Ribosomal antibiotics: Structural basis for resistance, synergism and selectivity

Trends in Biotechnology

Volumn 22, Issue 11, 2004, Pages 570-576

  Auerbach, Tamar ^a   Bashan, Anat ^a   Yonath, Ada ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIODIVERSITY; CELLS; DRUG PRODUCTS; PROTEINS; STRUCTURAL DESIGN;

CHEMICAL PROPERTIES; DRUG RESISTANCE; PEPTIDYL-TRANSFERASE CENTER (PTC); RIBOSOMAL PARTICLES;

ANTIBIOTICS;

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; AZITHROMYCIN; CARBOMYCIN; CHLORAMPHENICOL; CLARITHROMYCIN; DALFOPRISTIN; DALFOPRISTIN PLUS QUINUPRISTIN; ERYTHROMYCIN; KETOLIDE; LINCOSAMIDE DERIVATIVE; MACROLIDE; MIKAMYCIN B; NUCLEOTIDE; PEPTIDYLTRANSFERASE; PROTEIN; QUINUPRISTIN; ROXITHROMYCIN; SPIRAMYCIN; STREPTOGRAMIN; TROLEANDOMYCIN; TYLOSIN; VIRGINIAMYCIN M;

ARCHAEBACTERIUM; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG EFFICACY; DRUG POTENTIATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG USE; EUBACTERIUM; EUKARYOTE; MUTATION; NONHUMAN; PARTICULATE MATTER; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; RIBOSOME;

ARCHAEA; EUKARYOTA;

EID: 5644257352     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibtech.2004.09.006     Document Type: Article

References (51)

