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Volumn 16, Issue 6, 2004, Pages 702-708

The interplay of dendritic cells, Th2 cells and regulatory T cells in asthma

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; B7 ANTIGEN; CD134 ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR8; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4;

EID: 7044260960     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2004.09.010     Document Type: Review
Times cited : (103)

References (65)
  • 1
    • 0038387445 scopus 로고    scopus 로고
    • To respond or not to respond: T cells in allergic asthma
    • C.A. Herrick, and K. Bottomly To respond or not to respond: T cells in allergic asthma Nat Rev Immunol 3 2003 405 412
    • (2003) Nat Rev Immunol , vol.3 , pp. 405-412
    • Herrick, C.A.1    Bottomly, K.2
  • 2
    • 0346874493 scopus 로고    scopus 로고
    • Taking our breath away: Dendritic cells in the pathogenesis of asthma
    • B.N. Lambrecht, and H. Hammad Taking our breath away: dendritic cells in the pathogenesis of asthma Nat Rev Immunol 3 2003 994 1003
    • (2003) Nat Rev Immunol , vol.3 , pp. 994-1003
    • Lambrecht, B.N.1    Hammad, H.2
  • 3
    • 0035177431 scopus 로고    scopus 로고
    • Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes
    • K.Y. Vermaelen, I. Carro-Muino, B.N. Lambrecht, and R.A. Pauwels Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes J Exp Med 193 2001 51 60
    • (2001) J Exp Med , vol.193 , pp. 51-60
    • Vermaelen, K.Y.1    Carro-Muino, I.2    Lambrecht, B.N.3    Pauwels, R.A.4
  • 4
    • 0141958256 scopus 로고    scopus 로고
    • Prostaglandin D2 modifies airway dendritic cell migration and function in steady state conditions by selective activation of the DP-receptor
    • H. Hammad, H.J. de Heer, T. Souillie, H.C. Hoogsteden, F. Trottein, and B.N. Lambrecht Prostaglandin D2 modifies airway dendritic cell migration and function in steady state conditions by selective activation of the DP-receptor J Immunol 171 2003 3936 3940 Prostaglandin D2, which is produced by mast cells and macrophages, can slow down the steady-state migration of epithelial DCs to the lymph nodes.
    • (2003) J Immunol , vol.171 , pp. 3936-3940
    • Hammad, H.1    De Heer, H.J.2    Souillie, T.3    Hoogsteden, H.C.4    Trottein, F.5    Lambrecht, B.N.6
  • 5
    • 0141678970 scopus 로고    scopus 로고
    • Most lymphoid organ dendritic cell types are phenotypically and functionally immature
    • N.S. Wilson, D. El-Sukkari, G.T. Belz, C.M. Smith, R.J. Steptoe, W.R. Heath, K. Shortman, and J.A. Villadangos Most lymphoid organ dendritic cell types are phenotypically and functionally immature Blood 102 2003 2187 2194 A detailed study of DC phenotype in different lymphoid organs in steady state. Only lymph nodes draining epithelial sites have mature, freshly arriving DCs.
    • (2003) Blood , vol.102 , pp. 2187-2194
    • Wilson, N.S.1    El-Sukkari, D.2    Belz, G.T.3    Smith, C.M.4    Steptoe, R.J.5    Heath, W.R.6    Shortman, K.7    Villadangos, J.A.8
  • 6
    • 0037963473 scopus 로고    scopus 로고
    • Blood monocytes consist of two principal subsets wih distinct migratory properties
    • F. Geissmann, S. Jung, and D.R. Littman Blood monocytes consist of two principal subsets wih distinct migratory properties Immunity 19 2003 71 82 A very important paper with excellent in vivo tools showing that two different monocyte subsets with different functions exist in the bloodstream of mice and humans.
    • (2003) Immunity , vol.19 , pp. 71-82
    • Geissmann, F.1    Jung, S.2    Littman, D.R.3
  • 7
    • 0042410534 scopus 로고    scopus 로고
    • Accelerated airway dendritic cell maturation, trafficking, and elimination in a mouse model of asthma
    • K. Vermaelen, and R. Pauwels Accelerated airway dendritic cell maturation, trafficking, and elimination in a mouse model of asthma Am J Respir Cell Mol Biol 29 2003 405 409 As in [8], the authors show increased migration of DCs to the mediastinal nodes of allergic mice, where they are short lived due to the downregulation of the anti-apoptotic effector Bcl-2.
