Violence and serotonin: Influence of impulse control, affect regulation, and social functioning

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 15, Issue 3, 2003, Pages 294-305

  Krakowski, Menahem ^a  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; FLUOXETINE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR;

AGGRESSION; ANIMAL MODEL; ARSON; ARTICLE; BRAIN; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; CRIMINAL BEHAVIOR; EMOTION; HUMAN; IMPULSIVENESS; NEUROTRANSMISSION; NONHUMAN; OFFENDER; PERSONALITY DISORDER; PRIORITY JOURNAL; RATING SCALE; SEROTONINERGIC SYSTEM; SOCIAL BEHAVIOR; VIOLENCE;

EID: 0042161744     PISSN: 08950172     EISSN: None     Source Type: Journal    
DOI: 10.1176/jnp.15.3.294     Document Type: Article

References (79)

1. Stanley M, Traskman-Bendz L, Dorovini-Zis K: Correlations between aminergic metabolites simultaneously obtained from human CSF and brain. Life Sci 1985 37:1279-1286
2. Saudou F, Ait Amara D, Dierich A, et al: Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science 1994; 265: 1875-1878
3. Brunner D, Hen R Insights into the neurobiology of impulsive behavior from serotonin receptor knockout mice. Ann NY Acad Sci 1997 836:81-105.
4. Manuck SB, Flory JD, Ferrell RE, et al: A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiatry Res 2000 95:9-23;
5. Biver F, Lotstra F, Monclus M, et al: Sex difference in 5HT2 receptor in the living human brain. Neurosci Lett 1996 204:25-28
6. Pandey GN, Pandey SC, Dwivedi Y, et al: Platelet serotonin-2A receptors: a potential biological marker for suicidal behavior. Am J Psychiatry 1995; 152:850-855
7. Gibbons JL, Barr GA, Bridger WH, et al: Manipulations of dietary tryptophan: effects on mouse killing and brain serotonin in the rat. Brain Res 1979; 169:139-153
8. Eichelman BS, Thoa NB: The aggressive monoamines. Biol Psychiatry 1973; 6:143-164
9. Molina V, Ciesielski, L, Gobaille, S, et al: Inhibition of mouse killing behavior by serotonin-mimetic drugs: effects of partial alterations of serotonin neurotransmission. Pharmacol Biochem & Behav 1987 27:123-131
10. File SE, Hyde JR, MacLeod NK: 5,7-dihydroxytryptamine lesions of dorsal and median raphe nuclei and performance in the social interaction test of anxiety and in a home-cage aggression test. J Affect Dis 1979; 1:115-122
11. Miczek KA, Mos J, Olivier B: Brain 5-HT and inhibition of aggressive behavior in animals: 5-HIAA and receptor subtypes. Psychopharm Bulletin 1989; 25:399-403
12. Higley JD, Mehlman P, Taub D, et al: Cerebrospinal fluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys. Arch Gen Psychiatry 1992; 49:436-441
13. Mehlman PT, Higley JD, Faucher I, et al: Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates. Am J Psychiatry 1994; 151:1485-491
14. Higley JD, Mehlman PT, Poland RE, et al: CSF testosterone and 5-HIAA correlate with different types of aggressive behaviors. BiolPsychiatry 1996; 40, 1067-1082
15. Higley JD, King ST Jr, Hasert MF, et al: Stability of interindividual differences in serotonin function and its relationship to severe aggression and competent social behavior in rhesus macaque females. Neuropsychopharmacology 1996; 14:67-76
16. Higley JD, Mehlman PT, Higley SB, et al: Excessive mortality in young free-ranging male nonhuman primates with low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations. Arch Gen Psychiatry 1996 53:537-543
17. Raleigh JM, Brammer GL, Ritvo ER, et al: Effects of chronic fenfluramine on blood serotonin, cerebrospinal fluid metabolites, and behavior in monkeys. Psychopharmacology 1988; 90:503-508
18. Raleigh MJ: Differential behavioral effects of tryptophan and 5-hydroxytryptophan in vervet monkeys: influence of catecholaminergic systems. Psychopharmacology 1987; 93:44-50
19. Nishizawa S, Benkelfat C, Young SN, et al: Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci USA 1997; 94:5308-5313
20. Carlson JN, Visker KE, Nielsen DM, et al: Chronic antidepressant drug treatment reduces turning behavior and increases dopamine levels in the medial prefrontal cortex. Brain Res 1996; 707:122-126
21. Brown GL, Goodwin FK, Ballenger JC, et al: Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res 1979; 1:131-139
22. Brown GL, Ebert MH, Goyer PF, et al: Aggression, suicide, and serotonin: relationships to CSF amine metabolites. Am J Psychiatry 1982; 139:741-746
23. Coccaro EF, Kavoussi RJ, Cooper TB, et al: Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects. Am J Psychiatry 1997; 154:1430-1435
