Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling

Journal of Allergy and Clinical Immunology

Volumn 111, Issue 1 SUPPL., 2003, Pages

  Holgate, Stephen T ^a,e   Peters Golden, Marc ^b   Panettieri, Reynold A ^c   Henderson Jr , William R ^d   Bisgaard, Hans ^f   Sampson, Anthony ^f   Hamid, Qutayba ^f   Liu, Mark ^f   Peters, Stephen ^f   Henderson, Bill ^f  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^e SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^f NONE

Author keywords

Airway inflammation; Airway remodeling; Asthma pathophysiology; Cysteinyl leukotrienes; Epithelial mesenchymal trophic unit

Indexed keywords

FIBRONECTIN; INTERLEUKIN 13; INTERLEUKIN 4; LAMININ; LEUKOTRIENE RECEPTOR BLOCKING AGENT; PEPTIDOLEUKOTRIENE; PROSTAGLANDIN E2; TENASCIN;

AIRWAY OBSTRUCTION; CALCIUM MOBILIZATION; CELL FUNCTION; CELL PROLIFERATION; CONFERENCE PAPER; CYTOKINE RELEASE; DRUG EFFECT; EPITHELIUM CELL; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; LUNG FIBROSIS; MESENCHYME CELL; MUSCLE TONE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; RESPIRATORY TRACT INFECTION; SMOOTH MUSCLE FIBER;

EID: 0037246364     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2003.25     Document Type: Conference Paper

References (127)

