-
1
-
-
0031913246
-
Mechanism of activation and function of protein kinase B
-
Alessi, D. R., and P. Cohen. 1998. Mechanism of activation and function of protein kinase B. Curr. Opin. Genet. Dev. 8:55-62.
-
(1998)
Curr. Opin. Genet. Dev.
, vol.8
, pp. 55-62
-
-
Alessi, D.R.1
Cohen, P.2
-
2
-
-
12644301164
-
3-Phosphoinositide-dependent kinase 1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase
-
Alessi, D. R., M. Deak, A. Casamayor, F. B. Caudwell, N. Morrice, D. G. Norman, P. Gaffney, C. B. Reese, C. N. MacDougall, D. Harbison, A. Ashworth, and B. Bownes. 1997. 3-Phosphoinositide-dependent kinase 1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr. Biol. 7:776-789.
-
(1997)
Curr. Biol.
, vol.7
, pp. 776-789
-
-
Alessi, D.R.1
Deak, M.2
Casamayor, A.3
Caudwell, F.B.4
Morrice, N.5
Norman, D.G.6
Gaffney, P.7
Reese, C.B.8
MacDougall, C.N.9
Harbison, D.10
Ashworth, A.11
Bownes, B.12
-
3
-
-
0030590875
-
Molecular basis for substrate specificity of protein kinase B: Comparison with MAPKAP kinase-1 and p70 S6 kinase
-
Alessi, D. R., F. B. Caudwell, M. Andjelkovic, B. A. Hemmings, and P. Cohen. 1996. Molecular basis for substrate specificity of protein kinase B: comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett. 399:333-338.
-
(1996)
FEBS Lett.
, vol.399
, pp. 333-338
-
-
Alessi, D.R.1
Caudwell, F.B.2
Andjelkovic, M.3
Hemmings, B.A.4
Cohen, P.5
-
4
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-I
-
Alessi, D. R., M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, and B. A. Hemmings. 1996. Mechanism of activation of protein kinase B by insulin and IGF-I. EMBO J. 15:6541-6551.
-
(1996)
EMBO J.
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
5
-
-
0034610981
-
Deficiency of the stress kinase p38α results in embryonic lethality: Characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells
-
Allen, M., L. Svensson, M. Roach, J. Hambar, J. McNeish, and G. A. Gabel. 2000. Deficiency of the stress kinase p38α results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J. Exp. Med. 191:859-869.
-
(2000)
J. Exp. Med.
, vol.191
, pp. 859-869
-
-
Allen, M.1
Svensson, L.2
Roach, M.3
Hambar, J.4
McNeish, J.5
Gabel, G.A.6
-
6
-
-
0034704178
-
Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength
-
Alonso, G., C. Ambrosino, M. Jones, and A. R. Nebrada. 2000. Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength. J. Biol. Chem. 275:40641-40648.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 40641-40648
-
-
Alonso, G.1
Ambrosino, C.2
Jones, M.3
Nebrada, A.R.4
-
7
-
-
0032493105
-
Akt2 mRNA is highly expressed in embryonic brown fat and the Akt2 kinase is activated by insulin
-
Altomare, D. A., G. E. Lyons, Y. Mitsuuchi, J. Q. Cheng, and J. R. Testa. 1998. Akt2 mRNA is highly expressed in embryonic brown fat and the Akt2 kinase is activated by insulin. Oncogene 16:2407-2411.
-
(1998)
Oncogene
, vol.16
, pp. 2407-2411
-
-
Altomare, D.A.1
Lyons, G.E.2
Mitsuuchi, Y.3
Cheng, J.Q.4
Testa, J.R.5
-
8
-
-
15644381754
-
Role of translocation in the activation and function of protein kinase B
-
Andjelkovic, M., D. R. Alessi, R. Meier, A. Fernandez, N. J. C. Lamb, M. Frech, P. Cron, P. Cohen, J. M. Lucocq, and B. A. Hemmings. 1997. Role of translocation in the activation and function of protein kinase B. J. Biol. Chem. 272:31515-31524.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 31515-31524
-
-
Andjelkovic, M.1
Alessi, D.R.2
Meier, R.3
Fernandez, A.4
Lamb, N.J.C.5
Frech, M.6
Cron, P.7
Cohen, P.8
Lucocq, J.M.9
Hemmings, B.A.10
-
9
-
-
0036765743
-
Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific
-
Baudhuin, L. M., K. L. Kristina, J. Lu, and Y. Xu. 2002. Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific. Mol. Pharmacol. 62:660-672.
