sinigaglia, F.6
D'Ambrosio, D.7
-
59
-
-
0347480215
-
CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells
-
P. Serra, A. Amrani, J. Yamanouchi, B. Han, S. Thiessen, T. Utsugi, J. Verdaguer, and P. Santamaria CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells Immunity 19 2003 877 889 Treg cells suppress the maturation of DCs in a model of diabetes. Suppression is broken by innate immune signals or T cell cognate contact through CD40L.
-
(2003)
Immunity
, vol.19
, pp. 877-889
-
-
Serra, P.1
Amrani, A.2
Yamanouchi, J.3
Han, B.4
Thiessen, S.5
Utsugi, T.6
Verdaguer, J.7
Santamaria, P.8
-
60
-
-
12144285752
-
Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation
-
O. Fainaru, E. Woolf, J. Lotem, M. Yarmus, O. Brenner, D. Goldenberg, V. Negreanu, Y. Bernstein, D. Levanon, and S. Jung Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation EMBO J 23 2004 969 979 An elegant study, in which deficiency of downstream signalling through TGFβ leads to accumulation of mature DCs into the lung and spontaneous eosinophilic airway inflammation.
-
(2004)
EMBO J
, vol.23
, pp. 969-979
-
-
Fainaru, O.1
Woolf, E.2
Lotem, J.3
Yarmus, M.4
Brenner, O.5
Goldenberg, D.6
Negreanu, V.7
Bernstein, Y.8
Levanon, D.9
Jung, S.10
-
61
-
-
0346119234
-
Modulation of tryptophan catabolism by regulatory T cells
-
F. Fallarino, U. Grohmann, K.W. Hwang, C. Orabona, C. Vacca, R. Bianchi, M.L. Belladonna, M.C. Fioretti, M.L. Alegre, and P. Puccetti Modulation of tryptophan catabolism by regulatory T cells Nat Immunol 4 2003 1206 1212
-
(2003)
Nat Immunol
, vol.4
, pp. 1206-1212
-
-
Fallarino, F.1
Grohmann, U.2
Hwang, K.W.3
Orabona, C.4
Vacca, C.5
Bianchi, R.6
Belladonna, M.L.7
Fioretti, M.C.8
Alegre, M.L.9
Puccetti, P.10
-
62
-
-
4043170040
-
Inhibition of experimental asthma by indoleamine 2,3-dioxygenase
-
T. Hayashi, L. Beck, C. Rossetto, X. Gong, O. Takikawa, K. Takabayashi, D.H. Broide, D.A. Carson, and E. Raz Inhibition of experimental asthma by indoleamine 2,3-dioxygenase J Clin Invest 114 2004 270 279 Administration of CpG motifs suppresses asthma by inducing tryptophan catabolism in epithelial cells.
-
(2004)
J Clin Invest
, vol.114
, pp. 270-279
-
-
Hayashi, T.1
Beck, L.2
Rossetto, C.3
Gong, X.4
Takikawa, O.5
Takabayashi, K.6
Broide, D.H.7
Carson, D.A.8
Raz, E.9
-
63
-
-
0037436119
-
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
-
C. Pasare, and R. Medzhitov Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells Science 299 2003 1033 1036 Authors show that DC-derived IL-6 and an unidentified soluble factor render effector T cells resistant to Treg regulation after TLR ligation.
-
(2003)
Science
, vol.299
, pp. 1033-1036
-
-
Pasare, C.1
Medzhitov, R.2
-
64
-
-
1342308180
-
Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease
-
+ T cells isolated from atopic patients compared to healthy controls.
-
(2004)
Lancet
, vol.363
, pp. 608-615
-
-
Ling, E.M.1
Smith, T.2
Nguyen, X.D.3
Pridgeon, C.4
Dallman, M.5
Arbery, J.6
Carr, V.A.7
Robinson, D.S.8
-
65
-
-
2442522357
-
Regulation of αβ/γδ T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling
-
K is involved in Th2 differentiation.
-
(2004)
Immunity
, vol.20
, pp. 611-622
-
-
Tanigaki, K.1
Tsuji, M.2
Yamamoto, N.3
Han, H.4
Tsukada, J.5
Inoue, H.6
Kubo, M.7
Honjo, T.8
|