Cannabinoid withdrawal is dependent upon PKA activation in the cerebellum

European Journal of Neuroscience

Volumn 12, Issue 3, 2000, Pages 1038-1046

  Tzavara, Eleni Th ^a   Valjent, Emmanuel ^b,c   Firmo, Cedric ^a   Mas, Magdalena ^b   Beslot, Françoise ^b   Defer, Nicole ^a   Roques, Bernard P ^b   Hanoune, Jacques ^a   Maldonado, Rafael ^b,d  

^a HENRI MONDOR HOSPITAL   (France)

^b CNRS   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

Adenylyl cyclase; Cerebellum; Protein kinase A; Rp 8Br cAMPS; THC withdrawal

Indexed keywords

ADENYLATE CYCLASE; CALCIUM; CALMODULIN; CANNABINOID; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; RIMONABANT;

ABSTINENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVATION; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; WITHDRAWAL SYNDROME;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ADENYLATE CYCLASE; ANIMALS; BEHAVIOR, ANIMAL; CEREBELLUM; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; HALLUCINOGENS; INJECTIONS; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; PIPERIDINES; PYRAZOLES; RECEPTORS, DRUG; STEREOTAXIC TECHNIQUES; SUBSTANCE WITHDRAWAL SYNDROME; TETRAHYDROCANNABINOL; UP-REGULATION;

EID: 0034035522     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00971.x     Document Type: Article

References (43)

