Polyamine depletion prevents camptothecin-induced apoptosis by inhibiting the release of cytochrome c

American Journal of Physiology - Cell Physiology

Volumn 282, Issue 6 51-6, 2002, Pages

  Yuan, Qing ^a   Ray, Ramesh M ^a   Johnson, Leonard R ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Bcl 2 protein; Caspase 9; Mitochondria; Polyamines; difluoromethylornithine

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CAMPTOTHECIN; CASPASE 3; CASPASE 9; CYTOCHROME C; EFLORNITHINE; ORNITHINE DECARBOXYLASE; POLYAMINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; EPITHELIUM CELL; INTESTINE CELL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM;

ANIMALIA; MAMMALIA;

EID: 0036080433     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00351.2001     Document Type: Article

References (71)

1. Apoptosis induced by inhibition of intercellular contact
2. Differential expression of the VLA family of integrins along the crypt-villus axis in the human small intestine
3. Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis
4. Mitochondria and cell death. Mechanistic aspects and methodological issues
5. Modulation of tumor cell proliferation and apoptosis by polyamine depletion in cells of head and neck squamous cell carcinomas
6. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
7. Biochemical pathways of caspase activation during apoptosis
8. Dissociation of mitochondrial depolarization from cytochrome c release during apoptosis induced by photodynamic therapy
9. Polyamine-depletion induces p27Kip1 and enhances dexamethasone-induced G1 arrest and apoptosis in human T lymphoblastic leukemia cells
10. Setting a new standard-irinotecan (Campto) in the second-line therapy of colorectal cancer: Final results of two phase III studies and implications for clinical practice
11. A phase III study of irinotecan (CPT-11) vs. best supportive care in patients with metastatic colorectal cancer who have failed 5-fluorouracil therapy
12. Dissecting the pathways to death
13. Bcl-2 inhibits early apoptotic events and reveals postmitotic multinucleation without affecting cell cycle arrest in human epithelial tumor cells exposed to etoposide
14. 2+ ions
15. Apoptosis in human disease: A new skin for the old ceremony?
16. Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL
17. Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells
18. Regulated targeting of BAX to mitochondria
19. Mitochondria and apoptosis
20. BCL-2 family members and the mitochondria in apoptosis
21. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death
22. In vivo analysis of cadherin function in the mouse intestinal epithelium: Essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death
23. alpha-Difluoromethylornithine blocks thymocyte apoptosis via a reduction in tyrosine phosphorylation
24. Bax directly induces release of cytochrome c from isolated mitochondria
25. Bcl-2-family proteins: The role of the BH3 domain in apoptosis
26. Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH
27. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
28. Death and survival signals determine active/inactive conformations of pro-apoptotic BAX, BAD, and BID molecules
29. The mitochondrial death/life regulator in apoptosis and necrosis
30. Mitochondrial depolarization is not required for neuronal apoptosis
31. Cleavage of BID by caspase-8 mediates the mitochondrial damage in the Fas pathway of apoptosis
32. NF-ΚB activation and susceptibility to apoptosis after polyamine depletion in intestinal epithelial cells
33. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
34. Mechanism of action of camptothecin
35. The mitochondrion in cell death control: Certainties and incognita
36. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
37. The structure, function, and evolution of cytochromes
38. Increased intestinal Bak expression results in apoptosis
39. Bcl-2 inhibits a Fas-induced conformational change in the Bax N terminus and Bax mitochondrial translocation
40. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
41. Caspases: The proteases of the apoptotic pathway
42. Inhibition of ornithine decarboxylase by alpha-difluoromethylornithine induces apoptosis of HC11 mouse mammary epithelial cells
43. Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase-overproducing L1210 cells
44. BAX translocation is a critical event in neuronal apoptosis: Regulation by neuroprotectants, BCL-2, and caspases
45. Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria
46. Cell death by apoptosis: Basic concepts and disease relevance for the gastroenterologist
47. Polyamine depletion delays apoptosis of rat intestinal epithelial cells
48. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
49. Bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis
50. Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: A potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release
51. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
52. Spermine causes caspase activation in leukemia cells
53. Spermine triggers the activation of caspase-3 in a cell-free model of apoptosis
54. Effect of polyamine depletion on caspase activation: A study with spermine synthase-deficient cells
55. Polyamines directly induce release of cytochrome c from heart mitochondria
56. Molecular characterization of mitochondrial apoptosis-inducing factor
57. Alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model
58. Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis
59. Caspases: Enemies within
60. Control of apoptosis by proteases
61. Bcl-2 family: Life-or-death switch
62. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria
63. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB
64. Movement of Bax from the cytosol to mitochondria during apoptosis
65. Signal transduction activated by the cancer chemopreventive isothiocyanates: Cleavage of BID protein, tyrosine phosphorylation and activation of JNK
66. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
67. Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes
68. Putrescine does not support the migration and growth of IEC-6 cells
69. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis
70. Mitochondrial control of nuclear apoptosis
71. Release of mitochondrial cytochrome c is upstream of caspase activation in chemical-induced apoptosis in human monocytic tumor cells