Limited penetration of anticancer drugs through tumor tissue: A potential cause of resistance of solid tumors to chemotherapy

Clinical Cancer Research

Volumn 8, Issue 3, 2002, Pages 878-884

  Tannock, Ian F ^a   Lee, Carol M ^a   Tunggal, Jonathon K ^a   Cowan, David S M ^a   Egorin, Merrill J ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; COLLAGEN; ETOPOSIDE; GEMCITABINE; LAMININ; PACLITAXEL; SCLEROPROTEIN; VINBLASTINE;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESMOSOME; DRUG PENETRATION; DRUG RESISTANCE; DRUG TISSUE LEVEL; EXTRACELLULAR MATRIX; FLUORESCENCE; HEREDITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOLID TUMOR;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; CISPLATIN; DEOXYCYTIDINE; DIFFUSION; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MEMBRANES, ARTIFICIAL; MICE; NEOPLASM STAGING; PACLITAXEL; POLYTETRAFLUOROETHYLENE; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS; VINBLASTINE;

EID: 0036307898     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo
2. Multicellular resistance: A new paradigm to explain aspects of acquired drug resistance of solid tumors
3. Resistance to Adriamycin in multicellular spheroids
4. Penetration and binding of vinblastine and 5-fluorouracil in cellular spheroids
5. Cell selection from a murine tumour using the fluorescent probe Hoechst 33342
6. Distribution and activity of antineoplastic drugs in a tumor model
7. Classification of antineoplastic treatments by their differential toxicity towards putative oxygenated and hypoxic tumor subpopulations in vivo in the FsaIIC murine fibrosarcoma
8. Vascular and interstitial barriers to delivery of therapeutic agents in tumors
9. Delivery of molecular and cellular medicine to solid tumors
10. Penetration of anticancer drugs through solid tissue: A factor that limits the effectiveness of chemotherapy for solid tumors
11. Doxorubicin gradients in human breast cancer
12. The influence of P-glycoprotein on the penetration of anticancer drugs through multicellular layers
13. Factors that influence the penetration of methotrexate through solid tissue
14. An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours
15. Measurement of extravascular drug diffusion in multicellular layers
16. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
17. 2 gradients in solid tumors in vivo: Simultaneous high resolution measurements reveal a lack of correlation
18. Multicellular membranes as an in vitro model for extravascular diffusion in tumours
19. Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours
20. Multilayers of cells growing on a permeable support. An in vitro tumour model
21. Effects of storage on the binding of carboplatin to plasma proteins
22. Uptake of Adriamycin into large unilamellar vesicles in response to a pH gradient
23. Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in Adriamycin resistant cells (MCF-7adr)
24. Slow penetration of anthracyclines into spheroids and tumors: A therapeutic advantage?
25. Repopulation of tumour cells between cycles of chemotherapy: A neglected factor