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Expression of a single transfected cDNA converts fibroblasts to myoblasts
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Davis RL, Weintraub H, Lassar AB. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell. 51:1987;987-1000.
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Davis, R.L.1
Weintraub, H.2
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0029559722
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Transcription factor families: Muscling in on the myogenic program
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Ludolph DC, Konieczy SF. Transcription factor families: muscling in on the myogenic program. FASEB J. 9:1995;1595-1604.
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Ludolph, D.C.1
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MyoD or myf-5 is required for the formation of skeletal muscle
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Rudnicki MA, Schnegelsberg PNJ, Stead RH, Braun T, Arnold HH. MyoD or myf-5 is required for the formation of skeletal muscle. Cell. 75:1993;1351-1359.
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Rudnicki, M.A.1
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Stead, R.H.3
Braun, T.4
Arnold, H.H.5
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Skeletal muscle development and the role of the myogenic regulatory factors
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Buckingham M. Skeletal muscle development and the role of the myogenic regulatory factors. Biochem Soc Trans. 24:1995;506-509.
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Buckingham, M.1
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Determination versus differentiation and the MyoD family of transcription factors
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Megeney LA, Rudnicki MA. Determination versus differentiation and the MyoD family of transcription factors. Biochem Cell Biol. 73:1995;723-732.
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Megeney, L.A.1
Rudnicki, M.A.2
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Targeted inactivation of myogenic factor genes reveals their role during mouse myogenesis: A review
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Arnold H-H, Braun T. Targeted inactivation of myogenic factor genes reveals their role during mouse myogenesis: a review. Int J Dev Biol. 40:1996;345-363.
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Arnold, H.-H.1
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The MyoD family and myogenesis: Redundancy, networks, and thresholds
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Weintraub H. The MyoD family and myogenesis: redundancy, networks, and thresholds. Cell. 75:1993;1241-1244.
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, vol.75
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Weintraub, H.1
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8
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0029590104
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Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins
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of outstanding interest. This work defines physical interactions between MEF2 and MRF - E-protein heterodimers that are potentially important for understanding the molecular basis of muscle-specific gene expression. Complexes containing all three factors are shown to interact with either E-box or MEF2-box DNA binding sites, and only one of the factor types is required to have its DNA-binding capability. The authors have developed and applied a sensitized assay to detect such interactions in transfections, and have mapped the domains of each factor required for interaction. They present a very nice model for different modes of action for the complexed factors. This model is summarized in [8] and is the basis for Figure 2b of this review. The existence, importance, and function of MEF2 - MRF - E-protein complexes composed of wild-type proteins in vivo are not yet known.
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Molkentin JD, Black BL, Martin JF, Olson EN. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. of outstanding interest Cell. 83:1995;1125-1136 This work defines physical interactions between MEF2 and MRF - E-protein heterodimers that are potentially important for understanding the molecular basis of muscle-specific gene expression. Complexes containing all three factors are shown to interact with either E-box or MEF2-box DNA binding sites, and only one of the factor types is required to have its DNA-binding capability. The authors have developed and applied a sensitized assay to detect such interactions in transfections, and have mapped the domains of each factor required for interaction. They present a very nice model for different modes of action for the complexed factors. This model is summarized in [8] and is the basis for Figure 2b of this review. The existence, importance, and function of MEF2 - MRF - E-protein complexes composed of wild-type proteins in vivo are not yet known.
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(1995)
Cell
, vol.83
, pp. 1125-1136
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Molkentin, J.D.1
Black, B.L.2
Martin, J.F.3
Olson, E.N.4
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9
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0028047014
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Activation of the myogenic lineage by mef2a, a factor that induces and cooperates with myod
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Kaushal S, Schneider JW, Nadalginard B, Mahdavi V. Activation of the myogenic lineage by mef2a, a factor that induces and cooperates with myod. Science. 266:1994;1236-1240.
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(1994)
Science
, vol.266
, pp. 1236-1240
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Kaushal, S.1
Schneider, J.W.2
Nadalginard, B.3
Mahdavi, V.4
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10
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0030022190
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Activation of different myogenic pathways - Myf-5 is induced by the neural tube and MyoD by the dorsal ectoderm in mouse paraxial mesoderm
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of special interest. This very nice study shows that, in the mouse, two distinct signaling sources, the neural tube and the dorsal ectoderm, induce expression of myf5 and MyoD, respectively, in the developing mouse myotome. These distinctions in intiating signal and first MRF expressed appear to define separate myotomal domains, with the myf5-first domain going on to contribute to the epaxial musculature. Later, many cells coexpress both determination MRFs.
