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Volumn 90, Issue 11, 2004, Pages 2232-2242

In vivo evaluation of [18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography

Author keywords

2 nitroimidazole; Imaging; PET; Tumour hypoxia; 18F FETA

Indexed keywords

CARBOGEN; FLUOROETANIDAZOLE F 18; NITROGEN; NITROREDUCTASE; OCTANOL; TRACER; TUMOR MARKER; UNCLASSIFIED DRUG; WATER; DIAGNOSTIC AGENT; DRUG DERIVATIVE; ETANIDAZOLE; FLUORINE; FLUOROETANIDAZOLE;

EID: 3042742567     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601862     Document Type: Article
Times cited : (97)

References (71)
  • 1
    • 0031709082 scopus 로고    scopus 로고
    • Preclinical development and current status of the fluorinated 2-nitroimidazole hypoxia prob N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1- imidazolyl) acetamide (SR 4554, CRC 94/17): A non-invasive diagnostic probe for the measurement of tumor hypoxia by magnetic resonance spectroscopy and imaging, and by positron emission tomography
    • Aboagye EO, Kelson AB, Tracy M, Workman P (1998) Preclinical development and current status of the fluorinated 2-nitroimidazole hypoxia prob N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR 4554, CRC 94/17): a non-invasive diagnostic probe for the measurement of tumor hypoxia by magnetic resonance spectroscopy and imaging, and by positron emission tomography. Anti-Cancer Drug Des 13: 703-730
    • (1998) Anti-Cancer Drug des , vol.13 , pp. 703-730
    • Aboagye, E.O.1    Kelson, A.B.2    Tracy, M.3    Workman, P.4
  • 2
    • 0030723054 scopus 로고    scopus 로고
    • Bioreductive metabolism of the novel fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitroimidazolyl) acetamide (SR-4554)
    • Aboagye EO, Lewis AD, Tracy M, Workman P (1997a) Bioreductive metabolism of the novel fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3- trifluoropropyl)-2-(2-nitroimidazolyl) acetamide (SR-4554). Biochem Pharmacol 54: 1217-1224
    • (1997) Biochem Pharmacol , vol.54 , pp. 1217-1224
    • Aboagye, E.O.1    Lewis, A.D.2    Tracy, M.3    Workman, P.4
  • 3
    • 0030744656 scopus 로고    scopus 로고
    • Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia
    • Aboagye EO, Maxwell RJ, Kelson AB, Tracy M, Lewis AD, Graham MA, Horsman MR, Griffiths JR, Workman P (1997b) Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia. Cancer Res 57: 3314-3318
    • (1997) Cancer Res , vol.57 , pp. 3314-3318
    • Aboagye, E.O.1    Maxwell, R.J.2    Kelson, A.B.3    Tracy, M.4    Lewis, A.D.5    Graham, M.A.6    Horsman, M.R.7    Griffiths, J.R.8    Workman, P.9
  • 5
    • 0035300410 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
    • Aebersold DM, Burri P, Beer KT, Laissue J, Djonov V, Greiner RH, Semenza GL (2001) Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 61: 2911-2916
    • (2001) Cancer Res , vol.61 , pp. 2911-2916
    • Aebersold, D.M.1    Burri, P.2    Beer, K.T.3    Laissue, J.4    Djonov, V.5    Greiner, R.H.6    Semenza, G.L.7
  • 10
    • 0018848562 scopus 로고
    • Partition coefficient as a guide to the development of radiosensitizers which are less toxic than misonidazole
    • Brown JM, Workman P (1980) Partition coefficient as a guide to the development of radiosensitizers which are less toxic than misonidazole. Radiat Res 82: 171-190
    • (1980) Radiat Res , vol.82 , pp. 171-190
    • Brown, J.M.1    Workman, P.2
  • 12
    • 0033764934 scopus 로고    scopus 로고
