Drug addiction as dopamine-dependent associative learning disorder

European Journal of Pharmacology

Volumn 375, Issue 1-3, 1999, Pages 13-30

  Di Chiara, Gaetano ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Addiction; Dopamine; Incentive motivation; Learning; Reinforcement; Reward; Self administration

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; AMPHETAMINE; CAFFEINE; COCAINE; DESIPRAMINE; DIAMORPHINE; DOPAMINE; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; MORPHINE; NEUROLEPTIC AGENT; NICOTINE; OPIATE; PENTETRAZOLE; PHENCYCLIDINE;

ANIMAL EXPERIMENT; DOPAMINERGIC SYSTEM; DOPAMINERGIC TRANSMISSION; DRUG DEPENDENCE; DRUG SELF ADMINISTRATION; HEROIN DEPENDENCE; HUMAN; LEARNING DISORDER; MOTIVATION; NONHUMAN; NUCLEUS ACCUMBENS; OPIATE ADDICTION; PRIORITY JOURNAL; RAT; REINFORCEMENT; REVIEW; REWARD; STATE DEPENDENT LEARNING;

EID: 0032980748     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00372-6     Document Type: Article

References (145)

1. Abercrombie E.D., Keefe K.A., Di Frischa D.S., Zigmond M.J. Differential effects of stress on in vivo dopamine release in striatum, nucleus accumbens and medial frontal cortex. J. Neurochem. 52:1989;1655-1658.
2. Acquas E., Di Chiara G. Depression of mesolimbic dopamine transmission and sensitization to morphine during opiate abstinence. J. Neurochem. 58:1992;1620-1625.
3. 1 receptors blockade stereospecifically impairs the acquisition of drug-conditioned place-preference and place-aversion. Behav. Pharmacol. 5:1994;555-569.
4. Acquas E., Carboni E., Leone P., Di Chiara G. SCH 23390 blocks drug-conditioned place-preference and place-aversion: anhedonia (lack of reward) or apathy (lack of motivation) after dopamine receptor blockade? Psychopharmacology. 99:1989;151-155.
5. Acquas E., Carboni E., Di Chiara G. Profound depression of mesolimbic dopamine release after morphine withdrawal in dependent rats. Eur. J. Pharmacol. 193:1991;133-134.
6. Alheid G.F., Heimer L. New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: the striatopallidal, amygdaloid and corticopetal components of substantia innominata. Neuroscience. 27:1988;1-39.
7. American Psychiatric Association, 1994. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. DSM IV, Washington, DC.
8. Barrot, M., Marinelli, M., Abrous, D.N., Rougé-Pont, F., Le Moal, M., Piazza, P.V., 1998. Functional heterogeneity in dopamine release and in the expression of Fos-like proteins within the rat striatal complex. Eur. J. Neurosci., in press.
9. Bassareo V., Di Chiara G. Differential influence of associative and nonassociative learning mechanisms on the responsiveness of prefrontal and accumbal dopamine transmission to food stimuli in rats fed ad libitum. J. Neurosci. 17:1997;851-861.
10. Bassareo V., Di Chiara G. Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell/core compartments. Neuroscience. 89:1999;637-641.
11. Bassareo V., Tanda G., Di Chiara G. Increase of extracellular dopamine in the medial prefrontal cortex during spontaneous and naloxone-precipitated opiate abstinence. Psychopharmacology. 122:1995;202-205.
12. Bassareo V., Tanda G., Petromille P., Giua C., Di Chiara G. Non-psychostimulant drugs of abuse and anxiogenic drugs activate with differential selectivity dopamine transmission in the nucleus accumbens and in the medial prefrontal cortex. Psychopharmacology. 124:1996;293-299.
13. Bell J., Bowron P., Lewis J., Batey R. Serum levels of methadone in maintenance clients who persist in illicit drug use. Br. J. Addict. 85:1990;1599-1602.
14. Beninger R.J. The role of dopamine in locomotor activity and learning. Brain Res. 6:1983;173-196.
15. Beninger R.J., Phillips A.G. The effect of pimozide on the establishment of conditioned reinforcement. Psychopharmacology. 68:1980;147-153.