    • (2003) Am J Respir Cell Mol Biol , vol.29 , pp. 405-409
    • Vermaelen, K.1    Pauwels, R.2
  • 9
    • 0037332073 scopus 로고    scopus 로고
    • Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection
    • K.L. Legge, and T.J. Braciale Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection Immunity 18 2003 265 277
    • (2003) Immunity , vol.18 , pp. 265-277
    • Legge, K.L.1    Braciale, T.J.2
  • 10
    • 2942593821 scopus 로고    scopus 로고
    • Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus
    • G.T. Belz, C.M. Smith, L. Kleinert, P. Reading, A. Brooks, K. Shortman, F.R. Carbone, and W.R. Heath Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus Proc Natl Acad Sci USA 101 2004 8670 8675 This study shows that antigen is not only presented by a specific population of migrating lung DCs but also by a resident DC population in the lymph node.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8670-8675
    • Belz, G.T.1    Smith, C.M.2    Kleinert, L.3    Reading, P.4    Brooks, A.5    Shortman, K.6    Carbone, F.R.7    Heath, W.R.8
  • 11
    • 3142720367 scopus 로고    scopus 로고
    • Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen
    • H.J. De Heer, H. Hammad, T. Soullie, D. Hijdra, N. Vos, M.A. Willart, H.C. Hoogsteden, and B.N. Lambrecht Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen J Exp Med 200 2004 89 98 This is the first description of pDCs in the lung and the first study showing a tolerogenic role for pDCs in vivo.
    • (2004) J Exp Med , vol.200 , pp. 89-98
    • De Heer, H.J.1    Hammad, H.2    Soullie, T.3    Hijdra, D.4    Vos, N.5    Willart, M.A.6    Hoogsteden, H.C.7    Lambrecht, B.N.8
  • 12
    • 0037121946 scopus 로고    scopus 로고
    • Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen
    • S.C. Eisenbarth, D.A. Piggott, J.W. Huleatt, I. Visintin, C.A. Herrick, and K. Bottomly Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen J Exp Med 196 2002 1645 1651
    • (2002) J Exp Med , vol.196 , pp. 1645-1651
    • Eisenbarth, S.C.1    Piggott, D.A.2    Huleatt, J.W.3    Visintin, I.4    Herrick, C.A.5    Bottomly, K.6
  • 13
    • 0036569813 scopus 로고    scopus 로고
    • Toll-like receptor 4 is required for optimal development of Th2 immune responses: Role of dendritic cells
    • K. Dabbagh, M.E. Dahl, P. Stepick-Biek, and D.B. Lewis Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells J Immunol 168 2002 4524 4530
    • (2002) J Immunol , vol.168 , pp. 4524-4530
    • Dabbagh, K.1    Dahl, M.E.2    Stepick-Biek, P.3    Lewis, D.B.4
  • 14
    • 0038152841 scopus 로고    scopus 로고
    • Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, mormally nonimmunogenic protein
    • M.K. Brimnes, L. Bonifaz, R.M. Steinman, and T.M. Moran Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, mormally nonimmunogenic protein J Exp Med 198 2003 133 144 In the absence of any PAMP, inhalation of harmless antigen leads to tolerance. Tolerance is broken by viral infection through induction of DC maturation.
