Progressive ratio schedules in drug self-administration studies in rats: A method to evaluate reinforcing efficacy

Journal of Neuroscience Methods

Volumn 66, Issue 1, 1996, Pages 1-11

  Richardson, Nicole R ^a,b   Roberts, David C S ^a  

^a CARLETON UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Drug abuse; Drug self administration; Fixed ratio; Opiate; Progressive ratio; Psychomotor stimulant; Schedules of reinforcement

Indexed keywords

COCAINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; DRUG ABUSE PATTERN; DRUG SELF ADMINISTRATION; MATHEMATICAL ANALYSIS; NONHUMAN; OPIATE ADDICTION; PERFORMANCE; PRIORITY JOURNAL; RAT; REINFORCEMENT; REVIEW;

EID: 0029980944     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-0270(95)00153-0     Document Type: Review

References (71)

1. Aigner, T.G. and Balster, R.L. (1978) Choice behavior in rhesus monkeys: cocaine versus food. Science, 201: 534-535.
2. Balster, R.L. and Schuster, C.R. (1973) Fixed-interval schedule of cocaine reinforcement: effect of dose and infusion duration. J. Exp Anal. Behav., 20: 119-129.
3. Balster, R.L., Kilbey, M.M. and Ellinwood, E.H., Jr. (1976) Methamphetamine self-administration in the cat. Psychopharmacology, 46: 229-233.
4. Bedford, J.A., Bailey, L.P. and Wilson, M.C. (1978) Cocaine reinforced progressive ratio performance in the rhesus monkey. Pharmacol. Biochem. Behav., 9: 631-638.
5. Carey, R.J. (1983) Linear increments in behavioral perseveration induced by repeated apomorphine administration. Biol. Psychiat., 18: 249-253.
6. Carroll, M.E., Lac, S.T., Asencio, M. and Kragh, R. (1990a) Fluoxetine reduces intravenous cocaine self-administration in rats. Pharmacol. Biochem. Behav., 35: 237-244.
7. Carroll, M.E., Lac, S.T., Asencio, M. and Kragh, R. (1990b) Intravenous cocaine self-administration in rats is reduced by dietary L-tryptophan. Psychopharmacology, 100: 293-300.
8. Catania, A.C. (1976) Drug effects and concurrent performances. Pharmacol. Rev., 27: 385-394.
9. Deneau, G., Yanagita, T. and Seevers, M.H. (1969) Self-administration of psychoactive substances by the monkey. Psychopharmacology, 16: 30-48.
10. Depoortere, R.Y., Li, D.H., Lane, J.D. and Emmett-Oglesby, M.W. (1993). Parameters of self-administration of cocaine in rats under a progressive-ratio schedule. Pharmacol. Biochem. Behav., 45: 539-548.
11. Dougherty, J. and Pickens, R.W. (1973) Fixed-interval schedules of intravenous cocaine presentation in rats. J. Exp. Anal. Behav. 20: 111-118.
12. Elmer, G.I., Pieper, J.O., Goldberg, S.R. and George, F.R. (1995) Opioid operant self-administration, analgesia, stimulation and respiratory depression in μ-deficient mice. Psychopharmacology, 117: 23-31.
13. Ferster, C.B. and Skinner, B.F. (1957) Schedules of Reinforcement. Appleton-Century-Crofts, New York.
14. Fitch, T.E. and Roberts, D.C.S. (1993) The effects of dose and access restrictions on the periodicity of cocaine self-administration in the rat. Drug Alcohol Depend., 33: 199-128.
15. French, E.D., Lopez, M., Peper, S., Kamenka, J.-M. and Roberts, D.C.S. (1995) A comparison of the reinforcing efficacy of PCP, the PCP derivatives TCP and BTCP, and cocaine using a progressive ratio schedule in the rat. Behav. Pharmacol., 6: 223-228.
16. Gerber, G.J., Bozarth, M.A., Spindler, J.E. and Wise, R.A. (1985) Concurrent heroin self-administration and intracranial self-stimulation in rats. Pharmacol. Biochem. Behav., 23: 837-842.
