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Volumn 36, Issue 5, 2001, Pages 395-405

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase

(10) Zuccotto, Fabio a Zvelebil, Marketa b Brun, Reto c Chowdhury, Shafinaz F a Di Lucrezia, Raffaella a Leal, Isabel d Maes, Louis e Ruiz Perez, Luis M d Gonzalez Pacanowska, Dolores d Gilbert, Ian H a

a CARDIFF UNIVERSITY (United Kingdom)

b LUDWIG INSTITUTE FOR CANCER RESEARCH (United Kingdom)

c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE (Switzerland)

d INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA (Spain)

e TIBOTEC BVBA (Belgium)

Author keywords

Database searching; Docking; Drug design; Parasitic diseases

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; METHOTREXATE; PYRIMETHAMINE; TRIMETHOPRIM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DATA BASE; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; IC 50; MINIMUM INHIBITORY CONCENTRATION; MODEL; MOUSE; MYOBLAST; NONHUMAN; RAT; SEQUENCE HOMOLOGY; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE; TRYPANOSOMIASIS;

ANIMALS; CELL LINE; CHAGAS DISEASE; DATABASES; DISEASE MODELS, ANIMAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; INHIBITORY CONCENTRATION 50; MICE; MUSCLES; RATS; TETRAHYDROFOLATE DEHYDROGENASE; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI;

EID: 0035329232 PISSN: 02235234 EISSN: None Source Type: Journal
DOI: 10.1016/S0223-5234(01)01235-1 Document Type: Article

Times cited : (69)

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