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Cossu GK, Tajbakhsh R, Didonna S, Vivarelli SE, Buckingham M. Activation of different myogenic pathways - myf-5 is induced by the neural tube and MyoD by the dorsal ectoderm in mouse paraxial mesoderm. of special interest Development. 122:1996;429-437 This very nice study shows that, in the mouse, two distinct signaling sources, the neural tube and the dorsal ectoderm, induce expression of myf5 and MyoD, respectively, in the developing mouse myotome. These distinctions in intiating signal and first MRF expressed appear to define separate myotomal domains, with the myf5-first domain going on to contribute to the epaxial musculature. Later, many cells coexpress both determination MRFs.
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(1996)
Development
, vol.122
, pp. 429-437
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Cossu, G.K.1
Tajbakhsh, R.2
Didonna, S.3
Vivarelli, S.E.4
Buckingham, M.5
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11
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0029984170
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How is myogenesis initiated in the embryo
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of special interest. This excellent current review of muscle induction in vivo offers a comparison of two models of somitic myogenesis, one favored by the authors and derived substantially from studies in the mouse, and the other from B Christ and colleagues and based on studies in the chick. These models differ from each other in the initial positioning of myotome precursor cells, and in the subsequent migratory pathways proposed for them. This review [11] also discusses the as yet unresolved distinction between instructive inductive signals versus induction by selective derepression (elimination of negative regulation of myogenesis) which unveils a default myogenic pathway.
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Cossu G, Tajbakhsh S, Buckingham M. How is myogenesis initiated in the embryo. of special interest Trends Gene Ther. 12:1996;218-223 This excellent current review of muscle induction in vivo offers a comparison of two models of somitic myogenesis, one favored by the authors and derived substantially from studies in the mouse, and the other from B Christ and colleagues and based on studies in the chick. These models differ from each other in the initial positioning of myotome precursor cells, and in the subsequent migratory pathways proposed for them. This review [11] also discusses the as yet unresolved distinction between instructive inductive signals versus induction by selective derepression (elimination of negative regulation of myogenesis) which unveils a default myogenic pathway.
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(1996)
Trends Gene Ther
, vol.12
, pp. 218-223
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Cossu, G.1
Tajbakhsh, S.2
Buckingham, M.3
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12
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0342903231
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The role of positive and negative signals in somite patterning
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of special interest. This is an excellent and extensive current review of somite patterning that places induction of myogenic comartments in the context of patterning for the entire somite.
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Lassar AB, Munsterberg AE. The role of positive and negative signals in somite patterning. of special interest Curr Opin Neurobiol. 6:1996;57-63 This is an excellent and extensive current review of somite patterning that places induction of myogenic comartments in the context of patterning for the entire somite.
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(1996)
Curr Opin Neurobiol
, vol.6
, pp. 57-63
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Lassar, A.B.1
Munsterberg, A.E.2
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13
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0030219748
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Defining the regulatory networks for muscle development
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of special interest. This fine review relates the molecular biology of vertebrate MRF and MEF2 family members to cell cycle regulation, to myogenesis in Drosophila, and to inductive patterning signals. It contains an excellent and up-to-date discussion of the interface between the cell cycle and regulation of muscle differentiation, including a nice model that incorporates much current data on the subject. It also relates important additional unpublished results from the authors' laboratory that suggest that ectopic MEF2 cannot initiate myogenesis in 10T1/2 fibroblasts in the absence of MRF expression.
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Molkentin JD, Olson EN. Defining the regulatory networks for muscle development. of special interest Curr Opin Genet Dev. 6:1996;445-453 This fine review relates the molecular biology of vertebrate MRF and MEF2 family members to cell cycle regulation, to myogenesis in Drosophila, and to inductive patterning signals. It contains an excellent and up-to-date discussion of the interface between the cell cycle and regulation of muscle differentiation, including a nice model that incorporates much current data on the subject. It also relates important additional unpublished results from the authors' laboratory that suggest that ectopic MEF2 cannot initiate myogenesis in 10T1/2 fibroblasts in the absence of MRF expression.
