Molecular and Biological Properties of P2Y Receptors

Current Topics in Membranes

Volumn 54, Issue , 2003, Pages 59-96

  Lazarowski, Eduardo R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 21144434164     PISSN: 10635823     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1063-5823(03)01003-2     Document Type: Article

References (175)

1. G.K.M Akbar V.R Dasari T.E Webb K Ayyanathan K Pillarisetti A.K Sandhu R.S Athwal J.L Daniel B Ashby E.A Barnard S.P Kunapuli Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells J. Biol. Chem 271 1996 18363 18367
2. P Angel M Karin The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation Biochim. Biophys. Acta 1072 1991 129 157
3. Z Anwar J.L Albert S.E Gubby J.P Boyle J.A Roberts T.E Webb M.R Boarder Regulation of cyclic AMP by extracellular ATP in cultured brain capillary endothelial cells Br. J. Pharmacol 128 1999 465 471
4. 2+ in human erythroleukemia cells J. Biol. Chem 272 1997 10151 10159
5. A Baurand P Raboisson M Freund C Leon J.P Cazenave J.J Bourguignon C Gachet Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist Eur. J. Pharmacol 412 2001 213 221
6. J.S Bennett Novel platelet inhibitors Annu. Rev. Med 52 2001 161 184
7. M.R Boarder Cyclic AMP and tyrosine kinase cascades in the regulation of cellular function by P2Y nucleotide receptors J.Y Turner G.A Weisman J.S Fedan “The P2 Nucleotide Receptors” 1998 Humana Press Totowa, NJ 413 426
8. M.R Boarder S.M.O Hourani The regulation of vascular function by P2 receptors: Multiple sites and multiple receptors Trends Physiol. Sci 19 1998 99 107
9. S Boehm S Huck P Illes UTP- and ATP-triggered transmitter release from rat sympathetic neurones via separate receptors Br. J. Pharmacol 116 1995 2341 2343
10. E Bofill-Cardona N Vartian C Nanoff M Freissmuth S Boehm Two different signaling mechanisms involved in the excitation of rat sympathetic neurons by uridine nucleotides Mol. Pharmacol 57 2000 1165 1172
11. Y.D Bogdanov L Dale B.F King N Whittock G Burnstock Early expression of a novel nucleotide receptor in the neural plate of Xenopus embryos J. Biol. Chem 272 1997 12583 12590
12. 4 nucleotide receptor Br. J. Pharmacol 124 1998 428 430
13. 2+ elevation in mammalian brain astrocytic cultures Drug Dev. Res 52 Suppl. 2001 122 132
14. 2Y purinergic receptor agonists and guanine nucleotides J. Biol. Chem 264 1989 884 890
15. 2Y- purinergic receptor that inhibits adenylyl cyclase J. Pharm. Exp. Ther 267 1993 1140 1146
16. 1 receptor Mol. Pharmacol 50 1996 1323 1329
17. J.L Boyer G.L Waldo T.K Harden Molecular cloning and expression of an avian G protein-coupled P2Y receptor Mol. Pharmacol 52 1997 928 934
18. 6-methyl 2′-deoxyadenosine 3′,5′-bisphosphate Br. J. Pharmacol 124 1998 1 3
19. 4 receptor J. Biol. Chem 276 2001 11939 11948
20. H.A Brown E.R Lazarowski R.C Boucher T.K Harden Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5′-nucleotide receptor in human airway epithelial cells Mol. Pharmacol 40 1991 648 655
21. G Burnstock Purinergic nerves Pharmacol. Rev 24 1972 509 581
22. G Burnstock A basis for distinguishing two types of purinergic receptor L.B Straub “Cell Membrane Receptors for Drugs and Hormones: A Multidisciplinary Approach” 1978 Raven Press New York 107 118
23. 2-purinoceptor? Gen. Pharmacol 16 1985 433 440
24. G Burnstock M Williams P2 purinergic receptors: Modulation of cell function and therapeutic potential J. Pharmacol. Exp. Ther 295 2000 862 869
25. 2+ responses evoked by ATP and other nucleotides in mammalian brain astrocytes Br. J. Pharmacol 121 1997 1700 1706
