Baclofen inhibits heroin self-administration behavior and mesolimbic dopamine release

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 3, 1999, Pages 1369-1374

  Xi, Zheng Xiong ^a   Stein, Elliot A ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYSACLOFEN; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; DIAMORPHINE; DOPAMINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC SYSTEM; DRUG ABUSE; DRUG SELF ADMINISTRATION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; REINFORCEMENT; VENTRAL TEGMENTUM;

ANIMALS; BACLOFEN; BEHAVIOR, ANIMAL; DOPAMINE; ELECTRODES; GABA AGONISTS; HEROIN; LIMBIC SYSTEM; MALE; MESENCEPHALON; NARCOTIC ANTAGONISTS; NARCOTICS; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY; SELF ADMINISTRATION; SUBSTANCE-RELATED DISORDERS; VENTRAL TEGMENTAL AREA;

EID: 0032797572     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. B receptor site distribution in the rat central nervous system. Neuroscience 20:365-383.
2. Britt MD and Wise RA (1983) Ventral tegmental site of opiate reward: Antagonism by a hydrophilic opiate receptor blockade. Brain Res 258:105-108.
3. Chang HT and Kitai ST (1985) Projection neurons of the nucleus accumbens: An intracellular labeling study. Brain Res 347:112-116.
4. A receptors within the ventral tegmental area. Neurosci Res 17:101-106.
5. De France JF, Sikes RW and Chronister RB (1985) Dopamine action in the nucleus accumbens. J Neurophysiol 54:1568-1577.
6. Devine DP and Wise RA (1994) Self-administration of morphine, DAMGO and DPDPE into the ventral tegmental area of rats. J Neurosci 14:1978-1984.
7. Di Chiara G and Imperato A (1988) Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J Pharmacol Exp Ther 244:1067-1080.
8. Dilts RP and Kalivas PW (1989) Autoradiographic localization of μ-opioid and neurotensin receptor within the mesolimbic dopamine system. Brain Res 488:311-327.
9. Ettenberg A, Pettit HO, Bloom FE and Koob GF (1982) Heroin and cocaine self-administration in rats: Mediation by separate neural systems. Psychopharmacology 78:204-209.
10. Goeders NE, Lane JD and Smith JE (1984) Self-administration of methionine enkephalin into the nucleus accumbens. Pharmacol Biochem Behav 20:451-455.
11. Gysling K and Wang RY (1983) Morphine-induced activation of A10 dopamine neurons in the rat. Brain Res 277:119-127.
12. Johnson SW and North RA (1992a) Opioids excite dopamine neurons by hyperpolarization of local interneurons. J Neurosci 12:483-488.
13. Johnson SW and North RA (1992b) Two types of neurons in the rat ventral tegmental area and their synaptic input. J Physiol (Lond) 450:455-468.
14. Kalivas PW, Duffy P and Eberhardt H (1990) Modulation of A10 dopamine neurons by γ-aminobutyric acid agonists. J Pharmacol Exp Ther 253:858-866.
15. Kelley AE, Stinus L and Iversen SD (1980) Interaction between d-ala2-metenkephalin, A10 dopaminergic neurons and spontaneous behavior in the rat. Behav Brain Res 1:3-34.
16. Kita H and Kitai ST (1988) Glutamate decarboxylase immunoreactive neurons in rat neostriatum: Their morphological types and populations. Brain Res 447:346-352.
17. Kiyatkin EA, Wise RA and Gratton A (1993) Drug- and behavior-associated changes in dopamine-related electrochemical signals during intravenous heroin self-administration in rats. Synapse 14:60-72.
18. Klitenick MA, DeWitt P and Kalivas PW (1992) Regulation of somatodendritic dopamine release in the ventral tegmental area by opioids and GABA: An in vivo microdialysis study. J Neurosci 12:2623-2632.
19. Koob GF and Bloom FE (1988) Cellular and molecular mechanisms of drug dependence. Science (Wash DC) 242:715-723.
20. Ling W and Majewska D (1998) Baclofen as a cocaine anti-craving medication: A preliminary clinical study. Neuropsychopharmacology 18:403-404.
21. Mansour A, Khachaturian H, Lewis ME, Akil H and Watson SJ (1987) Autoradiographic differentiation of mu, delta, and kappa opiate receptors in the rat forebrain and midbrain. J Neurosci 7:2445-2464.
22. Mathews RT and German DC (1984) Electrophysiological evidence of rat ventral tegmental area dopamine neurons by morphine. Neuroscience 11:617-625.
23. Nagai T, McGeer PL and McGeer EG (1983) Distribution of GABA-T-intensive neurons in the rat forebrain and midbrain. J Comp Neurol 218:220-238.
24. O'Brien PD and White FJ (1987) Inhibition of non-dopamine cells in the ventral tegmental area by benzodiazepines: Relationship to A10 dopamine cell activity. Eur J Pharmacol 142:343-354.
25. Olpe HR, Koella WP, Wolf P and Haas HL (1977) The action of baclofen on neurons of the substantia nigra and of the ventral tegmental area. Brain Res 134:577-580.
26. Pettit HO, Ettenberg A, Bloom FE and Koob GF (1984) Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology 84:167-173.
27. Phillips AG and LePiane FG (1980) Reinforcing effects of morphine microinjection into the ventral tegmental area. Pharmacol Biochem Behav 12:965-968.
28. Rada P, Mark GP, Pothes E and Hoebel BG (1991) Systemic morphine simultaneously decreases extracellular acetylcholine and increases dopamine in the nucleus accumbens of freely moving rats. Neuropharmacology 30:1133-1136.
29. Renno WM, Mullett MA and Beitz AJ (1992) Systemic morphine reduces GABA release in the lateral but not the medial portion of the midbrain periaqueductal gray of the rat. Brain Res 594:221-223.
30. Roberts DCS, Andrews MM and Vickers GJ (1996) Baclofen attenuates the reinforcing effects of cocaine in rats. Neuropsychopharmacology 15:417-423.
31. Self DW, McClenahan AW, Beitner-Johnson D, Terwilliger RZ and Nestler EJ (1995) Biochemical adaptations in the mesolimbic dopamine system in response to heroin self-administration. Synapse 21:312-318.
32. Sesack SR and Pickel VM (1992) Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area. J Comp Neurosci 320:145-160.
33. Spanagel R, Herz A and Shippenberg TS (1990) The effects of opioid peptides on dopamine release in the nucleus accumbens: An in vivo microdialysis study. J Neurochem 55:1734-1740.
34. Spyraki C, Fibiger HC and Phillips AG (1982) Attenuation of heroin reward in rats by disruption of the mesolimbic dopamine system. Psychopharmacology 79:278-283.
35. B receptors inhibits morphine-induced place preference in rats. Eur J Pharmacol 313:169-173.
36. Vaccarino FJ, Bloom FE and Koob GF (1985) Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat. Psychopharmacology 86:37-42.
37. Waszczak BL and Walters JR (1980) Intravenous GABA agonist administration stimulates firing of A10 dopaminergic neurons. Eur J Pharmacol 66:141-144.
38. B and NMDA receptor agonists on medial forebrain bundle self-stimulation. Behav Brain Res 70:31-36.
39. Xi Z-X, Fuller SA and Stein EA (1998) Dopamine release in the nucleus accumbens during heroin self-administration is modulated by kappa opioid receptors: An in vivo fast-cyclic voltammetry study. J Pharmacol Exp Ther 284:151-161.
40. A receptors - An in vivo electrochemical study. Brain Res 798: 156-165.