Mouse behavioural analysis in systems biology

Biochemical Journal

Volumn 389, Issue 3, 2005, Pages 593-610

  Van Meer, Peter ^a   Raber, Jacob ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Apolipoprotein E; Behavioural phenotyping; Behavioural testing; Histamine; Histamine receptor; Mouse model; Transgenic gene

Indexed keywords

BEHAVIORAL RESEARCH; ENVIRONMENTAL IMPACT; GENETIC ENGINEERING; NEUROLOGY; PATHOLOGY;

ALIPOPROTEIN; BEHAVORAL PHENOTYPING; BEHAVORIAL TESTING; GENE EXPRESSION; HISTAMINE; MOUSE MODEL; TRANSGENIC GENE;

BIOCHEMISTRY;

APOLIPOPROTEIN E; HISTAMINE; HISTAMINE RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL CARE; ANIMAL MODEL; ANXIETY DISORDER; BRAIN FUNCTION; DIET; ENVIRONMENTAL FACTOR; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GROWTH; IN VIVO STUDY; KNOCKOUT GENE; LEARNING; MAZE TEST; MEMORY; MOUSE; MOUSE STRAIN; NEUROTRANSMISSION; NONHUMAN; OPEN FIELD BEHAVIOR; PASSIVE AVOIDANCE; PERFORMANCE; PHENOTYPE; PRENATAL CARE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REVIEW; STARTLE REFLEX; STRESS; TECHNIQUE; TRANSGENE;

ANIMALS; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM; HISTAMINE; MICE; RECEPTORS, HISTAMINE;

ANIMALIA; MUS MUSCULUS;

EID: 23644457499     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20042023     Document Type: Review

References (197)

1. Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A. et al. (2001) The sequence of the human genome. Science 291, 1304-1351
2. Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., Doyle, M., FitzHugh, W. et al. (2001) Initial sequencing and analysis of the human genome. Nature (London) 409, 860-921
3. Brudno, M., Poliakov, A., Salamov, A., Cooper, G. M., Sidow, A., Rubin, E. M., Solovyev, V., Batzoglou, S. and Dubchak, I. (2004) Automated whole-genome multiple alignment of rat, mouse, and human. Genome Res. 14, 685-692
4. Tecott, L. H. (2003) The genes and brains of mice and men. Am. J. Psychiatry 160, 646-656
5. Rhodes, J. S. and Garland, T. (2003) Differential sensitivity to acute administration of Ritalin, apomorphine, SCH 23390, but not raclopride in mice selectively bred for hyperactive wheel-running behavior. Psychopharmacology (Berlin) 167, 242-250
6. Farooqi, I. S. and O'Rahilly, S. (2004) Monogenic human obesity syndromes. Recent Prog. Horm. Res. 59, 409-424
7. Gardian, G. and Vecsei, L. (2004) Huntington's disease: pathomechanism and therapeutic perspectives. J. Neural Transm. 111, 1485-1494
8. Phillips, T. J. and Belknap, J. K. (2002) Complex-trait genetics: emergence of multivariate strategies. Nat. Rev. Neurosci. 3, 478-485
9. Crabbe, J. C. (1996) Quantitative trait locus gene mapping: a new method for locating alcohol response genes. Addict Biol. 1, 229-235
10. Johnson, A. B. (2004) Alexander disease: a leukodystrophy caused by a mutation in GFAP. Neurochem. Res. 29, 961-964
11. Parkinson, N. J., Olsson, C. L., Hallows, J. L., McKee-Johnson, J., Keogh, B. P., Noben-Trauth, K., Kujawa, S. G. and Tempel, B. L. (2001) Mutant beta-spectrin 4 causes auditory and motor neuropathies in quivering mice. Nat. Genet. 29, 61-65
12. Boillee, S., Peschanski, M. and Junier, M. P. (2003) The wobbler mouse: a neurodegeneration jigsaw puzzle. Mol. Neurobiol. 28, 65-106
13. Herron, B. J., Bryda, E. C., Heverly, S. A., Collins, D. N. and Flaherty, L. (1999) Scraggly, a new hair loss mutation on mouse chromosome 19. Mamm. Genome 10, 864-869
14. Russell, W. L., Kelly, E. M., Hunsicker, P. R., Bangham, J. W., Maddux, S. C. and Phipps, E. L. (1979) Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse. Proc. Natl. Acad. Sci. U.S.A. 76, 5818-5819
15. Balling, R. (2001) ENU mutagenesis: analyzing gene function in mice. Annu. Rev. Genomics Hum. Genet. 2, 463-492
16. Meyer, C. W., Korthaus, D., Jagla, W., Cornali, E., Grosse, J., Fuchs, H., Klingenspor, M., Roemheld, S., Tschop, M., Heldmaier, G. et al. (2004) A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity. Endocrinology 145, 2531-2541
17. Hrabe de Angelis, M. and Balling, R. (1998) Large scale ENU screens in the mouse: genetics meets genomics. Mutat. Res. 400, 25-32
18. Brown, S. D. and Balling, R. (2001) Systematic approaches to mouse mutagenesis. Curr. Opin. Genet. Dev. 11, 268-273
19. Tosal, L., Comendador, M. A. and Sierra, L. M. (2001) In vivo repair of ENU-induced oxygen alkylation damage by the nucleotide excision repair mechanism in Drosophila melanogaster. Mol. Genet. Genomics 265, 327-335
20. Graw, J., Pretsch, W. and Loster, J. (2003) Mutation in intron 6 of the hamster Mitf gene leads to skipping of the subsequent exon and creates a novel animal model for the human Waardenburg syndrome type II. Genetics 164, 1035-1041
