Role of H3-receptor-mediated signaling in anxiety and cognition in wild-type and Apoe-/- mice

Neuropsychopharmacology

Volumn 29, Issue 3, 2004, Pages 441-449

  Bongers, Gerald ^a,b   Leurs, Rob ^b   Robertson, Jennifer ^c   Raber, Jacob ^a,c,d,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Anxiety; apoE deficient mice; H1 receptor; H3 receptor; Histamine; HPA axis

Indexed keywords

APOLIPOPROTEIN E; CLOBENPROPIT; CORTICOSTERONE; CORTICOTROPIN; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR ANTAGONIST; MEPYRAMINE; THIOPERAMIDE; ANTIHISTAMINIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; COGNITION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; MENTAL TASK; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; DRUG EFFECT; EXPLORATORY BEHAVIOR; GENETICS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; ANXIETY; APOLIPOPROTEINS E; COGNITION; EXPLORATORY BEHAVIOR; HISTAMINE ANTAGONISTS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, HISTAMINE H3; SIGNAL TRANSDUCTION;

EID: 1642412424     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300352     Document Type: Article

References (79)

1. Airaksinen MS, Paetau A, Paljarvi L, Reinikainen K, Riekkinen P, Suomalainen R et al (1991). Histamine neurons in human hypothalamus: anatomy in normal and Alzheimer disease brains. Neuroscience 44: 465-481.
2. 3) of histamine receptor. Nature 302: 832-837.
3. 3-receptors. Neuroscience 23: 149-157.
4. 3 receptors in the brian. In: Leurs R, Timmerman H (eds). The Histamine H3 Receptor. Elsevier: Amsterdam. pp 1-12.
5. 3 Receptor. Elsevier: Amsterdam. pp 1-12.
6. 3 receptor activation in rats. Br J Pharmacol 119: 1656-1664.
7. Bradford MM (1976). A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
8. Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T et al (1999). Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/-mice: isoform-specific effects on neurodegeneration. J Neurosci 19: 4867-4880.
9. Cacabelos R, Yamatodani A, Niigawa H, Hariguchi S, Tada K, Nishimura T et al (1989). Brain histamine in Alzheimer's disease. Methods Find Exp Clin Pharmacol 11: 353-360.
10. Chikai T, Oishi R, Saeki K (1994). Increase in the extracellular histamine concentration in the rat striatum by -opioid receptor activation. J Neurochem 62: 724-729.
11. 3 receptor subtypes. Br J Pharmacol 107: 919-923.
12. 3 receptor isoforms with different brain expression and signaling properties. Mol Pharmacol 59: 108.
13. Ferretti L, McCurry SM, Logsdon R, Gibbons L, Teri L (2001). Anxiety and Alzheimer's disease. J Geriatr Psychiatry Neurol 14: 52-58.
14. 3 receptors in the inhibitory effect of histamine on serotonin release in the rat brain cortex. Naunyn Schmiedebergs Arch Pharmacol 342: 513-519.
15. Fox GB, Pan JB, Esbenschade TA, Bennai YL, Black LA, Faghih R et al (2002). Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup. Behav Brain Res 131: 151-161.
16. Ghi P, Orsetti M, Gamalero SR, Ferretti C (1999). Sex differences in memory performance in the object recognition test. Possible role of histamine receptors. Pharmacol Biochem Behav 64: 761-766.
17. 3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia. Behav Brain Res 104: 147-155.
18. Gulat-Marnay C, Lafitte A, Arrang JM, Schwartz JC (1989a). Modulation of histamine release and synthesis in the brain mediated by 2-adrenoceptors. J Neurochem 53: 513-518.
19. Gulat-Marnay C, Lafitte A, Arrang JM, Schwartz JC (1989b). Regulation of histamine release and synthesis in the brain by muscarinic receptors. J Neurochem 52: 248-254.
20. Gulat-Marnay C, Latte H, Arrang JM, Schwartz JC (1990). Modulation of histamine release in the rat brain by kappa-opioid receptors. J Neurochem 55: 17-53.
21. Hill SJ, Straw RM (1988). Alpha 2-adrenoceptor-mediated inhibition of histamine release from rat cerebral cortical slices. Br J Pharmacol 95: 1213-1219.
22. Huang M, Pang X, Letourneau R, Boucher W, Theoharides TC (2002). Acute stress induces cardiac mast cell activation and histamine release, effects that are increased in Apolipoprotein E knockout mice. Cardiovas Res 55: 150-160.
23. Igbavboa U, Avdulov NA, Chochina SV, Wood WG (1997). Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins. J Neurochem 69: 1661-1667.
24. Imaizumi M, Miyazaki S, Onodera K (1996). Effects of betahistine, a histamine H1 agonist and H3 antagonist, in a light/dark test in mice. Methods Find Exp Clin Pharmacol 18: 19-24.
