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Volumn 8, Issue 6, 1996, Pages 877-889

Skeletal muscle determination and differentiation: Story of a core regulatory network and its context

Author keywords

[No Author keywords available]

Indexed keywords

MUSCLE REGULATORY FACTOR; MYOCYTE ENHANCER FACTOR 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 0030560884     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(96)80091-3     Document Type: Article
Times cited : (333)

References (68)
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    • Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein twist
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    • Ma Q, Kintner C, Anderson DJ. Identification of neurogenin, a vertebrate neuronal determination gene. of outstanding interest Cell. 1996; This work describes the identification of neurogenin, a neurogenic class bHLH regulator in rodents and Xenopus. This regulator, like NeuroD [50] can display a dominant gain-of-function neurogenic phenotype when assayed in Xenopus embryos. Neurogenin is expressed before NeuroD in vivo and is proposed to execute a determination function roughly analogous to that of myf5 and MyoD. Neurogenin displays high sensitivity to Notch pathway signaling, consistent with its proposed role as a neural-determination gene.
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    • of outstanding interest. This paper, together with [53], which reported the first DMEF2 mutation, and [55], demonstrates that the single MEF2 homolog in Drosophila, named DMEF2, is essential for somatic muscle differentiation DMEF2 is also essential for cardiac myogenesis and proper gut musscle differentiation. It may also function in muscle pattern formation.
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    • of outstanding interest. See annotation [54].
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    • of special interest. This very nice work shows that a late function of the Drosophila bHLH-type regulator Twist (named after its early role in mesoderm formation) is in specification of somatic muscle. Its function appears roughly analogous to the role of determination-class MRFs in vertebrates.
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    • of special interest. This work documents the importance of Notch signaling in muscle precursor cells for proper somatic myogenesis in Drosophila. Mutation of Notch affects founder cell number at the expense of proper differentiation and does so in a mainly cell-autonomous manner.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.