21. De Stasio, E., Lephoto, C., Azuma, L., Holst, C., Stanislaus, D. and Uttam, J. (1997) Characterization of revertants of unc-93(e1500) in Caenorhabditis elegans induced by N-ethyl-N-nitrosourea. Genetics 147, 597-608
22. Voss, A. K., Thomas, T. and Gruss, P. (1998) Efficiency assessment of the gene trap approach. Dev. Dyn. 212, 171-180
23. Durick, K., Mendlein, J. and Xanthopoulos, K. G. (1999) Hunting with traps: genomewide strategies for gene discovery and functional analysis. Genome Res. 9, 1019-1025
24. Torres, M., Stoykova, A., Huber, O., Chowdhury, K., Bonaldo, P., Mansouri, A., Butz, S., Kemler, R. and Gruss, P. (1997) An alpha-E-catenin gene trap mutation defines its function in preimplantation development. Proc. Natl. Acad. Sci. U.S.A. 94, 901-906
25. Stewart, C. L., Ruther, U., Garber, C., Vanek, M. and Wagner, E. F. (1986) The expression of retroviral vectors in murine stem cells and transgenic mice. J. Embryol. Exp. Morphol. 97, 263-275
26. Muller, U. (1999) Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysis. Mech. Dev. 82, 3-21
27. Aszodi, A., Hunziker, E. B., Olsen, B. R. and Fassler, R. (2001) The role of collagen II and cartilage fibril-associated molecules in skeletal development. Osteoarthritis Cartilage 9 suppl. A, S150-S159
28. Lewandoski, M. (2001) Conditional control of gene expression in the mouse. Nat. Rev. Genet. 2, 743-755
29. Schneider, A., Guan, Y., Zhang, Y., Magnuson, M. A., Pettepher, C., Loftin, C. D., Langenbach, R., Breyer, R. M. and Breyer, M. D. (2004) Generation of a conditional allele of the mouse prostaglandin EP4 receptor. Genesis 40, 7-14
30. Araki, K., Araki, M. and Yamamura, K. (1997) Targeted integration of DNA using mutant lox sites in embryonic stem cells. Nucleic Acids Res. 25, 868-872
31. Gu, H., Marth, J. D., Orban, P. C., Mossmann, H. and Rajewsky, K. (1994) Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265, 103-106
32. Kuhn, R., Schwenk, F., Aguet, M. and Rajewsky, K. (1995) Inducible gene targeting in mice. Science 269, 1427-1429
33. Mansuy, I. M. and Bujard, H. (2000) Tetracycline-regulated gene expression in the brain. Curr. Opin. Neurobiol. 10, 593-596
34. Yamamoto, A., Lucas, J. J. and Hen, R. (2000) Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell 101, 57-66
35. Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J. and Rubinsztein, D. C. (2004) Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat. Genet. 36, 585-595
36. Letts, V. A., Valenzuela, A., Kirley, J. P., Sweet, H. O., Davisson, M. T. and Frankel, W. N. (1997) Genetic and physical maps of the stargazer locus on mouse chromosome 15. Genomics 43, 62-68
37. Parmigiani, S., Palanza, P., Rogers, J. and Ferrari, P. F. (1999) Selection, evolution of behavior and animal models in behavioral neuroscience. Neurosci. Biobehav. Rev. 23, 957-969
38. Owen, E. H., Logue, S. F., Rasmussen, D. L. and Wehner, J. M. (1997) Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative trait loci analyses. Neuroscience 80, 1087-1099
39. Crawley, J. N., Belknap, J. K., Collins, A., Crabbe, J. C., Frankel, W., Henderson, N., Hitzemann, R. J., Maxson, S. C., Miner, L. L., Silva, A. J. et al. (1997) Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology (Berlin) 132, 107-124
40. Fox, W. M. (1965) Reflex-ontogeny and behavioural development of the mouse. Anim. Behav. 13, 234-241
41. Hill, J. M., Gozes, I., Hill, J. L., Fridkin, M. and Brenneman, D. E. (1991) Vasoactive intestinal peptide antagonist retards the development of neonatal behaviors in the rat. Peptides 12, 187-192
42. Hill, J. M., Mervis, R. F., Avidor, R., Moody, T. W. and Brenneman, D. E. (1993) HIV envelope protein-induced neuronal damage and retardation of behavioral development in rat neonates. Brain Res. 603, 222-233
43. Wu, J. Y., Henins, K. A., Gressens, P., Gozes, I., Fridkin, M., Brenneman, D. E. and Hill, J. M. (1997) Neurobehavioral development of neonatal mice following blockade of VIP during the early embryonic period. Peptides 18, 1131-1137
44. Crawley, J. N. and Paylor, R. (1997) A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice. Horm. Behav. 31, 197-211
45. Irwin, S. (1968) Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacologia 13, 222-257
46. Moser, V. C., Cheek, B. M. and MacPhail, R. C. (1995) A multidisciplinary approach to toxicological screening: III. Neurobehavioral toxicity. J. Toxicol. Environ. Health 45, 173-210
