Screening and synthesis: High throughput technologies applied to parasitology

Parasitology

Volumn 128, Issue SUPPL., 2004, Pages

  Morgan, R E ^a   Westwood, N J ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

Affinity chromatography; Automated synthesis; Chemical genetics; Compound collection; High throughput screening; Phenotypic assay; Protozoan; Review; Target identification; Technology

Indexed keywords

AFFINITY CHROMATOGRAPHY; CHEMICAL GENETICS; CONFERENCE PAPER; GENE TECHNOLOGY; HIGH THROUGHPUT SCREENING; NONHUMAN; PARASITE; PHENOTYPE; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MODIFICATION; PROTEIN SYNTHESIS; PROTEIN TARGETING;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; PARASITOLOGY; PROTEOMICS; PROTOZOAN PROTEINS;

PROTOZOA;

EID: 20444451991     PISSN: 00311820     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0031182004007073     Document Type: Conference Paper

References (39)

1. ASAI, T., TAKEUCHI, T., DIFFENDERFER, J. & SIBLEY, D. (2002). Identification of small-molecule inhibitors of nucleoside triphosphate hydrolase in Toxoplasma gondii. Antimicrobial Agents and Chemotheraphy 46, 2393-2399.
2. ARONOV, A. M., MUNAGALA, N. R., ORTIZ DE MONTELLANO, P. R., KUNTZ, I. D. & WANG, C. C. (2000). Rational design of selective submicromolar inhibitors of Tritichomonas foetus hypoxanthine-guanine-xanthine phosphoribosyltransferase. Biochemistry 39, 4684-4691.
3. BOND, C. S., ZHANG, Y., BERRIMEN, M., CUNNINGHAM, M. L., FAIRLAMB, A. H. & HUNTER, W. N. (1999). Crystal structure of Trypanosoma cruzi trypanothoine reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors. Structure 7, 81-89.
4. BURDINE, L. & KODADEK, T. (2004). Target identification in chemical genetics: the (often) missing link. Chemistry and Biology 11, 593-597.
5. CAREY, K. L., WESTWOOD, N. J., MITCHISON, T. J. & WARD, G. E. (2004). A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii. Proceedings of the National Academy of Sciences, USA 101, 7433-7438.
6. CHOWDHURY, S. F., DI LUCREZIA, R., GUERRERO, R. H., BRUN, R., GOODMAN, J., RUIZ-PEREZ, L. M., PACANOWSKA, D. G. & GILBERT, I. H. (2001). Novel inhibitors of Leishmanial dihydrofolate reductase. Bioorganic and Medicinal Chemistry Letters 11, 977-980.
7. DONALD, R. G. K., ALLOCCO, J., SINGH, S. B., NARE, B., SALOWE, S. P., WILTSIE, J. & LIBERSTOR, P. A. (2002). Toxoplasma gondii cyclic GMP-dependent kinase: Chemotherapeutic targeting of an essential parasite protein kinase. Eukaryotic Cell 1, 317-328.
8. DORMÁN, G. & PRESTWICH, G. D. (2000). Using photolabile ligands in drug discovery and development. Trends in Biotechnology 18, 64-77.
9. FREYMANN, D. M., WENCK, M. A., ENGEL, J. C., FENG, J., FOCIA, P. J., EAKIN, A. E. & CRAIG III, S. P. (2000). Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi Chemistry and Biology 7, 957-968.
10. GRANT, K. M., DUNOIN, M. H., YARDLEY, V., SKALTSOUNIS, A.-L., MARKO, D., EISENBRAND, G., CROFT, S. L., MEIJER, L. & MOTTAM, J. C. (2004). Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase chemical library screen and anitleishmanial activity. Antimicrobial Agents and Chemotherapy 48, 3033-3042.
11. GRAVES, P. R., KWIEK, J. J., FADDEN, P., RAY, R., HARDEMAN, K., COLEY, A. M., FOLEY, M. & HAYSTEAD, T. A. J. (2002). Discovery of novel targets of quinoline drugs in the human purine binding proteome. Molecular Pharmacology 62, 1364-1373.
12. GRAY, N. S. (2001). Combinatorial libraries and biological discovery. Current Opinion in Neurobiology 11, 608-614.
13. GURNETT, A. M., LIBERATOR, P. A., DULSKI, P. M., SALOWE, S. P., DONALD, R. G. K., ANDERSON, J. W., WILTSIE, J., DIAZ, C. A., BLUM, P. S., MISURA, A. S., TAMAS, T., SARDANA, M. K., YUAN, J., BIFTU, T. & SCHMATZ, D. M. (2002). Purification and molecular characterization of cGMP-dependent protein kinase from apicomplexan parasites. A novel chemothreapeutic Target. Journal of Biological Chemistry 277, 15913-15922.
14. HARMSE, L., VANZYL, R., GRAY, N., SCHULTZ, P., LECLERC, S., MEIJER, L., DOERIG, C. & HAVLIK, I. (2001). Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum. Biochemical Pharmacology 62, 341-348.
15. HIRD, N. W. (1999). Automated synthesis: new tools for the organic chemist. Drug Discovery Today 4, 265-274.
16. HORVATH, D. (1997). A virtual screening approach applied to the search for trypanothoine reductase inhibitors. Journal of Medicinal Chemistry 40, 2412-2423.
17. KING, R. W. (1999). Chemistry or biology: which comes first after the genome is sequenced? Chemistry and Biology 6, R327-R333.
