Deficiency of the stress kinase p38α results in embryonic lethality: Characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells

Journal of Experimental Medicine

Volumn 191, Issue 5, 2000, Pages 859-869

  Allen, Melanie ^a   Svensson, Linne ^a   Roach, Marsha ^a   Hambor, John ^a   McNeish, John ^a   Gabel, Christopher A ^a  

^a PFIZER INC   (United States)

Author keywords

Cytokine suppressing antiinflammatory drug; Cytokines; Inflammation; Mitogen activated protein kinase; Signaling

Indexed keywords

ANTIINFLAMMATORY AGENT; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 6; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NEOMYCIN; SYNAPTOPHYSIN;

ALLELE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME DEFICIENCY; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE INACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL; STRESS;

ANIMALS; ANISOMYCIN; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; ARSENITES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CYTOKINES; EMBRYO; ENZYME ACTIVATION; FIBROBLASTS; GENES, LETHAL; INTERLEUKIN-1; INTERLEUKIN-6; ISOENZYMES; MICE; MICE, INBRED DBA; MICE, MUTANT STRAINS; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; SODIUM COMPOUNDS; STEM CELLS;

EID: 0034610981     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.5.859     Document Type: Article

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