47. Rogers, D. C., Fisher, E. M., Brown, S. D., Peters, J., Hunter, A. J. and Martin, J. E. (1997) Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment. Mamm. Genome 8, 711-713
48. Paylor, R., Nguyen, M., Crawley, J. N., Patrick, J., Beaudet, A. and Orr-Urtreger, A. (1998) Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice. Learn. Mem. 5, 302-316
49. Koehl, M., Battle, S. E. and Turek, F. W. (2003) Sleep in female mice: a strain comparison across the estrous cycle. Sleep 26, 267-272
50. Nordstrom, E. J. and Burton, F. H. (2002) A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry. Mol. Psychiatry 7, 617-625
51. Finn, D. A., Sinnott, R. S., Ford, M. M., Long, S. L., Tanchuck, M. A. and Phillips, T. J. (2004) Sex differences in the effect of ethanol injection and consumption on brain allopregnanolone levels in C57BL/6 mice. Neuroscience 123, 813-819
52. Gao, J., Cheon, K., Nusinowitz, S., Liu, Q., Bei, D., Atkins, K., Azimi, A., Daiger, S. P., Farber, D. B., Heckenlively, J. R. et al. (2002) Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene. Proc. Natl. Acad. Sci. U.S.A. 99, 5698-5703
53. Raber, J., Wong, D., Buttini, M., Orth, M., Bellosta, S., Pitas, R. E., Mahley, R. W. and Mucke, L. (1998) Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc. Natl. Acad. Sci. U.S.A. 95, 10914-10919
54. Raber, J., Wong, D., Yu, G. Q., Buttini, M., Mahley, R. W., Pitas, R. E. and Mucke, L. (2000) Apolipoprotein E and cognitive performance. Nature (London) 404, 352-354
55. Henry, K. R. (2004) Males lose hearing earlier in mouse models of late-onset age-related hearing loss; females lose hearing earlier in mouse models of early-onset hearing loss. Hear Res. 190, 141-148
56. Gimenez, E. and Montoliu, L. (2001) A simple polymerase chain reaction assay for genotyping the retinal degeneration mutation (Pdeb(rd1)) in FVB/N-derived transgenic mice. Lab. Anim. 35, 153-156
57. Brown, R. E., Stanford, L. and Schellinck, H. M. (2000) Developing standardized behavioral tests for knockout and mutant mice. ILAR J. 41, 163-174
58. Laviola, G. and Alleva, E. (1995) Sibling effects on the behavior of infant mouse litters (Mus domesticus). J. Comp. Psychol. 109, 68-75
59. vom Saal, F. S., Grant, W. M., McMullen, C. W. and Laves, K. S. (1983) High fetal estrogen concentrations: correlation with increased adult sexual activity and decreased aggression in male mice. Science 220, 1306-1309
60. vom Saal, F. S. and Bronson, F. H. (1978) In utero proximity of female mouse fetuses to males: effect on reproductive performance during later life. Biol. Reprod. 19, 842-853
61. Svare, B., Kinsley, C. H., Mann, M. A. and Broida, J. (1984) Infanticide: accounting for genetic variation in mice. Physiol. Behav. 33, 137-152
62. Wainwright, P. E., Gardner, D., Pelkman, C., McCutcheon, D. and Young, C. (1989) Effects of early rearing experience on feeding behavior in B6D2F2 mice. Physiol. Behav. 45, 1189-1195
63. Gervais, M. C., DeFries, J. C. and Kuse, A. R. (1977) Open-field behavior in mice: effect of litter size. Behav. Biol. 20, 519-522
64. LaBarba, R. C. and White, J. L. (1971) Litter size variations and emotional reactivity in BALB-c mice. J. Comp. Physiol. Psychol. 75, 254-257
65. Kikusui, T., Takeuchi, Y. and Mori, Y. (2004) Early weaning induces anxiety and aggression in adult mice. Physiol. Behav. 81, 37-42
66. Winslow, J. T., Hearn, E. F., Ferguson, J., Young, L. J., Matzuk, M. M. and Insel, T. R. (2000) Infant vocalization, adult aggression, and fear behavior of an oxytocin null mutant mouse. Horm. Behav. 37, 145-155
67. Reeb-Whitaker, C. K., Paigen, B., Beamer, W. G., Bronson, R. T., Churchill, G. A., Schweitzer, I. B. and Myers, D. D. (2001) The impact of reduced frequency of cage changes on the health of mice housed in ventilated cages. Lab. Anim. 35, 58-73
68. Bronson, F. H. (1979) The reproductive ecology of the house mouse. Q Rev. Biol. 54, 265-299
69. Tsai, P. P., Oppermann, D., Stelzer, H. D., Mahler, M. and Hackbarth, H. (2003) The effects of different rack systems on the breeding performance of DBA/2 mice. Lab. Anim. 37, 44-53
70. Dallman, M. F., Akana, S. F., Bell, M. E., Bhatnagar, S., Choi, S., Chu, A., Gomez, F., Laugero, K., Soriano, L. and Viau, V. (1999) Warning! Nearby construction can profoundly affect your experiments. Endocrine 11, 111-113
71. Milligan, S. R., Sales, G. D. and Khirnykh, K. (1993) Sound levels in rooms housing laboratory animals: an uncontrolled daily variable. Physiol. Behav. 53, 1067-1076
72. Ohlemiller, K. K., Wright, J. S. and Dugan, L. L. (1999) Early elevation of cochlear reactive oxygen species following noise exposure. Audiol. Neurootol. 4, 229-236
