Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells

Molecular and Cellular Biology

Volumn 25, Issue 17, 2005, Pages 7854-7867

  Bird, Catherina H ^a   Sun, Jiuru ^a   Ung, Kheng ^a   Karambalis, Diana ^a   Whisstock, James C ^a   Trapani, Joseph A ^b   Bird, Phillip I ^a  

^a MONASH UNIVERSITY   (Australia)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROITIN SULFATE; GLYCOSAMINOGLYCAN; GRANZYME B; HEPARIN DERIVATIVE; MANNOSE 6 PHOSPHATE; PROTEOGLYCAN;

ADSORPTION; AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CELL MEDIATED CYTOTOXICITY; CELL STRAIN HL 60; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXIC LYMPHOCYTE; ELECTRICITY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; INTERNALIZATION; LEUKEMIA CELL LINE; MUTATION; PINOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BINDING SITES; CATALYSIS; CATIONS; CELL LINE, TUMOR; ELECTROSTATICS; GENE PRODUCTS, GAG; GLYCOSAMINOGLYCANS; GRANZYMES; HEPARIN; HUMANS; MANNOSEPHOSPHATES; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PORE FORMING CYTOTOXIC PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SEQUENCE ALIGNMENT; SERINE ENDOPEPTIDASES;

TRIXIS;

EID: 23844453399     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.17.7854-7867.2005     Document Type: Article

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