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 660-672
-
-
Baudhuin, L.M.1
Kristina, K.L.2
Lu, J.3
Xu, Y.4
-
10
-
-
0035822699
-
Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase
-
Belham, C., M. J. Comb, and J. Avruch. 2001. Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. Curr. Biol. 11:1155-1167.
-
(2001)
Curr. Biol.
, vol.11
, pp. 1155-1167
-
-
Belham, C.1
Comb, M.J.2
Avruch, J.3
-
11
-
-
0036204443
-
Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression
-
Bergstrom, D. A., B. H. Penn, A. Strand, R. L. S. Perry, M. A. Rudnicki, and S. J. Tapscott. 2002. Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression. Mol. Cell 9:587-600.
-
(2002)
Mol. Cell
, vol.9
, pp. 587-600
-
-
Bergstrom, D.A.1
Penn, B.H.2
Strand, A.3
Perry, R.L.S.4
Rudnicki, M.A.5
Tapscott, S.J.6
-
12
-
-
0032578915
-
Induction of Akt2 correlates with differentiation in Sol8 muscle cells
-
Calera, M., and P. F. Pilch. 1998. Induction of Akt2 correlates with differentiation in Sol8 muscle cells. Biochem. Biophys. Res. Commun. 251:835-841.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.251
, pp. 835-841
-
-
Calera, M.1
Pilch, P.F.2
-
13
-
-
0034634574
-
Osmotic stress regulated the stability of cyclin D1 in a p38SAPK2-dependent manner
-
Casanovas, O., F. Miro, J. M. Estanyol, E. Itarte, N. Agell, and O. Bachs. 2000. Osmotic stress regulated the stability of cyclin D1 in a p38SAPK2-dependent manner. J. Biol. Chem. 275:35091-35097.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 35091-35097
-
-
Casanovas, O.1
Miro, F.2
Estanyol, J.M.3
Itarte, E.4
Agell, N.5
Bachs, O.6
-
14
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene
-
Chen, W. S., P.-Y. Xu, K. Gottlob, M.-L. Chen, K. Sokol, T. Shiyanova, I. Roninson, W. Weng, R. Suzuki, K. Tobe, T. Kadwaki, and N. Hay. 2001. Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene. Genes Dev. 15:2203-2208.
-
(2001)
Genes Dev.
, vol.15
, pp. 2203-2208
-
-
Chen, W.S.1
Xu, P.-Y.2
Gottlob, K.3
Chen, M.-L.4
Sokol, K.5
Shiyanova, T.6
Roninson, I.7
Weng, W.8
Suzuki, R.9
Tobe, K.10
Kadwaki, T.11
Hay, N.12
-
15
-
-
0035914388
-
Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
-
Cho, H., J. L. Thorvaldson, Q. Chu, F. Feng, and M. J. Birnbaum. 2001. Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J. Biol. Chem. 276:38349-38352.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38349-38352
-
-
Cho, H.1
Thorvaldson, J.L.2
Chu, Q.3
Feng, F.4
Birnbaum, M.J.5
-
16
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
-
Cho, H., J. Mu, J. K. Kim, J. L. Thorvaldsen, Q. Chu, E. B. Crenshaw III, K. H. Kaestner, M. S. Bartolmei, G. I. Shulman, and M. J. Birnbaum. 2001. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 292:1728-1731.