73. Pfaff, J. and Stecker, M. (1976) Loudness level and frequency content of noise in the animal house. Lab. Anim. 10, 111-117
74. Quintero, J. E., Kuhlman, S. J. and McMahon, D. G. (2003) The biological clock nucleus: a multiphasic oscillator network regulated by light. J. Neurosci. 23, 8070-8076
75. Landi, M. S., Kreider, J. W., Lang, C. M. and Bullock, L. P. (1982) Effects of shipping on the immune function in mice. Am. J. Vet. Res. 43, 1654-1657
76. Tuli, J. S., Smith, J. A. and Morton, D. B. (1995) Stress measurements in mice after transportation. Lab. Anim. 29, 132-138
77. Surwit, R. S., Wang, S., Petro, A. E., Sanchis, D., Raimbault, S., Ricquier, D. and Collins, S. (1998) Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice. Proc. Natl. Acad. Sci. U.S.A. 95, 4061-4065
78. Dess, N. K., Choe, S. and Minor, T. R. (1998) The interaction of diet and stress in rats: high-energy food and sucrose treatment. J. Exp. Psychol. Anim. Behav. Process 24, 60-71
79. Li, D., Graef, G. L., Yee, J. A. and Yan, L. (2004) Dietary supplementation with high-selenium soy protein reduces pulmonary metastasis of melanoma cells in mice. J. Nutr. 134, 1536-1540
80. Ravinet Trillou, C., Arnone, M., Delgorge, C., Gonalons, N., Keane, P., Maffrand, J. P. and Soubrie, P. (2003) Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice. Am. J. Physiol. 284, R345-R353
81. Collins, S., Martin, T. L., Surwit, R. S. and Robidoux, J. (2004) Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics. Physiol. Behav. 81, 243-248
82. Thiele, T. E., Naveilhan, P. and Ernfors, P. (2004) Assessment of ethanol consumption and water drinking by NPY Y(2) receptor knockout mice. Peptides 25, 975-983
83. McQuade, J. A., Xu, M., Woods, S. C., Seeley, R. J. and Benoit, S. C. (2003) Ethanol consumption in mice with a targeted disruption of the dopamine-3 receptor gene. Addict Biol. 8, 295-303
84. al Qatari, M., Shih, M. F. and Taberner, P. V. (1996) Chronic ethanol consumption ameliorates the maturity-onset diabetes-obesity syndrome in CBA mice. Alcohol Alcohol. 31, 89-99
85. Belknap, J. K., Richards, S. P., O'Toole, L. A., Helms, M. L. and Phillips, T. J. (1997) Short-term selective breeding as a tool for QTL mapping: ethanol preference drinking in mice. Behav. Genet. 27, 55-66
86. Belknap, J. K., Crabbe, J. C. and Laursen, S. E. (1989) Ethanol and diazepam withdrawal convulsions are extensively codetermined in WSP and WSR mice. Life Sci. 44, 2075-2080
87. Crabbe, J. C., Wahlsten, D. and Dudek, B. C. (1999) Genetics of mouse behavior: interactions with laboratory environment. Science 284, 1670-1672
88. Wahlsten, D., Metten, P., Phillips, T. J., Boehm, II, S. L., Burkhart-Kasch, S., Dorow, J., Doerksen, S., Downing, C., Fogarty, J., Rodd-Henricks, K. et al. (2003) Different data from different labs: lessons from studies of gene-environment interaction. J. Neurobiol. 54, 283-311
89. Bruserud, O., Frostad, S. and Foss, B. (1999) In vitro culture of acute myelogenous leukemia blasts: a comparison of four different culture media. J. Hematother. 8, 63-73
90. Chabbert, E., Lachaud, L., Crobu, L. and Bastien, P. (2004) Comparison of two widely used PCR primer systems for detection of toxoplasma in amniotic fluid, blood, and tissues. J. Clin. Microbiol. 42, 1719-1722
91. Roep, B. O., Atkinson, M. A., van Endert, P. M., Gottlieb, P. A., Wilson, S. B. and Sachs, J. A. (1999) Autoreactive T cell responses in insulin-dependent (Type 1) diabetes mellitus. Report of the first international workshop for standardization of T cell assays. J. Autoimmun. 13, 267-282
92. Brown, R. E., Stevens, D. R. and Haas, H. L. (2001) The physiology of brain histamine. Prog. Neurobiol. 63, 637-672
93. Le Coniat, M., Traiffort, E., Ruat, M., Arrang, J. M. and Berger, R. (1994) Chromosomal localization of the human histamine H1-receptor gene. Hum. Genet. 94, 186-188
94. Li, H., Burkhardt, C., Heinrich, U. R., Brausch, I., Xia, N. and Forstermann, U. (2003) Histamine upregulates gene expression of endothelial nitric oxide synthase in human vascular endothelial cells. Circulation 107, 2348-2354
95. Izumi, H., Makino, Y., Shirakawa, K. and Garfield, R. E. (1995) Role of nitric oxide on vasorelaxation in human umbilical artery. Am. J. Obstet. Gynecol. 172, 1477-1484
96. Garbarg, M. and Schwartz, J. C. (1985) Histamine receptors in the brain. N. Engl. Reg. Allergy Proc. 6, 195-200
97. Arrang, J. M., Garbarg, M. and Schwartz, J. C. (1983) Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature (London) 302, 832-837