24. Lidberg L, Tuck JR, Asberg M, et al: Homicide, suicide and CSF 5-HIAA. Acta Psychiatr Scand 1985 71:230-236
25. Linnoila M, Virkkunen M, Scheinin M, et al: Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci 1983; 33:2609-2614
26. Virkkunen M, Rawlings R, Tokola R, et al: CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry 1994; 51:20-27
27. Virkkunen M, De Jong J, Bartko J, et al: Relationship of psychobiological variables to recidivism in violent offenders and impulsive fire setters. A follow-up study. Archi Gen Psychiatry 1989 46:600-603
28. Virkkunen M, Nuutila A, Goodwin FK, et al: Cerebrospinal fluid monoamine metabolites in male arsonists. Arch Gen Psychiatry 1987; 44:241-247
29. Brown CS, Kent TA, Bryant SG, et al: Blood platelet uptake of serotonin in episodic aggression. Psychiatry Res 1989; 27:5-12
30. Stanley B, Molcho A, Stanley M, et al: Association of aggressive behavior with altered serotonergic function in patients who are not suicidal. Am J Psychiatry 2000; 157:609-614
31. Roy A, Adinoff B, Linnoila M: Acting out hostility in normal volunteers: negative correlation with levels of 5HIAA in cerebrospinal fluid. Psychiatry Res 1988; 24:187-194
32. Coccaro EF, Siever LJ, Klar HM, et al: Serotonergic studies in patients with affective and personality disorders: correlates with suicidal and impulsive aggressive behavior. Arch Gen Psychiatry 1989; 46:587-599
33. Manuck SB, Flory JD, McCaffery JM, et al: Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample. Neuropsychopharmacology 1998; 19:287-299
34. Fluoxetine and impulsive aggressive behavior in personality-disordered subjects Coccaro EF Kavoussi, R.J. Arch Gen Psychiatry. 1997; 54:1081-1088
35. Knutson, B et al: Selective alteration of Pprsonality and social behavior by serotonergic intervention. Am J Psychiatry 1998; 155:373-379
36. Smith SE, Pihl RO, Young SN, et al: Elevation and reduction of plasma tryptophan and their effects on aggression and perceptual sensitivity in normal males. Aggressive Behavior 1986; 12:393-407
37. LeMarquand DG, Benkelfat C, Pihl RO, et al: Behavioral inhibition induced by tryptophan depletion in nonalcoholic young men with multigenerational family histories of paternal alcoholism. Am. J. Psychiatry 1999; 156:1771-1779
38. Moeller FG, Dougherty DM, Swann AC, et al: Tryptophan depletion and aggressive responding in healthy males. Psychopharmacology 1996; 126:97-103
39. Bjork JM, Dougherty DM, Moeller FG, et al: The effects of tryptophan depletion and loading on laboratory aggression in men: time course and a food-restricted control. Psychopharmacology 1999; 142:24-30
40. Dougherty DM, Bjork JM, Marsh DM, et al: Influence of trait hostility on tryptophan depletion-induced laboratory aggression. Psychiatry Res 1999; 88:227-32
41. Cleare AJ, Bond AJ: The effect of tryptophan depletion and enhancement on subjective and behavioral aggression in normal male subjects. Psychopharmacology 1995; 118:72-81
42. Pihl RO, Young SN, Harden P, et al: Acute effect of altered tryptophan levels and alcohol on aggression in normal human males. Psychopharmacology 1995; 119:353-60
43. Hynan DJ, Grush JE: Effects of impulsivity, depression, provocation, and time on aggressive behavior. J Research in Personality 1986; 20:158-171
44. Barratt ES: The use of anticonvulsants in aggression and violence. Psychopharm Bulletin 1993; 29:75-81
45. LeDoux, Joseph E. Cognitive-emotional interactions in the brain. Cognition & Emotion 1989 (3): 267-289
46. Brown GL, Linnoila MI: CSF serotonin metabolite (5-HIAA) studies in depression, impulsivity, and violence. J Clin Psychiatry 1990; 51(suppl):31-41
47. Mann JJ: Psychobiologic predictors of suicide. J Clin Psychiatry 1987; 48(Suppl):39-43
48. Murray H: Explorations in personality. New York 1938; Oxford University Press
49. The DSM-IV edition. Washington, D.C.: American Psychiatric Press, 1994
50. Kafka, Martin P: The paraphilia-related disorders: nonparaphilic hypersexuality and sexual compulsivity/addiction, in Principles and practice of sex therapy,Edited by Leiblum, Sandra R. Rosen, Raymond C, et al. The Guilford Press New York, 2000; pp. 471-503
51. Linnoila M, De Jong J, Virkkunen M: Family history of alcoholism in violent offenders and impulsive fire setters. Arch Gen Psychiatry 1989, 46:613-616
52. Heilbrun AB: Psychopathy and violent crime. J Consult Clin Psychol 1979; 47:509-516
53. Soubrie P: Reconciling the role of central serotonin neurons in human and animal behavior. Behavioral Brain Science 1986; 9:319-363