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw III, E.B.6
Kaestner, K.H.7
Bartolmei, M.S.8
Shulman, G.I.9
Birnbaum, M.J.10
-
17
-
-
0034710832
-
Phosphatidylinositol 3-kinase stimulates muscle differentiation by activating p38 mitogen-activated protein kinase
-
Chun, Y. K., J. Kim, S. Kwon, S. H. Choi, F. Hong, K. Moon, J. M. Kim, S. L. Choi, B. S. Kim, J. Ha, and S. S. Kim. 2000. Phosphatidylinositol 3-kinase stimulates muscle differentiation by activating p38 mitogen-activated protein kinase. Biochem. Biophys. Res. Commun. 276:502-507.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.276
, pp. 502-507
-
-
Chun, Y.K.1
Kim, J.2
Kwon, S.3
Choi, S.H.4
Hong, F.5
Moon, K.6
Kim, J.M.7
Choi, S.L.8
Kim, B.S.9
Ha, J.10
Kim, S.S.11
-
18
-
-
0030934472
-
The mitogenic and myogenic actions of the insulin-like growth factors utilize distinct signalling pathways
-
Coolican, S. A., D. S. Samuel, D. Z. Ewton, F. J. McWade, and J. R. Florini. 1997. The mitogenic and myogenic actions of the insulin-like growth factors utilize distinct signalling pathways. J. Biol. Chem. 272:6653-6662.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6653-6662
-
-
Coolican, S.A.1
Samuel, D.S.2
Ewton, D.Z.3
McWade, F.J.4
Florini, J.R.5
-
19
-
-
0033548233
-
Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2 myogenesis
-
Cuenda, C., and P. Cohen. 1999. Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2 myogenesis. J. Biol. Chem. 274:4341-4346.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 4341-4346
-
-
Cuenda, C.1
Cohen, P.2
-
20
-
-
0032530482
-
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/Akt by the integrin-linked kinase
-
Delcommenne, M., C. Tan, V. Gray, L. Rue, J. Woogett, and S. Dedhar. 1998. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/Akt by the integrin-linked kinase. Proc. Natl. Acad. Sci. USA 95:11211-11216.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 11211-11216
-
-
Delcommenne, M.1
Tan, C.2
Gray, V.3
Rue, L.4
Woogett, J.5
Dedhar, S.6
-
21
-
-
0030991386
-
High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity
-
Frech, M., M. Andjelkovic, E. Ingley, K. K. Reddy, J. R. Falck, and B. A. Hemmings. 1997. High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity. J. Biol. Chem. 272:8474-8481.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 8474-8481
-
-
Frech, M.1
Andjelkovic, M.2
Ingley, E.3
Reddy, K.K.4
Falck, J.R.5
Hemmings, B.A.6
-
22
-
-
0033001501
-
Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival
-
Fujio, Y., K. Guo, T. Mano, Y. Mitsuuchi, J. R. Testa, and K. Walsh. 1999. Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival. Mol. Cell. Biol. 19:5073-5082.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 5073-5082
-
-
Fujio, Y.1
Guo, K.2
Mano, T.3
Mitsuuchi, Y.4
Testa, J.R.5
Walsh, K.6
-
23
-
-
0035670099
-
Activation of Akt2 inhibits anoikis and apoptosis induced by myogenic differentiation
-
Fujio, Y., Y. Mitsuuchi, J. R. Testa, and K. Walsh. 2001. Activation of Akt2 inhibits anoikis and apoptosis induced by myogenic differentiation. Cell Death Differ. 8:1207-1212.
-
(2001)
Cell Death Differ.
, vol.8
, pp. 1207-1212
-
-
Fujio, Y.1
Mitsuuchi, Y.2
Testa, J.R.3
Walsh, K.4
-
24
-
-
0033569755
-
Targeted down-regulation of caveolin-3 is sufficient to inhibit myotube formation in differentiating C2 myoblasts. Transient activation of p38 mitogen-activated protein kinase is required for induction of caveolin-3 expression and subsequent myotube formation
-
Galbiati, F., D. Volonte, J. A. Engelman, P. E. Scherer, and M. P. Lisanti. 1999. Targeted down-regulation of caveolin-3 is sufficient to inhibit myotube formation in differentiating C2 myoblasts. Transient activation of p38 mitogen-activated protein kinase is required for induction of caveolin-3 expression and subsequent myotube formation. J. Biol. Chem. 274:30315-30321.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 30315-30321
-
-
Galbiati, F.1
Volonte, D.2
Engelman, J.A.3
Scherer, P.E.4
Lisanti, M.P.5
-
25
-
-
0027936755
-
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
-
Han, J., J.-D. Lee, L. Bibbs, and R. J. Ulevitch. 1994. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808-811.