98. Lovenberg, T. W., Roland, B. L., Wilson, S. J., Jiang, X., Pyati, J., Huvar, A., Jackson, M. R. and Erlander, M. G. (1999) Cloning and functional expression of the human histamine H3 receptor. Mol. Pharmacol. 55, 1101-1107
99. Bockaert, J. and Pin, J. P. (1999) Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 18, 1723-1729
100. Leurs, R., Hoffmann, M., Wieland, K. and Timmerman, H. (2000) H3 receptor gene is cloned at last. Trends Pharmacol. Sci. 21, 11-12
101. Uveges, A. J., Kowal, D., Zhang, Y., Spangler, T. B., Dunlop, J., Semus, S. and Jones, P. G. (2002) The role of transmembrane helix 5 in agonist binding to the human H3 receptor. J. Pharmacol. Exp. Ther. 301, 451-458
102. Hancock, A. A., Esbenshade, T. A., Krueger, K. M. and Yao, B. B. (2003) Genetic and pharmacological aspects of histamine H3 receptor heterogeneity. Life Sci. 73, 3043-3072
103. Maggio, R., Barbier, P., Colelli, A., Salvadori, F., Demontis, G. and Corsini, G. U. (1999) G protein-linked receptors: pharmacological evidence for the formation of heterodimers. J. Pharmacol. Exp. Ther. 291, 251-257
104. Drutel, G., Peitsaro, N., Karlstedt, K., Wieland, K., Smit, M. J., Timmerman, H., Panula, P. and Leurs, R. (2001) Identification of rat H3 receptor isoforms with different brain expression and signaling properties. Mol. Pharmacol. 59, 1-8
105. Rouleau, A., Heron, A., Cochois, V., Pillot, C., Schwartz, J. C. and Arrang, J. M. (2004) Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms. J. Neurochem. 90, 1331-1338
106. Wieland, K., Bongers, G., Yamamoto, Y., Hashimoto, T., Yamatodani, A., Menge, W. M., Timmerman, H., Lovenberg, T. W. and Leurs, R. (2001) Constitutive activity of histamine H3 receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H3 antagonists. J. Pharmacol. Exp. Ther. 299, 908-914
107. Clark, E. A. and Hill, S. J. (1996) Sensitivity of histamine H3 receptor agonist-stimulated [35S]GTP gamma[S] binding to pertussis toxin. Eur. J. Pharmacol. 296, 223-225
108. Schlicker, E., Fink, K., Detzner, M. and Gothert, M. (1993) Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors. J. Neural Transm. Gen. Sect. 93, 1-10
109. Schlicker, E., Betz, R. and Gothert, M. (1988) Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex. Naunyn Schmiedebergs Arch. Pharmacol. 337, 588-590
110. Schlicker, E., Schunack, W. and Gothert, M. (1990) Histamine H3 receptor-mediated inhibition of noradrenaline release in pig retina discs. Naunyn Schmiedebergs Arch. Pharmacol. 342, 497-501
111. Garcia, M., Floran, B., Arias-Montano, J. A., Young, J. M. and Aceves, J. (1997) Histamine H3 receptor activation selectively inhibits dopamine D1 receptor-dependent [3H]GABA release from depolarization-stimulated slices of rat substantia nigra pars reticulata. Neuroscience 80, 241-249
112. Silver, R. B., Mackins, C. J., Smith, N. C., Koritchneva, I. L., Lefkowitz, K., Lovenberg, T. W. and Levi, R. (2001) Coupling of histamine H3 receptors to neuronal Na+/H+ exchange: a novel protective mechanism in myocardial ischemia. Proc. Natl. Acad. Sci. U.S.A. 98, 2855-2859
113. Hill, S. J., Ganellin, C. R., Timmerman, H., Schwartz, J. C., Shankley, N. P., Young, J. M., Schunack, W., Levi, R. and Haas, H. L. (1997) International Union of Pharmacology. XIII. Classification of histamine receptors. Pharmacol. Rev. 49, 253-278
114. Alguacil, L. F. and Perez-Garcia, C. (2003) Histamine H3 receptor: a potential drug target for the treatment of central nervous system disorders. Curr. Drug Targets CNS Neurol. Disord. 2, 303-313
115. Saper, C. B. and German, D. C. (1987) Hypothalamic pathology in Alzheimer's disease. Neurosci. Lett. 74, 364-370
116. Simpson, J., Yates, C. M., Watts, A. G. and Fink, G. (1988) Congo red birefringent structures in the hypothalamus in senile dementia of the Alzheimer type. Neuropathol. Appl. Neurobiol. 14, 381-393
117. Airaksinen, M. S., Reinikainen, K., Riekkinen, P. and Panula, P. (1991) Neurofibrillary tangles and histamine-containing neurons in Alzheimer hypothalamus. Agents Actions 33, 104-107
118. Mazurkiewicz-Kwilecki, I. M. and Nsonwah, S. (1989) Changes in the regional brain histamine and histidine levels in postmortem brains of Alzheimer patients. Can. J. Physiol. Pharmacol. 67, 75-78
119. Panula, P., Rinne, J., Kuokkanen, K., Eriksson, K. S., Sallmen, T., Kalimo, H. and Relja, M. (1998) Neuronal histamine deficit in Alzheimer's disease. Neuroscience 82, 993-997
120. Cacabelos, R., Yamatodani, A., Niigawa, H., Hariguchi, S., Tada, K., Nishimura, T., Wada, H., Brandeis, L. and Pearson, J. (1989) Brain histamine in Alzheimer's disease. Methods Find. Exp. Clin. Pharmacol. 11, 353-360