    • (2003) J Exp Med , vol.198 , pp. 133-144
    • Brimnes, M.K.1    Bonifaz, L.2    Steinman, R.M.3    Moran, T.M.4
  • 16
    • 0034890907 scopus 로고    scopus 로고
    • Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
    • O. Akbari, R.H. DeKruyff, and D.T. Umetsu Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen Nat Immunol 2 2001 725 731
    • (2001) Nat Immunol , vol.2 , pp. 725-731
    • Akbari, O.1    Dekruyff, R.H.2    Umetsu, D.T.3
  • 18
    • 0033198184 scopus 로고    scopus 로고
    • Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells
    • D.C. Tsitoura, R.H. Dekruyff, J.R. Lamb, and D.T. Umetsu Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells J Immunol 163 1999 2592 2600
    • (1999) J Immunol , vol.163 , pp. 2592-2600
    • Tsitoura, D.C.1    Dekruyff, R.H.2    Lamb, J.R.3    Umetsu, D.T.4
  • 19
    • 0037514382 scopus 로고    scopus 로고
    • Lung CD25 CD4 Regulatory T Cells Suppress Type 2 Immune Responses but Not Bronchial Hyperreactivity
    • H. Hadeiba, and R.M. Locksley Lung CD25 CD4 Regulatory T Cells Suppress Type 2 Immune Responses But Not Bronchial Hyperreactivity J Immunol 170 2003 5502 5510
    • (2003) J Immunol , vol.170 , pp. 5502-5510
    • Hadeiba, H.1    Locksley, R.M.2
  • 20
    • 1542724420 scopus 로고    scopus 로고
    • CD4+CD25+ T Cells Regulate Airway Eosinophilic Inflammation by Modulating the Th2 Cell Phenotype
    • Z. Jaffar, T. Sivakuru, and K. Roberts CD4+CD25+ T Cells Regulate Airway Eosinophilic Inflammation by Modulating the Th2 Cell Phenotype J Immunol 172 2004 3842 3849
    • (2004) J Immunol , vol.172 , pp. 3842-3849
    • Jaffar, Z.1    Sivakuru, T.2    Roberts, K.3
  • 24
    • 1542574200 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor pathway in dendritic cells inhibits development of eosinophilic airway inflammation in a mouse model of asthma
    • H. Hammad, H.J. de Heer, T. Souillie, V. Angeli, F. Trottein, H.C. Hoogsteden, and B.N. Lambrecht Activation of peroxisome proliferator-activated receptor pathway in dendritic cells inhibits development of eosinophilic airway inflammation in a mouse model of asthma Am J Pathol 164 2004 263 271
    • (2004) Am J Pathol , vol.164 , pp. 263-271
    • Hammad, H.1    De Heer, H.J.2    Souillie, T.3    Angeli, V.4    Trottein, F.5    Hoogsteden, H.C.6    Lambrecht, B.N.7
  • 25
    • 0034654008 scopus 로고    scopus 로고
    • Induction of rapid T cell activation, division, and recirculation by intratracheal injection of dendritic cells in a TCR transgenic model
    • B.N. Lambrecht, R.A. Pauwels, and B. Fazekas De St Groth Induction of rapid T cell activation, division, and recirculation by intratracheal injection of dendritic cells in a TCR transgenic model J Immunol 164 2000 2937 2946
    • (2000) J Immunol , vol.164 , pp. 2937-2946
    • Lambrecht, B.N.1    Pauwels, R.A.2    Fazekas De St Groth, B.3
  • 26
    • 0037148511 scopus 로고    scopus 로고
    • Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: A novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis
    • P. McGuirk, C. McCann, and K.H. Mills Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis J Exp Med 195 2002 221 231
    • (2002) J Exp Med , vol.195 , pp. 221-231
    • McGuirk, P.1    McCann, C.2    Mills, K.H.3
  • 27
    • 1642343980 scopus 로고    scopus 로고
    • Mycobacterium vaccae induces a population of pulmonary CD11c+ cells with regulatory potential in allergic mice
    • V.C. Adams, J.R. Hunt, R. Martinelli, R. Palmer, G.A. Rook, and L.R. Brunet Mycobacterium vaccae induces a population of pulmonary CD11c+ cells with regulatory potential in allergic mice Eur J Immunol 34 2004 631 638 In a mouse model of asthma, treatment with the saprophytic Mycobacterium vaccae significantly reduces allergic inflammation by inducing IL-10, TGFβ and IFN-α in lung DCs.