-
(1994)
Science
, vol.265
, pp. 808-811
-
-
Han, J.1
Lee, J.-D.2
Bibbs, L.3
Ulevitch, R.J.4
-
26
-
-
0032564422
-
An essential role of phosphatidylinositol 3-kinase in myogenic differentiation
-
Jiang, B.-H., J. Z. Zheng, and P. K. Vogt. 1998. An essential role of phosphatidylinositol 3-kinase in myogenic differentiation. Proc. Natl. Acad. Sci. USA 95:14179-14183.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 14179-14183
-
-
Jiang, B.-H.1
Zheng, J.Z.2
Vogt, P.K.3
-
27
-
-
0033515073
-
Myogenic signalling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B
-
Jiang, B.-H., M. Aoki, J. Z. Zheng, J. Li, and P. K. Vogt. 1999. Myogenic signalling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B. Proc. Natl. Acad. Sci. USA 96:2077-2081.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2077-2081
-
-
Jiang, B.-H.1
Aoki, M.2
Zheng, J.Z.3
Li, J.4
Vogt, P.K.5
-
28
-
-
0029741689
-
Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells
-
Kaliman, P., F. Viñals, X. Tester, M. Palacin, and A. Zorzano. 1996. Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells. J. Biol. Chem. 271:19146-19151.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 19146-19151
-
-
Kaliman, P.1
Viñals, F.2
Tester, X.3
Palacin, M.4
Zorzano, A.5
-
29
-
-
0031917412
-
Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: Dominant negative p85 expression blocks differentiation of L6E9 muscle cells
-
Kaliman, P., J. Canicio, P. R. Shepher, C. A. Beeton, X. Testar, M. Palacin, and A. Zorzano. 1998. Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells. Mol. Endocrinol. 12:66-77.
-
(1998)
Mol. Endocrinol.
, vol.12
, pp. 66-77
-
-
Kaliman, P.1
Canicio, J.2
Shepher, P.R.3
Beeton, C.A.4
Testar, X.5
Palacin, M.6
Zorzano, A.7
-
30
-
-
0037189574
-
Positive feedback regulation between Akt2 and MyoD during muscle differentiation: Cloning of the Akt2 promoter
-
Kaneko, S., R. I. Feldman, L. Yu, Z. Wu, T. Gritsko, S. A. Shelley, S. V. Nicosia, T. Nobori, and J. Q. Cheng. 2002. Positive feedback regulation between Akt2 and MyoD during muscle differentiation: cloning of the Akt2 promoter. J. Biol. Chem. 277:23230-23235.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 23230-23235
-
-
Kaneko, S.1
Feldman, R.I.2
Yu, L.3
Wu, Z.4
Gritsko, T.5
Shelley, S.A.6
Nicosia, S.V.7
Nobori, T.8
Cheng, J.Q.9
-
31
-
-
0036273201
-
Distinct cellular function of MK2
-
Kotlyarov, A., Y. Yannoni, S. Fritz, K. Laass, J.-B. Teliez, D. Pitman, and M. Gaestel. 2002. Distinct cellular function of MK2. Mol. Cell. Biol. 22:4827-4835.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 4827-4835
-
-
Kotlyarov, A.1
Yannoni, Y.2
Fritz, S.3
Laass, K.4
Teliez, J.-B.5
Pitman, D.6
Gaestel, M.7
-
32
-
-
0034629345
-
The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase
-
Lali, F. V., A. E. Hunt, S. J. Turner, and B. M. J. Foxwell. 2000. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J. Biol. Chem. 275:7395-7402.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 7395-7402
-
-
Lali, F.V.1
Hunt, A.E.2
Turner, S.J.3
Foxwell, B.M.J.4
-
33
-
-
0037147210
-
Myostatin inhibits myoblast differentiation by down-regulating MyoD expression
-