121. Perez-Garcia, C., Morales, L., Cano, M. V., Sancho, I. and Alguacil, L. F. (1999) Effects of histamine H3 receptor ligands in experimental models of anxiety and depression. Psychopharmacology (Berlin) 142, 215-220
122. Nakamura, T., Itadani, H., Hidaka, Y., Ohta, M. and Tanaka, K. (2000) Molecular cloning and characterization of a new human histamine receptor, HH4R. Biochem. Biophys. Res. Commun. 279, 615-620
123. Coge, F., Guenin, S. P., Rique, H., Boutin, J. A. and Galizzi, J. P. (2001) Structure and expression of the human histamine H4-receptor gene. Biochem. Biophys. Res. Commun. 284, 301-309
124. Liu, C., Wilson, S. J., Kuei, C. and Lovenberg, T. W. (2001) Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J. Pharmacol. Exp. Ther. 299, 121-130
125. O'Reilly, M., Alpert, R., Jenkinson, S., Gladue, R. P., Foo, S., Trim, S., Peter, B., Trevethick, M. and Fidock, M. (2002) Identification of a histamine H4 receptor on human eosinophils - role in eosinophil chemotaxis. J. Recept. Signal Transduct. Res. 22, 431-448
126. Hofstra, C. L., Desai, P. J., Thurmond, R. L. and Fung-Leung, W. P. (2003) Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells. J. Pharmacol. Exp. Ther. 305, 1212-1221
127. 126a Charrey, D. S. (2003) Neuroanatonical circuits modulating fear and anxiety. Acta Psychiatr. Scand., Suppl. 417, 38-50
128. Wilson, R. C., Vacek, T., Lanier, D. L. and Dewsbury, D. A. (1976) Open-field behavior in muroid rodents. Behav. Biol. 17, 495-506
129. Tremml, P., Lipp, H. P., Muller, U., Ricceri, L. and Wolfer, D. P. (1998) Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene. Behav. Brain Res. 95, 65-76
130. Meyer, L. and Caston, J. (2004) Stress alters caffeine action on investigatory behaviour and behavioural inhibition in the mouse. Behav. Brain Res. 149, 87-93
131. Lister, R. G. (1987) The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berlin) 92, 180-185
132. Mulder, G. B. and Pritchett, K. (2004) The elevated plus-maze. Contemp. Top. Lab. Anim. Sci. 43, 39-40
133. Imaizumi, M. and Onodera, K. (1993) The behavioral and biochemical effects of thioperamide, a histamine H3-receptor antagonist, in a light/dark test measuring anxiety in mice. Life Sci. 53, 1675-1683
134. Imaizumi, M., Miyazaki, S. and Onodera, K. (1996) Effects of betahistine, a histamine H1 agonist and H3 antagonist, in a light/dark test in mice. Methods Find. Exp. Clin. Pharmacol. 18, 19-24
135. Yuzurihara, M., Ikarashi, Y., Ishige, A., Sasaki, H. and Maruyama, Y. (2000) Anxiolytic-like effect of saiboku-to, an oriental herbal medicine, on histaminergics-induced anxiety in mice. Pharmacol. Biochem. Behav. 67, 489-495
136. Raber, J. (1998) Detrimental effects of chronic hypothalamic-pituitary- adrenal axis activation. From obesity to memory deficits. Mol. Neurobiol. 18, 1-22
137. Shepherd, J. K., Grewal, S. S., Fletcher, A., Bill, D. J. and Dourish, C. T. (1994) Behavioural and pharmacological characterisation of the elevated "zero-maze" as an animal model of anxiety. Psychopharmacology (Berlin) 116, 56-64
138. Killcross, S., Bobbins, T. W. and Everitt, B. J. (1997) Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala. Nature (London) 388, 377-380
139. Toyota, H., Dugovic, C., Koehl, M., Laposky, A. D., Weber, C., Ngo, K., Wu, Y., Lee, D. H., Yanai, K., Sakurai, E. et al. (2002) Behavioral characterization of mice lacking histamine H3 receptors. Mol. Pharmacol. 62, 389-397
140. Takahashi, K., Suwa, H., Ishikawa, T. and Kotani, H. (2002) Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype. J. Clin. Invest. 110, 1791-1799
141. DeVries, G. J., Buijs, R. M., Van Leeuwen, F. W., Caffe, A. R. and Swaab, D. F. (1985) The vasopressinergic innervation of the brain in normal and castrated rats. J. Comp. Neurol. 233, 236-254
142. Treit, D. and Menard, J. (1997) Dissociations among the anxiolytic effects of septal, hippocampal, and amygdaloid lesions. Behav. Neurosci. 111, 653-658
143. Kesner, R. P., Bolland, B. L. and Dakis, M. (1993) Memory for spatial locations, motor responses, and objects: triple dissociation among the hippocampus, caudate nucleus, and extrastriate visual cortex. Exp. Brain Res. 93, 462-470
144. Ennaceur, A. and Aggleton, J. P. (1997) The effects of neurotoxic lesions of the perirhinal cortex combined to fornix transection on object recognition memory in the rat. Behav. Brain Res. 88, 181-193
145. Bongers, G., Leurs, R., Robertson, J. and Raber, J. (2004) Role of H3-receptor-mediated signaling in anxiety and cognition in wild-type and Apoe-/- mice. Neuropsychopharmacology 29, 441-449
146. Morris, R. (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11, 47-60
