-
1
-
-
0036359548
-
Hypoxia - A key regulatory factor in tumour growth
-
HARRIS AL: Hypoxia - a key regulatory factor in tumour growth. Nat. Rev. Cancer (2002) 2:38-47.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
2
-
-
2942590732
-
Exploiting tumor hypoxia in cancer treatment
-
BROWN JM, WILSON WR: Exploiting tumor hypoxia in cancer treatment. Nat. Rev. Cancer (2004) 4:437-447.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 437-447
-
-
Brown, J.M.1
Wilson, W.R.2
-
3
-
-
12144290194
-
Comparative measurements of hypoxia in human brain rumors using needle electrodes and EF5 binding
-
EVANS SM, JUDY KD, DUNPHY I et al.: Comparative measurements of hypoxia in human brain rumors using needle electrodes and EF5 binding. Cancer Res. (2004) 64:1886-1892.
-
(2004)
Cancer Res.
, vol.64
, pp. 1886-1892
-
-
Evans, S.M.1
Judy, K.D.2
Dunphy, I.3
-
4
-
-
3042742567
-
18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography
-
18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography. Br. J. Cancer (2004) 90:2232-2242.
-
(2004)
Br. J. Cancer
, vol.90
, pp. 2232-2242
-
-
Barthel, H.1
Wilson, H.2
Collingridge, D.R.3
-
6
-
-
0032957390
-
Hypoxic regions exist in human prostate carcinoma
-
MOVSAS B, CHAPMAN JD, HORWITZ EM et al.: Hypoxic regions exist in human prostate carcinoma. Urology (1999) 53:11-18.
-
(1999)
Urology
, vol.53
, pp. 11-18
-
-
Movsas, B.1
Chapman, J.D.2
Horwitz, E.M.3
-
7
-
-
0036307898
-
Limited penetration of anticancer drugs through tumor tissue: A potential cause of resistance of solid tumors to chemotherapy
-
TANNOCK IF, LEE CM, TUNGGAL JK, COWAN DS, EGORIN MG: Limited penetration of anticancer drugs through tumor tissue: a potential cause of resistance of solid tumors to chemotherapy. Clin. Cancer Res. (2002) 8:878-884.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 878-884
-
-
Tannock, I.F.1
Lee, C.M.2
Tunggal, J.K.3
Cowan, D.S.4
Egorin, M.G.5
-
8
-
-
0032053823
-
The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
-
BROWN JM, GIACCIA AJ: The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res. (1998) 58:1405-1416.
-
(1998)
Cancer Res.
, vol.58
, pp. 1405-1416
-
-
Brown, J.M.1
Giaccia, A.J.2
-
9
-
-
0029884764
-
Recent developments in the design of bioreductive drugs
-
DENNY WA, WILSON WR, HAY MP: Recent developments in the design of bioreductive drugs. Br. J. Cancer (1996) 74 (Suppl.27):32-38.
-
(1996)
Br. J. Cancer
, vol.74
, Issue.SUPPL. 27
, pp. 32-38
-
-
Denny, W.A.1
Wilson, W.R.2
Hay, M.P.3
-
10
-
-
0035415493
-
Prodrug strategies in cancer therapy
-
DENNY WA: Prodrug strategies in cancer therapy. Eur. J. Med. Chem. (2001) 36:577-595.
-
(2001)
Eur. J. Med. Chem.
, vol.36
, pp. 577-595
-
-
Denny, W.A.1
-
11
-
-
13944258034
-
Extravascular transport of drugs in tumor tissue: Effect of lipophilicity on diffusion of tirapazamine analogues in multicellalar layer cultures
-
PRUIJN FB, STURMAN JR, LIYANAGE HDS, HICKS KO, HAY MP, WILSON WR: Extravascular transport of drugs in tumor tissue: effect of lipophilicity on diffusion of tirapazamine analogues in multicellalar layer cultures. J. Med. Chem. (2005) 48:1079-1087.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 1079-1087
-
-
Pruijn, F.B.1
Sturman, J.R.2
Liyanage, H.D.S.3
Hicks, K.O.4
Hay, M.P.5
Wilson, W.R.6
-
12
-
-
0022535929
-
Considerations for the design of nitrophenyl mustards as drugs selectively toxic for hypoxic mammalian cells
-
DENNY WA, WILSON WR: Considerations for the design of nitrophenyl mustards as drugs selectively toxic for hypoxic mammalian cells. J. Med. Chem. (1986) 29:879-887.