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(1996)
Curr Opin Genet Dev
, vol.6
, pp. 445-453
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Molkentin, J.D.1
Olson, E.N.2
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14
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0028875718
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Combinatorial signaling by sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite
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of outstanding interest. In this study, the authors demonstrate that sonic hedgehog and Wnts 1, 3, and 4 are candidate signaling molecules for the ventral and dorsal combinatorial signals that they had previously shown are needed to induce myogenesis in presegmented mesoderm.
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Munsterberg AE, Kitajewski J, Bumcrot DA, McMahon AP, Lassar AB. Combinatorial signaling by sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. of outstanding interest Genes Dev. 9:1995;2911-2922 In this study, the authors demonstrate that sonic hedgehog and Wnts 1, 3, and 4 are candidate signaling molecules for the ventral and dorsal combinatorial signals that they had previously shown are needed to induce myogenesis in presegmented mesoderm.
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(1995)
Genes Dev
, vol.9
, pp. 2911-2922
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Munsterberg, A.E.1
Kitajewski, J.2
Bumcrot, D.A.3
McMahon, A.P.4
Lassar, A.B.5
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15
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0028826466
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Myogenesis in paraxial mesoderm - Preferential induction by dorsal neural-tube and by cells expressing Wnt-1
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of outstanding interest. This study examines the relative inducing activities of dorsal and ventral neural tubes, and finds the dorsal neural tube to be the most robust source in their preparations. They also identify Wnt 1 as a candidate inducing signal from the dorsal neural tube.
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Stern HM, Brown AMC, Hauschka SD. Myogenesis in paraxial mesoderm - preferential induction by dorsal neural-tube and by cells expressing Wnt-1. of outstanding interest Development. 121:1995;3675-3686 This study examines the relative inducing activities of dorsal and ventral neural tubes, and finds the dorsal neural tube to be the most robust source in their preparations. They also identify Wnt 1 as a candidate inducing signal from the dorsal neural tube.
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(1995)
Development
, vol.121
, pp. 3675-3686
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Stern, H.M.1
Brown, A.M.C.2
Hauschka, S.D.3
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16
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0011818539
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MEF2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis
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Edmondson DG, Lyons GE, Martin JF, Olson EN. MEF2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development. 3:1994;265-274.
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(1994)
Development
, vol.3
, pp. 265-274
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Edmondson, D.G.1
Lyons, G.E.2
Martin, J.F.3
Olson, E.N.4
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17
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0029895310
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MEF2B is a potent transactivator expressed in early myogenic lineages
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Molkentin JD, Firulli AB, Black BL, Martin JF, Hustad CM, Copeland N, Jenkins N, Lyons G, Olson EN. MEF2B is a potent transactivator expressed in early myogenic lineages. Mol Cell Biol. 16:1996;3814-3824.
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(1996)
Mol Cell Biol
, vol.16
, pp. 3814-3824
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Molkentin, J.D.1
Firulli, A.B.2
Black, B.L.3
Martin, J.F.4
Hustad, C.M.5
Copeland, N.6
Jenkins, N.7
Lyons, G.8
Olson, E.N.9
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18
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0029993449
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Know your neighbors: Three phenotypes in mull mutant of the myogenic bHLH gene mrf4
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of special interest. This piece summarizes and compares the unexpectedly different phenotypes produced by three different MRF4-knockout alleles. These differences apparently reflect disruption of cis-regulatory control interactions within the closely linked myf5 - MRF4 locus. The effects of the existing MRF4 alleles on myf5 expression vary in magnitude, but need to be considered in interpretation of results from each.
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Olson E, Arnold H, Rigby P, Wold B. Know your neighbors: three phenotypes in mull mutant of the myogenic bHLH gene mrf4. of special interest Cell. 85:1986;1-4 This piece summarizes and compares the unexpectedly different phenotypes produced by three different MRF4-knockout alleles. These differences apparently reflect disruption of cis-regulatory control interactions within the closely linked myf5 - MRF4 locus. The effects of the existing MRF4 alleles on myf5 expression vary in magnitude, but need to be considered in interpretation of results from each.
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(1986)
Cell
, vol.85
, pp. 1-4
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Olson, E.1
Arnold, H.2
Rigby, P.3
Wold, B.4
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19
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13344277338
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Lateral and axial signals involved in avian somite patterning - A role for BMP4
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of outstanding interest. This work extends earlier observations from these authors that indicated that the chick lateral mesoderm is the source of a signal important in specifying the lateral myogenic lineage. Here, they demonstrate the existence of opposing diffusible signals from the neural tube and from lateral-plate mesoderm. They also implicate BMP4 as a candidate for the lateral signal and show that BMP4 induces expression of a marker (Sim1) of limb-muscle precursors and also repressed expression of MRFs in these cells.