Langley, B., M. Thomas, A. Bishop, M. Sharma, S. Gilmour, and R. Kambadur. 2002. Myostatin inhibits myoblast differentiation by down-regulating MyoD expression. J. Biol. Chem. 277:49831-49840.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49831-49840
-
-
Langley, B.1
Thomas, M.2
Bishop, A.3
Sharma, M.4
Gilmour, S.5
Kambadur, R.6
-
34
-
-
0037040925
-
Phosphatidylinositol-3-kinase controls human intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAPK activation
-
Laprise, P., P. Chailler, M. Houde, J.-F. Beaulieu, M.-J. Boucher, and N. Rivard. 2002. Phosphatidylinositol-3-kinase controls human intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAPK activation. J. Biol. Chem. 277:8226-8234.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 8226-8234
-
-
Laprise, P.1
Chailler, P.2
Houde, M.3
Beaulieu, J.-F.4
Boucher, M.-J.5
Rivard, N.6
-
35
-
-
0034462138
-
Insulin-like growth factor-mediated muscle cell survival: Central roles for Akt and cyclin-dependent kinase inhibitor p21
-
Lawlor, M. A., and P. Rotwein. 2000. Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21. Mol. Cell. Biol. 20:8983-8995.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 8983-8995
-
-
Lawlor, M.A.1
Rotwein, P.2
-
36
-
-
0034001543
-
Dual control of muscle cell survival by distinct growth factor-regulated signaling pathways
-
Lawlor, M. A., X. Feng, D. R. Everding, K. Sieger, C. E. H. Stewart, and P. Rotwein. 2000. Dual control of muscle cell survival by distinct growth factor-regulated signaling pathways. Mol. Cell. Biol. 20:3256-3265.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 3256-3265
-
-
Lawlor, M.A.1
Feng, X.2
Everding, D.R.3
Sieger, K.4
Stewart, C.E.H.5
Rotwein, P.6
-
37
-
-
0029911710
-
ERK6, a mitogen-activated protein kinase involved in C2 myoblast differentiation
-
Lechner, C., M. A. Zahalka, J.-F. Giot, N. P. H. Moller, and A. Ulrich. 1996. ERK6, a mitogen-activated protein kinase involved in C2 myoblast differentiation. J. Biol. Chem. 93:4355-4359.
-
(1996)
J. Biol. Chem.
, vol.93
, pp. 4355-4359
-
-
Lechner, C.1
Zahalka, M.A.2
Giot, J.-F.3
Moller, N.P.H.4
Ulrich, A.5
-
38
-
-
0028605318
-
Identification and characterization of a novel protein kinase involved in regulation of inflammatory cytokine biosynthesis
-
Lee, J. C., J. T. Laydon, P. C. McDonnell, T. F. Gallagher, S. Kumar, D. Green, D. McNulty, M. J. Blumenthal, R. J. Hayes, S. W. Landvatter, J. E. Strickler, M. M. McLaughlin, I. Siemens, S. Fisher, G. P. Livi, J. R. White, J. L. Adams, and P. R. Young. 1994. Identification and characterization of a novel protein kinase involved in regulation of inflammatory cytokine biosynthesis. Nature 372:739-746.
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
Laydon, J.T.2
McDonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
Green, D.6
McNulty, D.7
Blumenthal, M.J.8
Hayes, R.J.9
Landvatter, S.W.10
Strickler, J.E.11
McLaughlin, M.M.12
Siemens, I.13
Fisher, S.14
Livi, G.P.15
White, J.R.16
Adams, J.L.17
Young, P.R.18
-
39
-
-
0034528405
-
Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase
-
Li, Y., B.-H. Jiang, W. Y. Ensign, P. K. Vogt, and J. Han. 2000. Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase. Cell. Signal. 12:751-757.
-
(2000)
Cell. Signal.
