Relative hydrophobicity and lipophilicity of β-blockers and related compounds as measured by aqueous two-phase partitioning, octanol-buffer partitioning, and HPLC

European Journal of Pharmaceutical Sciences

Volumn 17, Issue 1-2, 2002, Pages 81-93

  Gulyaeva, Nellie ^a   Zaslavsky, Alexander ^a   Lechner, Pamela ^a   Chlenov, Michael ^b   Chait, Arnon ^a   Zaslavsky, Boris ^a  

^a Analiza Inc   (United States)

^b PFIZER INC   (United States)

Author keywords

Blockers; Aqueous two phase partitioning; Hydrophobicity; Lipophilicity; Octanol buffer partitioning

Indexed keywords

AMINO ACIDS; FREE ENERGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY;

LIPOPHILICITY;

DRUG PRODUCTS;

ACEBUTOLOL; ALPRENOLOL; AMINO ACID DERIVATIVE; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARBENE; DEXTRAN; EPHEDRINE; ISOPRENALINE; LABETALOL; MACROGOL; METHYLEPHEDRINE; METOPROLOL; NORADRENALIN; PINDOLOL; PROPRANOLOL; SALBUTAMOL; SOTALOL; TERBUTALINE; TIMOLOL;

ANALYTIC METHOD; ARTICLE; ENERGY TRANSFER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; LIPOPHILICITY; PARTITION COEFFICIENT; PH; PRIORITY JOURNAL;

ADRENERGIC BETA-ANTAGONISTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROPHOBICITY; LIPIDS; OCTANOLS; WATER;

EID: 0036804586     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(02)00146-X     Document Type: Article

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