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Pourquie O, Fan CM, Coltey M, Hirsinger E, Yatanabe Y, Breant C, Francis-West P, Brickell P, Tessier-Lavigne M, Le Douarin NM. Lateral and axial signals involved in avian somite patterning - a role for BMP4. of outstanding interest Cell. 84:1996;461-471 This work extends earlier observations from these authors that indicated that the chick lateral mesoderm is the source of a signal important in specifying the lateral myogenic lineage. Here, they demonstrate the existence of opposing diffusible signals from the neural tube and from lateral-plate mesoderm. They also implicate BMP4 as a candidate for the lateral signal and show that BMP4 induces expression of a marker (Sim1) of limb-muscle precursors and also repressed expression of MRFs in these cells.
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(1996)
Cell
, vol.84
, pp. 461-471
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Pourquie, O.1
Fan, C.M.2
Coltey, M.3
Hirsinger, E.4
Yatanabe, Y.5
Breant, C.6
Francis-West, P.7
Brickell, P.8
Tessier-Lavigne, M.9
Le Douarin, N.M.10
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20
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0030598829
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The spemann organizer signal noggin binds and inactivates bone morphogenetic protein-4
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Zimmerman LB, Dejesusescobar JM, Harland RM. The spemann organizer signal noggin binds and inactivates bone morphogenetic protein-4. Cell. 86:1996;599-606.
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(1996)
Cell
, vol.86
, pp. 599-606
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Zimmerman, L.B.1
Dejesusescobar, J.M.2
Harland, R.M.3
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21
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0030598867
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Dorsoventral patterning in Xenopus - Inhibition of ventral signals by direct binding of chordin to bmp-4
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Piccolo S, Sasai Y, Lu B, Derobertis EM. Dorsoventral patterning in Xenopus - inhibition of ventral signals by direct binding of chordin to bmp-4. Cell. 86:1996;589-598.
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(1996)
Cell
, vol.86
, pp. 589-598
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Piccolo, S.1
Sasai, Y.2
Lu, B.3
Derobertis, E.M.4
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22
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0030018672
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Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in splotch mice
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Yang XM, Vogan K, Gros P, Park M. Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in splotch mice. Development. 122:1996;2163-2171.
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(1996)
Development
, vol.122
, pp. 2163-2171
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Yang, X.M.1
Vogan, K.2
Gros, P.3
Park, M.4
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23
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0029134104
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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
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of special interest. Disruption of the tyrosine kinase receptor c-met is shown to eliminate the limb musculature although axial muscle development is normal, suggesting that c-met and its ligand, HGF/SF, are needed for migration away from the ventrolateral domain of the dermamyotome and into the limb buds.
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Bladt R, Riethmacher D, Isenmann S, Aguzzi A, Birchmeier C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. of special interest Nature. 375:1995;768-771 Disruption of the tyrosine kinase receptor c-met is shown to eliminate the limb musculature although axial muscle development is normal, suggesting that c-met and its ligand, HGF/SF, are needed for migration away from the ventrolateral domain of the dermamyotome and into the limb buds.
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(1995)
Nature
, vol.375
, pp. 768-771
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Bladt, R.1
Riethmacher, D.2
Isenmann, S.3
Aguzzi, A.4
Birchmeier, C.5
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24
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0029914928
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Pax3 modulates expression of the c-met receptor during limb muscle development
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Epstein JA, Shapiro DN, Cheng J, Lam PYP, Maas RL. Pax3 modulates expression of the c-met receptor during limb muscle development. Proc Natl Acad Sci USA. 93:1996;4213-4218.
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(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 4213-4218
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Epstein, J.A.1
Shapiro, D.N.2
Cheng, J.3
Lam, P.Y.P.4
Maas, R.L.5
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25
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0029915990
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PAX-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse
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Daston G, Lamar E, Olivier M, Goulding M. PAX-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse. Development. 122:1996;1017-1027.
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(1996)
Development
, vol.122
, pp. 1017-1027
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Daston, G.1
Lamar, E.2
Olivier, M.3
Goulding, M.4
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26
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0029585231
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Evidence for programmed transdifferentiation in mouse esophageal muscle
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of special interest. Evidence is presented for a novel pathway for skeletal myogenesis in which fully differentiated and apparently functional smooth muscle cells initiate expression of MRFs to create a transient intermediate phenotype cell. This is followed by a transition to fully differentiated skeletal myotubes of the adult mouse esophagus.