    • Pentoxifylline improves the oxygenation and radiation response of BA1112 rat rhabdomyosarcomas and EMT6 mouse mammary carcinomas
    • Collingridge DR, Rockwell S (2000) Pentoxifylline improves the oxygenation and radiation response of BA1112 rat rhabdomyosarcomas and EMT6 mouse mammary carcinomas. Int J Cancer 90: 256-264
    • (2000) Int J Cancer , vol.90 , pp. 256-264
    • Collingridge, D.R.1    Rockwell, S.2
  • 13
    • 0031058592 scopus 로고    scopus 로고
    • Measurement of tumor oxygenation: A comparison between polarographic needle electrodes and a time-resolved luminescence-based optical sensor
    • Collingridge DR, Young WK, Vojnovic B, Wardman P, Lynch EM, Hill SA, Chaplin DJ (1997) Measurement of tumor oxygenation: a comparison between polarographic needle electrodes and a time-resolved luminescence-based optical sensor. Radiat Res 147: 329-334
    • (1997) Radiat Res , vol.147 , pp. 329-334
    • Collingridge, D.R.1    Young, W.K.2    Vojnovic, B.3    Wardman, P.4    Lynch, E.M.5    Hill, S.A.6    Chaplin, D.J.7
  • 15
    • 0028362466 scopus 로고
    • Rapid tissue oxygen tension mapping using 19F inversion-recovery echo-planar imaging of perfluoro-15-crown-5-ether
    • Dardzinski BJ, Sotak CH (1994) Rapid tissue oxygen tension mapping using 19F inversion-recovery echo-planar imaging of perfluoro-15-crown-5-ether. Magn Reson Med 32: 88-97
    • (1994) Magn Reson Med , vol.32 , pp. 88-97
    • Dardzinski, B.J.1    Sotak, C.H.2
  • 17
    • 0030032543 scopus 로고    scopus 로고
    • 2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9L s.c. tumors
    • Evans SM, Jenkins WT, Joiner B, Lord EM, Koch CJ (1996) 2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9L s.c. tumors. Cancer Res 56: 405-411
    • (1996) Cancer Res , vol.56 , pp. 405-411
    • Evans, S.M.1    Jenkins, W.T.2    Joiner, B.3    Lord, E.M.4    Koch, C.J.5
  • 18
    • 0029917028 scopus 로고    scopus 로고
    • Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: Correlation with sensitivity to mitomycin C and EO9
    • Fitzsimmons SA, Workman P, Grever M, Paull K, Camalier R, Lewis AD (1996) Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9. J Natl Cancer Inst 88: 259-269
    • (1996) J Natl Cancer Inst , vol.88 , pp. 259-269
    • Fitzsimmons, S.A.1    Workman, P.2    Grever, M.3    Paull, K.4    Camalier, R.5    Lewis, A.D.6
  • 19
    • 0030811565 scopus 로고    scopus 로고
    • Copper-62-ATSM: A new hypoxia imaging agent with high membrane permeability and low redox potential
    • Fujibayashi Y, Taniuchi H, Yonekura Y, Ohtani H, Konishi J, Yokoyama A (1997) Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. Nucl Med 38: 1155-1160
    • (1997) Nucl Med , vol.38 , pp. 1155-1160
    • Fujibayashi, Y.1    Taniuchi, H.2    Yonekura, Y.3    Ohtani, H.4    Konishi, J.5    Yokoyama, A.6
  • 20
    • 0036467638 scopus 로고    scopus 로고
    • Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer
    • Fyles A, Milosevic M, Hedley D, Pintilie M, Levin W, Manchul L, Hill RP (2002) Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J Clin Oncol 20: 680-687
    • (2002) J Clin Oncol , vol.20 , pp. 680-687
    • Fyles, A.1    Milosevic, M.2    Hedley, D.3    Pintilie, M.4    Levin, W.5    Manchul, L.6    Hill, R.P.7
  • 22
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris AL (2002) Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 24
    • 0031858408 scopus 로고    scopus 로고