26. J.K Chambers L.E Macdonald H.M Sarau R.S Ames K Freeman J.J Foley Y Zhu M.M McLaughlin P Murdock L McMillan J Trill A Swift N Aiyar P Taylor L Vawter S Naheed P Szekeres G Hervieu C Scott J.M Watson A.J Murphy E Duzic C Klein D.J Bergsma S Wilson G.P Livi A G protein-coupled receptor for UDP-glucose J. Biol. Chem 275 2000 10767 10771
27. 2 nucleotide receptor J. Biol. Chem 270 1995 26152 26158
28. S.J Charlton C.A Brown G.A Weisman J.T Turner L Erb M.R Boarder PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors Br. J. Pharmacol 118 1996 704 710
29. –⧸– mice Proc. Natl. Acad. Sci. USA 91 1994 479 483
30. D Communi S Pirotton M Parmentier J.-M Boeynaems Cloning and functional expression of a human uridine nucleotide receptor J. Biol. Chem 270 1995 30849 30852
31. D Communi S Motte J.M Boeynaems S Pirotton Pharmacological characterization of the human P2Y4 receptor Eur. J. Pharmacol 317 1996 383 389
32. 6 receptor Biochem. Biophys. Res. Commun 222 1996 303 308
33. D Communi C Govaerts M Parmentier J.M Boeynaems Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase J. Biol. Chem 272 1997 31969 31973
34. D Communi P Paindavoine G.A Place M Parmentier J.M Boeynaems Expression of P2Y receptors in cell lines derived from the human lung Br. J. Pharmacol 127 1999 562 568
35. D Communi B Robaye J.M Boeynaems Pharmacological characterization of the human P2Y11 receptor Br. J. Pharmacol 128 1999 1199 1206
36. D Communi R Janssens N Suarez-Huerta B Robaye J.M Boeynaems Advances in signalling by extracellular nucleotides: The role and transduction mechanisms of P2Y receptors Cell Signal 12 2000 351 360
37. D Communi R Janssens B Robaye N Zeelis J.M Boeynaems Rapid up-regulation of P2Y messengers during granulocytic differentiation of HL-60 cells FEBS Lett 475 2000 39 42
38. D Communi N Suarez-Huerta D Dussossoy P Savi J.M Boeynaems Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes J. Biol. Chem 276 2001 16561 16566
39. A.D Conigrave J.Y Lee W.L van der L Jiang P Ward V Tasevski B.M Luttrell M.B Morris Pharmacological profile of a novel cyclic AMP-linked P2 receptor on undifferentiated HL-60 leukemia cells Br. J. Pharmacol 124 1998 1580 1585
40. G.P Connolly P.J Harrison Structure–activity relationship of a pyrimidine receptor in the rat isolated superior cervical ganglion Br. J. Pharmacol 116 1995 2764 2770
41. D.S Cowen M Sanders G Dubyak P2-purinergic receptors activate a guanine nucleotide-dependent phospholipase C in membranes from HL-60 cells Biochim. Biophys. Acta 1053 1990 195 203
42. − transport J. Biol. Chem 274 1999 26461 26468
43. α 11 signaling J. Biol. Chem 276 2001 5438 5444
44. E.G Delicado A.I Jimenez E Castro M.T Miras-Portugal Cerebellar astrocytes coexpress different purinoceptors: Cross-talk between several transduction mechanisms Drug Dev. Res 52 Suppl. 2001 114 121
45. 1 receptor Br. J. Pharmacol 130 2000 664 668
46. H.G Dohlman J Thorner RGS proteins and signaling by heterotrimeric G proteins J. Biol. Chem 272 1997 3871 3874
47. S.H Donaldson R.C Boucher Therapeutic applications for nucleotides in lung disease J.T Turner G.A Weisman J.S Fedan “The P2 Nucleotide Receptors” 1998 Humana Press Totowa, NJ 413 424
48. J.A Dranoff A.F O'Neill A.M Franco S.Y Cai G.C Connolly N Ballatori J.L Boyer M.H Nathanson A primitive ATP receptor from the little skate Raja erinacea J. Biol. Chem 275 2000 30701 30706
49. 2-purinergic receptors for extracellular ATP Am. J. Respir. Cell Mol. Biol 4 1991 295 300
50. 2+ mobilization activated by extracellular ATP in Ehrlich ascites tumor cells J. Biol. Chem 260 1985 10653 10661
51. 2U purinoceptors. Positively charged amino acids in transmembrane helices 6 and 7 affect agonist potency and specificity J. Biol. Chem 270 1995 4185 4188
52. o-mediated signal transduction J. Cell Biol 153 2001 491 501