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Patapoutian A, Wold BJ, Wagner RA. Evidence for programmed transdifferentiation in mouse esophageal muscle. of special interest Science. 270:1995;1818-1821 Evidence is presented for a novel pathway for skeletal myogenesis in which fully differentiated and apparently functional smooth muscle cells initiate expression of MRFs to create a transient intermediate phenotype cell. This is followed by a transition to fully differentiated skeletal myotubes of the adult mouse esophagus.
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(1995)
Science
, vol.270
, pp. 1818-1821
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Patapoutian, A.1
Wold, B.J.2
Wagner, R.A.3
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27
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0028808913
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Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors
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Olson EN, Perry M, Schulz RA. Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors. Dev Biol. 172:1995;2-14.
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(1995)
Dev Biol
, vol.172
, pp. 2-14
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Olson, E.N.1
Perry, M.2
Schulz, R.A.3
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28
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0026673591
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Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor mef-2
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Edmondson DG, Cheng TC, Cserjesi P, Chakraborty T, Olson EN. Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor mef-2. Mol Cell Biol. 12:1992;3665-3677.
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(1992)
Mol Cell Biol
, vol.12
, pp. 3665-3677
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Edmondson, D.G.1
Cheng, T.C.2
Cserjesi, P.3
Chakraborty, T.4
Olson, E.N.5
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29
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0027227469
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The regulation of myogenin gene expression during embryonic development of the mouse
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Yee SP, Rigby PW. The regulation of myogenin gene expression during embryonic development of the mouse. Genes Dev. 7:1993;1277-1289.
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(1993)
Genes Dev
, vol.7
, pp. 1277-1289
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Yee, S.P.1
Rigby, P.W.2
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30
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0028215362
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Crystal structure of MyoD bHLH domain - DNA complex: Perspectives on DNA recognition and implications for transcriptional activation
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Ma PCM, Rould MA, Weintraub H, Pabo CO. Crystal structure of MyoD bHLH domain - DNA complex: perspectives on DNA recognition and implications for transcriptional activation. Cell. 77:1994;451-459.
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(1994)
Cell
, vol.77
, pp. 451-459
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Ma, P.C.M.1
Rould, M.A.2
Weintraub, H.3
Pabo, C.O.4
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31
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0029994419
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Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C
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Molkentin JD, Black BL, Martin JF, Olson EN. Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C. Mol Cell Biol. 16:1996;2627-2636.
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(1996)
Mol Cell Biol
, vol.16
, pp. 2627-2636
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Molkentin, J.D.1
Black, B.L.2
Martin, J.F.3
Olson, E.N.4
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32
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0029960065
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Analysis of muscle creatine-kinase gene regulatory elements in skeletal and cardiac muscles of transgenic mice
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of special interest. Describes a very high quality transgenic analysis of the regulatory elements that drive expression of the MCK gene in skeletal and cardiac muscle. Includes the interesting observation that all known E-boxes can be mutated so that the resulting gene is virtually inactive in muscle cell culture transfections, but does prove to be active and skeletal muscle specific in transgenic animals.
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Donoviel DB, Shield MA, Buskin JN, Haugen H-S, Clegg CH, Hauschka SD. Analysis of muscle creatine-kinase gene regulatory elements in skeletal and cardiac muscles of transgenic mice. of special interest Mol Cell Biol. 16:1996;1649-1658 Describes a very high quality transgenic analysis of the regulatory elements that drive expression of the MCK gene in skeletal and cardiac muscle. Includes the interesting observation that all known E-boxes can be mutated so that the resulting gene is virtually inactive in muscle cell culture transfections, but does prove to be active and skeletal muscle specific in transgenic animals.
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(1996)
Mol Cell Biol
, vol.16
, pp. 1649-1658
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Donoviel, D.B.1
Shield, M.A.2
Buskin, J.N.3
Haugen, H.-S.4
Clegg, C.H.5
Hauschka, S.D.6
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33
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0026765031
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Overexpression of ld protein inhibits the muscle differentiation program: In vivo association of ld with E2A proteins
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Jen Y, Weintraub H, Benezra R. Overexpression of ld protein inhibits the muscle differentiation program: in vivo association of ld with E2A proteins. Genes Dev. 6:1992;1466-1479.
