Cyclosporin A, but not FK506, prevents the downregulation of phosphorylated Akt after transient focal ischemia in the rat

Brain Research

Volumn 899, Issue 1-2, 2001, Pages 148-158

  Yoshimoto, Tetsuyuki ^a,b   Uchino, Hiroyuki ^a   He, Qing P ^a   Li, Ping A ^a   Siesjö, Bo K ^a  

^a QUEEN S MEDICAL CENTER   (United States)

^b Kashiwaba Neurosurgical Hospital   (Japan)

Author keywords

Akt; Calcineurin; CsA; FK506; MCA occlusion; Mitochonria

Indexed keywords

CALCINEURIN; CYCLOPHILIN; CYCLOSPORIN A; ENZYME AKT; PHOSPHOTRANSFERASE; PROTEIN BAD; TACROLIMUS; THREONINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; BRAIN MITOCHONDRION; CONTROLLED STUDY; DISEASE DURATION; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG BRAIN LEVEL; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HISTOPATHOLOGY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL; RAT; REPERFUSION; TISSUE INJURY;

ANIMALS; BRAIN; CYCLOSPORINE; DOWN-REGULATION; IMMUNOSUPPRESSIVE AGENTS; ISCHEMIC ATTACK, TRANSIENT; MALE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; TACROLIMUS;

EID: 0035957808     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02220-X     Document Type: Article

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