Antibiotics targeting ribosomes: Resistance, selectivity, synergism, and cellular regulation

Annual Review of Biochemistry

Volumn 74, Issue , 2005, Pages 649-679

  Yonath, Ada ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Antibiotic synergism; Nascent protein exit tunnel; Peptide bond formation; Ribosomal crystallography

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; AZITHROMYCIN; CARBOMYCIN; CETHROMYCIN; CHLORAMPHENICOL; CLARITHROMYCIN; CLINDAMYCIN; DALFOPRISTIN; DALFOPRISTIN PLUS QUINUPRISTIN; EDEINE; ERYTHROMYCIN; KETOLIDE; LINCOSAMIDE; MACROLIDE; MIKAMYCIN B; PAROMOMYCIN; PEPTIDYLTRANSFERASE; PUROMYCIN; RIBONUCLEOPROTEIN; ROXITHROMYCIN; SPARSOMYCIN; SPECTINOMYCIN; TELITHROMYCIN; TETRACYCLINE DERIVATIVE; TIAMULIN; TRANSFER RNA; TROLEANDOMYCIN; TYLOSIN; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; BINDING AFFINITY; BINDING SITE; CELL MOTILITY; CELL ORGANELLE; CELL STRUCTURE; DRUG BINDING; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; PRIORITY JOURNAL; PROTEIN POLYMERIZATION; PROTEIN TARGETING; REVIEW; RIBOSOME; RNA BINDING; RNA CONFORMATION; RNA STRUCTURE; RNA TRANSPORT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BINDING SITES; DEINOCOCCUS; DRUG RESISTANCE, MICROBIAL; DRUG SYNERGISM; ESCHERICHIA COLI; HALOARCULA MARISMORTUI; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; RIBOSOMES; THERMUS THERMOPHILUS;

ARCHAEA; EUKARYOTA;

EID: 22244433549     PISSN: 00664154     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.biochem.74.082803.133130     Document Type: Review

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