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(1992)
Genes Dev
, vol.6
, pp. 1466-1479
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Jen, Y.1
Weintraub, H.2
Benezra, R.3
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34
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0027997963
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Myod expression marks the onset of skeletal myogenesis in myf-5 mutant mice
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Braun TE, Bober E, Rudnicki MA, Jaenisch R, Arnold HH. Myod expression marks the onset of skeletal myogenesis in myf-5 mutant mice. Development. 120:1994;3083-3092.
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(1994)
Development
, vol.120
, pp. 3083-3092
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Braun, T.E.1
Bober, E.2
Rudnicki, M.A.3
Jaenisch, R.4
Arnold, H.H.5
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35
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0030025046
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Functional redundancy of the muscle-specific transcription factors myf5 and myogenin
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of outstanding interest. Substitution of myogenin for myf5 in the mouse germline tests the importance of molecular differences between a determination MRF (myf5) and a differentiation MRF (myogenin). This initial germline transplacement analysis shows that these MRFs are readily interchangeable in vivo. It appears that early myotomal myogenesis, which normally depends on myf5, can run on myogenin alone. This argues that it is the amount and timing of MRF expression in the vertebrates, rather than molecular distinctions between the proteins, that requires multiple MRF genes.
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Wang YK, Schnegelsberg PNJ, Dausman J, Jaenisch R. Functional redundancy of the muscle-specific transcription factors myf5 and myogenin. of outstanding interest Nature. 379:1996;823-825 Substitution of myogenin for myf5 in the mouse germline tests the importance of molecular differences between a determination MRF (myf5) and a differentiation MRF (myogenin). This initial germline transplacement analysis shows that these MRFs are readily interchangeable in vivo. It appears that early myotomal myogenesis, which normally depends on myf5, can run on myogenin alone. This argues that it is the amount and timing of MRF expression in the vertebrates, rather than molecular distinctions between the proteins, that requires multiple MRF genes.
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(1996)
Nature
, vol.379
, pp. 823-825
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Wang, Y.K.1
Schnegelsberg, P.N.J.2
Dausman, J.3
Jaenisch, R.4
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36
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Kopan, R.1
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39
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Kopan, R.1
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40
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0028950732
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Jagged - A mammalian ligand that activates notch1
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of outstanding interest. Previous work [39] had shown that an activated Notch mutant can dominantly suppress myogenesis in transfected cells. This work [40] demonstrates that a myogenic cell line expressing wild-type Notch can be prevented from differentiating by coculture and presumed cell - cell interaction with cells expressing the Notch family ligand called jagged.
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Lindsell CE, Shawber CJ, Boulter J, Weinmaster G. Jagged - a mammalian ligand that activates notch1. of outstanding interest Cell. 80:1995;909-917 Previous work [39] had shown that an activated Notch mutant can dominantly suppress myogenesis in transfected cells. This work [40] demonstrates that a myogenic cell line expressing wild-type Notch can be prevented from differentiating by coculture and presumed cell - cell interaction with cells expressing the Notch family ligand called jagged.
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Lindsell, C.E.1
Shawber, C.J.2
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45
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0029890899
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Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein twist
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of outstanding interest. This work shows that Twist can inhibit myogenesis by two molecular mechanisms. One mechanism involves competition between Twist and MRFs for E-protein partners. The second mechanism is novel and involves physical interaction of Twist with MEF2. The authors suggest a model in which expression of Twist titrates MEF2, making it unavailable for cooperation with MRFs.
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Spicer DB, Rhee J, Cheung WL, Lassar AB. Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein twist. of outstanding interest Science. 272:1996;1476-1480 This work shows that Twist can inhibit myogenesis by two molecular mechanisms. One mechanism involves competition between Twist and MRFs for E-protein partners. The second mechanism is novel and involves physical interaction of Twist with MEF2. The authors suggest a model in which expression of Twist titrates MEF2, making it unavailable for cooperation with MRFs.
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Science
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Spicer, D.B.1
Rhee, J.2
Cheung, W.L.3
Lassar, A.B.4
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California: California Institute of Technology
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Yun K. The murine twist bHLH regulator inhibits myogenesis by multiple molecular mechanisms. PhD thesis. 1996;California Institute of Technology, California.
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Yun, K.1
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Neuhold LA, Wold B. HLH forced dimers: tethering MyoD to E47 generates a dominant positive myogenic factor insulated from the negative regulator Id. Cell. 74:1993;1033-1042.