-
(1986)
J. Med. Chem.
, vol.29
, pp. 879-887
-
-
Denny, W.A.1
Wilson, W.R.2
-
13
-
-
0025021102
-
Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines
-
PALMER BD, WILSON WR, PULLEN SM, DENNY WA: Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines. J. Med. Chem. (1990) 33:112-121.
-
(1990)
J. Med. Chem.
, vol.33
, pp. 112-121
-
-
Palmer, B.D.1
Wilson, W.R.2
Pullen, S.M.3
Denny, W.A.4
-
14
-
-
0028090161
-
Self-immolative prodrugs: Candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme
-
MAUGER AB, BURKE PJ, SOMANI HH, FRIEDLOS F, KNOX RJ: Self-immolative prodrugs: candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme. J. Med. Chem. (1994) 37:3452-3458.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 3452-3458
-
-
Mauger, A.B.1
Burke, P.J.2
Somani, H.H.3
Friedlos, F.4
Knox, R.J.5
-
15
-
-
0035846072
-
Hypoxia-selective antitumor agents. 16. Nitroarylmethyl quaternary salts as bioreduccive prodrugs of the alkylating agent mechlorethamine
-
TERCEL M, LEE AE, HOGG A et al.: Hypoxia-selective antitumor agents. 16. Nitroarylmethyl quaternary salts as bioreduccive prodrugs of the alkylating agent mechlorethamine. J. Med. Chem. (2001) 44:3511-3522.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 3511-3522
-
-
Tercel, M.1
Lee, A.E.2
Hogg, A.3
-
16
-
-
0027220811
-
Rationale for the use of aliphatic N-oxides of cyrotoxic anthraquinones as prodrug DNA binding agents: A new class of bioreductive agent
-
PATTERSON LH: Rationale for the use of aliphatic N-oxides of cyrotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent. Cancer Met. Rev. (1993) 12:119-134.
-
(1993)
Cancer Met. Rev.
, vol.12
, pp. 119-134
-
-
Patterson, L.H.1
-
17
-
-
0027160629
-
Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards are a newclass of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards
-
WARE DC, PALMER BD, WILSON WR, DENNY WA: Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards are a newclass of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards. J. Med. Chem. (1993) 36:1839-1846.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 1839-1846
-
-
Ware, D.C.1
Palmer, B.D.2
Wilson, W.R.3
Denny, W.A.4
-
18
-
-
0031278015
-
The mitomycin bioreductive antitumor agents: Cross-linking and alkylation of DNA as the molecular basis of their activity
-
TOMASZ M, Y. PALOM Y: The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity. Pharmacol. Ther. (1997) 76:73-87.
-
(1997)
Pharmacol. Ther.
, vol.76
, pp. 73-87
-
-
Tomasz, M.Y.1
Palom, Y.2
-
19
-
-
3843072098
-
Nuclear overexpression of NAD(P)H: Quinone oxidoreductase 1 in Chinese hamster ovary cells increases the cytotoxicity of micomycin C under aerobic and hypoxic conditions
-
SEOW HA, PENKETH PG, BELCOURT MF, TOMASZ M, ROCKWELL S, SARTORELLI AC: Nuclear overexpression of NAD(P)H:quinone oxidoreductase 1 in Chinese hamster ovary cells increases the cytotoxicity of micomycin C under aerobic and hypoxic conditions. J. Biol. Chem. (2004) 279:31606-31612.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 31606-31612
-
-
Seow, H.A.1
Penketh, P.G.2
Belcourt, M.F.3
Tomasz, M.4
Rockwell, S.5
Sartorelli, A.C.6
-
20
-
-
0023902264
-
Therapeutic attack of hypoxic cells of solid tumors: Presidential address
-
SARTORELLI AC: Therapeutic attack of hypoxic cells of solid tumors: presidential address. Cancer Res. (1988) 48:775-778.
-
(1988)
Cancer Res.
, vol.48
, pp. 775-778
-
-
Sartorelli, A.C.1
-
21
-
-
19944420798
-
Concurrent chemo-radiotherapy with mitomycin C compared with porfiromycin in squamous cell cancer of the head and neck: Final results of a randomized clinical trial
-
HAFFTY BG, WILSON LD, SON YH et al.: Concurrent chemo-radiotherapy with mitomycin C compared with porfiromycin in squamous cell cancer of the head and neck: Final results of a randomized clinical trial. Int. J. Radiat. Oncol. Biol. Phys. (2005) 61:119-128.