53. D Erlinge M Hou T.E Webb E.A Barnard S Moller Phenotype changes of the vascular smooth muscle cell regulate P2 receptor expression as measured by quantitative RT-PCR Biochem. Biophys. Res. Commun 248 1998 864 870
54. J.E Fabre M Nguyen A Latour J.A Keifer L.P Audoly T.M Coffman B.H Koller Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice Nat. Med 5 1999 1199 1202
55. 2+ wave propagation in dorsal spinal cord astrocytes J. Neurosci 20 2000 2800 2808
56. + currents in rat sympathetic neurones Br. J. Pharmacol 126 1999 1009 1017
57. 2+ channel in neurones, with both adenosine triphosphates and diphosphates as potent agonists Br. J. Pharmacol 129 2000 1063 1066
58. 2Y purinergic receptor that couples to phospholipase C Mol. Pharmacol 46 1994 8 14
59. N.J Freedman R.J Lefkowitz Desensitization of G protein-coupled receptors Recent Prog. Horm. Res 51 1996 319 351
60. C Gachet Platelet activation by ADP: The role of ADP antagonists Ann. Med 32 Suppl. 1 2000 15 20
61. R.C Garrad M.A Otero L Erb P.M Theiss L.L Clarke F.A Gonzalez J.T Turner G.A Weisman Structural basis of agonist-induced desensitization and sequestration of the P2Y2 nucleotide receptor: Consequences of truncation of the C terminus J. Biol. Chem 273 1998 29437 29444
62. S Godecke U.K Decking A Godecke J Schrader Cloning of the rat P2u receptor and its potential role in coronary vasodilation Am. J. Physiol 270 1996 C570 C577
63. B.R Grubb Ion transport across the murine intestine in the absence and presence of CFTR Comp. Biochem. Physiol. A Physiol 118 1997 277 282
64. + exchanger regulatory factor family of PDZ proteins Proc. Natl. Acad. Sci. USA 95 1998 8496 8501
65. T.K Harden P.T Hawkins L Stephens J.L Boyer C.P Downes Phosphoinositide hydrolysis by guanosine 5′-[γ-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes Biochem. J 252 1988 583 593
66. T.K Harden J.L Boyer R.A Nicholas P2-purinergic receptors: Subtype-associated signaling responses and structure Annu. Rev. Pharmacol. Toxicol 35 1995 541 579
67. S Harper T.E Webb S.J Charlton L.L Ng M.R Boarder Evidence that P2Y4 nucleotide receptors are involved in the regulation of rat aortic smooth muscle cells by UTP and ATP Br. J. Pharmacol 124 1998 703 710
68. D Haussinger T Stehle W Gerok Actions of extracellular UTP and ATP in perfused rat liver: A comparative study Eur. J. Biochem 167 1987 65 71
69. D Haussinger E Busshardt T Stehle B Stoll M Wettstein W Gerok Stimulation of thromboxane release by extracellular UTP and ATP from perfused rat liver: Role of icosanoids in mediating the nucleotide responses Eur. J. Biochem 178 1988 249 256
70. B Hechler P Vigne C Leon J.P Breittmayer C Gachet C Frelin ATP derivatives are antagonists of the P2Y1 receptor: Similarities to the platelet ADP receptor Mol. Pharmacol 53 1998 727 733
71. D.J Henderson D.G Elliot G.M Smith T.E Webb I.A Dainty Cloning and characterisation of a bovine P2Y receptor Biochem. Biophys. Res. Commun 212 1995 648 656
72. C.L Herold A Oi C Kennedy T.K Harden R.A Nicholas Analysis of chimeric human and rat P2Y4 receptors FASEB J 13 Suppl. I 1999 A464
73. C Hoffmann S Moro R.A Nicholas T.K Harden K.A Jacobson The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes J. Biol. Chem 274 1999 14639 14647
74. G Hollopeter H.M Jantzen D Vincent G Li L England V Ramakrishnan R.B Yang P Nurden A Nurden D Julius P.B Conley Identification of the platelet ADP receptor targeted by antithrombotic drugs Nature 409 2001 202 207
75. L Homolya W.C Watt E.R Lazarowski B.H Koller R.C Boucher Nucleotide-regulated calcium signaling in lung fibroblasts and epithelial cells from normal and P2Y2 receptor–⧸– mice J. Biol. Chem 274 1999 26454 26460