17. Gerber, G.J. and Wise, R.A. (1989) Pharmacological regulation of intravenous cocaine and heroin self-administration in rats: a variable dose paradigm. Pharmacol. Biochem. Behav., 32: 527-531.
18. Goldberg, S.R. (1973) Comparative behavior maintained under fixed-ratio and second-order schedules of food presentation, cocaine injection or D-amphetamine injections in the squirrel monkey. J. Pharmacol. Exp. Ther., 186: 18-30.
19. Griffiths, R.R., Bradford, L.D. and Brady, J.V. (1979) Progressive ratio and fixed ratio schedules of cocaine-maintained responding in baboons. Psychopharmacology, 65: 125-136.
20. Griffiths, R.R., Brady, J.V. and Snell, J.D. (1978) Progressive-ratio performance maintained by drug infusions: comparison of cocaine, diethylpropion, chlorphentermine and fenfluramine. Psychopharmacology, 56: 5-13.
21. Griffiths, R.R., Findley, J.D., Brady, J.V., Dolan-Gutcher, K. and Robinson, W.W. (1975) Comparison of progressive-ratio performance maintained by cocaine, methylphenidate and secobarbital. Psychopharmacology, 43: 81-83.
22. Harvey, J.A. and Hunt, H.F. (1965) Effect of septal lesions on thirst in the rat as indicated by water consumption and operant responding for water reward. J. Comp. Physiol. Psych., 59: 49-56.
23. Hawkins, T.D. and Pliskoff, S.S. (1964) Brain stimulation intensity, rate of self-stimulation, and reinforcing strength: an analysis through chaining. J. Exp. Anal. Behav., 7: 285-288.
24. Hernstein, R.J. (1961) Relative and absolute strength of response as a function of reinforcement. J. Exp. Anal. Behav., 4: 267-272.
25. Hodos, W. (1961) Progressive ratio as a measure of reward strength. Science, 134: 943-944.
26. Hoffmeister, F. (1979) Progressive-ratio performance in the rhesus monkey maintained by opiate infusions. Psychopharmacology, 62: 181-186.
27. Hubner, C.B. and Koob, G.F. (1990) The ventral pallidum plays a role in mediating cocaine and heroin self-administration in the rat. Brain Res., 508: 20-29.
28. Hubner, C.B. and Moreton, J.E. (1991) Effects of selective D1 and D2 dopamine antagonists on cocaine self-administration in the rat. Psychopharmacology, 105: 151-156.
29. Iglauer, C. and Woods, J.H. (1974) Concurrent performances: reinforcement by different doses of intravenous cocaine in rhesus monkeys. J. Exp. Anal. Behav., 22: 179-196.
30. Johanson, C.E. (1982) Behavior maintained under fixed-interval and second-order schedules of cocaine or pentobarbital in rhesus monkeys. J. Pharmacol. Exp. Ther., 221: 384-393.
31. Johanson, C.E. and Aigner, T. (1981) Comparison of the reinforcing properties of cocaine and procaine in rhesus monkeys. Pharmacol. Biochem. Behav., 15: 49-53.
32. Johanson, C.E. and Schuster, C.R. (1975) A choice procedure for drug reinforcers: cocaine and methylphenidate in the rhesus monkey. J. Pharmacol. Exp. Ther., 193: 676-688.
33. Koob, G.F., Vaccarino, F.J., Amalric, M. and Bloom, F.E. (1987) Positive reinforcement properties of drugs: search for neural substrates. In: J. Engel and L. Oreland (Eds.), Brain Reward Systems and Abuse, Raven Press, New York, pp. 35-50.
34. Li, D.-H., Depoortere, R.Y. and Emmett-Oglesby, M.W. (1994) Tolerance to the reinforcing effects of cocaine in a progressive ratio paradigm. Psychopharmacology, 116: 326-332.
35. Llewellyn, M.E., Iglauer, C. and Woods, J.H. (1976) Relative reinforcer magnitude under a non-independent concurrent schedule of cocaine reinforcement in rhesus monkeys. J. Exp. Anal. Behav., 25: 81-91.