-
(2005)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.61
, pp. 119-128
-
-
Haffty, B.G.1
Wilson, L.D.2
Son, Y.H.3
-
22
-
-
0032007820
-
Pharmacological and biochemical determinants of the antitumor activity of the indoloquinone EO9
-
CUMMINGS J, SPANSWICK VJ, GARDINER J, RITCHIE A, SMYTH JF: Pharmacological and biochemical determinants of the antitumor activity of the indoloquinone EO9. Biochem. Pharmacol. (1998) 55:253-260.
-
(1998)
Biochem. Pharmacol.
, vol.55
, pp. 253-260
-
-
Cummings, J.1
Spanswick, V.J.2
Gardiner, J.3
Ritchie, A.4
Smyth, J.F.5
-
23
-
-
0035877252
-
Relationship between NAD(P)H: Quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones
-
WINSKI SL, SWANN E, HARGREAVES RH et al.: Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones. Biochem. Pharmacol. (2001) 61:1509-1516.
-
(2001)
Biochem. Pharmacol.
, vol.61
, pp. 1509-1516
-
-
Winski, S.L.1
Swann, E.2
Hargreaves, R.H.3
-
24
-
-
0141628918
-
3-Substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: Mechanism of activation and cytotoxicity in vitro
-
JAFFAR M, PHILLIPS RM, WILLIAMS KJ et al.: 3-Substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro. Biochem. Pharmacol. (2003) 66:1199-1206.
-
(2003)
Biochem. Pharmacol.
, vol.66
, pp. 1199-1206
-
-
Jaffar, M.1
Phillips, R.M.2
Williams, K.J.3
-
25
-
-
7444258436
-
Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs
-
PHILLIPS RM, JAFFAR M, MAITLAND DJ et al.: Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs. Biochem. Pharmacol. (2004) 68:2107-2116.
-
(2004)
Biochem. Pharmacol.
, vol.68
, pp. 2107-2116
-
-
Phillips, R.M.1
Jaffar, M.2
Maitland, D.J.3
-
26
-
-
0031969730
-
Retinal degeneration in rats induced by CI-1010, a 2-nitroimidazole radiosensitizer
-
BREIDER MA, PILCHER GD, GRAZIANO MJ, GOUGH AW: Retinal degeneration in rats induced by CI-1010, a 2-nitroimidazole radiosensitizer. Toxicol. Pathol. (1988) 26:234-239.
-
(1988)
Toxicol. Pathol.
, vol.26
, pp. 234-239
-
-
Breider, M.A.1
Pilcher, G.D.2
Graziano, M.J.3
Gough, A.W.4
-
27
-
-
0026536057
-
NLA-1: A 2-nitroimidazole radiosensitizer targeted to DNA by intercalation
-
DENNY WA, ROBERTS PB, ANDERSON RF, BROWN JM, WILSON WR: NLA-1: a 2-nitroimidazole radiosensitizer targeted to DNA by intercalation. Int. J. Radiat. Oncol. Biol. Phys. (1992) 22:553-556.
-
(1992)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.22
, pp. 553-556
-
-
Denny, W.A.1
Roberts, P.B.2
Anderson, R.F.3
Brown, J.M.4
Wilson, W.R.5
-
28
-
-
0026594484
-
Radiosensitization and hypoxic cell toxicity of NLA-1 and NLA-2, two new bioreductive compounds
-
PAPADOPOULOU MV, EPPERLY MW, SHIELDS DS, BLOOMER WD: Radiosensitization and hypoxic cell toxicity of NLA-1 and NLA-2, two new bioreductive compounds. Jan. J. Cancer Res. (1992) 83:410-414.
-
(1992)
Jan. J. Cancer Res.
, vol.83
, pp. 410-414
-
-
Papadopoulou, M.V.1
Epperly, M.W.2
Shields, D.S.3
Bloomer, W.D.4
-
29
-
-
0344629821
-
NLCQ-1 (NSC 709257): Exploiting hypoxia with a weak DNA-intercalating bioreducrive drug
-
PAPADOPOULOU MV, BLOOMER WD: NLCQ-1 (NSC 709257): Exploiting hypoxia with a weak DNA-intercalating bioreducrive drug. Clin. Cancer Res. (2003) 9:5714-5720.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 5714-5720
-
-
Papadopoulou, M.V.1
Bloomer, W.D.2
-
30
-
-
0029896076
-
Hypoxia-selective antitumor agents. 14. Synthesis and hypoxic cell cytotoxicity of regioisomers of the hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide
-
PALMER BD, WILSON WR, ANDERSON RF, BOYD M, DENNY WA: Hypoxia-selective antitumor agents. 14. Synthesis and hypoxic cell cytotoxicity of regioisomers of the hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide. J. Med. Chem. (1996) 39:2518-2528.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 2518-2528
-
-
Palmer, B.D.1
Wilson, W.R.2
Anderson, R.F.3
Boyd, M.4
Denny, W.A.5
-
31
-
-
0036494169
-
Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures
-
WILSON WR, PULLEN SM, HOGG A, HELSBY NA, HICKS KO, DENNY WA: Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures. Cancer Res. (2002) 62:1425-1432.