1. D. Vazquez Inhibitors of protein biosynthesis Mol. Biol. Biochem. Biophys. 30 1979 1 312
2. E.F. Gale The Molecular Basis of Antibiotic Action 1981 John Wiley & Sons
3. E. Cundliffe Antibiotic Inhibitors of Ribosome Function 1981 John Wiley & Sons
4. C.M. Spahn, and C.D. Prescott Throwing a spanner in the works: antibiotics and the translation apparatus J. Mol. Med. 74 1996 423 439
5. T. Auerbach Antibiotics targeting ribosomes: crystallographic studies Curr. Drug Targets Infect. Disord. 2 2002 169 186
6. F. Schluenzen Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution Cell 102 2000 615 623
7. B.T. Wimberly Structure of the 30S ribosomal subunit Nature 407 2000 327 339
8. J. Harms High resolution structure of the large ribosomal subunit from a mesophilic eubacterium Cell 107 2001 679 688
9. N. Ban The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution Science 289 2000 905 920
10. A.P. Carter Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics Nature 407 2000 340 348
11. D.E. Brodersen The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit Cell 103 2000 1143 1154
12. M. Pioletti Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3 EMBO J. 20 2001 1829 1839
13. F. Schluenzen Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria Nature 413 2001 814 821
14. F. Schluenzen Structural basis for the antibiotic activity of ketolides and azalides Structure 11 2003 329 338
15. J.L. Hansen The structures of four macrolide antibiotics bound to the large ribosomal subunit Mol. Cell 10 2002 117 128
16. J.L. Hansen Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit J. Mol. Biol. 330 2003 1061 1075
17. R. Berisio Structural insight into the role of the ribosomal tunnel in cellular regulation Nat. Struct. Biol. 10 2003 366 370
18. R. Berisio Structural insight into the antibiotic action of telithromycin against resistant mutants J. Bacteriol. 185 2003 4276 4279
19. J. Harms Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin BMC Biol. 2 2004 4
20. B. Weisblum Erythromycin resistance by ribosome modification Antimicrob. Agents Chemother. 39 1995 577 585
21. S. Douthwaite Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA Mol. Microbiol. 36 2000 183 193
22. L. Xiong A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre Mol. Microbiol. 31 1999 633 639
23. L.H. Hansen The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA Mol. Microbiol. 31 1999 623 631
24. S. Alvarez-Elcoro, and M.J. Enzler The macrolides: erythromycin, clarithromycin, and azithromycin Mayo Clin. Proc. 74 1999 613 634
25. H. Nakatogawa, and K. Ito The ribosome exit tunnel functions as a discriminating gate Cell 108 2002 629 636
26. F. Gong, and C. Yanofsky Instruction of translating ribosome by nascent peptide Science 297 2002 1864 1867
27. C.A. Woolhead Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins Cell 116 2004 725 736
28. A. Bashan Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression Mol. Cell 11 2003 91 102
29. A. Bashan Ribosomal crystallography: peptide bond formation and its inhibition Biopolymers 70 2003 19 41
30. I. Agmon On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes Eur. J. Biochem. 270 2003 2543 2556
31. B.T. Porse Direct crosslinking of the antitumor antibiotic sparsomycin, and its derivatives, to A2602 in the peptidyl transferase center of 23S-like rRNA within ribosome-tRNA complexes Proc. Natl. Acad. Sci. U. S. A. 96 1999 9003 9008
32. I.H. Goldberg, and K. Mitsugi Sparsomycin, an inhibitor of aminoacyl transfer to polypeptide Biochem. Biophys. Res. Commun. 23 1966 453 459
33. R.E. Monro Action of sparsomycin on ribosome-catalysed peptidyl transfer Nature 222 1969 356 358
34. I. Agmon Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism FEBS Lett. 567 2004 20 26
35. M.M. Yusupov Crystal structure of the ribosome at 5.5 Å resolution Science 292 2001 883 896
36. A.S. Mankin, and R.A. Garrett Chloramphenicol resistance mutations in the single 23S rRNA gene of the archaeon Halobacterium halobium J. Bacteriol. 173 1991 3559 3563
37. T. Izard, and J. Ellis The crystal structures of chloramphenicol phosphotransferase reveal a novel inactivation mechanism EMBO J. 19 2000 2690 2700
38. W.V. Shaw, and A.G. Leslie Chloramphenicol acetyltransferase Annu. Rev. Biophys. Biophys. Chem. 20 1991 363 386
39. B.T. Porse, and R.A. Garrett Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23S rRNA and the synergism of their inhibitory mechanisms J. Mol. Biol. 286 1999 375 387
40. A. Yonath The search and its outcome: high-resolution structures of ribosomal particles from mesophilic, thermophilic, and halophilic bacteria at various functional states Annu. Rev. Biophys. Biomol. Struct. 31 2002 257 273
41. A. Zamir The inactivation and reactivation of Escherichia coli ribosomes Methods Enzymol. 30 1974 406 426
42. M.A. Bayfield A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition Proc. Natl. Acad. Sci. U. S. A. 98 2001 10096 10101
43. P.B. Moore, and T.A. Steitz After the ribosome structures: how does peptidyl transferase work? RNA 9 2003 155 159
44. B. Vester, and S. Douthwaite Macrolide resistance conferred by base substitutions in 23S rRNA Antimicrob. Agents Chemother. 45 2001 1 12
45. G.T. Tan Mutations in the peptidyl transferase center of 23S rRNA reveal the site of action of sparsomycin, a universal inhibitor of translation J. Mol. Biol. 261 1996 222 230
46. H.G. Wittmann Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins Mol. Gen. Genet. 127 1973 175 189
47. H.S. Chittum, and W.S. Champney Ribosomal protein gene sequence changes in erythromycin-resistant mutants of Escherichia coli J. Bacteriol. 176 1994 6192 6198
48. N. Davydova L22 ribosomal protein and effect of its mutation on ribosome resistance to erythromycin J. Mol. Biol. 322 2002 635 644
49. I.S. Gabashvili The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22 Mol. Cell 8 2001 181 188
50. S.T. Gregory, and A.E. Dahlberg Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23S ribosomal RNA J. Mol. Biol. 289 1999 827 834
51. E.C. Bottger Structural basis for selectivity and toxicity of ribosomal antibiotics EMBO Rep 2 318 2001 23