18. KNOCKAERT, M., GRAY, N., DAMIENS, E., CHANG, Y.-T., GRELLIER, P., GRANT, K., FERGUSSON, D., MATTRAM, J., SOETE, M., DUBREMETZ, J.-F., LEROCH, K., DOERIG, C., SCHULTZ, P. G. & MEIJER, L. (2000). Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. Chemistry and Biology 7, 411-422.
19. KOEHLER, A. N., SHAMJI, A. F. & SCHREIBER, S. L. (2003). Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis. Journal of the American Chemical Society 125, 8420-8421.
20. LEY, S. V. & BAXENDALE, I. R. (2002). New tools and concepts for modern organic synthesis. Nature Reviews Drug Discovery 1, 573-586.
21. LIN, H., ABIDA, W. M., SAUER, R. T. & CORNISH, V. W. (2000). Dexamethasone-Methotrexate: an efficient chemical inducer of protein dimerization in vivo. Journal of the American Chemical Society 122, 4247-4248.
22. LOKEY, H. S. (2003). Forward chemical genetics: progress and obstacles on the path to new pharmacopoeia. Current Opinion in Chemical Biology 7, 91-96.
23. MAYER, T. U., KAPOOR, T. M., HAGGARTY, S. J., KING, R. W., SCHREIBER, S. L. & MITCHISON, T. J. (1999). Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286, 971-974.
24. NARE, B., ALLOCCO, J. J., LIBERATOR, P. A. & DONALD, R. G. K. (2002). Evaluation of a cyclic GMP-dependent protein kinase inhibitor in treatment of murine toxoplasmosis: gamma interferon is required for efficacy. Antimicrobial Agents and Chemotherapy 46, 300-307.
25. PATTERSON, S., LORENZ, C., SLAWIN, A. M. Z. & WESTWOOD, N. J. (2004). Rapid access to a pentacyclic library core structure: a microwave assisted approach. QSAR and Combinatorial Science 23, 883-890.
26. RASTELLI, G., PACCHIONI, S., SIRAWARAPON, R., PARENTI, M. D. & FERRARI, A. M. (2003). Docking and database screening reveal new classes of Plasmodium falciparum dihydrofolate reductase inhibitors. Journal of Medicinal Chemistry 46, 2834-2845.
27. RING, C. S., SUN, E., MCKERROW, J. H., LEE, G. K., ROSENTHAL, P. J., KUNTZ, I. D. & COHEN, F. E. (1993). Structure-based inhibitor design by using protein models for the development of antiparasitic agents. Proceedings of the National Academy of Sciences, USA 90, 3583-3587.
28. SAMSON, I., KERREMANS, L., ROZENSKI, J., SAMYN, B., VAN BEEUMEN, J., VAN AERSCOT, A. & HERDEWIJN, P. (1995). Identification of a peptide inhibitor against glycosomal phosphoglycerate kinase of Trypanosoma brucei by a synthetic peptide library approach. Bioorganic and Medicinal Chemistry 3, 257-265.
29. SCHWIKKARD, S. & VAN HEERDEN, F. R. (2002). Antimalarial activity of plant metabolites. Natural Products Reports 19, 675-692.
30. SELZER, P. M., CHEN, X., CHAN, V. J., CHENG, M., KENYON, G. L., KUNTZ, I. D., SAKANARI, J. A., COHEN, F. E. & MCKERROW, J. H. (1997). Leishmania major: Molecular modeling of cysteine proteases and prediction of new Nonpeptide Inhibitors. Experimental Parasitology 87, 212-221.
31. SMITH, T. K., CROSSMAN, A., BRIMACOMBE, J. S. & FERGUSON, A. J. (2004). Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness. The EMBO Journal 23, 4701-4708.
32. SPENCER, D. M., WANDLESS, T. J., SCHREIBER, S. L. & CRABTREE, G. R. (1993). Controlling signal-transduction with synthetic ligands. Science 262, 1019-1024.
33. TOYODA, T., BROBEY, R. K. B., SANO, G.-I., HORII, T., TOMIOKA, N. & ITAI, A. (1997). Lead discovery of inhibitors if the dihydrofolate reductase domain of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase. Biochemical and Biophysical Research Communications 235, 515-519.
34. VERKMAN, A. S. (2004). Drug discovery in academia. American Journal of Physiology and Cell Physiology 286, C465-C474.
35. WARD, G. E., CAREY, K. L. & WESTWOOD, N. J. (2002). Using small molecules to study big questions in cellular microbiology. Cellular Microbiology 4, 471-482.
36. WERBOVETZ, K. A. (2000). Target based drug discovery for Malaria, Leishmaniasis and Trypanosomiasis. Current Medicinal Chemistry 7, 835-860.
37. WIERSMA, H. I., GALUSKA, S. E., TOMLEY, F. M., SIBLEY, L. D., LIBERATOR, P. A. & DONALD, R. G. K. (2004). A role for coccidian cGMP-dependent protein kinase in motility and invasion. International Journal for Parasitology 34, 369-380.
38. YARROW, J. C., PERLMAN, Z. E., WESTWOOD, N. J. & MITCHISON, T. J. (2004). A high throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods. BMC Biotechnology 4, 1-9.
39. ZUCCOTTO, F., ZVELEBIL, M., BRUN, R., CHOWDHURY, S. F., DI LUCREZIA, R., RIUZ-PEREZ, L. M., PACANOWSKA, D. G. & GILBERT, I. H. (2001). Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase. European Journal of Medicinal Chemistry 36, 395-405.