-
(2002)
Cancer Res.
, vol.62
, pp. 1425-1432
-
-
Wilson, W.R.1
Pullen, S.M.2
Hogg, A.3
Helsby, N.A.4
Hicks, K.O.5
Denny, W.A.6
-
32
-
-
1942424798
-
2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreducrase GDEPT
-
HELSBY NA, FERRY DM, PATTERSON AV, PULLEN SM, WILSON WR: 2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreducrase GDEPT. Br. J. Cancer (2004) 90:1084-1092.
-
(2004)
Br. J. Cancer
, vol.90
, pp. 1084-1092
-
-
Helsby, N.A.1
Ferry, D.M.2
Patterson, A.V.3
Pullen, S.M.4
Wilson, W.R.5
-
33
-
-
0029782488
-
CC-1065 and the duocarmycins: Understanding their biological function through mechanistic studies
-
BOGER DL, JOHNSON DS: CC-1065 and the duocarmycins: understanding their biological function through mechanistic studies. Angew Chem. Int. Ed. (1996) 35:1438-1474.
-
(1996)
Angew Chem. Int. Ed.
, vol.35
, pp. 1438-1474
-
-
Boger, D.L.1
Johnson, D.S.2
-
34
-
-
0032957259
-
Comparison of the patterns of DNA alkylation by phenol and amino seco-CBI-TMI compounds: Use of a PCR method for the facile preparation of single end-labelled double stranded DNA
-
GIESEG MA, MATEJOVIC J, DENNY WA: Comparison of the patterns of DNA alkylation by phenol and amino seco-CBI-TMI compounds: use of a PCR method for the facile preparation of single end-labelled double stranded DNA. Anticancer Drug Des. (1999) 14:77-84.
-
(1999)
Anticancer Drug Des.
, vol.14
, pp. 77-84
-
-
Gieseg, M.A.1
Matejovic, J.2
Denny, W.A.3
-
35
-
-
0038101357
-
Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e] indoline minor groove alkylating agents as prodrugs for gene therapy in conjunction with E. coli nitroreductase
-
HAY MP, ATWELL GJ, WILSON WR, PULLEN SM, DENNY WA: Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e] indoline minor groove alkylating agents as prodrugs for gene therapy in conjunction with E. coli nitroreductase. J. Med. Chem. (2003) 46:2456-2466.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 2456-2466
-
-
Hay, M.P.1
Atwell, G.J.2
Wilson, W.R.3
Pullen, S.M.4
Denny, W.A.5
-
36
-
-
0030916634
-
Synthesis and cytotoxicity of amino analogues of the potent DNA alkylating agent seco-CBI-TMI
-
ATWELL G.J, WILSON WR, DENNY WA: Synthesis and cytotoxicity of amino analogues of the potent DNA alkylating agent seco-CBI-TMI. Bioorg. Med. Chem. Lett. (1997) 7:1493-1496.
-
(1997)
Bioorg. Med. Chem. Lett.
, vol.7
, pp. 1493-1496
-
-
Atwell, G.J.1
Wilson, W.R.2
Denny, W.A.3
-
37
-
-
0037073905
-
A new short synthesis of 3-substituted-1-(chloromethyl)-2, 3-dihydro-(1H)-benzo[e]indol-5-ylamines (amino-CBIs)
-
YANG S, DENNY WA: A new short synthesis of 3-substituted-1-(chloromethyl)-2, 3-dihydro-(1H)-benzo[e]indol-5-ylamines (amino-CBIs). J. Org. Chem. (2002) 67:8958-8961.
-
(2002)
J. Org. Chem.
, vol.67
, pp. 8958-8961
-
-
Yang, S.1
Denny, W.A.2
-
38
-
-
0001662224
-
Substituent effects on the kinetics of reductively-initiated fragmentation of nitrobenzyl carbamates designed as triggers for bioreductive drugs
-
HAY MP, SYKES BM, O'CONNOR CJ, DENNY WA: Substituent effects on the kinetics of reductively-initiated fragmentation of nitrobenzyl carbamates designed as triggers for bioreductive drugs. J. Chem. Soc. Perkin Trans. I (1999) 2759-2770.