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Jan YN, Jan LY. HLH proteins, fly neurogenesis and vertebrate myogenesis. Cell. 75:1993;827-830.
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Jan, Y.N.1
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49
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Identification of neurogenin, a vertebrate neuronal determination gene
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This work describes the identification of neurogenin, a neurogenic class bHLH regulator in rodents and Xenopus. This regulator, like NeuroD [50] can display a dominant gain-of-function neurogenic phenotype when assayed in Xenopus embryos. Neurogenin is expressed before NeuroD in vivo and is proposed to execute a determination function roughly analogous to that of myf5 and MyoD. Neurogenin displays high sensitivity to Notch pathway signaling, consistent with its proposed role as a neural-determination gene. of outstanding interest
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Ma Q, Kintner C, Anderson DJ. Identification of neurogenin, a vertebrate neuronal determination gene. of outstanding interest Cell. 1996; This work describes the identification of neurogenin, a neurogenic class bHLH regulator in rodents and Xenopus. This regulator, like NeuroD [50] can display a dominant gain-of-function neurogenic phenotype when assayed in Xenopus embryos. Neurogenin is expressed before NeuroD in vivo and is proposed to execute a determination function roughly analogous to that of myf5 and MyoD. Neurogenin displays high sensitivity to Notch pathway signaling, consistent with its proposed role as a neural-determination gene.
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(1996)
Cell
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Ma, Q.1
Kintner, C.2
Anderson, D.J.3
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50
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0029068316
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Conversion of Xenopus extoderm into neurons by NeuroD, a basic helix-loop-helix protein
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of outstanding interest. NeuroD is a vertebrate neurogenic bHLH gene. In dominant gain of function assays in Xenopus embryos, it can convert some presumptive skin to neurons.
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Lee JE, Hollenberg SM, Snider L, Turner DL, Lipnick N, Weintraub H. Conversion of Xenopus extoderm into neurons by NeuroD, a basic helix-loop-helix protein. of outstanding interest Science. 268:1995;836-844 NeuroD is a vertebrate neurogenic bHLH gene. In dominant gain of function assays in Xenopus embryos, it can convert some presumptive skin to neurons.
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Science
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Lee, J.E.1
Hollenberg, S.M.2
Snider, L.3
Turner, D.L.4
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Weintraub, H.6
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51
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Cooperative transcriptional activation by the neurogenic bHLH protein MASH1 and members of the MEF2 family
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in press
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Black BL, Ligon KL, Zhang Y, Olson EN. Cooperative transcriptional activation by the neurogenic bHLH protein MASH1 and members of the MEF2 family. J Biol Cell. 1996;. in press.
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Black, B.L.1
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Zhang, Y.3
Olson, E.N.4
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52
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Lyons GE, Micales BK, Schwarz J, Martin JF, Olson EN. Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation. J Neurosci. 15:1995;5727-5738.
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Lyons, G.E.1
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Schwarz, J.3
Martin, J.F.4
Olson, E.N.5
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53
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D-MEF2: A MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embrogenesis
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Lilly B, Galewsky S, Firulli AB, Schulz RA, Olson EN. D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embrogenesis. Proc Natl Acad Sci USA. 91:1994;5662-5666.
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Proc Natl Acad Sci USA
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Lilly, B.1
Galewsky, S.2
Firulli, A.B.3
Schulz, R.A.4
Olson, E.N.5
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54
-
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0028933143
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Drosophila MEF2, a transcription factor that is essential for myogenesis
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of outstanding interest. This paper, together with [53], which reported the first DMEF2 mutation, and [55], demonstrates that the single MEF2 homolog in Drosophila, named DMEF2, is essential for somatic muscle differentiation DMEF2 is also essential for cardiac myogenesis and proper gut musscle differentiation. It may also function in muscle pattern formation.
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Bour BA, O'Brien MA, Lockwood WL, Goldstein ES, Bodmer R, Taghert PH, Abmayr SM, Ngugen HT. Drosophila MEF2, a transcription factor that is essential for myogenesis. of outstanding interest Genes Dev. 9:1995;730-741 This paper, together with [53], which reported the first DMEF2 mutation, and [55], demonstrates that the single MEF2 homolog in Drosophila, named DMEF2, is essential for somatic muscle differentiation DMEF2 is also essential for cardiac myogenesis and proper gut musscle differentiation. It may also function in muscle pattern formation.
