Targeting the metabotropic glutamate receptor mGluR4 for the treatment of diseases of the central nervous system

Current Topics in Medicinal Chemistry

Volumn 5, Issue 9, 2005, Pages 885-895

  Marino, Michael J ^a   Hess, J Fred ^a   Liverton, Nigel ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Glutamate; mGluR4; Parkinson's disease

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; 2 METHYL 6 (2 PHENYLVINYL)PYRIDINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 4 AMINOBUTYRIC ACID; BICUCULLINE; BINDING PROTEIN; CYCLOBUTANE DERIVATIVE; CYCLOPENTANE DERIVATIVE; CYSTEIC ACID; CYSTEINE SULFINIC ACID; GLUTAMATE RECEPTOR AGONIST; GLUTAMIC ACID; HOMOCYSTEIC ACID; HOMOCYSTEINE SULFINIC ACID; LY 387379; MEMBRANE PROTEIN; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 4; METABOTROPIC RECEPTOR 4 AGONIST; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR 6; METABOTROPIC RECEPTOR 7; METABOTROPIC RECEPTOR 8; METABOTROPIC RECEPTOR AGONIST; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RANTES; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTICONVULSANT ACTIVITY; APOPTOSIS; CENTRAL NERVOUS SYSTEM DISEASE; DEGENERATIVE DISEASE; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; EPILEPSY; EXCITOTOXICITY; HUMAN; LIGAND BINDING; MOLECULAR CLONING; NERVOUS SYSTEM INJURY; NEUROPROTECTION; NONHUMAN; PALLIATIVE THERAPY; PARKINSON DISEASE; PATHOPHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; RECEPTOR AFFINITY; REVIEW;

ANIMALS; CENTRAL NERVOUS SYSTEM DISEASES; DRUG DELIVERY SYSTEMS; DRUG DESIGN; EXCITATORY AMINO ACID AGONISTS; HUMANS; LIGANDS; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 24644438160     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568026054750263     Document Type: Review

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