-
(1999)
J. Chem. Soc. Perkin Trans. I
, pp. 2759-2770
-
-
Hay, M.P.1
Sykes, B.M.2
O'connor, C.J.3
Denny, W.A.4
-
39
-
-
0033545676
-
Hypoxia-selective nitrobenzyloxycarbonyl derivatives of 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines
-
SHYAM K, PENKETH PG, SHAPIRO M, et al.: Hypoxia-selective nitrobenzyloxycarbonyl derivatives of 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines. J. Med. Chem. (1999) 42:941-946.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 941-946
-
-
Shyam, K.1
Penketh, P.G.2
Shapiro, M.3
-
40
-
-
0028276290
-
Nitrobenzyl phosphoramidates as potential hypoxia-selective alkylating agents
-
MULCAHY RT, GIPP JJ, SCHMIDT JP, JOSWIG C, BORCH RT. Nitrobenzyl phosphoramidates as potential hypoxia-selective alkylating agents. J. Med. Chem. (1994) 37:1610-1615.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1610-1615
-
-
Mulcahy, R.T.1
Gipp, J.J.2
Schmidt, J.P.3
Joswig, C.4
Borch, R.T.5
-
41
-
-
0033516908
-
A 2-nitroimidazole carbamate prodrug of 5-amino-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl) carbonyl]-1,2-dihydro-3H-benz[e]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT
-
HAY MP, SYKES BM, DENNY WA et al.: A 2-nitroimidazole carbamate prodrug of 5-amino-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl) carbonyl]-1,2-dihydro-3 H-benz[e]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT. Bioorg. Med. Chem. Lett. (1999) 15:2237-2242.
-
(1999)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 2237-2242
-
-
Hay, M.P.1
Sykes, B.M.2
Denny, W.A.3
-
42
-
-
0030004578
-
Hypoxia-selective antitumor agents. 12. Nitrobenzyl quaternary salts as bioreducrive prodrugs of the alkylating agent mechlorethamine
-
TERCEL M, WILSON WR, ANDERSON RF, DENNY WA: Hypoxia-selective antitumor agents. 12. Nitrobenzyl quaternary salts as bioreducrive prodrugs of the alkylating agent mechlorethamine. J. Med. Chem. (1996) 39:1084-1094.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1084-1094
-
-
Tercel, M.1
Wilson, W.R.2
Anderson, R.F.3
Denny, W.A.4
-
43
-
-
0031938856
-
Reduction of nitroarylmethyl quaternary ammonium prodrugs of mechlorethamine by radiation
-
WILSON WR, FERRY DM, TERCEL M, ANDERSON RF, DENNY WA: Reduction of nitroarylmethyl quaternary ammonium prodrugs of mechlorethamine by radiation. Radiat. Res. (1998) 149:237-245.
-
(1998)
Radiat. Res.
, vol.149
, pp. 237-245
-
-
Wilson, W.R.1
Ferry, D.M.2
Tercel, M.3
Anderson, R.F.4
Denny, W.A.5
-
44
-
-
0029935930
-
Tertiary amine N-oxides as bioreductive drugs: DACA N-oxide, nitracrine N-oxide and AQ4N
-
WILSON WR, DENNY WA, PULLEN SM, et al.: Tertiary amine N-oxides as bioreductive drugs: DACA N-oxide, nitracrine N-oxide and AQ4N. Br. J. Cancer (1996) 74 (Suppl.27):43-47.
-
(1996)
Br. J. Cancer
, vol.74
, Issue.SUPPL. 27
, pp. 43-47
-
-
Wilson, W.R.1
Denny, W.A.2
Pullen, S.M.3
-
45
-
-
0036041236
-
Bioreductively activated antitumor N-oxides: The case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy
-
PATTERSON, LH: Bioreductively activated antitumor N-oxides: the case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy. Drug Met. Rev. (2002) 34:581-592.
-
(2002)
Drug Met. Rev.
, vol.34
, pp. 581-592
-
-
Patterson, L.H.1
-
46
-
-
0034029002
-
Enhancement of chemotherapy and radiotherapy of murine tumors by AQ4N, a bioreductively activated anti-tumor agent
-
PATTERSON LH, MCKEOWN SR, RUPARELIA K, et al.: Enhancement of chemotherapy and radiotherapy of murine tumors by AQ4N, a bioreductively activated anti-tumor agent. Br. J. Cancer (2000) 82:1984-1990.