16. Beninger R.J., Phillips A.G. The effects of pimozide during pairing on the transfer of classical conditioning to an operant discrimination. Pharmacol. Biochem. Behav. 14:1981;101-105.
17. Beninger R.J., Mason S.T., Phillips A.G., Fibiger H.C. The use of extinction to investigate the nature of neuroleptic-induced avoidance deficits. Psychopharmacology. 69:1980;11-18.
18. Berridge K.C. Food reward: brain substrates of wanting and liking. Neurosci. Biobehav. Rev. 20:1996;1-25.
19. Berridge K.C., Robinson T.E. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res. Rev. 28:1998;309-369.
20. Bindra D. A motivational view of learning, performance, and behavior modification. Psychol. Rev. 81:1974;199-213.
21. Bindra D. How adaptive behavior is produced: a perceptual-motivation alternative to response reinforcement. Behav. Brain Sci. 1:1978;41-91.
22. Blackburn J.R., Phillips A.G., Fibiger H.C. Dopamine and preparatory behavior: I. Effects of pimozide. Behav. Neurosci. 101:1987;352-360.
23. Bolles R.C. Reinforcement, expectancy, and learning. Psychol. Rev. 79:1972;394-409.
24. Brauer L.H., De Wit H. Subjective responses to D-amphetamine alone and after pimozide pretreatment in normal, healthy volunteers. Biol. Psychiatry. 39:1996;26-32.
25. Brauer L.H., De Wit H. High dose pimozide does not block amphetamine-induced euphoria in normal volunteers. Pharmacol. Biochem. Behav. 56:1997;265-272.
26. Brauer L.H., Gooooudie A.J., de Wit H. Dopamine ligands and the stimulus effects of amphetamine: animal models versus human laboratory data. Psychopharmacology. 130:1997;2-13.
27. Brazell M.P., Mitchell S.N., Joseph M.H., Gray J.A. Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: comparison with caudate-putamen. Neuropharmacology. 29:1990;1177-1185.
28. Cadoni C., Di Chiara G. Reciprocal changes in dopamine responsiveness in the nucleus accumbens shell and core and in the dorsal caudate-putamen in rats sensitized to morphine. Neuroscience. 90:1999;447-455.
29. Carboni E., Imperato A., Perezzani L., Di Chiara G. Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in the nucleus accumbens of freely moving rats. Neuroscience. 28:1989;653-661.
30. Cass W.A., Gerhardt G.A., Mayfield R.D., Curella P., Zahniser N.R. Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. J. Neurochem. 59:1992;259-266.
31. Caulliez R., Meile M.-J., Nicolaidis S. A lateral hypothalamic D1 dopaminergic mechanism in conditioned taste aversion. Brain Res. 729:1996;234-245.
32. Childress, A.R., McLellan, A.T., Ehrman, R., O'Brien, C.P., 1988. Classically conditioned responses in opioid and cocaine dependence: a role in relapse? In: Learning Factors in Substance Abuse. NIDA Research Monograph 94, Washington, DC, US Government Print Office, pp. 25-43.
33. De Vos, J.W., van Wilgenburg, H., van den Brink, W., Kaplan, C.D., de Vries, M.W., 1996. Patterns of craving and pharmacokinetics in long-term opiate addicts in methadone maintenance. Addict Res., in press.
34. Diana M., Pistis M., Carboni S., Gessa G.L., Rossetti Z.L. Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence. Proc. Natl. Acad. Sci. U.S.A. 90:1993;7966-7969.
35. Diana M., Pistis M., Muntoni A., Gessa G.L. Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats. J. Pharmacol. Exp. Ther. 272:1995;781-785.
36. Di Chiara G. On the preferential release of mesolimbic dopamine by amphetamine. Neuropsychopharmacology. 5:1991;243-244.
37. Di Chiara G. The role of dopamine in drug abuse viewed from the perspective of its role in motivation. Drug Alcohol Depend. 38:1995;95-137.
