Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia

British Journal of Haematology

Volumn 114, Issue 1, 2001, Pages 70-77

  Pepper, Chris ^a   Thomas, Alun ^a   Hoy, Terry ^b   Fegan, Chris ^c   Bentley, Paul ^a  

^a LLANDOUGH HOSPITAL   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; B cell chronic lymphocytic leukaemia; Bax; Flavopiridol; p53

Indexed keywords

FLAVONE DERIVATIVE; FLAVOPIRIDOL; FLUDARABINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1; PROTEIN P53;

APOPTOSIS; ARTICLE; B CELL LEUKEMIA; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LD 50; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; DRUG RESISTANCE, NEOPLASM; FLAVONOIDS; FLOW CYTOMETRY; HUMANS; LETHAL DOSE 50; LEUKEMIA, B-CELL, CHRONIC; LYMPHOCYTES; PIPERIDINES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53; VIDARABINE;

EID: 0034935026     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02895.x     Document Type: Article

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