36. Loh, E.A., Fitch, T., Vickers, G.J. and Roberts, D.C.S. (1992) Clozapine increases breaking points on a progressive-ratio schedule reinforced by intravenous cocaine. Pharmacol. Biochem. Behav., 42: 559-562.
37. Loh, E.A. and Roberts, D.C.S. (1990) Break-points on a progressive ratio schedule reinforced by intravenous cocaine increase following depletion of forebrain serotonin. Psychopharmacology, 101: 262-266.
38. Lyon, M. and Robbins, T. (1975) The action of central nervous system stimulant drugs: a general theory concerning amphetamine effects. In: W.B. Essman and L. Valzelli (Eds.), Current Developments in Psychology, Vol. 2, Spectrum Publ., New York, pp. 80-163.
39. McGregor, A., Baker, G.B. and Roberts, D.C.S. (1994) Effect of 6-hydroxydopamine lesions of the amygdala on intravenous cocaine self-administration under a progressive ratio schedule of reinforcement. Brain Res., 646: 273-278.
40. McGregor, A., Lacosta, S. and Roberts, D.C.S. (1993) L-tryptophan decreases the breaking point under a progressive ratio schedule of intravenous cocaine reinforcement in the rat. Pharmacol. Biochem. Behav., 44: 651-655.
41. McGregor, A. and Roberts, D.C.S. (1993) Dopaminergic antagonism within the nucleus accumbens or the amygdala produces differential effects on intravenous cocaine self-administration under fixed ratio and progressive ratio schedules of reinforcement. Brain Res., 624: 245-252.
42. McGregor, A. and Roberts, D.C.S. (1995) Effect of medial prefrontal cortex injections of SCH 23390 on intravenous cocaine self-administration under both a fixed and progressive ratio schedule of reinforcement. Behav. Brain Res., 67: 75-80.
43. McLeod, D.R. and Griffiths, R.R. (1983) Human progressive-ratio performance: maintenance by pentobarbital. Psychopharmacology, 79: 4-9.
44. Pickens, R. (1968) Self-administration of stimulants by rats. Int. J. Addict., 3: 215-221.
45. Richardson, N.R., Smith, A.M. and Roberts, D.C.S. (1994) A single injection of either flupenthixol decanoate or haloperidol decanoate produces long-term changes in cocaine self-administration in rats. Drug Alcohol Depend., 36: 23-25.
46. Risner, M.E. and Goldberg, S.R. (1983) A comparison of nicotine and cocaine self-administration in the dog: FR and PR schedules of intravenous drug infusions. J. Pharmacol. Exp. Ther., 224: 319-326.
47. Risner, M.E. and Jones, B.E. (1975) Self-administration of CNS stimulants by dog. Psychopharmacology, 43: 207-213.
48. Risner, M.E. and Silcox, D.L. (1981) Psychostimulant self-administration by beagle dogs in a progressive-ratio paradigm. Psychopharmacology, 75: 25-30.
49. Roberts, D.C.S. (1989) Breaking points on a progressive ratio schedule reinforced by intravenous apomorphine increase daily following 6-hydroxydopamine lesions of the nucleus accumbens. Pharmacol. Biochem. Behav., 32: 43-47.
50. Roberts, D.C.S. and Bennett, S.A.L. (1989) Qualitative differences in heroin and cocaine self-administration behavior. Soc. Neurosci. Abst., 15: 637.
51. Roberts, D.C.S. and Bennett, S.A.L. (1993) Heroin self-administration in rats under a progressive ratio schedule of reinforcement. Psychopharmacology, 111: 215-218.
52. Roberts, D.C.S., Bennett, S.A.L. and Vickers, G.J. (1989a) The estrous cycle affects cocaine self-administration on a progressive ratio schedule in rats. Psychopharmacology, 98: 408-411.