38. Di Chiara G. A motivational learning hypothesis of the role of dopamine in compulsive drug use. J. Psychopharmacol. 12:1998;54-67.
39. Di Chiara G., Imperato A. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc. Natl. Acad. Sci. U.S.A. 85:1988;5274-5278.
40. Di Chiara G., Imperato A. Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J. Pharmacol. Exp. Ther. 244:1988;1067-1080.
41. Di Chiara G., Acquas E., Tanda G., Cadoni C. Drugs of abuse: biochemical surrogates of specific aspects of natural reward? Biochem. Soc. Symp. 59:1993;65-81.
42. Di Chiara G., Tanda G., Frau R., Carboni E. On the preferential release of dopamine in the nucleus accumbens by amphetamine: further evidence obtained by vertically implanted concentric dialysis probes. Psychopharmacology. 112:1993;398-402.
43. Di Ciano P., Blaha C.D., Phillips A.G. Conditioned changes in dopamine oxidation currents in the nucleus accumbens of rats by stimuli paired with self-administration or yoked-administration of D-amphetamine. Eur. J. Neurosci. 10:1998;1121-1127.
44. Di Ciano P., Blaha C.D., Phillips A.G. The relation between dopamine oxidation currents in the nucleus accumbens and conditioned increases in motor activity in rats following repeated administration of D-amphetamine or cocaine. Eur. J. Neurosci. 10:1998;1113-1120.
45. Dickinson A., Balleine B. Motivational control of instrumental action. Curr. Dir. Psychol. Sci. 4:1995;162-167.
46. Emmett-Oglesby M.W., Mathis D.A., Moon R.T.Y., Lal H. Animal models of drug withdrawal symptoms. Psychopharmacology. 101:1990;292-309.
47. Ettenberg A. Dopamine, neuroleptics and reinforced behavior. Neurosci. Biobehav. Rev. 13:1989;105-111.
48. Ettenberg A. Haloperidol prevents the reinstatement of amphetamine-rewarded runway responding in rats. Pharmacol. Biochem. Behav. 36:1990;635-638.
49. Ettenberg A., Horvitz J.C. Pimozide prevents the response-reinstating effects of water reinforcement in rats. Pharmacol. Biochem. Behav. 37:1990;465-469.
50. Ettenberg A., MacConell L.A., Geist T.D. Effects of haloperidol in a response-reinstatement model of heroin relapse. Psychopharmacology. 124:1996;205-210.
51. Fischman M.W. Relationship between self-reported drug effects and their reinforcing effects: studies with stimulant drugs. NIDA Res. Monogr. 92:1989;211-230.
52. Franklin K.B.J. Catecholamines and self-stimulation: reward and performance deficits dissociated. Pharmacol. Biochem. Behav. 9:1978;813-820.
53. Franklin K.B.J., McCoy S.N. Pimozide-induced extinction in rats: stimulus control of responding rules out motor deficit. Pharmacol. Biochem. Behav. 11:1979;71-76.
54. Gallistel C.R., Boytim M., Gomita Y., Kebanoff L. Does pimozide block the reinforcing effect of brain stimulation? Pharmacol. Biochem. Behav. 17:1982;769-781.
55. Gessa G.L., Muntoni F., Collu M., Vargiu L., Mereu G.P. Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain Res. 348:1985;201-203.
56. Goldberg S.R. Stimuli associated with drug injections as events that control behavior. Pharmacol. Rev. 27:1976;325-340.
57. Gratton A., Wise R.A. Drug- and behavior-associated changes in dopamine-related electrochemical signals during intravenous cocaine self-administration in rats. J. Neurosci. 14:1994;4130-4146.
58. Gray T., Wise R.A. Effects of pimozide on lever-pressing behavior maintained on an intermittent reinforcement schedule. Pharmacol. Biochem. Behav. 12:1980;931-935.
59. Gray J.A., Young A.M., Joseph M.H. Dopamine's role [letter]. Science. 278:1997;1548-1549.
60. Grill H.J., Norgren R. The taste reactivity test: I. Mimetic responses to gustatory stimuli in neurologically normal rats. Brain Res. 143:1978;263-279.