76. L Homolya A.D Steinberg R.C Boucher Cell to cell communication in response to mechanical stress via bilateral release of ATP and UTP in polarized epithelia J. Cell Biol 150 2000 1349 1360
77. 6 receptors Am. J. Physiol. Heart Circ. Physiol 282 2002 H784 H792
78. S.M.O Hourani N.J Cusack Pharmacological receptors on blood platelets Pharmacol. Rev 43 1991 243 298
79. K.A Jacobson C Hoffmann Y.C Kim E Camaioni E Nandanan S.Y Jang D.P Guo X.D Ji I von Kugelgen S Moro A.U Ziganshin A Rychkov B.F King S.G Brown S.S Wildman G Burnstock J.L Boyer A Mohanram T.K Harden Molecular recognition in P2 receptors: Ligand development aided by molecular modeling and mutagenesis Prog. Brain Res 120 1999 119 132
80. 1 receptor Biochem. Biophys. Res. Commun 221 1996 588 593
81. R Janssens P Paindavoine M Parmentier J.M Boeynaems Human P2Y2 receptor polymorphism: Identification and pharmacological characterization of two allelic variants Br. J. Pharmacol 127 1999 709 716
82. A.I Jimenez E Castro D Communi J.M Boeynaems E.G Delicado M.T Miras-Portugal Coexpression of several types of metabotropic nucleotide receptors in single cerebellar astrocytes J. Neurochem 75 2000 2071 2079
83. J Jin J.L Daniel S.P Kunapuli Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets J. Biol. Chem 273 1998 2030 2034
84. J Jin V.R Dasari F.D Sistare S.P Kunapuli Distribution of P2Y receptor subtypes on haematopoietic cells Br. J. Pharmacol 123 1998 789 794
85. 12 receptor Br. J. Pharmacol 133 2001 521 528
86. 4 receptor Mol. Pharmacol 57 2000 926 931
87. B.F King A Townsend-Nicholson G Burnstock Metabotropic receptors for ATP and UTP: Exploring the correspondence between native and recombinant nucleotide receptors Trends Pharmacol. Sci 19 1998 506 514
88. B.F King G Burnstock J.L Boyer J.-M Boeynaems G.A Weisman C Kennedy K.A Jacobson R.G Humphries M.P Abbracchio C Gachet M.T Miras-Portugal “P2Y Receptors: The IUPHAR Compendium of Receptor Characterization of Classification 2000.” 2000 International Union of Pharmacology Irvine, CA
89. M.R Knowles L.L Clarke R.C Boucher Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis N. Engl. J. Med 325 1991 533 538
90. E.R Lazarowski T.K Harden Identification of a uridine nucleotide-selective G-protein-linked receptor that activates phospholipase C J. Biol. Chem 269 1994 11830 11836
91. E.R Lazarowski W.C Watt M.J Stutts R.C Boucher T.K Harden Pharmacological selectivity of the cloned human P2U-receptor: Potent activation by diadenosine tetraphosphate Br. J. Pharmacol 116 1995 1619 1627
92. 2U-purinergic receptors Br. J. Pharmacol 117 1996 203 209
93. E.R Lazarowski L Homolya R.C Boucher T.K Harden Identification of an ectonucleoside diphosphokinase and its contribution to interconversion of P2 receptor agonists J. Biol. Chem 272 1997 20402 20407
94. E.R Lazarowski L Homolya R.C Boucher T.K Harden Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation J. Biol. Chem 272 1997 24348 24354
95. 2 receptor Proc. Natl. Acad. Sci. USA 94 1997 2599 2603
96. E.R Lazarowski R.C Boucher T.K Harden Constitutive release of ATP and evidence for major contribution of ecto- nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations J. Biol. Chem 275 2000 31061 31068
97. E.R Lazarowski R.C Boucher T.K Harden Interplay of constitutively released nucleotides, nucleotide metabolism and activity of P2Y receptors Drug Dev. Res 53 2001 66 71
98. E.R Lazarowski L.G Rochelle W.K O'Neal C.M Ribeiro B.R Grubb V Zhang T.K Harden R.C Boucher Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder J. Pharmacol. Exp. Ther 297 2001 43 49
99. 2Y purinoceptor subtypes recruit different mek activators in astrocytes Br. J. Pharmacol 129 2000 927 936