1. Aceto, M.D., Scates, S.M., Lowe, J.A. & Martin, B.R. (1996) Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal. J. Pharmacol. Exp. Ther., 278, 1290-1295.
2. Adams, I.B. & Martin, B.R. (1996) Cannabis: pharmacology and toxicology in animals and humans. Addiction, 91, 1585-1614.
3. Boundy, V.A., Chen, J. & Nestler, E.J. (1998) Regulation of cAMP-dependent protein kinase subunit expression in CATH.a and SH-SY5Y cells. J. Pharmacol. Exp. Ther., 286, 1058-1065.
4. Burstein, S.H. & Hunter, S.A. (1995) Stimulation of anandamide biosynthesis in N-18TG2: neuroblastoma cells by delta 9-tetrahydrocannabinol (THC). Biochem. Pharmacol., 49, 855-858.
5. Chavis, P., Mollard, P., Bockaert, J. & Manzoni, O. (1998) Visualization of cyclic AMP-regulated presynaptic activity at cerebellar granule cells. Neuron, 20, 773-781.
6. Childers, S.R., Pacheco, M.A., Bennett, B.A., Edwards, T.A., Hampson, R.E., Mu, J. & Deadwyler, S.A. (1993) Cannabinoid receptors: G-protein-mediated signal transduction mechanisms. Biochem. Soc. Symp, 59, 27-50.
7. Cook, S.A., Lowe, J.A. & Martin, B.R. (1998) CB1: receptor antagonist precipitates withdrawal in mice exposed to Delta 9-tetrahydrocannabinol. J. Pharmacol. Exp. Ther., 285, 1150-1156.
8. Daniel, H., Levenes, C. & Crepel, F. (1998) Cellular mechanisms of cerebellar LTD. Trends Neurosci, 21, 401-407.
9. Denton, D.A., Blair-West, J.R., McBurnie, M., Osborne, P.O., Tarjan, E., Williams, R.M. & Weisinger, R.S. (1990) Angiotensin and salt appetite of BALB/c mice. Am. J. Physiol., 259, R729-R735.
10. Dostmann, W.R. (1995) (RP)-cAMPS inhibits the cAMP-dcpendent protein kinase by blocking the cAMP-induced conformational transition. FEBS Lett, 375, 231-234.
11. Dostmann, W.R., Taylor, S.S., Genieser, H.G., Jastorff, B., Doskeland, S.O. & Ogreid, D. (1990) Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3′,5′-cyclic phosphorothioates. J. Biol. Chem., 265, 10484-10491.
12. Duman, R.S., Tallman, J.F. & Nestler, E.J. (1988) Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus. J. Pharmacol. Exp. Ther., 246, 1033-1039.
13. Ebner, T.J. (1998) A role for the cerebellum in the control of limb movement velocity. Curr. Opin. Neurobiol., 8, 762-769.
14. Gaoni, Y. & Mechoulam, R. (1971) The isolation and structure of delta-1-tetrahydrocannabinol and other neutral cannabinoids from hashish. J. Am. Chem. Soc., 93, 217-224.
15. Gastel, J.A., Roseboom, P.H., Rinaldi, P.A., Weller, J.L. & Klein, D.C. (1998) Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation. Science, 279, 1358-1360,
16. Gjertsen, B.T., Mellgren, G., Otten, A., Maronde, E., Genieser, H.G., Jastorff, B., Vintermyr, O.K., McKnight, G.S. & Doskeland, S.O. (1995) Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1 beta action. J. Biol. Chem, 270, 20599-20607.
17. Glickstein, M. (1992) The cerebellum and motor learning. Curr. Opin. Neurobiol., 2, 802-806.
18. Herkenham, M., Groen, B.G., Lynn, A.B., De Costa, B.R. & Richfield, E.K. (1991) Neuronal localization of cannabinoid receptors and second messengers in mutant mouse cerebellum. Brain Res., 552, 301-310.
19. Herkenham, M., Lynn, A.B., Little, M.D., Johnson, M.R., Melvin, L.S., de Costa, B.R. & Rice, K.C. (1990) Cannabinoid receptor localization in brain. Proc. Natl Acad. Sci. USA, 87, 1932-1936.
20. Howlett, A.C., Scott, D.K. & Wilken, G.H. (1989) Regulation of adenylate cyclase by cannabinoid drugs. Insights based on thermodynamic studies. Biochem. Pharmacol., 38, 3297-3304.
21. Hutcheson, D.M., Tzavara, E.T., Smadja, C., Valjent, E., Roques, B.P., Hanoune, J. & Maldonado, R. (1998) Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-tetrahydrocannabinol. Br. J. Pharmacol., 125, 1567-1577.
22. Jueptner, M. & Weiller, C. (1998) A review of differences between basal ganglia and cerebellar control of movements as revealed by functional imaging studies. Brain, 121, 1437-1449.
23. Kawasaki, H., Springett, G.M., Mochizuki, N., Toki, S., Nakaya, M., Matsuda, M., Housman, D.E. & Graybiel, A.M. (1998) A family of cAMP-binding proteins that directly activate Rap1. Science, 282, 2275-2279.
24. Lane-Ladd, S.B., Pineda, J., Boundy, V.A., Pfeuffer, T., Krupinski, J., Aghajanian, G.K. & Nestler, E.J. (1997) CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence. J. Neurosci, 17, 7890-7901.
25. Levenes, C., Daniel, H., Soubrie, P. & Crepel, F. (1998) Cannabinoids decrease excitatory synaptic transmission and impair long-term depression in rat cerebellar Purkinje cells. J. Physiol. (Lond.), 510, 867-879.
26. Lichtman, A.H., Wiley, J.L., LaVecchia, K.L., Neviaser, S.T., Arthur, D.B., Wilson, D.M. & Martin, B.R. (1998) Effects of SR 141716A after acute or chronic cannabinoid administration in dogs. Eur. J. Pharmacol., 357, 139-148.
27. Martin, B.R., Compton, D.R., Thomas, B.F., Prescott, W.R., Little, P.J., Razdan, R.K., Johnson, M.R., Melvin, L.S., Mechoulam, R. & Ward, S.J. (1991) Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs. Pharmacol. Biochem. Behav., 40, 471-478.
28. Martin, B.R., Prescott, W.R. & Zhu, M. (1992) Quantitation of rodent catalepsy by a computer-imaging technique. Pharmacol. Biochem. Behav., 43, 381-386.
29. Matsuda, L.A., Bonner, T.I. & Lolait, S.J. (1993) Localization of cannabinoid receptor mRNA in rat brain. J Comp. Neurol., 327, 535-550.
30. Middleton, F.A. & Strick, P.L. (1998) The cerebellum: an overview. Trends Neurosci., 21, 367-369.
31. 2+-insensitive adenylyl cyclases in the rat brain. Synapse, 14, 51-59.
32. Nestler, E.J. & Aghajanian, G.K. (1997) Molecular and cellular basis of addiction. Science, 278, 58-63.
33. Nevo, I., Avidor-Reiss, T., Levy, R., Bayewitch, M., Heldman, E. & Vogel, Z. (1998) Regulation of adenylyl cyclase isozymes on acute and chronic activation of inhibitory receptors. Mol. Pharmacol., 54, 419-426.
34. Punch, L.J., Self, D.W., Nestler, E.J. & Taylor, J.R. (1997) Opposite modulation of opiate withdrawal behaviors on microinfusion of a protein kinase A inhibitor versus activator into the locus coeruleus or periaqueductal gray. J. Neurosci., 17, 8520-8527.
35. Rasmussen, K., Beitner-Johnson, D.B., Krystal, J.H., Aghajanian, G.K. & Nestler, E.J. (1990) Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. J. Neurosci., 10, 2308-2317.
36. Rinaldi-Carmona, M., Barth, F., Heaulme, M., Shire, D., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D. &. et al. (1994) SR 141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett., 350, 240-244.
37. de Rooij, J., Zwartkruis, F.J., Verheijen, M.H., Cool, R.H., Nijman, S.M., Wittinghofer, A. & Bos, J.L. (1998) Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature, 396, 474-477.
38. Salin, P.A., Malenka, R.C. & Nicoll, R.A. (1996) Cyclic AMP mediates a presynaptic form of LTP at cerebellar parallel fiber synapses. Neuron, 16, 797-803.
39. Self, D.W., Geneva, L.M., Hope, B.T., Barnhart, W.J., Spencer, J.J. & Nestler, E.J. (1998) Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. J. Neurosci., 18, 1848-1859.
40. Storm, D.R., Hansel, C., Hacker, B., Parent, A. & Linden, D.J. (1998) Impaired cerebellar long-term potentiation in type I adenylyl cyclase mutant mice. Neuron, 20, 1199-1210.
41. Tsou, K., Brown, S., Sanudo-Pena, M.C., Mackie, K. & Walker, J.M. (1998) Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience, 83, 393-411.
42. Tsou, K., Patrick, S.L. & Walker, J.M. (1995) Physical withdrawal in rats tolerant to delta 9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist. Eur. J. Pharmacol., 280, R13-R15.
43. Xia, Z. & Storm, D.R. (1997) Calmodulin-regulated adenylyl cyclases and neuromodulation. Curr. Opin. Neurobiol., 7, 391-396.