61. Heidbreder C., Feldon J. Amphetamine-induced neurochemical and locomotor responses are expressed differentially across the anteroposterior axis of the core and shell subterritories of the nucleus accumbens. Synapse. 29:1998;310-322.
62. Heimer, L., Wilson, R.D., 1975. The subcortical projections of allocortex: similarities in the neuronal associations of the hippocampus, the piriform cortex and the neocortex. In: Santini, M. (Ed.), Golgi Centennial Symposium Proceedings. Raven Press, New York, pp. 173-193.
63. Heimer L., de Olmos J., Alheid G.F., Zaborszky L. 'Perestroika' in the basal forebrain: opening the border between neurology and psychiatry. Prog. Brain Res. 87:1991;109-165.
64. Hemby S.E., Co C., Koves T.R., Smith J.E., Dworkin S.I. Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. Psychopharmacology. 133:1997;7-16.
65. Hernandez L., Hoebel B.G. Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. Life Sci. 42:1988;1705-1712.
66. Hill, R.T., 1970. Facilitation of conditioned reinforcement as a mechanism of psychomotor stimulation. In: Costa, E., Garattini, S. (Eds.), Amphetamine and Related Compounds. Raven Press, New York.
67. Himmelsbach C.K. Morphine, with reference to physical dependence. Fed. Proc. 2:1943;201-203.
68. Hitchcott P.K., Phillips G.D. Double dissociation of the behavioural effects of R(+) 7-OH-DPAT infusions in the central and basolateral amygdala nuclei upon Pavlovian and instrumental conditioned appetitive behaviours. Psychopharmacology. 140:1998;458-469.
69. Hitchcott P.K., Bonardi C.M.T., Phillips G.D. Enhanced stimulus-reward learning by intra-amygdala administration of a D-3 dopamine receptor agonist. Psychopharmacology. 133:1997;240-248.
70. Hitchcott P.K., Harmer C.J., Phillips G.D. Enhanced acquisition of discriminative approach following intra-amygdala D-amphetamine. Psychopharmacology. 132:1997;237-246.
71. Holland P.C., Straub J.J. Differential effects of two ways of devaluing the unconditioned stimulus after Pavlovian appetitive conditioning. J. Exp. Psychol. Anim. Behav. 5:1979;65-78.
72. Horns W.H., Rado M., Goldstein A. Plasma levels and symptom complaints in patients maintained on daily dosage of methadone hydrochloride. Clin. Pharm. Ther. 17:1975;636-649.
73. Horvitz J.C., Ettenberg A. Haloperidol blocks the response reinstating effects of food reward: a methodology for separating neuroleptic effects on reinforcement and motor processes. Pharmacol. Biochem. Behav. 31:1988;861-865.
74. Horvitz J.C., Ettenberg A. Conditioned incentive properties of a food-paired conditioned stimulus remain intact during dopamine receptor blockade. Behav. Neurosci. 105:1991;536-541.
75. Imperato A., Di Chiara G. Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J. Pharmacol. Exp. Ther. 239:1986;219-228.
76. Imperato A., Mulas A., Di Chiara G. Nicotine preferentially stimulates dopamine released in the limbic system of freely moving rats. Eur. J. Pharmacol. 132:1986;337-338.
77. Johanson, C.E., 1978. Drugs as reinforcers. In: Blackman, D.E., Sanger, D.J. (Eds.), Contemporary Research in Behavioral Pharmacology. Plenum, New York, pp. 325-390.
78. Kiyatkin E.A., Gratton A. Electrochemical monitoring of extracellular dopamine in nucleus accumbens of rats lever-pressing for food. Brain Res. 652:1994;225-234.
79. Kiyatkin E.A., Stein E.A. Fluctuations in nucleus accumbens dopamine during cocaine self-administration behavior: an in vivo electrochemical study. Neuroscience. 64:1996;599-614.
