Direct crosslinking of the antitumor antibiotic sparsomycin, and its derivatives, to A2602 in the peptidyl transferase center of 23S-like rRNA within ribosome-tRNA complexes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 16, 1999, Pages 9003-9008

  Porse, Bo T ^a   Kirillov, Stanislav V ^a,b   Awayez, Mariana J ^a   Ottenheijm, Harry C J ^c   Garrett, Roger A ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b PETERSBURG NUCLEAR PHYSICS INSTITUTE   (Russian Federation)

^c NV ORGANON   (Netherlands)

Author keywords

125I phenol alanine sparsomycin; RNase H analysis; Sparsomycin tRNA crosslink

Indexed keywords

ALANINE; ANTINEOPLASTIC ANTIBIOTIC; IODINE 125; NUCLEOTIDE; PEPTIDYLTRANSFERASE; PHENOL; RIBONUCLEASE H; RIBOSOME RNA; SPARSOMYCIN; SPARSOMYCIN DERIVATIVE; TRANSFER RNA; URACIL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CROSS LINKING; DRUG STRUCTURE; LOW ENERGY RADIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; ULTRAVIOLET RADIATION;

ANTIBIOTICS, ANTINEOPLASTIC; BACILLUS MEGATERIUM; BASE SEQUENCE; CROSS-LINKING REAGENTS; ESCHERICHIA COLI; HALOBACTERIUM SALINARUM; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PEPTIDYL TRANSFERASES; RIBOSOMES; RNA, BACTERIAL; RNA, FUNGAL; RNA, RIBOSOMAL, 23S; RNA, TRANSFER; SACCHAROMYCES CEREVISIAE; SPARSOMYCIN;

ARCHAEA; BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 0033529799     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.16.9003     Document Type: Article

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