100. G Lenz D Goncalves Z Luo J Avruch R Rodnight J.T Neary Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures J. Neurochem 77 2001 1001 1009
101. C Leon C Vial J.P Cazenave C Gachet Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor Gene 171 1996 295 297
102. C Leon B Hechler C Vial C Leray J.P Cazenave C Gachet The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells FEBS Lett 403 1997 26 30
103. 1 receptor-null mice J. Clin. Invest 104 1999 1731 1737
104. Q Li M Olesky R.K Palmer T.K Harden R.A Nicholas Evidence that the p2y3 receptor is the avian homologue of the mammalian P2Y6 receptor Mol. Pharmacol 54 1998 541 546
105. P Liu M Wen J Hayashi Characterization of ATP receptor responsible for the activation of phospholipase A2 and stimulation of prostaglandin E2 production in thymic epithelial cells Biochem. J 308 1995 399 404
106. M.J Lohse Molecular mechanisms of membrane receptor desensitization Biochim. Biophys. Acta 1179 1993 171 188
107. K.D Lustig A.K Shiau A.J Brake D Julius Expression cloning of an ATP receptor from mouse neuroblastoma cells Proc. Natl. Acad. Sci. USA 90 1993 5113 5117
108. M Malmsjo M Hou T.K Harden W Pendergast E Pantev L Edvinsson D Erlinge Characterization of contractile P2 receptors in human coronary arteries by use of the stable pyrimidines uridine 5′- O -thiodiphosphate and uridine 5′- O -3-thiotriphosphate J. Pharmacol. Exp. Ther 293 2000 755 760
109. M Malmsjo M Adner T.K Harden W Pendergast L Edvinsson D Erlinge The stable pyrimidines UDPβS and UTPγS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery Br. J. Pharmacol 131 2000 51 56
110. S.J Mason A.M Paradiso R.C Boucher Regulation of transepithelial ion transport and intracellular calcium by extracellular adenosine triphosphate in human normal and cystic fibrosis airway epithelium Br. J. Pharmacol 103 1991 1649 1656
111. 2+ in human eosinophils: Activation of purinergic P2Y receptors J. Allergy Clin. Immunol 107 2001 849 855
112. D.M Morse J.L Smullen C.W Davis Differential effects of UTP, ATP, and adenosine of ciliary activity of human nasal epithelial cells Am. J. Physiol 280 2001 C1485 C1497
113. q⧸11 J. Biol. Chem 273 1998 4695 4704
114. 1 receptor ligands J. Med. Chem 43 2000 829 842
115. J.T Neary Trophic actions of extracellular ATP: Gene expression profiling by DNA array analysis J. Auton. Nerv. Syst 81 2000 200 204
116. J.T Neary M.P Rathbone F Cattabeni M.P Abbracchio G Burnstock Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells Trends Neurosci 19 1996 13 18
117. J.T Neary Y Kang Y Bu E Yu K Akong C.M Peters Mitogenic signaling by ATP⧸P2Y purinergic receptors in astrocytes: Involvement of a calcium-independent protein kinase C, extracellular signal-regulated protein kinase pathway distinct from the phosphatidylinositol-specific phospholipase C⧸calcium pathway J. Neurosci 19 1999 4211 4220
118. E.J Neer Heterotrimeric G proteins: Organizers of transmembrane signals Cell 80 1995 249 257
119. T Nguyen L Erb G.A Weisman A Marchese H.H.Q Heng R.C Garrad S.R George J.T Turner B.F O'Dowd Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene J. Biol. Chem 270 1995 30845 30848
120. 2 receptors: Identification of a UTP-selective, a UTP-selective, and an ATP- and UTP-specific receptor Mol. Pharmacol 50 1996 224 229
121. S.E O'Connor I.A Dainty P Leff Further subclassification of ATP receptors based on agonist studies Trends Pharmacol. Sci 12 1991 137 141
122. q-deficient mice Nature 389 1997 183 186
123. A Ogilvie R Blasius E Schulze-Lohoff R.B Sterzel Adenine dinucleotides: A novel class of signalling molecules J. Auton. Pharmacol 16 1996 325 328