80. Kiyatkin E.A., Wise R.A., Gratton A. Drug- and behavior-associated changes in dopamine-related electrochemical signals during intravenous heroin self-administration in rats. Synapse. 14:1993;60-72.
81. Konorski, J., 1967. Integrative activity of the brain. Univ. of Chicago Press.
82. Koob G.F., Caine S.B., Parsons L., Markou A., Weiss F. Opponent process model and psychostimulant addiction. Pharmacol. Bioochem. Behav. 57:1997;513-521.
83. Koob G.F., Stinus L., Le Moal M., Bloom F.E. Opponent process theory of motivation: neurobiological evidence from studies of opiate dependence. Neurosci. Biobehav. Rev. 13:1989;135-140.
84. Kuczenski R., Segal D.S. Differential effects of amphetamine and dopamine uptake blockers (cocaine, nomifensine) on caudate and accumbens dialysate dopamine and 3-methoxytyramine. J. Pharmacol. Exp. Ther. 262:1992;1085-1094.
85. Le Magnen J. Peripheral and systemic actions of food in the caloric regulation of intake. Ann. NY Acad. Sci. 157:1969;1126-1157.
86. Loimer N., Schmid R. The use of plasma levels to optimize methadone maintenance treatment. Drug Alcohol Depend. 30:1992;241-246.
87. Mackintosh, N.J., 1974. The Psychology of Animal Learning. Academic Press, London.
88. Mark G.P., Blander D.S., Hoebel B.G. A conditioned stimulus decreases extracellular dopamine in the nucleus accumbens after the development of a learned taste aversion. Brain Res. 551:1991;308-310.
89. Markou A., Koob G.F. Postcocaine anhedonia. An animal model of cocaine withdrawal. Neuropsychopharmacology. 4:1991;17-26.
90. McFarland K., Ettenberg A. Haloperidol differentially affects reinforcement and motivational processes in rats running an alley for intravenous heroin. Psychopharmacology. 122:1995;346-350.
91. McFarland K., Ettenberg A. Reinstatement of drug-seeking behavior produced by heroin-predictive environmental stimuli. Psychopharmacology. 131:1997;86-92.
92. Matthews R.T., German D.C. Electrophysiological evidence for excitation of rat ventral tegmental area dopamine neurons by morphine. Neuroscience. 11:1984;617-628.
93. Mereu G., Yoon K.-W.P., Boi V., Gessa G.L., Naes L., Westfall T.C. Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine. Eur. J. Pharmacol. 141:1987;395-399.
94. Mogenson G.J., Jones D.L., Yim C.Y. From motivation to action: functional interface between the limbic system and the motor system. Prog. Neurobiol. 14:1980;69-97.
95. Neisewander J.L., O'Dell L.E., Ly M.A., Tran-Nguyen T.L., Castañeda M.A.E., Fuchs R.A. Dopamine overflow in the nucleus accumbens during extinction and reinstatement of cocaine. Neuropsychopharmacology. 15:1996;506-514.
96. O'Brien, C.P., Childress, A.R., McLellan, A.T., Ehrman, R., 1992. Classical conditioning in drug-dependent humans. In: The Neurobiology of Drug and Alcohol Addiction. Ann. NY Acad. Sci. 654, 400-415.
97. Orzi F., Passarelli F., La Riccia M., Di Grezia R., Pontieri F.E. Intravenous morphine increases glucose utilization in the shell of the rat nucleus accumbens. Eur. J. Pharmacol. 302:1996;49-51.
98. Palkovits, M., 1979. Dopamine Levels of Individual Brain Regions: Biochemical Aspects of dopamine Distribution in the Central Nervous System. Academic Press, London, pp. 343-356.
99. Pavlov, I.P., 1927. Conditioned Reflexes. Oxford Univ. Press, London, p. 12.
100. Peciña S., Berridge K.C., Parker L.A. Pimozide does not shift palatability: separation of anhedonia from sensorimotor effects. Pharmacol. Biochem. Behav. 58:1997;801-811.
101. Pettit H.O., Justice J.B. Jr. Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis. Pharmacol. Biochem. Behav. 34:1989;899-904.