1. ST Holgate Genetic and environmental interactions in allergy and asthma J Allergy Clin Immunol 104 1999 1139 1146
2. S Lau S Illi C Sommerfeld Early exposure to house-dust mite and cat allergens and development of childhood asthma: A cohort study: Multicentre Allergy Study Group Lancet 356 2000 1392 1397
3. SS Salsi KS Babu ST Holgate Is asthma really due to a polarized T cell response toward a helper T cell type 2 phenotype? Am J Respir Crit Care Med 164 2001 1343 1346
4. MJ Leckie A ten Brinke J Khan Effects of interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness and the late asthmatic response Lancet 356 2000 2144 2148
5. JC Kips BJ O’Connor SJ Langley Results of a phase 1 trial with SCH 55700, a humanised anti-IL-5 antibody in severe persistent asthma [abstract] Am J Respir Crit Care Med 161 2000 A505
6. LR Skadhauge K Christensen KO Kyvik Genetic and environmental influence on asthma: A population-based study of 11,688 Danish twin pairs Eur Respir J 13 1999 8 14
7. I Rahman W MacNee Oxidative stress and regulation of glutathione in lung inflammation Eur Respir J 16 2000 534 554
8. A Seaton G Devereux Diet, infection and wheezy illness: Lessons from adults Pediatr Allergy Immunol 11 Suppl 13 2000 37 40
9. SL Johnston The role of viral and atypical bacterial pathogens in asthma pathogenesis Pediatr Pulmonol Suppl 18 1999 141 143
10. DJ Klinke AK Lewis S-P Wong Airway hyperresponsiveness: Exploration of mechanisms using a dynamic, computer based model [abstract] Am J Respir Crit Care Med 163 2001 A832
11. P Lange J Parner J Vestbo A 15-year follow-up study of ventilatory function in adults with asthma N Engl J Med 339 1998 1194 1200
12. H Cokugras N Akcakaya Seckin Y Camcioglu Ultrastructural examination of bronchial biopsy specimens from children with moderate asthma Thorax 56 2001 25 29
13. P Pohunek WR Roche J Tarzikova Eosinophilic inflammation in the bronchial mucosa of children with bronchial asthma [abstract] Eur Respir J 10 Suppl 25 1997 160s
14. Long-term effects of budesonide or nedocromil in children with asthma: The Childhood Asthma Management Program Research Group N Engl J Med 343 2000 1054 1063
15. CE Brightling P Bradding FA Symon Mast-cell infiltration of airway smooth muscle in asthma N Engl J Med 346 2002 1699 1705
16. KF Chung PJ Barnes Cytokines in asthma Thorax 54 1999 825 857
17. C Ordonez R Ferrando DM Hyde Epithelial desquamation in asthma: Artifact or pathology? Am J Respir Crit Care Med 162 2000 2324 2329
18. SM Puddicombe R Polosa A Richter Involvement of the epidermal growth factor receptor in epithelial repair in asthma FASEB J 14 2000 1362 1374
19. F Bucchieri J Lordan D Richter Increased sensitivity of asthmatic bronchial epithelial cells to oxidant-induced injury [abstract] Am J Respir Crit Care Med 161 2000 A153
20. CE Brewster PH Howarth R Djukanovic Myofibroblasts and subepithelial fibrosis in bronchial asthma Am J Respir Cell Mol Biol 1990 3
21. S Zhang H Smartt ST Holgate Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: An in vitro co-culture model of airway remodeling in asthma Lab Invest 79 1999 395 405
22. M Hoshino Y Nakamura JJ Sim Inhaled corticosteroid reduced lamina reticularis of the basement membrane by modulation of insulin-like growth factor (IGF)-I expression in bronchial asthma Clin Exp Allergy 28 1998 568 577
23. A Richter SM Puddicombe J Lordan The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma Am J Respir Cell Mol Biol 25 2001 385 391
24. D Warburton M Schwarz D Tefft The molecular basis of lung morphogenesis Mech Dev 92 2000 55 81
25. ST Holgate DE Davies PM Lackie Epithelial-mesenchymal intereactions in the pathogenesis of asthma J Allergy Clin Immunol 105 2000 193 204
26. C Laprise M Laviolette M Boutet Asymptomatic airway hyperresponsiveness: Relationships with airway inflammation and remodelling Eur Respir J 14 1999 63 73
27. C Dezateux J Stocks Lung development and early origins of respiratory illness Br Med Bull 53 1997 40 57
28. Z Zhu RJ Homer Z Wang Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production J Clin Invest 103 1999 779 788
29. RE Mullings SJ Wilson SM Puddicombe Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium J Allergy Clin Immunol 108 2001 832 838
30. JL Lordan F Bucchieri A Richter Co-operative effects of Th-2 cytokines and allergen on normal and asthmatic bronchial epithelial cells J Immunol 169 2002 407 414
31. R Rajah SE Nunn DJ Herrick Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells Am J Physiol 271 1996 L1014 L1022
32. RA Panettieri EM Tan V Ciocca Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction in vitro: Differential sensitivity to cysteinyl leukotriene receptor antagonists Am J Respir Cell Mol Biol 19 1998 453 461