    • (2004) Eur J Immunol , vol.34 , pp. 631-638
    • Adams, V.C.1    Hunt, J.R.2    Martinelli, R.3    Palmer, R.4    Rook, G.A.5    Brunet, L.R.6
  • 28
    • 0037100317 scopus 로고    scopus 로고
    • Characterization of a new subpopulation of mouse CD8alpha(+) B220(+) dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential
    • P. Martin, G.M. Del Hoyo, F. Anjuere, C.F. Arias, H.H. Vargas, L.A. Fernandez, V. Parrillas, and C. Ardavin Characterization of a new subpopulation of mouse CD8alpha(+) B220(+) dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential Blood 100 2002 383 390
    • (2002) Blood , vol.100 , pp. 383-390
    • Martin, P.1    Del Hoyo, G.M.2    Anjuere, F.3    Arias, C.F.4    Vargas, H.H.5    Fernandez, L.A.6    Parrillas, V.7    Ardavin, C.8
  • 30
    • 0035901102 scopus 로고    scopus 로고
    • Early childhood infectious diseases and the development of asthma up to school age: A birth cohort study
    • S. Illi, E. von Mutius, S. Lau, R. Bergmann, B. Niggemann, C. Sommerfeld, and U. Wahn Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study BMJ 322 2001 390 395
    • (2001) BMJ , vol.322 , pp. 390-395
    • Illi, S.1    Von Mutius, E.2    Lau, S.3    Bergmann, R.4    Niggemann, B.5    Sommerfeld, C.6    Wahn, U.7
  • 31
    • 0033987139 scopus 로고    scopus 로고
    • Dendritic cells are associated with augmentation of antigen sensitization by influenza a virus infection in mice
    • N. Yamamoto, S. Suzuki, A. Shirai, M. Suzuki, M. Nakazawa, Y. Nagashima, and T. Okubo Dendritic cells are associated with augmentation of antigen sensitization by influenza A virus infection in mice Eur J Immunol 30 2000 316 326
    • (2000) Eur J Immunol , vol.30 , pp. 316-326
    • Yamamoto, N.1    Suzuki, S.2    Shirai, A.3    Suzuki, M.4    Nakazawa, M.5    Nagashima, Y.6    Okubo, T.7
  • 32
    • 1542347573 scopus 로고    scopus 로고
    • Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells
    • M.E. Dahl, K. Dabbagh, D. Liggitt, S. Kim, and D.B. Lewis Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells Nat Immunol 5 2004 337 343 A mechanism for the observation that children infected with respiratory viruses have increased risk of asthma. IFNγ produced at the time of viral infection enhances the Th2 priming function of DCs.
    • (2004) Nat Immunol , vol.5 , pp. 337-343
    • Dahl, M.E.1    Dabbagh, K.2    Liggitt, D.3    Kim, S.4    Lewis, D.B.5
  • 33
    • 2942655175 scopus 로고    scopus 로고
    • 'Educated' dendritic cells act as messengers from memory to naive T helper cells
    • O. Alpan, E. Bachelder, E. Isil, H. Arnheiter, and P. Matzinger 'Educated' dendritic cells act as messengers from memory to naive T helper cells Nat Immunol 5 2004 615 622 This is a rigorous study using allophenic mice (genetic mosaics) showing that effector T cells can influence subsequent priming of T cells specific for a unrelated antigen by signalling via DCs.