    • On the correlation between the water diffusion coefficient and oxygen tension in RIF-1 tumors
    • Helmer KG, Han S, Sotak CH (1998) On the correlation between the water diffusion coefficient and oxygen tension in RIF-1 tumors. NMR Biomed 11: 120-130
    • (1998) NMR Biomed , vol.11 , pp. 120-130
    • Helmer, K.G.1    Han, S.2    Sotak, C.H.3
  • 26
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Höckel M, Schlenger K, Aral B, Mitze M, Schafer U, Vaupel P (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56: 4509-4515
    • (1996) Cancer Res , vol.56 , pp. 4509-4515
    • Höckel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schafer, U.5    Vaupel, P.6
  • 27
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biological, and molecular aspects
    • Höckel M, Vaupel P (2001) Tumor hypoxia: definitions and current clinical, biological, and molecular aspects. J Natl Cancer Inst 93: 266-276
    • (2001) J Natl Cancer Inst , vol.93 , pp. 266-276
    • Höckel, M.1    Vaupel, P.2
  • 28
    • 0016697619 scopus 로고
    • Studies on the reaction mechanism of DT diaphorase. Action of dead-end inhibitors and effects of phospholipids
    • Hollander PM, Ernster L (1975) Studies on the reaction mechanism of DT diaphorase. Action of dead-end inhibitors and effects of phospholipids. Arch Biochem Biophys 169: 560-567
    • (1975) Arch Biochem Biophys , vol.169 , pp. 560-567
    • Hollander, P.M.1    Ernster, L.2
  • 29
    • 0029057395 scopus 로고
    • Perfusion changes in the RIF-1 tumour and normal tissues after carbogen and nicotinamide, individually and combined
    • Honess DJ, Bleehen NM (1995) Perfusion changes in the RIF-1 tumour and normal tissues after carbogen and nicotinamide, individually and combined. Br J Cancer 71: 1175-1180
    • (1995) Br J Cancer , vol.71 , pp. 1175-1180
    • Honess, D.J.1    Bleehen, N.M.2
  • 31
    • 0026657350 scopus 로고
    • Overcoming tumour radiation resistance resulting from acute hypoxia
    • Horsman MR, Overgaard J (1992) Overcoming tumour radiation resistance resulting from acute hypoxia. Eur J Cancer 28A: 2084-2085
    • (1992) Eur J Cancer , vol.28 A , pp. 2084-2085
    • Horsman, M.R.1    Overgaard, J.2
  • 33
    • 0036788267 scopus 로고    scopus 로고
    • In vivo measurement of regional oxygenation and imaging of redox status in RIF-1 murine tumor: Effect of carbogen-breathing
    • Ilangovan G, Li H, Zweier JL, Krishna MC, Mitchell JB, Kuppusamy P (2002) In vivo measurement of regional oxygenation and imaging of redox status in RIF-1 murine tumor: effect of carbogen-breathing. Magn Reson Med 48: 723-730
    • (2002) Magn Reson Med , vol.48 , pp. 723-730
    • Ilangovan, G.1    Li, H.2    Zweier, J.L.3    Krishna, M.C.4    Mitchell, J.B.5    Kuppusamy, P.6
  • 34
    • 0033335619 scopus 로고    scopus 로고
    • A 3D HIDAC-PET camera with sub-millimetre resolution for imaging small animals
    • Jeavons AP, Chandler RA, Dettmat CA (1999) A 3D HIDAC-PET camera with sub-millimetre resolution for imaging small animals. IEEE Trans Nucl Sci 46: 468-473
    • (1999) IEEE Trans Nucl Sci , vol.46 , pp. 468-473
    • Jeavons, A.P.1    Chandler, R.A.2    Dettmat, C.A.3
  • 35
    • 0022437135 scopus 로고
    • Synthesis and biodistribution of 18F-labeled fluoronitroimidazoles: Potential in vivo markers of hypoxic tissue
    • Jerabek PA, Patrick TB, Kilbourn MR, Dischino DD, Welch MJ (1986) Synthesis and biodistribution of 18F-labeled fluoronitroimidazoles: potential in vivo markers of hypoxic tissue. Int J Radiat Appl Instrum (A) 37: 599-605