102. Pettit H.O., Justice J.B. Effect of dose on cocaine self-administration behavior and dopamine levels in the nucleus accumbens. Brain Res. 539:1991;94-102.
103. Phillips A.G., Fibiger H.C. Decreased resistance to extinction after haloperidol: implications for the role of dopamine in reinforcement. Pharmacol. Biochem. Behav. 10:1979;751-761.
104. Piazza P.V., Le Moal M. Pathophysiological basis of vulnerability to drug abuse: Role of an interaction between stress, glucocorticoids, and dopaminergic neurons. Annu. Rev. Pharmacol. Toxicol. 36:1996;359-378.
105. Piazza P.V., Deminière J.M., Le Moal M., Simon H. Factors that predict individual vulnerability to amphetamine self-administration. Science. 245:1989;1511-1513.
106. Piazza P.V., Deminière J.-M., Le Moal M., Simon H. Stress- and pharmacologically induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration. Brain Res. 514:1990;22-26.
107. Pontieri F.E., Colangelo V., La Riccia M., Pozzilli C., Passarelli F., Orzi F. Psychostimulant drugs increase glucose utilization in the shell of the rat nucleus accumbens. NeuroReport. 5:1994;2561-2564.
108. Pontieri F.E., Tanda G., Di Chiara G. Intravenous cocaine, morphine and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens. Proc. Natl. Acad. Sci. U.S.A. 92:1995;12304-12308.
109. Pontieri F.E., Tanda G., Orzi F., Di Chiara G. Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Nature. 382:1996;255-257.
110. Pothos E., Rada P., Mark G.P., Hoebel B.G. Dopamine microdialysis in the nucleus accumbens during acute and chronic morphine, naloxone-precipitated withdrawal and clonidine treatment. Brain Res. 566:1991;348-350.
111. Radhakishun F.S., Van Ree J.M., Westearink H.B.C. Scheduled eating increases dopamine release in the nucleus accumbens of food-deprived rats as assessed with on-line brain microdialysis. Neurosci. Lett. 85:1988;351-356.
112. Raiteri M., Del Carmine R., Bertollini A., Levi G. Effects of sympathomimetic amines on the synaptosomal transport of noradrenaline, dopamine and 5-hydroxytryptamine. Eur. J. Pharmacol. 41:1977;133-143.
113. Redgrave P., Prescott T.J., Gurney K. Is the short-latency dopamine response too short to signal reward error? TINS. 22:1999;146-151.
114. Rescorla R.A., Solomon R.L. Two-process learning theory: relationship between Pavlovian conditioning and instrumental learning. Psychol. Rev. 74:1967;151-182.
115. Richardson N.R., Gratton A. Behavior-relevant changes in nucleus accumbens dopamine transmission elicited by food reinforcement: an electrochemical study in rat. J. Neurosci. 16:1996;8160-8169.
116. Robbins T.W. The potentiation of conditioned reinforcement by psychomotor stimulant drugs: a test of Hill hypothesis. Psychopharmacol. 45:1975;103-114.
117. Robinson T.E., Berridge K.C. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res. Rev. 18:1993;247-291.
118. Robinson T.E., Camp D.M. Does amphetamine preferentially increase the extracellular concentration of dopamine in the mesolimbic system of freely moving rats? Neuropsychopharmacology. 3:1990;163-173.
119. Rossetti Z.L., Hmaidan Y., Gessa G.L. Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats. Eur. J. Pharmacol. 221:1992;227-234.
120. Salamone J.D. Complex motor and sensorimotor functions of striatal and accumbens dopamine: involvement in instrumental behavior processes. Psychopharmacology. 107:1992;160-174.
121. Salamone J.D. The involvement of nucleus accumbens dopamine in appetitive and aversive motivation. Behav. Brain Res. 61:1994;117-133.
122. Salamone J.D., Cousins M.S., Snyder B.J. Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis. Neurosci. Biobehav. Rev. 21:1997;341-359.
123. Saulskaya N., Marsden C.A. Conditional dopamine release: dependence upon N-methyl-D-aspartate receptors. Neuroscience. 67:1995;57-63.