54. Cairns RB: Social Development: The Origins and Plasticity of Interactions. San Francisco, Freeman, 1979
55. Benkelfat C, Ellenbogen MA, Dean P, et al: Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective disorders. Arch of Gen Psychiatry 1994; 51:687-697
56. Leyton M, Young SN, Pihl RO, et al: A comparison of the effects of acute tryptophan depletion and acute phenylalanine/tyrosine depletion in healthy women in Tryptophan, Serotonin and Melatonin: Advances in Experimental Medicine and Biology, Edited by Huether et al, Kluwer Academic/Plenum Publishers, New York vol 467, pp 67-71; 1999
57. Ellenbogen MA, Young SN, Dean P, et al: Mood response to acute tryptophan depletion in healthy volunteers: sex differences and temporal stability. Neuropsychopharmacology 1996; 15:465-474
58. Smith SE, Pihl RO, Young SN, et al: A test of possible cognitive and environmental influences on the mood lowering effect of tryptophan depletion in normal males. Psychopharmacology 1987; 91:451-457
59. Coccaro EF, Gabriel S, Siever LJ: Buspirone challenge: preliminary evidence for a role for central 5-HT-sub(1a) receptor function in impulsive aggressive behavior in humans. Psychopharmacology Bulletin 1990; 26:393-405
60. Rubey RN, Johnson MR, Emmanuel, N, et al: Fluoxetine in the treatment of anger: an open clinical trial. J Clin Psychiatry 19967:398-401
61. Fava M, Alpert J, Nierenberg AA, et al: Fluoxetine treatment of anger attacks: a replication study. Anna of Clin Psychiatry 1996; 8:7-10
62. Shay, Jonathan. Fluoxetine reduces explosiveness and elevates mood of Vietnam combat vets with PTSD. Journal of Traumatic Stress 5:97-101, 1992
63. Salzman, C; Wolfson, AN; Schatzberg, A; Looper, J. Effect of fluoxetine on anger in symptomatic volunteers with borderline personality disorder. Journal of Clinical Psychopharmacology. 15:23-29; 1995
64. Mehlman PT, Higley JD, Faucher I, Lilly AA, Taub DM, Vickers J, Suomi SJ, Linnoila M: Correlation of CSF 5-HIAA concentration with sociality and the timing of emigration in free-ranging primates. Am J Psychiatry 152:907-13, 1995.
65. Raleigh MJ, Brammer GL, Yuwiler A, et al: Serotonergic influences on the social behavior of vervet monkeys (Cercopithecus aethiops sabaeus). Exp Neurol 1980; 68:322-334
66. Raleigh MJ, Brammer GL, McGuire MT, et al: Dominant social status facilitates the behavioral effects of serotonergic agonists. Brain Res 1985; 348:274-282
67. Raleigh MJ, McGuire MT: Social influences on endocrine function in male vervet monkeys, in Socioendocrinology of Primate Reproduction. Edited by Ziegler TE, Bercovitch FB. New York, Wiley-Liss, 1990
68. Dodge KA, Pettit GS, McClaskey CL, et al: Social competence in children. Monogr Soc Res Child Dev 51:Ser. No. 213
69. Dodge KA, Murphy RR, Buchsbaum K: The assessment of intention-cue detection skills in children: implications for developmental psychopathology. Child Dev 1984; 55:163-173
70. Dodge KA, Somberg, DR: Hostile attributional biases among aggressive boys are exacerbated under conditions of threats to the self. Child Dev 1987; 58:213-224
71. Sackin Steve, Thelen Esther: An ethological study of peaceful associative outcomes to conflict in preschool children. Child Dev 1984; 55(3), 1098-1102
72. Ljungberg T, Westlund K, Forsberg A, et al: Conflict resolution in 5-year-old boys: Does postconflict affiliative behaviour have a reconciliatory role? Animal Behaviour 1999; 58:1007-1016
73. Volling BL, MacKinnon LC, Rabiner D, et al: Children's social competence and sociometric status: further exploration of aggression, social withdrawal, and peer rejection. Dev Psychopathol 1993; 5:459-483
74. Bierman KL, Smoot DL, Aumiller K: Characteristics of aggressive-rejected, aggressive (nonrejected), and rejected (nonaggressive) boys. Child Dev 1993; 64:139-151
75. Pope AW, Bierman KL, Mumma GH: Relations between hyperactive and aggressive behavior and peer relations at three elementary grade levels. J Abnorm Child Psychol 1989 17:253-267
76. Harcourt H, de Waal FB: Coalitions in Humans and other Animals, Oxford, UK, Oxford University Press 1992
77. de Waal FB: Chimpanzee Politics: Power and Sex Among Apes, rev. ed. Baltimore, MD, USA: Johns Hopkins University Press 1998
78. Raleigh MJ, McGuire MT, Brammer GL, et al: Serotonergic mechanisms promote dominance acquisition in adult male vervet monkeys. Brain Res 1991; 559:181-190
79. Yeh SR, Fricke RA, Edwards DH: The effect of social experience on serotonergic modulation of the escape circuit of crayfish. Science 1996; 271:366-369