-
(2000)
Br. J. Cancer
, vol.82
, pp. 1984-1990
-
-
Patterson, L.H.1
McKeown, S.R.2
Ruparelia, K.3
-
47
-
-
0035902851
-
The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N
-
GALLAGHER R, HUGHES CM, MURRAY MM et al.: The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N. Br. J. Cancer (2001) 85:625-629.
-
(2001)
Br. J. Cancer
, vol.85
, pp. 625-629
-
-
Gallagher, R.1
Hughes, C.M.2
Murray, M.M.3
-
48
-
-
0037279816
-
Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N
-
McCARTHY HO, YAKKUNDI A, McERLANE et al.: Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N. Cancer Gene Ther. (2003) 10:40-48.
-
(2003)
Cancer Gene Ther.
, vol.10
, pp. 40-48
-
-
McCarthy, H.O.1
Yakkundi, A.2
McErlane3
-
49
-
-
4444369682
-
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α
-
WELSH S, WILLIAMS R, KIRKPATRICK L, PAINE-MURRIETA G, POWIS G: Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α. Mol. Cancer Ther (2004) 3:233-244.
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 233-244
-
-
Welsh, S.1
Williams, R.2
Kirkpatrick, L.3
Paine-Murrieta, G.4
Powis, G.5
-
50
-
-
16644377045
-
Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: A randomized Phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02)
-
RISCHIN D, PETERS L, FISHER R et al.: Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: a randomized Phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02). J. Clin. Oncol. (2005) 23:79-87.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 79-87
-
-
Rischin, D.1
Peters, L.2
Fisher, R.3
-
51
-
-
0034104328
-
Tirapazamine plus cisplatin versus cisptatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group
-
VON PAWEL J, VON ROEMELING R, GATZEMEIER U et al.: Tirapazamine plus cisplatin versus cisptatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. J. Clin. Oncol. (2000) 18:1351-1359.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 1351-1359
-
-
Von Pawel, J.1
Von Roemeling, R.2
Gatzemeier, U.3
-
52
-
-
0031656983
-
Enzymology of tirapazamine metabolism: A review
-
PATTERSON AV, SAUNDERS MP, CHINJE EC, PATTERSON LH, STRATFORD IJ: Enzymology of tirapazamine metabolism: a review. Anticancer Drug Des. (1998) 13:541-573.
-
(1998)
Anticancer Drug Des.
, vol.13
, pp. 541-573
-
-
Patterson, A.V.1
Saunders, M.P.2
Chinje, E.C.3
Patterson, L.H.4
Stratford, I.J.5
-
53
-
-
0037460188
-
Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction
-
ANDERSON RF, SHINDE SS, FLAY MP, GAMAGE SA, DENNY WA: Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction. J. Am. Chem. Soc. (2003) 125:748-756.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 748-756
-
-
Anderson, R.F.1
Shinde, S.S.2
Flay, M.P.3
Gamage, S.A.4
Denny, W.A.5
-
54
-
-
3042544368
-
Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-aminobenzotriazine 1,4-dioxides
-
SHINDE S, ANDERSON RF, HAY MP, GAMAGE SA, DENNY WA: Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-aminobenzotriazine 1,4-dioxides. J. Am. Chem. Soc. (2004) 126:7865-7874.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 7865-7874
-
-
Shinde, S.1
Anderson, R.F.2
Hay, M.P.3
Gamage, S.A.4
Denny, W.A.5
-
55
-
-
0033607196
-
Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1′-radical in single-stranded and double-scranded DNA: The drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions
-
HWANG JT, GREENBERG MM, FUCHS T, GATES KS: Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1′-radical in single-stranded and double-scranded DNA: The drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions. Biochemistry (1999) 38:14248-14255.
-
(1999)
Biochemistry
, vol.38
, pp. 14248-14255
-
-
Hwang, J.T.1
Greenberg, M.M.2
Fuchs, T.3
Gates, K.S.4
-
56
-
-
0027227590
-
Unusual concentration dependence of toxicity of SR-4233, a hypoxic cell toxin
-
KOCH CJ: Unusual concentration dependence of toxicity of SR-4233, a hypoxic cell toxin. Cancer Res. (1993) 53:3992-3997.
-
(1993)
Cancer Res.