124. Schneirla, T.C., 1959. An evolutionary and developmental theory of biphasic processes underlying approach and withdrawal. In: Jones, M.R. (Ed.), Nebraska Symposium on Motivation. Univ. of Nebraska Press, Lincoln, pp. 1-42.
125. Schultz W., Apicella P., Ljungberg T. Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task. J. Neurosci. 13:1993;900-913.
126. Schultz W., Dayan P., Montague P.R. A neural substrate of prediction and reward. Science. 275:1997;1593-1599.
127. Skinner B.F. Two types of conditioned reflex and a pseudotype. J. Gen. Psychol. 12:1935;66-77.
128. Skinner B.F. Two types of conditioned reflex: a reply to Konorski and Miller. J. Gen. Psychol. 16:1937;272-279.
129. Solomon, R.L., 1977. An opponent-process theory of motivation: IV. The affective dynamics of addiction. In: Maser, J.D., Seligman, M.E.P. (Eds.), Psychopathology: Experimental Models. Freeman, San Francisco.
130. Stewart J., de Wit H., Eikelboom R. Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants. Psychol. Rev. 91:1984;251-268.
131. 1 opioid link in the rat ventral tegmentum shared by palatable food (Fonzies) and non-psychostimulant drugs of abuse. Eur. J. Neurosci. 10:1998;1179-1187.
132. Tanda G., Carboni E., Frau R., Di Chiara G. Increase of extracellular dopamine in the prefrontal cortex: a trait of drugs with antidepressant potential? Psychopharmacology. 115:1994;285-288.
133. 1 opioid receptor mechanism. Science. 276:1997;2048-2050.
134. Tanda G., Pontieri F.E., Frau R., Di Chiara G. Contribution of blockade of the noradrenaline carrier to the increase of extracellular dopamine in the rat prefrontal cortex by amphetamine and cocaine. Eur. J. Neurosci. 9:1997;2077-2085.
135. Tjon G.H.K., Voorn P., Vanderschuren L.J.M.J., De Vries T.J., Michiels N.H.L.M., Jonker A.J., Klop H., Nestby P., Mulder A.H., Schoffelmeer A.N.M. Delayed occurrence of enhanced striatal preprodynorphin gene expression in behaviorally sensitized rats: differential long-term effects of intermittent and chronic morphine administration. Neuroscience. 76:1997;167-176.
136. Westerink B.H.C. Brain microdialysis and its application for the study of animal behavior. Behav. Brain Res. 70:1995;103-124.
137. Wikler A. Dynamics of drug dependence: implications of a conditioning theory for research and treatment. Arch. Gen. Psychiatry. 28:1973;611-616.
138. Wise R.A. Neuroleptics and operant behavior: the anhedonia hypothesis. Behav. Brain Sci. 5:1982;39-87.
139. Wise R.A. The anhedonia hypothesis: Mark III. Behav. Brain Sci. 8:1985;178-186.
140. Wise R.A., Bozarth M.A. A psychomotor stimulant theory of addiction. Psychol. Rev. 94:1987;469-492.
141. Wise R.A., Leone P., Rivest P., Leeb K. Elevations of nucleus accumbens dopamine and DOPAC levels during intravenous heroin self-administration. Synapse. 21:1995;140-148.
142. Wise R.A., Newton P., Leeb K., Burnette B., Pocock D., Justice J.B. Jr. Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. Psychopharmacology. 120:1995;10-20.
143. Young A.M.J. Intracerebral microdialysis in the study of physiology and behavior. Rev. Neurosci. 4:1994;373-395.
144. Young A.M.J., Joseph M.H., Gray J.A. Latent inhibition of conditioned dopamine release in rat nucleus accumbens. Neuroscience. 54:1993;5-9.
145. Young A.M.J., Ahier R.G., Upton R.L., Joseph M.H., Gray J.A. Increased extracellular dopamine in the nucleus accumbens of the rat during associative learning of neutral stimuli. Neuroscience. 83:1998;1175-1183.