    • (2004) Nat Immunol , vol.5 , pp. 615-622
    • Alpan, O.1    Bachelder, E.2    Isil, E.3    Arnheiter, H.4    Matzinger, P.5
  • 35
    • 0031775744 scopus 로고    scopus 로고
    • Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity
    • P.A. Stumbles, J.A. Thomas, C.L. Pimm, P.T. Lee, T.J. Venaille, S. Proksch, and P.G. Holt Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity J Exp Med 188 1998 2019 2031
    • (1998) J Exp Med , vol.188 , pp. 2019-2031
    • Stumbles, P.A.1    Thomas, J.A.2    Pimm, C.L.3    Lee, P.T.4    Venaille, T.J.5    Proksch, S.6    Holt, P.G.7
  • 36
    • 0037339779 scopus 로고    scopus 로고
    • Dendritic cells recruited to the lung shortly after intranasal delivery of Mycobacterium bovis BCG drive the primary immune response towards a type 1 cytokine production
    • M. Lagranderie, M.A. Nahori, A.M. Balazuc, H. Kiefer-Biasizzo, J.R. Lapa e Silva, G. Milon, G. Marchal, and B.B. Vargaftig Dendritic cells recruited to the lung shortly after intranasal delivery of Mycobacterium bovis BCG drive the primary immune response towards a type 1 cytokine production Immunology 108 2003 352 364
    • (2003) Immunology , vol.108 , pp. 352-364
    • Lagranderie, M.1    Nahori, M.A.2    Balazuc, A.M.3    Kiefer-Biasizzo, H.4    Lapa Silva, E.J.R.5    Milon, G.6    Marchal, G.7    Vargaftig, B.B.8
  • 37
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • G. Trinchieri Interleukin-12 and the regulation of innate resistance and adaptive immunity Nat Rev Immunol 3 2003 133 146
    • (2003) Nat Rev Immunol , vol.3 , pp. 133-146
    • Trinchieri, G.1
  • 39
    • 7044277061 scopus 로고    scopus 로고
    • Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization
    • H. Kuipers, C. Heirman, D. Hijdra, F. Muskens, M. Willart, A.J. Coyle, K. Thielemans, H.C. Hoogsteden, and B.N. Lambrecht Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization J Leukoc Biol 2004 DOI:10.1189/jlb.0604325
    • (2004) J Leukoc Biol
    • Kuipers, H.1    Heirman, C.2    Hijdra, D.3    Muskens, F.4    Willart, M.5    Coyle, A.J.6    Thielemans, K.7    Hoogsteden, H.C.8    Lambrecht, B.N.9
  • 41
    • 1642362240 scopus 로고    scopus 로고
    • Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production
    • D. Voehringer, K. Shinkai, and R.M. Locksley Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production Immunity 20 2004 267 277 Using IL-4 reporter mice it is shown that eosinophils, basophils and Th2 cells are early sources of IL-4 in helminth-induced eosinophilia. Eosinophil and Th2 cell recruitment depends on Stat6 expression by a bone-marrow-derived lung-tissue-resident DCs.
    • (2004) Immunity , vol.20 , pp. 267-277
    • Voehringer, D.1    Shinkai, K.2    Locksley, R.M.3
  • 42
    • 2342496710 scopus 로고    scopus 로고
    • Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
    • D. Amsen, J.M. Blander, G.R. Lee, K. Tanigaki, T. Honjo, and R.A. Flavell Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells Cell 117 2004 515 526 The authors provide a model for instructive Th2 development by DCs. The downstream Notch signalling molecule RBP Jκ directly induces GATA3 independently of STAT6.
    • (2004) Cell , vol.117 , pp. 515-526
    • Amsen, D.1    Blander, J.M.2    Lee, G.R.3    Tanigaki, K.4    Honjo, T.5    Flavell, R.A.6
  • 43
    • 0348135024 scopus 로고    scopus 로고
    • Dendritic-cell control of pathogen-driven T-cell polarization
    • M.L. Kapsenberg Dendritic-cell control of pathogen-driven T-cell polarization Nat Rev Immunol 3 2003 984 993
    • (2003) Nat Rev Immunol , vol.3 , pp. 984-993
    • Kapsenberg, M.L.1
  • 44
    • 0038448930 scopus 로고    scopus 로고
    • Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma
    • J.C. Huh, D.H. Strickland, F.L. Jahnsen, D.J. Turner, J.A. Thomas, S. Napoli, I. Tobagus, P.A. Stumbles, P.D. Sly, and P.G. Holt Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma J Exp Med 198 2003 19 30 The first description that antigen presentation to memory Th2 cells occurs by DCs in the respiratory epithelium, leading to bidirectional interactions.