25. Imaizumi M, Onodera K (1993). The behavioral and biochemical effects of thioperamide, a histamine H3-receptor antagonist, in a light/dark test measuring anxiety in mice. Life Sci 53: 1675-1683.
26. Inagaki N, Yamatodani A, Ando-Yamamoto M, Tohyama M, Watanabe T, Wada H (1988). Organization of histaminergic fibers in the rat brain. J Comp Neurol 273: 283-300.
27. 3 receptor ligands, immepip and clobenpropit. Effects of intrahypothalamic and peripheral application. Eur J Pharmacol 362: 149-155.
28. Knigge U, Willems E, Kjaer A, Jorgensen H, Warberg J (1999). Histaminergic and catecholaminergic interactions in the central regulation of vasopressin and oxytocin secretion. Endocrinology 140: 3713-3719.
29. Laitinen KS, Tuomisto L, MacDonald E (1995). Effects of a selective alpha 2-adrenoceptor antagonist, atipamezole, on hypothalamic histamine and noradrenaline release in vivo. Eur J Pharmacol 285: 255-260.
30. 3 receptor agonists and antagonists. Trends Pharmacol Sci 19: 177-183.
31. Liu C, Ma X, Jiang X, Wilson SJ, Hofstra CL, Blevitt J et al (2001). Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol 59: 420-426.
32. Lovenberg TW, Pyati J, Chang H, Wilson SJ, Erlander MG (2000). Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles. J Pharmacol Exp Ther 293: 771-778.
33. Mahley RW (1988). Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240: 622-630.
34. Masliah E, Mallory M, Ge N, Alford M, Veinbergs I, Roses AD (1995). Neurodegeneration in the central nervous system of apoE-deficient mice. Exp Neurol 136: 107-122.
35. Mazurkiewicz-Kwilecki IM, Nsonwah S (1989). Changes in the regional brain histamine and histidine levels in postmortem brains of Alzheimer patients. Can J Physiol Pharmacol 67: 75-78.
36. 3-receptor antagonist, on a scopolamine-induced learning deficit using an elevated plus-maze test in mice. Life Sci 57: 2137-2144.
37. Miyazaki S, Imaizumi M, Onodera K (1995b). Effects of thioperamide on the cholinergic system and the step-through passive avoidance test in mice. Methods Find Exp Clin Pharmacol 17: 653-658.
38. 3-receptor antagonist, on learning and memory, and on cholinergic and monoaminergic systems in mice. Life Sci 61: 355-361.
39. Molinengo L, Di Carlo G, Ghi P (1999). Combined action of thioperamide plus scopolamine, diphenhydramine, or memethysergide on memory in mice. Pharmacol Biochem Behav 63: 221-227.
40. 3 receptors regulates histamine neurons in brain. Nature 408: 860-864.
41. Morse KL, Behan J, Laz TM, West Jr RE, Greenfeder SA, Anthes JC et al (2001). Cloning and characterization of a novel human histamine receptor. J Pharmacol Exp Ther 296: 1058-1066.
42. Nakamura T, Itadani H, Hidaka Y, Ohta M, Tanaka K (2000). Molecular cloning and characterization of a new human histamine receptor, HH4R. Biochem Biophys Res Commun 279: 615-620.
43. Nakamura S, Takemura M, Ohnishi K, Suenaga T, Nishimura M, Akiguchi I et al (1993). Loss of large neurons and occurrence of neurofibrillary tangles in the tuberomammillary nucleus of patients with Alzheimer's disease. Neurosci Lett 151: 196-199.
44. Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R et al (2001). Discovery of a novel member of the histamine receptor , family. Mol Pharmacol 59: 427-433.
45. Oda T, Morikawa N, Saito Y, Masuho Y, Matsumoto S (2000). Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes. J Biol Chem 275: 36781-36786.
46. Ono J, Yamatodani A, Kishino J, Okada S, Wada H (1992). Cholinergic influence of K(+)-evoked release of endogenous histamine from rat hypothalamic slices in vitro. Methods Find Exp Clin Pharmacol 14: 35-40.
47. Onodera K, Yamatodani A, Watanabe T, Wada H (1994). Neuropharmacology of the histaminergic neuron system in the brain and its relationship with behavioral disorders. Prog Neurobiol 42: 685-702.
48. 3-receptor antagonist, of learning and memory in the elevated plus-maze test in mice. Naunyn Schmiedebergs Arch Pharmacol 357: 508-513.
49. Panuk P, Pirvola U, Auvinen S, Airaksinen MS (1989). Histamine- immunoreactive nerve fibers in the rat brain. Neuroscience 28: 585-610.
50. Panula P, Rinne J, Kuokkanen K, Eriksson KS, Sallmen T, Kalimo H et al (1998). Neuronal histamine deficit in Alzheimer's disease. Neuroscience 82: 993-997.