, vol.12
, pp. 751-757
-
-
Li, Y.1
Jiang, B.-H.2
Ensign, W.Y.3
Vogt, P.K.4
Han, J.5
-
40
-
-
0030727172
-
Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bβ
-
Meier, R., D. R. Alessi, P. Cron, M. Andjelkovic, and B. A. Hemmings. 1997. Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bβ. J. Biol. Chem. 272:30491-30497.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30491-30497
-
-
Meier, R.1
Alessi, D.R.2
Cron, P.3
Andjelkovic, M.4
Hemmings, B.A.5
-
41
-
-
0034907223
-
Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase
-
Ming, X.-F., G. Stoeklin, M. Lu, R. Looser, and C. Moroni. 2001. Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase. Mol. Cell. Biol. 21:5778-5789.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5778-5789
-
-
Ming, X.-F.1
Stoeklin, G.2
Lu, M.3
Looser, R.4
Moroni, C.5
-
42
-
-
0034213138
-
p38 MAP kinases: Beyond the stress response
-
Nebrada, A. R., and A. Porras. 2000. p38 MAP kinases: beyond the stress response. Trends Biochem. Sci. 25:257-260.
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 257-260
-
-
Nebrada, A.R.1
Porras, A.2
-
43
-
-
0038624395
-
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
-
Peng, X., P.-Z. Xu, M.-L. Chen, A. Hahn-Windgassen, J. Skeen, J. Jacobs, D. Sundararajan, W. S. Chen, S. E. Crawford, K. Coleman, and N. Hay. 2003. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev. 17:1352-1365.
-
(2003)
Genes Dev.
, vol.17
, pp. 1352-1365
-
-
Peng, X.1
Xu, P.-Z.2
Chen, M.-L.3
Hahn-Windgassen, A.4
Skeen, J.5
Jacobs, J.6
Sundararajan, D.7
Chen, W.S.8
Crawford, S.E.9
Coleman, K.10
Hay, N.11
-
44
-
-
0034267997
-
Molecular mechanisms regulating myogenic determination and differentiation
-
Perry, R. L. S., and M. A. Rudnicki. 2000. Molecular mechanisms regulating myogenic determination and differentiation. Front. Biosci. 5:750-767.
-
(2000)
Front. Biosci.
, vol.5
, pp. 750-767
-
-
Perry, R.L.S.1
Rudnicki, M.A.2
-
45
-
-
0035920145
-
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase and amino acids arginine 211 and serine 343
-
Persad, S., S. Attwell, V. Gray, N. Mawji, J. T. Deng, D. Leung, J. Yan, J. Sanghera, M. P. Walsh, and S. Dedhar. 2001. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase and amino acids arginine 211 and serine 343. J. Biol. Chem. 276:27462-27469.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 27462-27469
-
-
Persad, S.1
Attwell, S.2
Gray, V.3
Mawji, N.4
Deng, J.T.5
Leung, D.6
Yan, J.7
Sanghera, J.8
Walsh, M.P.9
Dedhar, S.10
-
46
-
-
0034162714
-
Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells
-
Puri, P. L., Z. Wu, P. Xhang, L. D. Wood, K. S. Bhakta, J. Han, J. R. Feramisco, M. Karin, and J. Y. J. Wang. 2000. Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes Dev. 14:574-584.
-
(2000)
Genes Dev.
, vol.14
, pp. 574-584
-
-
Puri, P.L.1
Wu, Z.2
Xhang, P.3
Wood, L.D.4
Bhakta, K.S.5
Han, J.6
Feramisco, J.R.7
Karin, M.8
Wang, J.Y.J.9
-
47
-
-
0035793574
-
p38 kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils
-
Rane, M. J., P. Y. Coxon, D. W. Powell, R. Webster, J. B. Klein, W. Pierce, P. Ping, and K. R. McLeish. 2001. p38 kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. J. Biol. Chem. 276:3517-3523.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 3517-3523
-
-
Rane, M.J.1
Coxon, P.Y.2
Powell, D.W.3
Webster, R.4
Klein, J.B.5
Pierce, W.6
Ping, P.7
McLeish, K.R.8
-
49
-
-
0036333737
-
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
-
Scheid, M. P., P. A. Marignani, and J. R. Woodgett. 2002. Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol. Cell. Biol. 22:6247-6260.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 6247-6260
-
-
Scheid, M.P.1
Marignani, P.A.2
Woodgett, J.R.3
-
50
-
-
0032533546
-
2 or heat shock is mediated by phosphoinositide-3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2
-
2 or heat shock is mediated by phosphoinositide-3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2. Biochem. J. 336:241-246.