53. Roberts, D.C.S., Loh, E.A., Baker, G.B. and Vickers, G.J. (1994) Lesions of central serotonin systems affect responding on a progressive ratio schedule reinforced either by intravenous cocaine or by food. Pharmacol. Biochem. Behav., 49: 177-182.
54. Roberts, D.C.S., Loh, E. and Vickers, G. (1989b) Self-administration of cocaine on a progressive ratio schedule in rats: dose-response relationship and effect of haloperidol pretreatment. Psychopharmacology, 97: 535-538.
55. Roberts, D.C.S. and Richardson, N.R. (1992) Self-administration of psychomotor stimulants using progressive ratio schedules of reinforcement. In: A. Boulton, G. Baker and P.H. Wu (Eds.), Neuromethods, Vol. 24, Animal Models of Drug Addiction, Humana Press, Totowa, NJ, pp. 233-269.
56. Roberts, D.C.S. and Vickers, G. (1984) Atypical neuroleptics increase self-administration of cocaine: an evaluation of a behavioral screen for antipsychotic activity. Psychopharmacology, 82: 135-139.
57. Shaham, Y. and Stewart, J. (1994) Exposure to mild stress enhances the reinforcing efficacy of intravenous heroin self-administration in rats. Psychopharmacology, 114: 523-527.
58. Smith, A., Piercey, M. and Roberts, D.C.S. (1995) The effect of (-)-DS 121 and (+)-UH 232 on cocaine self-administration in rats. Psychopharmacology, in press.
59. Stretch, R. (1977) Discrete-trial control of morphine self-injection in squirrel monkeys: effects of naloxone, morphine, and chlorpromazine. Can. J. Physiol. Pharmacol., 55: 615-627.
60. Thompson, T. and Schuster, C.R. (1964) Morphine self-administration, food-reinforced, and avoidance behaviors in rhesus monkeys. Psychopharmacology, 5: 87-94.
61. Valenstein E.S. (1964) Problems of measurement and interpretation with reinforcing brain stimulation. Psych. Rev., 71: 415-437.
62. Weeks, J.R. (1961) Self-maintained 'addiction' a method for chronic programmed intravenous injection in unrestrained rats. Fed. Proc., 20: 397.
63. Weeks, J.R. (1962) Experimental morphine addiction: method for automatic intravenous injections in unrestrained rats. Science, 138: 143-144.
64. Wilson, M.C. and Schuster, C.R. (1973) Cholinergic influence on intravenous cocaine self-administration by rhesus monkey. Pharmacol. Biochem. Behav., 1: 643-649.
65. Winsauer, P.J. and Thompson, D.M. (1991) Cocaine self-administration in pigeons. Pharmacol. Biochem. Behav., 40: 41-52.
66. Wise, R.A., Yokel, R.A., Hanson, P.A. and Gerber, G.J. (1977) Concurrent intracranial self-stimulation and amphetamine self-administration in rats. Pharmacol. Biochem. Behav., 7: 459-461.
67. Woolverton, W.L. (1987) Evaluation of the role of norepinephrine in the reinforcing effects of psychomotor stimulants in rhesus monkeys. Pharmacol. Biochem. Behav., 26: 835-839.
68. Woolverton, W.L. and Balster, R.L. (1979) Reinforcing properties of some local anesthetics in rhesus monkeys. Pharmacol. Biochem. Behav., 11: 669-672.
69. Yanagita, T. and Takahashi, S. (1973) Dependence liability of several sedative-hypnotic agents evaluated in monkeys. J. Pharm. Exp. Ther., 185: 307-316.
70. Yokel, R.A. and Wise, R.A. (1975) Increased lever-pressing for amphetamine after pimozide in rats: implications for a dopamine theory of reward. Science, 187: 547-549.
71. Young, A.M. and Woods, J.H. (1980) Behavior maintained by intravenous injection of codeine, cocaine, and etorphine in the rhesus macaque and the pigtail macaque. Psychopharmacology, 70: 263-271.