    • (2003) J Exp Med , vol.198 , pp. 19-30
    • Huh, J.C.1    Strickland, D.H.2    Jahnsen, F.L.3    Turner, D.J.4    Thomas, J.A.5    Napoli, S.6    Tobagus, I.7    Stumbles, P.A.8    Sly, P.D.9    Holt, P.G.10
  • 45
    • 0036280217 scopus 로고    scopus 로고
    • Rapid response of circulating myeloid dendritic cells to inhaled allergen in asthmatic subjects
    • J.W. Upham, J.A. Denburg, and P.M. O'Byrne Rapid response of circulating myeloid dendritic cells to inhaled allergen in asthmatic subjects Clin Exp Allergy 32 2002 818 823
    • (2002) Clin Exp Allergy , vol.32 , pp. 818-823
    • Upham, J.W.1    Denburg, J.A.2    O'Byrne, P.M.3
  • 46
    • 0034778994 scopus 로고    scopus 로고
    • Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge
    • F.L. Jahnsen, E.D. Moloney, T. Hogan, J.W. Upham, C.M. Burke, and P.G. Holt Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge Thorax 56 2001 823 826
    • (2001) Thorax , vol.56 , pp. 823-826
    • Jahnsen, F.L.1    Moloney, E.D.2    Hogan, T.3    Upham, J.W.4    Burke, C.M.5    Holt, P.G.6
  • 47
    • 3442892041 scopus 로고    scopus 로고
    • Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma
    • L.S. Van Rijt, N. Vos, M. Willart, A. Kleinjan, A.J. Coyle, H.C. Hoogsteden, and B.N. Lambrecht Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma J Allergy Clin Immunol 114 2004 166 173 DCs are sufficient to induce all the features of asthma in sensitized mice. During secondary immune responses, co-stimulation by B7 family members is not necessary.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 166-173
    • Van Rijt, L.S.1    Vos, N.2    Willart, M.3    Kleinjan, A.4    Coyle, A.J.5    Hoogsteden, H.C.6    Lambrecht, B.N.7
  • 48
    • 0038785779 scopus 로고    scopus 로고
    • Matrix metalloproteinse-9-mediated dendritic cell recruitment into the airways is a critical step in mouse model of asthma
    • K. Vermaelen, D. Cataldo, K.G. Tournoy, T. Maes, A. Dhulst, R. Louis, J.-M. Foidart, A. Noel, and R.A. Pauwels Matrix metalloproteinse-9-mediated dendritic cell recruitment into the airways is a critical step in mouse model of asthma J Immunol 171 2003 1016 1022 Nice paper showing the necessity for matrix metalloproteinase 9 in DC migration in the lung. Lung DCs are a predominant source of TARC.
    • (2003) J Immunol , vol.171 , pp. 1016-1022
    • Vermaelen, K.1    Cataldo, D.2    Tournoy, K.G.3    Maes, T.4    Dhulst, A.5    Louis, R.6    Foidart, J.-M.7    Noel, A.8    Pauwels, R.A.9
  • 49
    • 1642457392 scopus 로고    scopus 로고
    • Monocyte-derived dendritic cells exposed to der p 1 allergen enhance the recruitment of Th2 cells: Major involvement of the chemokines TARC/CCL17 and MDC/CCL22
    • H. Hammad, H.H. Smits, C. Ratajczak, A. Nithiananthan, E.A. Wierenga, G.A. Stewart, A. Jacquet, A.B. Tonnel, and J. Pestel Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC/CCL17 and MDC/CCL22 Eur Cytokine Netw 14 2003 219 228
    • (2003) Eur Cytokine Netw , vol.14 , pp. 219-228
    • Hammad, H.1    Smits, H.H.2    Ratajczak, C.3    Nithiananthan, A.4    Wierenga, E.A.5    Stewart, G.A.6    Jacquet, A.7    Tonnel, A.B.8    Pestel, J.9
  • 51
    • 0032522829 scopus 로고    scopus 로고
    • Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice
    • B.N. Lambrecht, B. Salomon, D. Klatzmann, and R.A. Pauwels Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice J Immunol 160 1998 4090 4097
    • (1998) J Immunol , vol.160 , pp. 4090-4097
    • Lambrecht, B.N.1    Salomon, B.2    Klatzmann, D.3    Pauwels, R.A.4
  • 52
    • 0141989811 scopus 로고    scopus 로고
    • Airway eosinophils accumulate in the mediastinal lymph nodes but lack antigen-presenting potential for naive T cells
    • L.S. Van Rijt, N. Vos, D. Hijdra, V.C. De Vries, H.C. Hoogsteden, and B.N. Lambrecht Airway eosinophils accumulate in the mediastinal lymph nodes but lack antigen-presenting potential for naive T cells J Immunol 171 2003 3372 3378
    • (2003) J Immunol , vol.171 , pp. 3372-3378
    • Van Rijt, L.S.1    Vos, N.2    Hijdra, D.3    De Vries, V.C.4    Hoogsteden, H.C.5    Lambrecht, B.N.6
  • 54
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • S. Gordon Alternative activation of macrophages Nat Rev Immunol 3 2003 23 35
    • (2003) Nat Rev Immunol , vol.3 , pp. 23-35
    • Gordon, S.1
  • 55
    • 0042512461 scopus 로고    scopus 로고
    • Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells
    • S. Yamazaki, T. Iyoda, K. Tarbell, K. Olson, K. Velinzon, K. Inaba, and R.M. Steinman Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells J Exp Med 198 2003 235 247 Only mature DCs can induce the expansion of Treg cells. Expanded Treg cells have enhanced suppression function. The use of DCs to expand Tregs could be used therapeutically.