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(1995)
Genes Dev
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, pp. 730-741
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Bour, B.A.1
O'Brien, M.A.2
Lockwood, W.L.3
Goldstein, E.S.4
Bodmer, R.5
Taghert, P.H.6
Abmayr, S.M.7
Ngugen, H.T.8
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55
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0028841777
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A series of mutations in the D-MEF2 transcription factor reveals multiple functions in larval and adult myogenesis in Drosophila
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of outstanding interest. See annotation [54].
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Ranganayakulu G, Zhao B, Dokidis A, Molkentin JD, Olson EN, Schulz RA. A series of mutations in the D-MEF2 transcription factor reveals multiple functions in larval and adult myogenesis in Drosophila. of outstanding interest Dev Biol. 171:1995;169-181 See annotation [54].
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Dev Biol
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Ranganayakulu, G.1
Zhao, B.2
Dokidis, A.3
Molkentin, J.D.4
Olson, E.N.5
Schulz, R.A.6
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56
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0029890668
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Twist: A myogenic switch in Drosophila
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of special interest. This very nice work shows that a late function of the Drosophila bHLH-type regulator Twist (named after its early role in mesoderm formation) is in specification of somatic muscle. Its function appears roughly analogous to the role of determination-class MRFs in vertebrates.
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Baylies MK, Bate M. twist: a myogenic switch in Drosophila. of special interest Science. 272:1996;1481-1484 This very nice work shows that a late function of the Drosophila bHLH-type regulator Twist (named after its early role in mesoderm formation) is in specification of somatic muscle. Its function appears roughly analogous to the role of determination-class MRFs in vertebrates.
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(1996)
Science
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Baylies, M.K.1
Bate, M.2
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57
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0029061491
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Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta
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Chitnis A, Henrique D, Lewis J, Ish-Horowicz D, Kintner C. Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta. Nature. 375:1995;761-766.
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Nature
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Chitnis, A.1
Henrique, D.2
Lewis, J.3
Ish-Horowicz, D.4
Kintner, C.5
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58
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0028557131
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Jan YN, Jan LY. Genetic control of cell fate specification in Drosophila peripheral nervous system. Annu Rev Genet. 28:1994;373-393.
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Jan, Y.N.1
Jan, L.Y.2
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59
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0030020645
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Autonomous and nonautonomous notch functions for embryonic muscle and epidermis development in Drosophila
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of special interest. This work documents the importance of Notch signaling in muscle precursor cells for proper somatic myogenesis in Drosophila. Mutation of Notch affects founder cell number at the expense of proper differentiation and does so in a mainly cell-autonomous manner.
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Baker R, Schubiger G. Autonomous and nonautonomous notch functions for embryonic muscle and epidermis development in Drosophila. of special interest Development. 122:1996;617-626 This work documents the importance of Notch signaling in muscle precursor cells for proper somatic myogenesis in Drosophila. Mutation of Notch affects founder cell number at the expense of proper differentiation and does so in a mainly cell-autonomous manner.
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Development
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Baker, R.1
Schubiger, G.2
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60
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0028839922
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Wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis
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Baylies MK, Arias AM, Bate M. Wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis. Development. 121:1995;3829-3837.
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Development
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Baylies, M.K.1
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Bate, M.3
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61
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Wingless signaling induces nautilus expression in the ventral mesoderm of the Drosophila embryo
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Ranganayakulu G, Schulz RA, Olson EN. Wingless signaling induces nautilus expression in the ventral mesoderm of the Drosophila embryo. Dev Biol. 176:1996;143-148.
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Dev Biol
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Ranganayakulu, G.1
Schulz, R.A.2
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62
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Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila
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Rulifson EJ. Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila. Development. 121:1995;2813-2824.
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Development
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Rulifson, E.J.1
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63
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The Drosophila smoothened gene encodes a seven-pass membrane protein a putative receptor for the hedgehog signal
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Alcedo J, Ayzenzon M, Von Ohlen T, Noll M, Hooper JE. The Drosophila smoothened gene encodes a seven-pass membrane protein a putative receptor for the hedgehog signal. Cell. 86:1996;221-232.
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Alcedo, J.1
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64
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Floss T, Arnold HH, Braun T. Myf-5(m1)/myf-6(m1) compound heterozygous mouse mutants down-regulate myf-5 expression and exert rib defects - evidence for long-range cis effects on myf-5 transcription. Dev Biol. 174:1996;140-147.
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