Hypoxia-selective antitumor agents. 14. Synthesis and hypoxic cell cytotoxicity of regioisomers of the hypoxia-selective cytotoxin 5-[N,N-Bis(2-chloroethyl)amino]-2,4-dinitrobenzamide

Journal of Medicinal Chemistry

Volumn 39, Issue 13, 1996, Pages 2518-2528

  Palmer, Brian D ^a   Wilson, William R ^a   Anderson, Robert F ^a   Boyd, Maruta ^a   Denny, William A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

5 [N,N BIS(2 CHLOROETHYL)AMINO] 2,4 DINITROBENZAMIDE; BENZAMIDE DERIVATIVE; CYTOTOXIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CLONOGENIC ASSAY; CYTOTOXICITY; DNA ALKYLATION; DRUG DISPOSITION; DRUG SYNTHESIS; ENZYME ACTIVATION; HYPOXIA; HYPOXIC CELL; ISOMERISM; NONHUMAN;

ANILINE MUSTARD; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL HYPOXIA; CELL LINE; CELL SURVIVAL; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; ISOMERISM; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED C3H; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0029896076     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960057p     Document Type: Article

References (29)

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