Rational design of selective submicromolar inhibitors of Tritrichomonas foetus hypoxanthine-guanine-xanthine phosphoribosyltransferase

Biochemistry

Volumn 39, Issue 16, 2000, Pages 4684-4691

  Aronov, Alex M ^a   Munagala, Narsimha R ^a   Ortiz De Montellano, Paul R ^a   Kuntz, Irwin D ^a   Wang, Ching C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARASITIC AGENT; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

ARTICLE; DRUG DESIGN; ENZYME INHIBITION; ENZYME SPECIFICITY; NONHUMAN; PARASITISM; PRIORITY JOURNAL; PURINE SYNTHESIS; TRICHOMONAS FOETUS;

ANILIDES; ANIMALS; BINDING, COMPETITIVE; CELL DIVISION; CELLS, CULTURED; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYPOXANTHINE; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR MIMICRY; PENTOSYLTRANSFERASES; PHTHALIMIDES; PROTEIN BINDING; SOFTWARE; SUBSTRATE SPECIFICITY; TRITRICHOMONAS FOETUS;

PROTOZOA; TRICHOMONAS; TRITRICHOMONAS FOETUS;

EID: 0034712714     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992555g     Document Type: Article

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