PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis

Molecular Brain Research

Volumn 124, Issue 1, 2004, Pages 51-61

  Hirai, Kiyoshi ^a   Hayashi, Takeshi ^b   Chan, Pak H ^b   Zeng, Jianying ^a   Yang, Guo Yuan ^a   Basus, Vladimir J ^c   James, Thomas L ^c   Litt, Lawrence ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Akt; Bad; Brain slice; Cytochrome c; Disorders of the Nervous System; Hypoxia; Ischemia; PI3K

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CARRIER PROTEIN; CYTOCHROME C; DNA FRAGMENT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN HYPOXIA; BRAIN SLICE; CONTROLLED STUDY; CYTOSOL; ENZYME INHIBITION; NICK END LABELING; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REOXYGENATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANIMALS, NEWBORN; ANOXIA; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BRAIN; CARRIER PROTEINS; CHAPERONIN 60; CHROMONES; CYTOCHROMES C; CYTOSOL; DNA FRAGMENTATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; IN SITU NICK-END LABELING; MAGNETIC RESONANCE IMAGING; MITOCHONDRIA; MORPHOLINES; NEURAL INHIBITION; NEURONS; PHOSPHORUS ISOTOPES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SERINE; STAINING AND LABELING; TIME FACTORS;

EID: 1942517481     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.02.009     Document Type: Article

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