51. Panula P, Yang HY, Costa E (1984). Histamine-containing neurons in the rat hypothalamus. Proc Natl Acad Sci USA 81: 2572-2576.
52. Passani MB, Bacciottini L, Mannaioni PF, Blandina P (2000). Central histaminergic system and cognition. Neurosci Biobehav Rev 24: 107-113.
53. 3 receptor ligands in experimental models of anxiety and depression. Psychopharmacology (Berl) 142: 215-220.
54. Piedrahita JA, Zhang SH, Hagaman JR, Oliver PM, Maeda N (1992). Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci USA 89: 4471-4475.
55. Plump AS, Smith JD, Hayek T, Aalto-Setala K, Walsh A, Verstuyft JG et al (1992). Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71: 343-353.
56. Prast H, Argyriou A, Philippu A (1996). Histaminergic neurons facilitate social memory in rats. Brain Res 734: 316-318.
57. Prast H, Heistracher M, Philippu A (1991). In vivo modulation of the histamine release in the hypothalamus by adrenoreceptor agonists and antagonists. Naunyn Schmiedebergs Arch Pharmacol 344: 183-186.
58. Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE et al (1998). Isoform-specific effects of human apolipoprotein E on brain function revealed in Apoe knockout mice: increased susceptibility of females. Proc Natl Acad Sci USA 95: 10914-10919.
59. Raber J, Akana SF, Bhatnagar S, Dallman MF, Wong D, Mucke L (2000). Hypothalamic-pituitary-adrenal dysfunction in Apoe (-/-) mice: possible role in behavioral and metabolic alterations. J Neurosci 20: 2064-2071.
60. Raber J, Bongers G, LeFevour A, Buttini M, Mucke L (2002). Androgens protect against apoE4-induced cognitive deficits. J Neurosci 22: 5204-5209.
61. Raber J, Merlo Pich E, Koob GF, Bloom FE (1994). IL-1 potentiates the azetylcholine induced release of vasopressin from the hypothalamus in vitro, but not from the amygdala. Neuroendocrinology 59: 208-217.
62. Rampon C, Yang YP, Goodhouse J, Shimizu E, Kyin M, Tsien JZ (2000). Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat Neurosci 3: 238-244.
63. Rubio S, Begega A, Santin LJ, Arias JL (2002). Improvement of spatial memory by (R)-methylhistamine, a histamine H3-receptor agonist, on the Morris water-maze in rat. Behav Brain Res 129: 77-82.
64. 3 receptor-mediated inhibition of serotonin release in the rat brain cortex. Naunyn Schmiedebergs Arch Pharmacol 337: 588-590.
65. 3 receptors. J Neural Transm Gen Sect 93: 1-10.
66. 3 receptors. Naunyn Schmiedebergs Arch Pharmacol 340: 633-638.
67. Silverman AJ, Sutherland AK, Wilhelm M, Silver R (2000). Mast cells migrate from blood to brain. J Neurosci 20: 401-408.
68. Smith CP, Hunter AJ, Bennett GW (1994). Effects of (R)-methylhistamine and scopolamine on spatial learning in the rat assessed using a water maze. Psychopharmacology (Berl) 114: 651-656.
69. Sooksawate T, Simmonds MA (2001). Effects of membrane cholesterol on the sensitivity of the GABA(A) receptor to GABA in acutely dissociated rat hippocampal neurones. Neuropharmacology 40: 178-184.
70. 3 receptor antagonist: in vitro and in vivo studies. J Pharmacol Exp Ther 275: 598-604.
71. 3 ligands: just pharmacological tools of potential therapeutic agents? J Med Chem 33: 4-11.
72. Valastro B, Ghribi O, Poirier J, Krzywkowski P, Masicotte G (2001). AMPA receptor regulation and LTP in the hippocampus of young and aged apolipoprotein E-deficient mice. Neurobiol Aging 22: 9-15.
73. Van der Werf JF, Bast A, Bijloo GJ, Van der Vliet A, Timmerman H (1987). HA autoreceptor assay with superfused slices of rat brain cortex and electrical stimulation. Eur J Pharmacol 138: 199-206.
74. Watanabe T, Taguchi Y, Shiosaka S, Tanaka J, Kubota H, Terano Y et al (1984). Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decarboxylase as a marker. Brain Res 295: 13-25.
75. Weisgraber KH, Mahley RW (1996). Human apolipoprotein E: the Alzheimer's disease connection. FASEB J 10: 1485-1494.
76. 3 antagonists. J Pharmacol Exp Ther 299: 908-914.
77. 1 receptors in mice: behavioral and Neurochemical characterization. Life Sci 62: 1607-1610.
78. Yuzurihara M, Ikarashi Y, Ishige A, Sasaki H, Kuribara H, Maruyama Y (2000). Effects of drugs acting as histamine releasers or histamine receptor blockers on an experimental anxiety model in mice. Pharmacol Biochem Behav 67: 145-150.
79. Zhu Y, Michalovich D, Wu H, Tan KB, Dytko GM, Mannan IJ et al (2001). Cloning, expression, and pharmacological characterization of a novel human histamine receptor. Mol Pharmacol 59: 434-441.