    • (1986) Int J Radiat Appl Instrum (A) , vol.37 , pp. 599-605
    • Jerabek, P.A.1    Patrick, T.B.2    Kilbourn, M.R.3    Dischino, D.D.4    Welch, M.J.5
  • 36
    • 0028338580 scopus 로고
    • The role of specific reductases in the intracellular activation and binding of 2-nitroimidazoles
    • Joseph P, Jaiswal AK, Stobbe CC, Chapman JD (1994) The role of specific reductases in the intracellular activation and binding of 2-nitroimidazoles. Int J Radiat Oncol Biol Phys 29: 351-355
    • (1994) Int J Radiat Oncol Biol Phys , vol.29 , pp. 351-355
    • Joseph, P.1    Jaiswal, A.K.2    Stobbe, C.C.3    Chapman, J.D.4
  • 40
    • 0029021223 scopus 로고
    • Secretion rates and levels of vascular endothelial growth factor in clone A or HCT-8 human colon tumour cells as a function of oxygen concentration
    • Leith JT, Michelson S (1995) Secretion rates and levels of vascular endothelial growth factor in clone A or HCT-8 human colon tumour cells as a function of oxygen concentration. Cell Prolif 28: 415-430
    • (1995) Cell Prolif , vol.28 , pp. 415-430
    • Leith, J.T.1    Michelson, S.2
  • 41
    • 0025870484 scopus 로고
    • Radioiodinated 1-(5-iodo-5-deoxy-beta-D-arabinofuranosyl)-2- nitroimidazole (iodoazomycin arabinoside: IAZA): A novel marker of tissue hypoxia
    • Mannan RH, Somayaji VV, Lee J, Mercer JR, Chapman JD, Wiebe LI (1991) Radioiodinated 1-(5-iodo-5-deoxy-beta-D-arabinofuranosyl)-2-nitroimidazole (iodoazomycin arabinoside: IAZA): a novel marker of tissue hypoxia. J Nucl Med 32: 1764-1770
    • (1991) J Nucl Med , vol.32 , pp. 1764-1770
    • Mannan, R.H.1    Somayaji, V.V.2    Lee, J.3    Mercer, J.R.4    Chapman, J.D.5    Wiebe, L.I.6
  • 42
    • 0021276479 scopus 로고
    • Hypoxic fractions of solid tumors: Experimental techniques, methods of analysis, and a survey of existing data
    • Moulder JE, Rockwell S (1984) Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. Int J Radiat Oncol Biol Phys 10: 695-712
    • (1984) Int J Radiat Oncol Biol Phys , vol.10 , pp. 695-712
    • Moulder, J.E.1    Rockwell, S.2
  • 43
    • 0034307112 scopus 로고    scopus 로고
    • A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy
    • Nordsmark M, Overgaard J (2000) A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy. Radiother Oncol 57: 39-43
    • (2000) Radiother Oncol , vol.57 , pp. 39-43
    • Nordsmark, M.1    Overgaard, J.2
  • 44
    • 0029955072 scopus 로고    scopus 로고
    • Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
    • Nordsmark M, Overgaard M, Overgaard J (1996) Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 41: 31-39
    • (1996) Radiother Oncol , vol.41 , pp. 31-39
    • Nordsmark, M.1    Overgaard, M.2    Overgaard, J.3
  • 47
  • 50
    • 0025285228 scopus 로고
    • Characteristics of the binding of labeled fluoromisonidazole in cells in vitro
    • Rasey JS, Nelson NJ, Chin L, Evans ML, Grunbaum Z (1990) Characteristics of the binding of labeled fluoromisonidazole in cells in vitro. Radiat Res 122: 301-308
    • (1990) Radiat Res , vol.122 , pp. 301-308
    • Rasey, J.S.1    Nelson, N.J.2    Chin, L.3    Evans, M.L.4    Grunbaum, Z.5
  • 51
    • 0025328583 scopus 로고
    • Hypoxic fractions of human tumors xenografted into mice: A review
    • Rockwell S, Moulder JE (1990) Hypoxic fractions of human tumors xenografted into mice: a review. Int J Radiat Oncol Biol Phys 19: 197-202