124. q Blood 96 2000 2134 2139
125. 1 receptor Mol. Pharmacol 54 1998 1118 1123
126. 2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy Proc. Natl. Acad. Sci. USA 91 1994 3275 3279
127. O Pastoris S Raimondo M Dossena D Fulle UDP-glucose effect on phrenic diaphragm preparation of the rat Farmaco Sci 36 1981 721 728
128. M Paulmichl F Lang Enhancement of intracellular calcium concentration by extracellular ATP and UTP in Madin Darby canine kidney cells Biochem. Biophys. Res. Commun 156 1988 1139 1143
129. G Pearson F Robinson G.T Beers B Xu M Karandikar K Berman M.H Cobb Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions Endocr. Rev 22 2001 153 183
130. W Pendergast B.R Yerxa J.G Douglass S.R Shaver III R.W Dougherty C.C Redick I.F Sims J.L Rideout Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5′-polyphosphates Bioorg. Med. Chem. Lett 11 2001 157 160
131. J Pfeilschifter Comparison of extracellular ATP and UTP signalling in rat renal mesangial cells Biochem. J 272 1990 469 472
132. J Pintor M Diaz-Hernandez J Gualix R Gomez-Villafuertes F Hernando M.T Miras-Portugal Diadenosine polyphosphate receptors. from rat and guinea-pig brain to human nervous system Pharmacol. Ther 87 2000 103 115
133. S Pirotton D Communi S Motte R Janssens J.M Boeynaems Endothelial P2-purinoceptors: Subtypes and signal transduction J. Auton. Pharmacol 16 1996 353 356
134. J.R Purkiss G.F Wilkinson M.R Boarder Differential regulation of inositol 1,4,5-trisphosphate by co-existing P2Y-purinoceptors and nucleotide receptors on bovine aortic endothelial cells Br. J. Pharmacol 111 1994 723 728
135. 11 receptor to phospholipase C and adenylyl cyclase Br. J. Pharmacol 132 2001 318 326
136. V Ralevic G Burnstock Receptors for purines and pyrimidines Pharmacol. Rev 50 1998 413 492
137. 2U-purinergic receptor Am. J. Respir. Cell Mol. Biol 12 1995 27 32
138. B Robaye J.M Boeynaems D Communi Slow desensitization of the human P2Y6 receptor Eur. J. Pharmacol 329 1997 231 236
139. C.M Satterwhite A.M Farrelly M.E Bradley Chemotactic, mitogenic, and angiogenic actions of UTP on vascular endothelial cells Am. J. Physiol 276 1999 H1091 H1097
140. 12, a new platelet ADP receptor, target of clopidogrel Biochem. Biophys. Res. Commun 283 2001 379 383
141. J.B Schachter Q Li J.L Boyer R.A Nicholas T.K Harden Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor Br. J. Pharmacol 118 1996 167 173
142. R Seifert G Schultz Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides Trends Pharmacol. Sci 10 1989 365 369
143. R Seifert R Burde G Schultz Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides Biochem. J 259 1989 813 819
144. R Seifert K Wenzel F Eckstein G Schultz Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins Eur. J. Biochem 181 1989 277 285
145. L.A Sellers J Simon T.S Lundahl D.J Cousens P.P Humphrey E.A Barnard Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis J. Biol. Chem 276 2001 16379 16390
146. 2Y2 purinergic receptor Nucleotides Nucleosides 16 1997 1099 1102
147. S.M Short J.L Boyer R.L Juliano Integrins regulate the linkage between upstream and downstream events in G protein-coupled receptor signaling to mitogen-activated protein kinase J. Biol. Chem 275 2000 12970 12977
148. i elevation can substitute for receptor activation J. Biol. Chem 273 1998 23110 23117
149. 2 receptor Mol. Pharmacol 54 1998 485 494
150. J Stutchfield S Cockcroft Undifferentiated HL60 cells respond to extracellular ATP and UTP by stimulating phospholipase C activation and exocytosis FEBS Lett 262 1990 256 258
151. 4 nucleotide receptor Eur. J. Pharmacol 416 2001 197 202
152. 2 receptor in mouse pineal gland tumor cells J. Neurochem 77 2001 1475 1485
