In vitro and in vivo antimalarial activity of ferrochloroquine, a ferrocenyl analogue of chloroquine against chloroquine-resistant malaria parasites

Parasitology Research

Volumn 87, Issue 3, 2001, Pages 239-244

  Delhaes, L ^a,b   Abessolo, H ^b,d   Biot, C ^d   Berry, L ^b   Delcourt, P ^b   Maciejewski, L ^d   Brocard, J ^d   Camus, D ^b,c   Dive, D ^a,b  

^a INSTITUT PASTEUR DE LILLE   (France)

^b INSERM   (France)

^c UNIV LILLE   (France)

^d Ecole Nationale Superieure de Chimie de Lille   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; FERROCHLOROQUINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIMALARIAL ACTIVITY; ARTICLE; DRUG EFFECT; DRUG POTENCY; DRUG SAFETY; GROWTH INHIBITION; MALARIA; MOUSE; NONHUMAN; PARASITE DEVELOPMENT; PLASMODIUM; PRIORITY JOURNAL;

ANIMALIA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM VINCKEI; PROTOZOA;

EID: 0035090876     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004360000317     Document Type: Article

References (37)

1. Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue
2. Novel metallocenic compounds as antimalarial agents. Study of the position of ferrocene in chloroquine
3. Synthesis and antimalarial activity in vitro of potential metabolites of ferrochloroquine and related compounds
4. Synthetic ferrocenic mefloquine and quinine analogues as potential antimalarial agents
5. Structure-activity relationships for antiplasmodial activity among 7-substituted 4-aminoquinolines
6. Action préférentielle de la chloroquine sur les Plasmodium hebergés dans des hématies matures
7. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique
8. In vitro antimalarial activity of a new organometallic analog, ferrocene-chloroquine
9. Quinoline antimalarials: Mechanisms of action and resistance
10. New quinoline di-mannich base compounds with greater antimalarial activity than chloroquine, amodiaquine, or pyronaridine
11. MICMAC, a general and rigorous multiparameter refinement program for the determination of equilibrium constants using various physical methods
12. Toxicological evaluation of substituted dicyclopentadienyliron (ferrocene) compounds
13. Research toward vaccines against malaria
14. Program PKAS: A novel algorithm for the computation of successive protonation constants
15. An overview of chemotherapeutic targets for antimalarial drug discovery
16. 4-Aminoquinolines - Past, present, and future: A chemical perspective
17. Correlation of antimalarial activity of artemisinin derivatives with binding affinity with ferroprotoporphyrin IX
18. The chemotherapy of rodent malaria. II. Host-parasite relationships, part 2: The relationship between chloroquine sensitivity and the age of the host cell
19. The chemotherapy of rodent malaria. V. Dynamics of drug resistance, part1: Methods for studying the acquisition and loss of resistance to chloroquine by Plasmodium berghei
20. The chemotherapy of rodent malaria X. Dynamics of drug-resistance, Part 2. Acquisition and loss of chloroquine resistance in Plasmodium berghei observed by continuous bioassay
21. The chemotherapy of rodent malaria XXII. The value of drug resistant strains of P. berghei in screening for blood schizonticidal activity
22. Plasmodium vinckei: Production of chloroquine-resistant strain
23. Haemaglobin degradation and haem polymerization as antimalarial drug targets
24. Plasmodium: Drug discovery and development - An industrial perpective
25. Quinoline antimalarials
26. 4-Aminoquinoline analogs of chloroquine with shortened side chain retain activity against chloroquine-resistant Plasmodium falciparum
27. Estimating mortality, morbidity and disability due to malaria among Africa's non-pregnant population
28. Cultivation of malaria Parasites
29. Human malaria parasites in continuous culture
30. In vitro antimalarial activity of penduline, a bisbenzylisoquinoline from Isopyrum thalictroides
31. Effect of gastric emptying rate on the intestinal absorption of chloroquine in rats
32. Chloroquine treatment of severe malaria in children
33. World malaria situation in 1994. Part I
34. World malaria situation in 1994. Part III
35. Chronic toxicity of dicyclopentadienyl iron (ferrocene) in dogs