147. Bach, M. E., Hawkins, R. D., Osman, M., Kandel, E. R. and Mayford, M. (1995) Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency. Cell 81, 905-915
148. Barnes, C. A., Jung, M. W., McNaughton, B. L., Korol, D. L., Andreasson, K. and Worley, P. F. (1994) LTP saturation and spatial learning disruption: effects of task variables and saturation levels. J. Neurosci. 14, 5793-5806
149. Rizk, A., Curley, J., Robertson, J. and Raber, J. (2004) Anxiety and cognition in histamine H3 receptor-/- mice. Eur. J. Neurosci. 19, 1992-1996
150. Hall, M. E. and Mayer, M. A. (1975) Effects of alpha methyl-para-tyrosine on the recall of a passive avoidance response. Pharmacol. Biochem. Behav. 3, 579-582
151. Yanai, K., Son, L. Z., Endou, M., Sakurai, E. and Watanabe, T. (1998) Targeting disruption of histamine H1 receptors in mice: behavioral and neurochemical characterization. Life Sci. 62, 1607-1610
152. Fiore, M., Carere, C., Moroni, R. and Aloe, L. (2002) Passive avoidance response in mice infected with Schistosoma mansoni. Physiol. Behav. 75, 449-454
153. Jones, B. J. and Roberts, D. J. (1968) A rotarod suitable for quantitative measurements of motor incoordination in naive mice. Naunyn Schmiedebergs Arch. Exp. Pathol. Pharmakol. 259, 211
154. Carter, R. J., Lione, L. A., Humby, T., Mangiarini, L., Mahal, A., Bates, G. P., Dunnett, S. B. and Morton, A. J. (1999) Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. J. Neurosci. 19, 3248-3257
155. Rustay, N. R., Wahlsten, D. and Crabbe, J. C. (2003) Influence of task parameters on rotarod performance and sensitivity to ethanol in mice. Behav. Brain Res. 141, 237-249
156. Jobst, E. E., Enriori, P. J. and Cowley, M. A. (2004) The electrophysiology of feeding circuits. Trends Endocrinol. Metab. 15, 488-499
157. Speakman, J. R. (2004) Obesity: the integrated roles of environment and genetics. J. Nutr. 134, 2090S-2105S
158. Ahima, R. S. and Osei, S. Y. (2004) Leptin signaling. Physiol. Behav. 81, 223-241
159. Wilding, J. P. (2002) Neuropeptides and appetite control. Diabet. Med. 19, 619-627
160. Sainsbury, A., Cooney, G. J. and Herzog, H. (2002) Hypothalamic regulation of energy homeostasis. Best Pract. Res. Clin. Endocrinol. Metab. 16, 623-637
161. Young, L. J., Pitkow, L. J. and Ferguson, J. N. (2002) Neuropeptides and social behavior: animal models relevant to autism. Mol. Psychiatry 7 (suppl. 2), S38-S39
162. Sluyter, F., Arseneault, L., Moffitt, T. E., Veenema, A. H., de Boer, S. and Koolhaas, J. M. (2003) Toward an animal model for antisocial behavior: parallels between mice and humans. Behav. Genet. 33, 563-574
163. Bielsky, I. F. and Young, L. J. (2004) Oxytocin, vasopressin, and social recognition in mammals. Peptides 25, 1565-1574
164. Haxby, J. V., Hoffman, E. A. and Gobbini, M. I. (2002) Human neural systems for face recognition and social communication. Biol. Psychiatry 51, 59-67
165. Insel, T. R., Winslow, J. T., Wang, Z. and Young, L. J. (1998) Oxytocin, vasopressin, and the neuroendocrine basis of pair bond formation. Adv. Exp. Med. Biol. 449, 215-224
166. Winslow, J. T. and Insel, T. R. (2004) Neuroendocrine basis of social recognition. Curr. Opin. Neurobiol. 14, 248-253
167. Hatton, G. I. and Li, Z. (1998) Mechanisms of neuroendocrine cell excitability. Adv. Exp. Med. Biol. 449, 79-95
168. Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R. and Winslow, J. T. (2000) Social amnesia in mice lacking the oxytocin gene. Nat. Genet. 25, 284-288
169. Ostermeyer, M. C. and Elwood, R. W. (1983) Pup recognition in Mus musculus: parental discrimination between their own and alien young. Dev. Psychobiol. 16, 75-82
170. Miczek, K. A., Maxson, S. C., Fish, E. W. and Faccidomo, S. (2001) Aggressive behavioral phenotypes in mice. Behav. Brain Res. 125, 167-181
171. Miczek, K. A. (1999) Aggressive and social stress responses in genetically modified mice: from horizontal to vertical strategy. Psychopharmacology (Berlin) 147, 17-19
172. D'Souza, U. M., Kel, A. and Sluyter, F. (2003) From transcriptional regulation to aggressive behavior. Behav. Genet. 33, 549-562
173. Karl, T., Lin, S., Schwarzer, C., Sainsbury, A., Couzens, M., Wittmann, W., Boey, D., von Horsten, S. and Herzog, H. (2004) Y1 receptors regulate aggressive behavior by modulating serotonin pathways. Proc. Natl. Acad. Sci. U.S.A. 101, 12742-12747
174. Murphy, D. L., Andrews, A. M., Wichems, C. H., Li, Q., Tohda, M. and Greenberg, B. (1998) Brain serotonin neurotransmission: an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs. J. Clin. Psychiatry 59 (suppl. 15), 4-12
