Synthesis and antimalarial activity in vitro of potential metabolites of ferrochloroquine and related compounds

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 12, 1999, Pages 2843-2847

  Biot, C ^a   Delhaes, L ^b,c   N'Diaye, C M ^a   MacIejewski, L A ^a   Camus, D ^b,c   Dive, D ^b   Brocard, J S ^a  

^a Laboratoire de Catalyse   (France)

^b INSERM   (France)

^c Faculty of Medicine   (France)

Author keywords

Chloroquine; Ferrocene; In vitro activity; Malaria; Metabolites; Plasmodium falciparum; Synthesis

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; DEETHYLCHLOROQUINE; DESMETHYLFERROCHLOROQUINE; DIDEETHYLCHLOROQUINE; DIDESMETHYLFERROCHLOROQUINE; DRUG METABOLITE; FERROCHLOROQUINE; FERROCHLOROQUINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; NONHUMAN; PLASMODIUM FALCIPARUM; SCHIZONT;

ANIMALS; ANTIMALARIALS; CHLOROQUINE; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 0033398868     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00224-2     Document Type: Article

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