33. AJ James PM Lackie L Corbett Expression and regulation of leukotriene pathway enzymes in human airway smooth muscle cells [abstract] Am J Respir Crit Care Med 163 2001 A513
34. AJ James PM Lackie AP Sampson The expression of leukotriene pathway enzymes in human bronchial epithelial cells [abstract] Eur Respir J 14 1999 365S
35. D Steinhilber O Radmark B Samuelsson Transforming growth factor beta upregulates 5-lipoxygenase activity during myeloid cell maturation Proc Natl Acad Sci U S A 90 1993 5984 5988
36. 4 synthase expression in the monocyte-like cell line, THP-1 J Immunol 162 1999 1101 1107
37. L Baud J Perez M Denis Modulation of fibroblast proliferation by sulfidopeptide leukotrienes: Effect of indomethacin J Immunol 138 1987 1190 1195
38. 4 to rat lung fibroblasts and stimulation of collagen synthesis in vitro Biochemistry 27 1988 2846 2853
39. M Selman TE King A Pardo Idiopathic pulmonary fibrosis: Prevailing and evolving hypotheses about its pathogenesis and implications for therapy Ann Intern Med 134 2001 136 151
40. T Ozaki H Hayashi K Tani Neutrophil chemotactic factors in the respiratory tract of patients with chronic airway diseases or idiopathic pulmonary fibrosis Am Rev Respir Dis 145 1992 85 91
41. J Wilborn M Bailie M Coffey Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis J Clin Invest 97 1996 1827 1836
42. M Peters-Golden M Bailie T Marshall Protection from pulmonary fibrosis in leukotriene-deficient mice Am J Respir Crit Care Med 165 2002 229 235
43. O Kowal-Bielecka O Distler M Neidhart Evidence of 5-lipoxygenase overexpression in the skin of patients with systemic sclerosis: A newly identified pathway to skin inflammation in systemic sclerosis Arthritis Rheum 44 2001 1865 1875
44. L Alric E Pinelli G Carrera Involvement of calcium in macrophage leukotriene release during experimental cirrhosis Hepatology 23 1996 614 622
45. ST Holgate P Lackie S Wilson Bronchial epithelium as a key regulator of airway allergen sensitization and remodeling in asthma Am J Respir Crit Care Med 162 2000 S113 S117
46. PR Gray FJ Derksen NE Robinson Epithelial strips: An alternative technique for examining arachidonate metabolism in equine tracheal epithelium Am J Respir Cell Mol Biol 6 1992 29 36
47. JB Chauncey M Peters-Golden RH Simon Arachidonic acid metabolism by rat alveolar epithelial cells Lab Invest 58 1988 133 140
48. T Kohyama RF Ertl V Valenti Prostaglandin E(2) inhibits fibroblast chemotaxis Am J Physiol Lung Cell Mol Physiol 281 2001 L1257 L1263
49. MG Belvisi M Saunders M Yacoub Expression of cyclo-oxygen-ase-2 in human airway smooth muscle is associated with profound reductions in cell growth Br J Pharmacol 125 1998 1102 1108
50. PB Bitterman MD Wewers SI Rennard Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators J Clin Invest 77 1986 700 708
51. RH Goldstein P Polgar The effect and interaction of bradykinin and prostaglandins on protein and collagen production by lung fibroblasts J Biol Chem 257 1982 8630 8633
52. 2 Free Radic Biol Med 3 1987 15 20
53. 2 J Immunol 152 1994 5703 5713
54. 2 mechanism J Immunol 151 1993 2096 2104
55. 2 regulates macrophage-derived tumor necrosis factor gene expression J Biol Chem 263 1988 5380 5384
56. J Heusinger-Ribeiro M Eberlein NA Wahab Expression of connective tissue growth factor in human renal fibroblasts: Regulatory roles of RhoA and cAMP J Am Soc Nephrol 12 2001 1853 1861
57. 2 and prostacyclin inhibit the production and secretion of endothelin from cultured endothelial cells J Biol Chem 269 1994 11938 11944
58. C Picado JC Fernandez-Morata M Juan Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics Am J Respir Crit Care Med 160 1999 291 296
59. M Peters-Golden A Feyssa Transcellular eicosanoid synthesis in cocultures of alveolar epithelial cells and macrophages Am J Physiol 264 1993 L438 L447
60. SH Gavett SL Madison PC Chulada Allergic lung responses are increased in prostaglandin H synthase-deficient mice J Clin Invest 104 1999 721 732
61. 4, and histamine in normal human subjects Thorax 39 1984 500 504
62. C Labat JL Ortiz X Norel A second cysteinyl leukotriene receptor in human lung J Pharmacol Exp Ther 263 1992 800 805
63. RA Coleman RM Eglen RL Jones Prostanoid and leukotriene receptors: A progress report from the IUPHAR working parties on classification and nomenclature Adv Prostaglandin Thromboxane Leukot Res 23 1995 283 285
64. KM Metters Leukotriene receptors J Lipid Mediat Cell Signal 12 1995 413 427
65. I Gorenne X Norel C Brink Cysteinyl leukotriene receptors in the human lung: What's new? Trends Pharmacol Sci 17 1996 342 345