175. Lesch, K. P. and Merschdorf, U. (2000) Impulsivity, aggression, and serotonin: a molecular psychobiological perspective. Behav. Sci. Law 18, 581-604
176. White, S. M., Kucharik, R. F. and Moyer, J. A. (1991) Effects of serotonergic agents on isolation-induced aggression. Pharmacol. Biochem. Behav. 39, 729-736
177. Malick, J. B. (1979) The pharmacology of isolation-induced aggressive behavior in mice. Curr. Dev. Psychopharmacol. 5, 1-27
178. Olivier, B. and Mos, J. (1992) Rodent models of aggressive behavior and serotonergic drugs. Prog. Neuropsychopharmacol. Biol. Psychiatry 16, 847-870
179. Winslow, J. T. and Miczek, K. A. (1983) Habituation of aggression in mice: pharmacological evidence of catecholaminergic and serotonergic mediation. Psychopharmacology (Berlin) 81, 286-291
180. Yanai, K., Son, L. Z., Endou, M., Sakurai, E., Nakagawasai, O., Tadano, T., Kisara, K., Inoue, I. and Watanabe, T. (1998) Behavioural characterization and amounts of brain monoamines and their metabolites in mice lacking histamine H1 receptors. Neuroscience 87, 479-487
181. Krakowski, M. (2003) Violence and serotonin: influence of impulse control, affect regulation, and social functioning. J Neuropsychiatry Clin. Neurosci. 15, 294-305
182. Son, L. Z., Yanai, K., Mobarakeh, J. I., Kuramasu, A., Li, Z. Y., Sakurai, E., Hashimoto, Y. and Watanabe, T. (2001) Histamine H1 receptor-mediated inhibition of potassium-evoked release of 5-hydroxytryptamine from mouse forebrains. Behav. Brain Res. 124, 113-120
183. Raghavendra, V., Kaur, G. and Kulkarni, S. K. (2000) Anti-depressant action of melatonin in chronic forced swimming-induced behavioral despair in mice, role of peripheral benzodiazepine receptor modulation. Eur. Neuropsychopharmacol. 10, 473-481
184. Zomkowski, A. D., Hammes, L., Lin, J., Calixto, J. B., Santos, A. R. and Rodrigues, A. L. (2002) Agmatine produces antidepressant-like effects in two models of depression in mice. Neuroreport 13, 387-391
185. Liu, X., Peprah, D. and Gershenfeld, H. K. (2003) Tail-suspension induced hyperthermia: a new measure of stress reactivity. J. Psychiatr. Res. 37, 249-259
186. Rubio, S., Begega, A., Santin, L. J. and Arias, J. L. (2002) Improvement of spatial memory by R-alpha-methylhistamine, a histamine H3-receptor agonist, on the Morris water-maze in rat. Behav. Brain Res. 129, 77-82
187. Prast, H., Argyriou, A. and Philippu, A. (1996) Histaminergic neurons facilitate social memory in rats. Brain Res. 734, 316-318
188. Miyazaki, S., Imaizumi, M. and Onodera, K. (1995) Effects of thioperamide, a histamine H3-receptor antagonist, on a scopolamine-induced learning deficit using an elevated plus-maze test in mice. Life Sci. 57, 2137-2144
189. Miyazaki, S., Onodera, K., Imaizumi, M. and Timmerman, H. (1997) Effects of clobenpropit (VUF-9153), a histamine H3-receptor antagonist, on learning and memory, and on cholinergic and monoaminergic systems in mice. Life Sci. 61, 355-361
190. Blandina, P. B. M., Giovannini, M. G. and Mannaoioni, P. F. (1998) H3 receptor modulation of the release of neurotransmitters in vivo. In The Histamine H3 Receptor (Leurs, R. and Timmerman, H., eds.), pp. 27-40, Elsevier, Amsterdam
191. Gulat-Marnay, C., Lafitte, A., Arrang, J. M. and Schwartz, J. C. (1989) Regulation of histamine release and synthesis in the brain by muscarinic receptors. J. Neurochem. 52, 248-254
192. Giovannini, M. G., Bartolini, L., Bacciottini, L., Greco, L. and Blandina, P. (1999) Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia. Behav. Brain Res. 104, 147-155
193. Molinengo, L., Di Carlo, G. and Ghi, P. (1999) Combined action of thioperamide plus scopolamine, diphenhydramine, or methysergide on memory in mice. Pharmacol. Biochem. Behav. 63, 221-227
194. Ghi, P., Orsetti, M., Gamalero, S. R. and Ferretti, C. (1999) Sex differences in memory performance in the object recognition test. Possible role of histamine receptors. Pharmacol. Biochem. Behav. 64, 761-766
195. Smith, C. P., Hunter, A. J. and Bennett, G. W. (1994) Effects of R-alpha-methylhistamine and scopolamine on spatial learning in the rat assessed using a water maze. Psychopharmacology (Berlin) 114, 651-656
196. Nakamura, S., Takemura, M., Ohnishi, K., Suenaga, T., Nishimura, M., Akiguchi, I., Kimura, J. and Kimura, T. (1993) Loss of large neurons and occurrence of neurofibrillary tangles in the tuberomammillary nucleus of patients with Alzheimer's disease. Neurosci. Lett. 151, 196-199
197. Bongers, G., LeFevour, A., Robertson, J. and Raber, J. (2004) Role of H3 receptor-mediated signaling in cognition. Inflamm. Res. 53 (suppl. 1), S51-S52