The effect of intravenous administration of delta-9-tetrahydrocannabinol on the activity of A10 dopamine neurons recorded in vivo in anesthetized rats

Neuropsychobiology

Volumn 36, Issue 2, 1997, Pages 96-99

  Gifford, Andrew N ^a   Gardner, Eliot L ^b   Ashby, Charles R ^c  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c ST JOHN'S UNIVERSITY   (United States)

Author keywords

Cannabinoid; Cannabis; Delta 9 tetrahydrocannabinol; Dopamine; Electrophysiology; Reinforcement; Reward; Ventral tegmental area

Indexed keywords

DOPAMINE; DRONABINOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE UNIT ACTIVITY; VENTRAL TEGMENTUM;

ANESTHESIA; ANIMALS; APOMORPHINE; DOPAMINE; DOPAMINE AGONISTS; EXTRACELLULAR SPACE; INJECTIONS, INTRAVENOUS; MALE; NEURONS; PILOT PROJECTS; RATS; RATS, SPRAGUE-DAWLEY; TETRAHYDROCANNABINOL;

EID: 0030791135     PISSN: 0302282X     EISSN: 14230224     Source Type: Journal    
DOI: 10.1159/000119369     Document Type: Article

References (15)

1. Gardner EL: Cannabinoid interaction with brain reward systems-The ncurobiological basis of cannabinoid abuse: in Murphy L, Bartke A (eds): Marijuana/C'annabinoids: Neu-robiology and Neurophysiology, Boca Raton, CRC Press, 1992. pp 275-335.
2. Gardner EL: Brain reward mechanisms: in Lo-winson JH, Ruiz P, Millman RB, Langrod JG (eds): Substance Abuse: A Comprehensive Textbook, ed 2. Baltimore, Williams &Wilkins, 1992. pp 70-99.
3. Di Chiara G, lmperato A: Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats, Proc Natl Acad Sci USA 1988;85:5274-5278.
4. Carboni E, lmperato A, Pcrezzani L, Di Chiara DG: Amphetamine, cocaine, phencyclidine, and nomifensine increase extracellular dopamine concentrations preferentially in the rat nucleus accumbcns of freely moving rats, Neuroscience 1989:28:653-661.
5. Ross SB, Renvi AL: Inhibition of the uptake of tritiated catecholamines by antidepressant and related agents, Eur J Pharmacol 1966:2:81-187.
6. Grcnhof TJ, Aston-Jones G, Svensson TH: Nicotinic cITccts on the firing pattern of midbrain dopamine neurons, Acta Physiol Scand 1986; 128:351-358.
7. Gysling K, Wang RY: Morphine-induced activation of A10 dopamine neurons in the rat, Brain Res 1983:277:119-127.
8. Abood ME, Martin BR: Neurobiology of marijuana abuse, Trend Neurosci 1986; 13:201-206.
9. Chen J, Marmur R, Pulles A, Paredes W, Gardner EL: Ventral tegmental microinjections of dcIta-9-tetrahydrocannabinol enhance ventral tegmental somatodendritic dopamine levels but not forebrain dopamine levels: Evidence for local neural activity by marijuana's psychoactive ingredient, Brain Res 1993:621: 65-70.
10. Gonon FG: Non-linear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry, Neuroscience 1988: 24:19-28.
11. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates, New York, Academic Press, 1986.
12. Chiodo LA: Dopamine-containing neurons in the mammalian central nervous system: Elec-trophysiologv and pharmacology, Neurosci Biobehav Rev 1986:12:49-91.
13. Grace AA, Bunney BS: The control of firing pattern in nigral dopamine neurons: Burst firing, J Neurosci 1984:4:2877-2890.
14. Gessa GL, Muntoni F, Collu M, Vargiu L, Mercu G: Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area, Brain Res 1985:348:201-203.
15. Lepore M, Liu X, Savage V, Matalon D, Gardner EL: Genetic differences in delta-9-tetrahydrocannabinol-induced facilitation of brain stimulation reward as measured by a ratc-frequency curve-shift electrical brain stimulation paradigm in three different rat strains, Life Sci 1996:58:365-372.