66. CE Heise BF O’Dowd DJ Figueroa Characterization of the human cysteinyl leukotriene 2 receptor J Biol Chem 275 2000 30531 30536
67. 2+-independent Am J Respir Crit Care Med 163 2001 266 272
68. KR Lynch GP O’Neill Q Liu Characterization of the human cysteinyl leukotriene CysLT1 receptor Nature 399 1999 789 793
69. JE Gern WW Busse Association of rhinovirus infections with asthma Clin Microbiol Rev 12 1999 9 18
70. Y Amrani PE Moore R Hoffman Interferon-gamma modulates cysteinyl leukotriene receptor-1 expression and function in human airway myocytes Am J Respir Crit Care Med 164 2001 2098 2101
71. DJ Figueroa RM Breyer SK Defoe Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes Am J Respir Crit Care Med 163 2001 226 233
72. M Cembrzynska-Nowak E Szklarz AD Inglot Elevated release of tumor necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma Am Rev Respir Dis 147 1993 291 295
73. FH Guo SA Comhair S Zheng Molecular mechanisms of increased nitric oxide (NO) in asthma: Evidence for transcriptional and post-translational regulation of NO synthesis J Immunol 164 2000 5970 5980
74. D Sampath M Castro DC Look Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma J Clin Invest 103 1999 1353 1361
75. EM Hessel AJ Van Oosterhout I Van Ark Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration Am J Respir Cell Mol Biol 16 1997 325 334
76. DB Jacoby HQ Xiao NH Lee Virus- and interferon-induced loss of inhibitory M2 muscarinic receptor function and gene expression in cultured airway parasympathetic neurons J Clin Invest 102 1998 242 248
77. SM van Schaik RC Welliver JL Kimpen Novel pathways in the pathogenesis of respiratory syncytial virus disease Pediatr Pulmonol 30 2000 131 138
78. DK Ng AK Law KW Chau Use of montelukast in the treatment of early childhood wheezing from clinical experience with three cases Respirology 5 2000 389 392
79. B Fabry GN Maksym SA Shore Selected contribution: Time course and heterogeneity of contractile responses in cultured human airway smooth muscle cells J Appl Physiol 91 2001 986 994
80. RD Hubmayr SA Shore JJ Fredberg Pharmacological activation changes stiffness of cultured human airway smooth muscle cells Am J Physiol 271 1996 C1660 C1668
81. B Everding S Wilhelm S Averesch IFN-gamma-induced change in microtubule organization and alpha-tubulin expression during growth inhibition of lung squamous carcinoma cells J Interferon Cytokine Res 20 2000 983 990
82. Y Amrani H Chen RA Panettieri Jr Activation of tumor necrosis factor receptor 1 in airway smooth muscle: A potential pathway that modulates bronchial hyper-responsiveness in asthma? Respir Res 1 2000 49 53
83. DW Hay Pharmacology of leukotriene receptor antagonists: More than inhibitors of bronchoconstriction Chest 111 1997 35S 45S
84. AN Fonteh T LaPorte D Swan A decrease in remodeling accounts for the accumulation of arachidonic acid in murine mast cells undergoing apoptosis J Biol Chem 276 2001 1439 1449
85. J Gu Y Liu Y Wen Evidence that increased 12-lipoxygenase activity induces apoptosis in fibroblasts J Cell Physiol 186 2001 357 365
86. 4 in allergen-induced increases in airway smooth muscle in the rat Am Rev Respir Dis 148 1993 413 417
87. 4 facilitates airway smooth muscle cell proliferation via modulation of the IGF axis Am J Physiol 269 1995 L151 L157
88. JA Elias Z Zhu G Chupp Airway remodeling in asthma J Clin Invest 104 1999 1001 1006
89. T Aikawa S Shimura H Sasaki Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack Chest 101 1992 916 921
90. M Jonas ML Su WR Henderson In situ hybridization and immunochemistry of type 1 collagen in idiopathic and asthmatic lung fibrosis [abstract] Am J Respir Crit Care Med 151 1995 A704
91. LP Boulet M Laviolette H Turcotte Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine Chest 112 1997 45 52
92. B Eckes P Zigrino D Kessler Fibroblast-matrix interactions in wound healing and fibrosis Matrix Biol 19 2000 325 332
93. EM Minshall DY Leung RJ Martin Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma Am J Respir Cell Mol Biol 17 1997 326 333
94. JD Aubert S Hayashi J Hards Platelet-derived growth factor and its receptor in lungs from patients with asthma and chronic airflow obstruction Am J Physiol 266 1994 L655 L663
95. WW Busse S Banks-Schlegel SE Wenzel Pathophysiology of severe asthma J Allergy Clin Immunol 106 2000 1033 1042
96. M Hoshino Y Nakamura JJ Sim Expression of growth factors and remodelling of the airway wall in bronchial asthma Thorax 53 1998 21 27
97. CS Ulrik Outcome of asthma: Longitudinal changes in lung function Eur Respir J 13 1999 904 918
98. K Chan M Koss R Barbers Remodeling in near-fatal asthma [abstract] J Allergy Clin Immunol 105 2000 S193
