Chemistry or biology: Which comes first after the genome is sequenced?

Chemistry and Biology

Volumn 6, Issue 12, 1999, Pages

  King, Randall W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL PROCESS; BIOLOGY; CHEMISTRY; PROTEIN FUNCTION;

EID: 0033485896     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)80002-2     Document Type: Short Survey

References (23)

1. Taunton, J., Hassig, C.A. & Schreiber, S.L. (1996). A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272, 408-411.
2. Jones, D.A. & Fitzpatrick, F.A. (1999). Genomics and the discovery of new drug targets. Curr. Opin. Chem. Biol. 3, 71-76.
3. Mitchison, T.J. (1994). Towards a pharmacological genetics. Chem. Biol. 1, 3-6.
4. Schreiber, S.L. (1998). Chemical genetics resulting from a passion for synthetic organic chemistry. Bioorg. Med. Chem. 6, 1127-1152.
5. Crews, C.M. & Splittgerber, U. (1999). Chemical genetics: Exploring and controlling cellular processes with chemical probes. Trends Biochem. Sci. 24, 317-320.
6. Brown, P.O. & Botstein, D. (1999). Exploring the new world of the genome with DNA microarrays. Nat. Genet. 21, 33-37.
7. Schena, M., Shalon, D., Davis, R.W. & Brown, P.O. (1995). Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270, 467-470.
8. Lockhart, D.J., et al., & Brown, E.L. (1996). Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat. Biotechnol. 14, 1675-1680.
9. Gray, N.S., et al., & Schultz, P.G. (1998). Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281, 533-538.
10. Marton, M.J., et al., & Friend, S.H. (1998). Drug target validation and identification of secondary drug target effects using DNA microarrays. Nat. Med. 4, 1293-1301.
11. Winzeler, E.A., et al., & Davis, R.W. (1999). Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285, 901-906.
12. Giaever, G., et al., & Davis, R.W. (1999). Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat. Genet. 21, 278-283.
13. Young, R.A. & Davis, R.W. (1983). Yeast RNA polymerase II genes: Isolation with antibody probes. Science 222, 778-782.
14. Simonsen, H. & Lodish, H.F. (1994). Cloning by function: Expression cloning in mammalian cells. Trends Pharmacol. Sci. 15, 437-441.
15. Fields, S. & Song, O. (1989). A novel genetic system to detect protein-protein interactions. Nature 340, 245-246.
16. King, R.W., Lustig, K.D., Stukenberg, P.T., McGarry, T.J. & Kirschner, M.W. (1997). Expression cloning in the test tube. Science 277, 973-974.
17. Licitra, E.J. & Liu, J.O. (1996). A three-hybrid system for detecting small ligand-protein receptor interactions. Proc. Natl Acad. Sci. 93, 12817-12821.
18. Liberles, S.D., Diver, S.T., Austin, D.J., & Schreiber, S.L. (1997). Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen. Proc. Natl Acad. Sci. USA 94, 7825-7830.
19. Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D. & Julius, D. (1997). The capsaicin receptor - A heat- activated ion channel in the pain pathway. Nature 389, 816-824.
20. Tanaka, H., Ohshima, N. & Hidaka, H. (1999). Isolation of cDNAs encoding cellular drug-binding proteins using a novel expression cloning procedure: Drug-western. Mol. Pharmacol. 55, 356-363.
21. Sche, P.P., McKenzie, K.M., White, J.D. & Austin, D.J. (1999). Display cloning: Functional identification of natural product receptors using cDNA-phage display. Chem. Biol. 6, 707-716.
22. Liu, J., Farmer, J.D., Jr, Lane, W.S., Friedman, J., Weissman, I. & Schreiber, S.L. (1991). Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66, 807-815.
23. Roberts, R.W. (1999). Totally in vitro protein selection using mRNA-protein fusions and ribosome display. Curr. Opin. Chem. Biol. 3, 268-273.