Synthesis and cytotoxicity of amino analogues of the potent DNA alkylating agent seco-CBI-TMI

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 12, 1997, Pages 1493-1496

  Atwell, G J ^a   Wilson, W R ^a   Denny, W A ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; ANTINEOPLASTIC AGENT; CARZELESIN; DUOCARMYCIN A; INDOLE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

EID: 0030916634     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00259-X     Document Type: Article

References (9)

1. Boger, D. L.; Johnson, D. S. Angew. Chem. Int. Ed. Engl. 1996, 35, 1438.
2. CBI = 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one; TMI = 5,6,7-trimethoxyindole-2-carboxylate: CI = 1,2,7,7a-tetrahydrocyclopropa[1,2-c]indol-4-one.
3. Boger, D. L.; Yun, W. J. Am. Chem. Soc. 1994, 116, 7996.
4. Boger, D. L.; Ishizaki, T.; Zarrinmayeh, H.; Kitos, P. A; Suntornwat, O. J. Org. Chem. 1990, 55, 4499.
5. Denny, W. A.; Hay, M. P.; Wilson, W. R. Br. J. Cancer (Suppl. 17), 1996, 74, 32.
6. Denny, W. A. Curr. Pharm. Des. 1996, 2, 281.
7. Li, L. H.; DeKoning, T. F.; Kelly, R. C.; Krueger, W. C.; McGovren, J. P.; Padbury, G. E.; Petzold, G. L.; Wallace, T. L.; Ouding, R. J.; Prairie, M. D.; Gebhard, I. Cancer Res. 1992, 52, 4904.
8. Tercel, M.; Denny, W. A.; Wilson, W. R. Bioorg. Med. Chem. Lett. 1996, 6, 2741.
9. Tercel, M.; Denny, W. A.; Wilson, W. R. Bioorg. Med. Chem. Lett. 1996, 6, 2735.