, vol.53
, pp. 3992-3997
-
-
Koch, C.J.1
-
57
-
-
0141507967
-
Multicellular resistance to tirapazamine is due to restricted extravascular transport: A pharmacokinetic/pharmacodynamic study using multicellular layer cultures
-
HICKS KO, PRUIJN FB, STURMAN JR, DENNY WA, WILSON WR: Multicellular resistance to tirapazamine is due to restricted extravascular transport: a pharmacokinetic/pharmacodynamic study using multicellular layer cultures. Cancer Res. (2003) 63:5970-5977.
-
(2003)
Cancer Res.
, vol.63
, pp. 5970-5977
-
-
Hicks, K.O.1
Pruijn, F.B.2
Sturman, J.R.3
Denny, W.A.4
Wilson, W.R.5
-
58
-
-
0037164618
-
New and versatile syntheses of 3-alkyl-1,2,4-benzotriazine-1,4-dioxides: Preparation of the bioreductive cytotoxins SR4895 and SR4941
-
HAY MP, DENNY WA: New and versatile syntheses of 3-alkyl-1,2,4-benzotriazine-1,4-dioxides: preparation of the bioreductive cytotoxins SR4895 and SR4941. Tet. Lett. (2002) 43:9569-9571.
-
(2002)
Tet. Lett.
, vol.43
, pp. 9569-9571
-
-
Hay, M.P.1
Denny, W.A.2
-
59
-
-
0037413529
-
Structure-activicy relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine
-
HAY MP, GAMAGE SA, KOVACS MS et al.: Structure-activicy relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine. J. Med. Chem. (2003), 46:169-182.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 169-182
-
-
Hay, M.P.1
Gamage, S.A.2
Kovacs, M.S.3
-
60
-
-
0038054178
-
Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting
-
DELAHOUSSAYE YM, HAY MP, PRUIJN FB, DENNY WA, BROWN JM: Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting. Biochem. Pharmacol. (2003) 65:1807-1815.
-
(2003)
Biochem. Pharmacol.
, vol.65
, pp. 1807-1815
-
-
Delahoussaye, Y.M.1
Hay, M.P.2
Pruijn, F.B.3
Denny, W.A.4
Brown, J.M.5
-
61
-
-
0347593966
-
DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: Potent analogues of the hypoxia-selective cytotoxin tirapazamine
-
HAY MP, PRUIJN FB, GAMAGE SA et al.: DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine. J. Med. Chem. (2004) 47:475-488.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 475-488
-
-
Hay, M.P.1
Pruijn, F.B.2
Gamage, S.A.3
-
62
-
-
1642475109
-
Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317
-
SIIM BG, PRUIJN FB, STURMAN JR et al.: Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317. Cancer Res. (2004) 64:736-742.
-
(2004)
Cancer Res.
, vol.64
, pp. 736-742
-
-
Siim, B.G.1
Pruijn, F.B.2
Sturman, J.R.3
-
63
-
-
0001727431
-
Kinetics of ammonia detachment from reduced cobalt(III) complexes based on conductometric pulse radiolysis
-
SIMIC M, LILIE J: Kinetics of ammonia detachment from reduced cobalt(III) complexes based on conductometric pulse radiolysis. J. Am. Chem. Soc. (1974) 96:291-292.
-
(1974)
J. Am. Chem. Soc.
, vol.96
, pp. 291-292
-
-
Simic, M.1
Lilie, J.2
-
64
-
-
0029931345
-
Pulse radiolysis studies on the mechanism of hypoxia-selective cytotoxicity of the cobalt(III)-nitrogen mustard complex SN 24771
-
ANDERSON RF, DENNY WA, WARE DC, WILSON WR: Pulse radiolysis studies on the mechanism of hypoxia-selective cytotoxicity of the cobalt(III)-nitrogen mustard complex SN 24771. Br. J. Cancer (1996) 74 (Suppl.27):48-51.
-
(1996)
Br. J. Cancer
, vol.74
, Issue.SUPPL. 27
, pp. 48-51
-
-
Anderson, R.F.1
Denny, W.A.2
Ware, D.C.3
Wilson, W.R.4
-
65
-
-
7444241438
-
A novel design strategy for stable metal complexes of nitrogen mustards as bioreductive prodrugs
-
PARKER LL, LACY SM, FARRUGIA LJ et al.: A novel design strategy for stable metal complexes of nitrogen mustards as bioreductive prodrugs. J. Med. Chem. (2004) 47:5683-5689.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 5683-5689
-
-
Parker, L.L.1
Lacy, S.M.2
Farrugia, L.J.3
-
66
-
-
4644296027
-
Optimization of the auxiliary ligand shell of cobalt(III) (8-hydroxyquinoline) complexes as model hypoxia-setective radiation-activated prodrugs
-
AHN G-O, WARE DC, DENNY WA, WILSON WR: Optimization of the auxiliary ligand shell of cobalt(III) (8-hydroxyquinoline) complexes as model hypoxia-setective radiation-activated prodrugs. Radiat. Res. (2004) 162:315-325.