    • (2003) J Exp Med , vol.198 , pp. 235-247
    • Yamazaki, S.1    Iyoda, T.2    Tarbell, K.3    Olson, K.4    Velinzon, K.5    Inaba, K.6    Steinman, R.M.7
  • 56
    • 0037446531 scopus 로고    scopus 로고
    • Cutting edge: Cure of colitis by CD4+CD25+ regulatory T cells
    • C. Mottet, H.H. Uhlig, and F. Powrie Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells J Immunol 170 2003 3939 3943 First report that Tregs, effector T cells and DCs cluster within sites of chronic inflammation.
    • (2003) J Immunol , vol.170 , pp. 3939-3943
    • Mottet, C.1    Uhlig, H.H.2    Powrie, F.3
  • 58
    • 0035903307 scopus 로고    scopus 로고
    • Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells
    • A. Iellem, M. Mariani, R. Lang, H. Recalde, P. Panina-Bordignon, F. Sinigaglia, and D. D'Ambrosio Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells J Exp Med 194 2001 847 853
    • (2001) J Exp Med , vol.194 , pp. 847-853
    • Iellem, A.1    Mariani, M.2    Lang, R.3    Recalde, H.4    Panina-Bordignon, P.5    Sinigaglia, F.6    D'Ambrosio, D.7
  • 59
    • 0347480215 scopus 로고    scopus 로고
    • CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells
    • P. Serra, A. Amrani, J. Yamanouchi, B. Han, S. Thiessen, T. Utsugi, J. Verdaguer, and P. Santamaria CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells Immunity 19 2003 877 889 Treg cells suppress the maturation of DCs in a model of diabetes. Suppression is broken by innate immune signals or T cell cognate contact through CD40L.
    • (2003) Immunity , vol.19 , pp. 877-889
    • Serra, P.1    Amrani, A.2    Yamanouchi, J.3    Han, B.4    Thiessen, S.5    Utsugi, T.6    Verdaguer, J.7    Santamaria, P.8
  • 60
    • 12144285752 scopus 로고    scopus 로고
    • Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation
    • O. Fainaru, E. Woolf, J. Lotem, M. Yarmus, O. Brenner, D. Goldenberg, V. Negreanu, Y. Bernstein, D. Levanon, and S. Jung Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation EMBO J 23 2004 969 979 An elegant study, in which deficiency of downstream signalling through TGFβ leads to accumulation of mature DCs into the lung and spontaneous eosinophilic airway inflammation.
    • (2004) EMBO J , vol.23 , pp. 969-979
    • Fainaru, O.1    Woolf, E.2    Lotem, J.3    Yarmus, M.4    Brenner, O.5    Goldenberg, D.6    Negreanu, V.7    Bernstein, Y.8    Levanon, D.9    Jung, S.10
  • 63
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • C. Pasare, and R. Medzhitov Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells Science 299 2003 1033 1036 Authors show that DC-derived IL-6 and an unidentified soluble factor render effector T cells resistant to Treg regulation after TLR ligation.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2


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