    • (1990) Int J Radiat Oncol Biol Phys , vol.19 , pp. 197-202
    • Rockwell, S.1    Moulder, J.E.2
  • 53
    • 0034980373 scopus 로고    scopus 로고
    • Measurement of tumor oxygenation: In vivo comparison of a luminescence fibre-optic sensor and a polarographic electrode in the P22 tumors
    • Seddon BM, Honess DJ, Vojnovic B, Tozer G, Workman P (2001) Measurement of tumor oxygenation: in vivo comparison of a luminescence fibre-optic sensor and a polarographic electrode in the P22 tumors. Radiat Res 55: 837-846
    • (2001) Radiat Res , vol.55 , pp. 837-846
    • Seddon, B.M.1    Honess, D.J.2    Vojnovic, B.3    Tozer, G.4    Workman, P.5
  • 54
    • 0035992408 scopus 로고    scopus 로고
    • Validation of the fluorinated 2-nitroimidazole SR-4554 as a non-invasive hypoxia marker detected by magnetic resonance spectroscopy
    • Seddon BM, Maxwell RJ, Honess DJ, Grimshaw R, Raynaud F, Tozer GM, Workman P (2002) Validation of the fluorinated 2-nitroimidazole SR-4554 as a non-invasive hypoxia marker detected by magnetic resonance spectroscopy. Clin Cancer Res 8: 2323-2335
    • (2002) Clin Cancer Res , vol.8 , pp. 2323-2335
    • Seddon, B.M.1    Maxwell, R.J.2    Honess, D.J.3    Grimshaw, R.4    Raynaud, F.5    Tozer, G.M.6    Workman, P.7
  • 55
    • 0037872699 scopus 로고    scopus 로고
    • Angiogenesis in ischemic and neoplastic disorders
    • Semenza GL (2003) Angiogenesis in ischemic and neoplastic disorders. Annu Rev Med 54: 17-28
    • (2003) Annu Rev Med , vol.54 , pp. 17-28
    • Semenza, G.L.1
  • 56
    • 0033785989 scopus 로고    scopus 로고
    • Establishment of an isogenic human colon tumor model for NQO1 gene expression: Application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo
    • Sharp SY, Kelland LR, Valenti MR, Brunton LA, Hobbs S, Workman P (2000) Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo. Mol Pharmacol 58: 1146-1155
    • (2000) Mol Pharmacol , vol.58 , pp. 1146-1155
    • Sharp, S.Y.1    Kelland, L.R.2    Valenti, M.R.3    Brunton, L.A.4    Hobbs, S.5    Workman, P.6
  • 57
    • 0023164712 scopus 로고
    • Increase in pO2 and radiosensitivity of tumors by Fluosol-DA (20%) and carbogen
    • Song CW, Lee I, Hasegawa T, Rhee JG, Levitt SH (1987) Increase in pO2 and radiosensitivity of tumors by Fluosol-DA (20%) and carbogen. Cancer Res 47: 442-446
    • (1987) Cancer Res , vol.47 , pp. 442-446
    • Song, C.W.1    Lee, I.2    Hasegawa, T.3    Rhee, J.G.4    Levitt, S.H.5
  • 58
    • 0038058799 scopus 로고    scopus 로고
    • 18FFluoroazomycinarabinofuranoside ((18)FAZA) and [(18)F] Fluoromisonidazole ((18)FMISO): A comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors
    • Sorger D, Patt M, Kumar P, Wiebe LI, Barthel H, Seese A, Dannenberg C, Tannapfel A, Sabri O (2003) 18)F]Fluoroazomycinarabinofuranoside ((18)FAZA) and [(18)F]Fluoromisonidazole ((18)FMISO): a comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors. Nucl Med Biol 30: 317-326
    • (2003) Nucl Med Biol , vol.30 , pp. 317-326
    • Sorger, D.1    Patt, M.2    Kumar, P.3    Wiebe, L.I.4    Barthel, H.5    Seese, A.6    Dannenberg, C.7    Tannapfel, A.8    Sabri, O.9
  • 59
    • 0031661074 scopus 로고    scopus 로고
    • Bioreductive drugs into the next millennium
    • Stratford IJ, Workman P (1998) Bioreductive drugs into the next millennium. Anticancer Drug Des 13: 519-528
    • (1998) Anticancer Drug des , vol.13 , pp. 519-528