-
(2004)
Radiat. Res.
, vol.162
, pp. 315-325
-
-
Ahn, G.-O.1
Ware, D.C.2
Denny, W.A.3
Wilson, W.R.4
-
67
-
-
0031706557
-
Radiation-activated prodrugs as hypoxia-selective cytotoxins: Model studies with nitroarylmethyl quaternary salts
-
WILSON WR, TERCEL M, ANDERSON RF, DENNY WA: Radiation-activated prodrugs as hypoxia-selective cytotoxins: model studies with nitroarylmethyl quaternary salts. Anticancer Drug Des. (1998) 13:663-685.
-
(1998)
Anticancer Drug Des.
, vol.13
, pp. 663-685
-
-
Wilson, W.R.1
Tercel, M.2
Anderson, R.F.3
Denny, W.A.4
-
68
-
-
10644256629
-
The Japanese experiences with hypoxia-targeting pharmacoradiotherapy; from hypoxic cell sensitizers to radiation-activated prodrugs
-
SHIBAMOTO Y, SUGIE C, ITO M, OGINO H: The Japanese experiences with hypoxia-targeting pharmacoradiotherapy; from hypoxic cell sensitizers to radiation-activated prodrugs. Expert Opin. Pharmacother. (2004) 5:2459-2467.
-
(2004)
Expert Opin. Pharmacother.
, vol.5
, pp. 2459-2467
-
-
Shibamoto, Y.1
Sugie, C.2
Ito, M.3
Ogino, H.4
-
69
-
-
0035254229
-
In vivo evaluation of a novel antitumor prodrug, 1-(2′-oxopropyl)-5-fluorouracil (OFU001), which releases 5-fluorouracil upon hypoxic irradiation
-
SHIBAMOTO Y, ZHOU L, HATTA H, MORI M, NISHMOTO S: In vivo evaluation of a novel antitumor prodrug, 1-(2′-oxopropyl)-5-fluorouracil (OFU001), which releases 5-fluorouracil upon hypoxic irradiation. Int. J. Radiat. Oncol. Biol. Phys. (2001) 49:407-413.
-
(2001)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.49
, pp. 407-413
-
-
Shibamoto, Y.1
Zhou, L.2
Hatta, H.3
Mori, M.4
Nishmoto, S.5
-
70
-
-
0018098489
-
The liquefaction (oncolysis) of malignant gliomas by a non pathogenic Clostridium
-
HEPPNER F, MOSE JR: The liquefaction (oncolysis) of malignant gliomas by a non pathogenic Clostridium. Acta Neurochir. (1978) 42:123-125.
-
(1978)
Acta Neurochir.
, vol.42
, pp. 123-125
-
-
Heppner, F.1
Mose, J.R.2
-
71
-
-
0029932035
-
Anaerobic bacteria as a delivery system for cancer gene therapy: In vitro activation of 5-fluorocytosine by genetically engineered Clostridia
-
FOX ME. LEMMON MJ, MAUCHLINE ML et al.: Anaerobic bacteria as a delivery system for cancer gene therapy: in vitro activation of 5-fluorocytosine by genetically engineered Clostridia. Gene Ther. (1996) 3:173-178.
-
(1996)
Gene Ther.
, vol.3
, pp. 173-178
-
-
Fox, M.E.1
Lemmon, M.J.2
Mauchline, M.L.3
-
72
-
-
0030865697
-
Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment
-
LEMMON MJ, VAN ZIJL P, FOX ME et al.: Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment. Gene Ther. (1997) 4:791-796.
-
(1997)
Gene Ther.
, vol.4
, pp. 791-796
-
-
Lemmon, M.J.1
Van Zijl, P.2
Fox, M.E.3
-
73
-
-
85047697737
-
Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis
-
LIU SC, MINTON NP, GIACCIA AJ, BROWN JM: Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis. Gene Ther. (2002) 9:291-296.
-
(2002)
Gene Ther.
, vol.9
, pp. 291-296
-
-
Liu, S.C.1
Minton, N.P.2
Giaccia, A.J.3
Brown, J.M.4
|