-
(1998)
Biochem. J.
, vol.336
, pp. 241-246
-
-
Shaw, M.1
Cohen, P.2
Alessi, D.R.3
-
51
-
-
0030799706
-
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
-
Stokoe, D., L. R. Stephens, T. Copeland, P. R. Gaffney, C. B. Reese, G. F. Painter, A. B. Holmes, F. McCormick, and P. T. Hawkins. 1997. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 277:567-570.
-
(1997)
Science
, vol.277
, pp. 567-570
-
-
Stokoe, D.1
Stephens, L.R.2
Copeland, T.3
Gaffney, P.R.4
Reese, C.B.5
Painter, G.F.6
Holmes, A.B.7
McCormick, F.8
Hawkins, P.T.9
-
52
-
-
0034602320
-
Phosphoinositide 3-kinase induces the transcriptional activity of MEF2 proteins during muscle differentiation
-
Tamir, Y., and E. Bengal. 2000. Phosphoinositide 3-kinase induces the transcriptional activity of MEF2 proteins during muscle differentiation. J. Biol. Chem. 275:34424-34432.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34424-34432
-
-
Tamir, Y.1
Bengal, E.2
-
53
-
-
0034697904
-
Requirement of p38a in erythropoietin expression: A role for stress kinases in erythropoiesis
-
Tamura, K., T. Sudo, U. Senttleben, A. Dadak, R. Johnson, and M. Karin. 2000. Requirement of p38a in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102:221-231.
-
(2000)
Cell
, vol.102
, pp. 221-231
-
-
Tamura, K.1
Sudo, T.2
Senttleben, U.3
Dadak, A.4
Johnson, R.5
Karin, M.6
-
54
-
-
0033046010
-
Signals from Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts
-
Tang, Y., J. Yu, and J. Field. 1999. Signals from Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts. Mol. Cell. Biol. 19:1881-1891.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1881-1891
-
-
Tang, Y.1
Yu, J.2
Field, J.3
-
55
-
-
0037666792
-
Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation
-
Troussard, A. A., N. M. Mawji, C. Ong, A. Mui, R. St.-Arnaud, and S. Dedhar. 2003. Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J. Biol. Chem. 278:22374-22378.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22374-22378
-
-
Troussard, A.A.1
Mawji, N.M.2
Ong, C.3
Mui, A.4
St.-Arnaud, R.5
Dedhar, S.6
-
56
-
-
0035914338
-
Insulin-like growth factor-mediated muscle differentiation
-
Tureckova, J., E. M. Wilson, J. L. Cappalonga, and P. Rotwein. 2001. Insulin-like growth factor-mediated muscle differentiation. J. Biol. Chem. 276:39264-39270.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 39264-39270
-
-
Tureckova, J.1
Wilson, E.M.2
Cappalonga, J.L.3
Rotwein, P.4
-
57
-
-
0035896630
-
Protein kinase Bβ/Akt2 plays a specific role in muscle differentiation
-
Vandromme, M., A. Roche, R. Meier, G. Carnac, D. Besser, B. A. Hemmings, A. Fernandez, and N. J. C. Lamb. 2001. Protein kinase Bβ/Akt2 plays a specific role in muscle differentiation. J. Biol. Chem. 276:8173-8179.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 8173-8179
-
-
Vandromme, M.1
Roche, A.2
Meier, R.3
Carnac, G.4
Besser, D.5
Hemmings, B.A.6
Fernandez, A.7
Lamb, N.J.C.8
-
58
-
-
0033559703
-
Regulation of Rb and E2F by signal transduction cascades: Divergent effects of JNK1 and p38 kinases
-
Wang, S., N. Nath, A. Minden, and S. Chellappan. 1999. Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases. EMBO J. 18:1559-1570.
-
(1999)
EMBO J.
, vol.18
, pp. 1559-1570
-
-
Wang, S.1
Nath, N.2
Minden, A.3
Chellappan, S.4
-
59
-
-
0034176579
-
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
-
Williams, M. R., J. S. Arthur, A. Balendran, J. van der Kaay, V. Poli, P. Cohen, and D. R. Alessi. 2000. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr. Biol. 10:439-448.
