Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum

Biochemical Pharmacology

Volumn 62, Issue 3, 2001, Pages 341-348

  Harmse, Leonie ^a   Van Zyl, Robyn ^a   Gray, Nathanael ^b   Schultz, Peter ^b   Leclerc, Sophie ^c   Meijer, Laurent ^c   Doerig, Christian ^d   Havlik, Ivan ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c STATION BIOLOGIQUE   (France)

^d INSERM   (France)

Author keywords

Cyclin dependent kinases; Kinase inhibitors; Malaria; Olomoucine; Plasmodium falciparum; Purvalanol; Roscovitine

Indexed keywords

6 N (3,3 DIMETHYLALLYL)ADENINE; CHLOROQUINE; CYCLIN B; CYCLIN DEPENDENT KINASE 1; HYPOXANTHINE; OLOMOUCINE; PURINE DERIVATIVE; PURVALANOL A; PURVALANOL B; ROSCOVITINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; ASTERIAS; BRAIN MALARIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SENSITIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; IN VITRO STUDY; LIFE CYCLE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ADENINE; ANIMALS; ANTIMALARIALS; CELL CYCLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ISOPENTENYLADENOSINE; KINETIN; PARASITIC SENSITIVITY TESTS; PHOSPHOTRANSFERASES; PLASMODIUM FALCIPARUM; PURINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035427503     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00644-X     Document Type: Article

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