153. K Szabo M.J Stutts R.C Boucher S.L Milgram The COOH-terminus of the human P2Y2 receptor binds p53-binding protein 2 (53BP2) Mol. Biol. Cell 11 2001 105a
154. 2Y purinoceptors Biochem. Biophys. Res. Commun 211 1995 211 218
155. J.D Troadec S Thirion D Petturiti M.T Bohn P Poujeol ATP acting on P2Y receptors triggers calcium mobilization in primary cultures of rat neurohypophysial astrocytes (pituicytes) Pflugers Arch 437 1999 745 753
156. H Valeins M Merle J Labouesse Pre-steady state study of β-adrenergic and purinergic receptor interaction in C6 cell membranes: Undelayed balance between positive and negative coupling to adenylyl cyclase Mol. Pharmacol 42 1992 33 41
157. L van der Wyden V Rakyan B.M Luttrell M.B Morris A.D Conigrave Extracellular ATP couples to cAMP generation and granulocytic differentiation in human NB4 promyelocytic leukaemia cells Immunol. Cell Biol 78 2000 467 473
158. P.M Vanhoutte P.P Humphrey M Spedding X. International Union of Pharmacology recommendations for nomenclature of new receptor subtypes Pharmacol. Rev 48 1996 1 2
159. B.A Walker B.E Hagenlocker V.K Douglas S.J Tarapchak P.A Ward Nucleotide responses of human neutrophils Lab. Invest 64 1991 105 112
160. T.E Webb J Simon B.J Krishek A.N Bateson T.G Smart B.F King G Burnstock E.A Barnard Cloning and functional expression of a brain G-protein-coupled ATP receptor FEBS Lett 324 1993 219 225
161. T.E Webb M.O Boluyt E.A Barnard Molecular biology of P2Y purinoceptors: Expression in rat heart J. Auton. Pharmacol 16 1996 303 307
162. T.E Webb D.J Henderson J.A Roberts E.A Barnard Molecular cloning and characterization of the rat P2Y4 receptor J. Neurochem 71 1998 1348 1357
163. P.J White R Kumari K.E Porter N.J London L.L Ng M.R Boarder Antiproliferative effect of UTP on human arterial and venous smooth muscle cells Am. J. Physiol. Heart Circ. Physiol 279 2000 H2735 H2742
164. C Widmann S Gibson M.B Jarpe G.L Johnson Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human Physiol. Rev 79 1999 143 180
165. C.M Yang Y.J Tsai S.L Pan C.T Tsai W.B Wu C.T Chiu S.F Luo J.T Ou Purinoceptor-stimulated phosphoinositide hydrolysis in Madin-Darby canine kidney (MDCK) cells Naunyn Schmiedebergs Arch. Pharmacol 356 1997 1 7
166. S Yang I.L Buxton C.B Probert J.N Talbot M.E Bradley Evidence for a discrete UTP receptor in cardiac endothelial cells Br. J. Pharmacol 117 1996 1572 1578
167. T Yokomizo T Izumi K Chang Y Takuwa T Shimizu A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis Nature 387 1997 620 624
168. 2 receptor of MDCK cells: Cloning, expression, and cell-specific signaling Am. J. Physiol 279 2000 F1045 F1052
169. 11 receptors in Madin Darby canine kidney cells Mol. Pharmacol 60 2001 26 35
170. A.L Zhang G.M Roomans Regulation of intracellular calcium by extracellular nucleotides in pig tracheal submucosal gland cells Respir. Physiol 118 1999 237 246
171. F.L Zhang L Luo E Gustafson J Lachowicz M Smith X Qiao Y.H Liu G Chen B Pramanik T.M Laz K Palmer M Bayne F.J Monsma Jr. ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999 J. Biol. Chem 276 2001 8608 8615
172. H Zhang B.K Weir L.S Marton K.S Lee R.L Macdonald P2 purinoceptors in cultured bovine middle cerebral artery endothelial cells J. Cardiovasc. Pharmacol 30 1997 767 774
173. Y Zhong P.M Dunn G Burnstock Multiple P2X receptors on guinea-pig pelvic ganglion neurons exhibit novel pharmacological properties Br. J. Pharmacol 132 2001 221 233
174. 2 receptors in freshly isolated astrocytes from rat hippocampus J. Neurochem 77 2001 530 541
175. H Zimmermann Ectonucleotidases: Some recent development and note on nomenclature Drug Dev. Res 52 2001 44 56