-
(2000)
Curr. Biol.
, vol.10
, pp. 439-448
-
-
Williams, M.R.1
Arthur, J.S.2
Balendran, A.3
Van Der Kaay, J.4
Poli, V.5
Cohen, P.6
Alessi, D.R.7
-
60
-
-
0034067079
-
p38 and extracellular signal-related kinases regulate the myogenic program at multiple stages
-
Wu, Z., P. J. Woodring, K. S. Bhakta, K. Tamura, F. Wen, J. R. Feramisco, M. Karin, J. Y. J. Wang, and P. L. Puri. 2000. p38 and extracellular signal-related kinases regulate the myogenic program at multiple stages. Mol. Cell. Biol. 20:3951-3964.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 3951-3964
-
-
Wu, Z.1
Woodring, P.J.2
Bhakta, K.S.3
Tamura, K.4
Wen, F.5
Feramisco, J.R.6
Karin, M.7
Wang, J.Y.J.8
Puri, P.L.9
-
61
-
-
0034711278
-
The insulin-like growth factor-phosphatidylinositol 3-kinase-Akt signalling pathway regulates myogenin expression in normal myogenic cells but not in rhabdomyosarcoma-derived RD cells
-
Xu, Q., and Z. Wu. 2000. The insulin-like growth factor-phosphatidylinositol 3-kinase-Akt signalling pathway regulates myogenin expression in normal myogenic cells but not in rhabdomyosarcoma-derived RD cells. J. Biol. Chem. 275:36750-36757.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 36750-36757
-
-
Xu, Q.1
Wu, Z.2
-
62
-
-
0035072833
-
A motif-based profile scanning approach for genome-wide prediction of signalling pathways
-
Yaffe, M. B., G. G. Leparc, J. Lai, T. Obata, S. Volinia, and L. C. Cantley. 2001. A motif-based profile scanning approach for genome-wide prediction of signalling pathways. Nat. Biotechnol. 19:348-353.
-
(2001)
Nat. Biotechnol.
, vol.19
, pp. 348-353
-
-
Yaffe, M.B.1
Leparc, G.G.2
Lai, J.3
Obata, T.4
Volinia, S.5
Cantley, L.C.6
-
63
-
-
0033011595
-
Targeting of p38 mitogen-activated protein kinase to MEF2 transcription factors
-
Yang, S.-H., A. Galamis, and A. D. Sharrocks. 1999. Targeting of p38 mitogen-activated protein kinase to MEF2 transcription factors. Mol. Cell. Biol. 19:4028-4038.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 4028-4038
-
-
Yang, S.-H.1
Galamis, A.2
Sharrocks, A.D.3
-
64
-
-
0030560884
-
Skeletal muscle determination and differentiation: Story of a core regulatory network and its context
-
Yun, K., and B. Wold. 1996. Skeletal muscle determination and differentiation: story of a core regulatory network and its context. Curr. Opin. Cell Biol. 8:877-889.
-
(1996)
Curr. Opin. Cell Biol.
, vol.8
, pp. 877-889
-
-
Yun, K.1
Wold, B.2
-
65
-
-
0033582459
-
p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation: Participation of the MEF2C transcription factor
-
Zetser, A., E. Gredinger, and E. Bengal. 1999. p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation: participation of the MEF2C transcription factor. J. Biol. Chem. 274:5193-5200.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 5193-5200
-
-
Zetser, A.1
Gredinger, E.2
Bengal, E.3
-
66
-
-
0032953307
-
Regulation of MEF2 transcription factor family by p38
-
Zhao, M., L. New, V. V. Kravchenko, Y. Kato, H. Gram, F. di Padova, E. N. Olsen, R. J. Ulevitch, and J. Han. 1999. Regulation of MEF2 transcription factor family by p38. Mol. Cell. Biol. 19:21-30.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 21-30
-
-
Zhao, M.1
New, L.2
Kravchenko, V.V.3
Kato, Y.4
Gram, H.5
Di Padova, F.6
Olsen, E.N.7
Ulevitch, R.J.8
Han, J.9
|