    • Stratford, I.J.1    Workman, P.2
  • 60
    • 0030608674 scopus 로고    scopus 로고
    • 18F]fluoroetanidazole: A potential new tracer for imaging hypoxia
    • 18F]fluoroetanidazole: a potential new tracer for imaging hypoxia. Nucl Med Biol 24: 755-760
    • (1997) Nucl Med Biol , vol.24 , pp. 755-760
    • Tewson, T.J.1
  • 61
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel P, Kallinowski F, Okunieff P (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49: 6449-6465
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 62
    • 0025893246 scopus 로고
    • The role of NAD(P)H: Quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9
    • Walton MI, Smith PJ, Workman P (1991) The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9. Cancer Commun 3: 199-206
    • (1991) Cancer Commun , vol.3 , pp. 199-206
    • Walton, M.I.1    Smith, P.J.2    Workman, P.3
  • 63
    • 0037865312 scopus 로고    scopus 로고
    • A simplified synthesis of 2,3,5,6-tetrafluorophenyl 2-(2-nitroimidazol-1- yl) acetate
    • Wilson HK (2003) A simplified synthesis of 2,3,5,6-tetrafluorophenyl 2-(2-nitroimidazol-1-yl) acetate. J Labelled Compound Radiopharm 46: 511-513
    • (2003) J Labelled Compound Radiopharm , vol.46 , pp. 511-513
    • Wilson, H.K.1
  • 64
    • 0032435478 scopus 로고    scopus 로고
    • A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: Identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent
    • Winski SL, Hargreaves RH, Butler J, Ross D (1998) A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent. Clin Cancer Res 4: 3083-3088
    • (1998) Clin Cancer Res , vol.4 , pp. 3083-3088
    • Winski, S.L.1    Hargreaves, R.H.2    Butler, J.3    Ross, D.4
  • 65
    • 3042710019 scopus 로고
    • Lipophilicity and the pharmacokinetics of nitroimidazoles
    • Breccia A, Rimondi C, Adams GE (eds). Pienum Press: Amsterdam
    • Workman P (1982) Lipophilicity and the pharmacokinetics of nitroimidazoles. In Advanced Topics on Radiosensitizers of Hypoxic Cells, Breccia A, Rimondi C, Adams GE (eds). pp 143-163. Pienum Press: Amsterdam
    • (1982) Advanced Topics on Radiosensitizers of Hypoxic Cells , pp. 143-163
    • Workman, P.1
  • 66
    • 0019418024 scopus 로고
    • Structure - Pharmacokinetic relationships for misonidazole analogues in mice
    • Workman P, Brown JM (1981) Structure - pharmacokinetic relationships for misonidazole analogues in mice. Cancer Chemother Pharmacol 6: 39-49
    • (1981) Cancer Chemother Pharmacol , vol.6 , pp. 39-49
    • Workman, P.1    Brown, J.M.2
  • 69
    • 0028917959 scopus 로고
    • Development of F-18-labeled fluoroerythronitroimidazole as a PET agent for imaging tumor hypoxia
    • Yang DJ, Wallace S, Cherif A, Li C, Gretzer MB, Kim EE, Podoloff DA (1995) Development of F-18-labeled fluoroerythronitroimidazole as a PET agent for imaging tumor hypoxia. Radiology 194: 795-800
    • (1995) Radiology , vol.194 , pp. 795-800
    • Yang, D.J.1    Wallace, S.2    Cherif, A.3    Li, C.4    Gretzer, M.B.5    Kim, E.E.6    Podoloff, D.A.7
  • 70
    • 0029993224 scopus 로고    scopus 로고
    • Measurement of oxygen tension in tumours by time-resolved fluorescence
    • Young WK, Vojnovic B, Wardman P (1996) Measurement of oxygen tension in tumours by time-resolved fluorescence. Br J Cancer 27(Suppl): S256-S259
    • (1996) Br J Cancer , vol.27 , Issue.SUPPL.
    • Young, W.K.1    Vojnovic, B.2    Wardman, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.