99. SE Wenzel LB Schwartz EL Langmack Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics Am J Respir Crit Care Med 160 1999 1001 1008
100. SE Wenzel SJ Szefler DY Leung Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids Am J Respir Crit Care Med 156 1997 737 743
101. JW Wilson X Li Inflammation and cytokines in airway wall remodelling 1996 CRC Press Inc Boca Raton, Fla
102. M Romaris A Heredia A Molist Differential effect of transforming growth factor beta on proteoglycan synthesis in human embryonic lung fibroblasts Biochim Biophys Acta 1093 1991 229 233
103. WR Henderson Jr DB Lewis RK Albert The importance of leukotrienes in airway inflammation in a mouse model of asthma J Exp Med 184 1996 1483 1494
104. Y Zhang WJ Lamm RK Albert Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response Am J Respir Crit Care Med 155 1997 661 669
105. WR Henderson Jr EY Chi RK Albert Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma J Clin Invest 100 1997 3083 3092
106. SJ Chu LO Tang E Watney In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade J Immunol 165 2000 4640 4648
107. WR Henderson LO Tang SJ Chu A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model Am J Respir Crit Care Med 165 2002 108 116
108. B Knorr J Matz JA Bernstein Montelukast for chronic asthma in 6- to 14-year-old children: A randomized, double-blind trial. Pediatric Montelukast Study Group JAMA 279 1998 1181 1186
109. MJ Noonan P Chervinsky M Brandon Montelukast, a potent leukotriene receptor antagonist, causes dose-related improvements in chronic asthma: Montelukast Asthma Study Group Eur Respir J 11 1998 1232 1239
110. K Malmstrom G Rodriguez-Gomez J Guerra Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma: A randomized, controlled trial: Montelukast/Beclomethasone Study Group Ann Intern Med 130 1999 487 495
111. E Pizzichini JA Leff TF Reiss Montelukast reduces airway eosinophilic inflammation in asthma: A randomized, controlled trial Eur Respir J 14 1999 12 18
112. B Volovitz E Tabachnik M Nussinovitch Montelukast, a leukotriene receptor antagonist, reduces the concentration of leukotrienes in the respiratory tract of children with persistent asthma J Allergy Clin Immunol 104 1999 1162 1167
113. A Macfarlane Zafirlukast and low dose beclomethasone protect against early (EAR) and late asthmatic responses (LAR) and allergen induced eosinophilia in mild atopic asthma Eur Respir J 14 1999 S121
114. Z Diamant DC Grootendorst M Veselic-Charvat The effect of montelukast (MK-0476), a cysteinyl leukotriene receptor antagonist, on allergen-induced airway responses and sputum cell counts in asthma Clin Exp Allergy 29 1999 42 51
115. E Lee T Robertson J Smith Leukotriene receptor antagonists and synthesis inhibitors reverse survival in eosinophils of asthmatic individuals Am J Respir Crit Care Med 161 2000 1881 1886
116. E Israel R Dermarkarian M Rosenberg The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air N Engl J Med 323 1990 1740 1744
117. LA Laitinen A Laitinen T Haahtela Leukotriene E4 and granulocytic infiltration into asthmatic airways Lancet 341 1993 989 990
118. D Ihaku L Cameron M Suzuki Montelukast, a leukotriene receptor antagonist, inhibits the late airway response to antigen, airway eosinophilia, and IL-5-expressing cells in Brown Norway rats J Allergy Clin Immunol 104 1999 1147 1154
119. T Hisada M Salmon Y Nasuhara Cysteinyl-leukotrienes partly mediate eotaxin-induced bronchial hyperresponsiveness and eosinophilia in IL-5 transgenic mice Am J Respir Crit Care Med 160 1999 571 575
120. Y Tohda H Nakahara H Kubo Effects of ONO-1078 (pranlukast) on cytokine production in peripheral blood mononuclear cells of patients with bronchial asthma Clin Exp Allergy 29 1999 1532 1536
121. 4, increase the release of mucus from human airways in vitro Am Rev Respir Dis 126 1982 449 451
122. JD Lundgren JH Shelhamer Pathogenesis of airway mucus hypersecretion J Allergy Clin Immunol 85 1990 399 417
123. S Sapienza T Du DH Eidelman Structural changes in the airways of sensitized Brown Norway rats after antigen challenge Am Rev Respir Dis 144 1991 423 427
124. M Salmon DA Walsh TJ Huang Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats Br J Pharmacol 127 1999 1151 1158
125. SH Phan BM McGarry KM Loeffler Regulation of macrophage-derived fibroblast growth factor release by arachidonate metabolites J Leukoc Biol 42 1987 106 113
126. S Meghji JR Sandy W Harvey Stimulation of bone collagen and non-collagenous protein synthesis by products of 5- and 12-lipoxygen-ase: Determination by use of a simple quantitative assay Bone Miner 18 1992 119 132
127. 4 upregulates collagenase expression and synthesis in human lung fibroblasts Biochim Biophys Acta 1224 1994 168 174