-
1
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25: 585-621.
-
(1961)
Exp Cell Res
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
2
-
-
0035253719
-
Cellular senescence as a tumor-protection mechanism: The essential role of counting
-
Wright WE, Shay JW. Cellular senescence as a tumor-protection mechanism: the essential role of counting. Curr Opin Genet Dev 2001; 11: 98-103.
-
(2001)
Curr Opin Genet Dev
, vol.11
, pp. 98-103
-
-
Wright, W.E.1
Shay, J.W.2
-
3
-
-
2342570379
-
Hallmarks of senescence in carcinogenesis and cancer therapy
-
Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 2004; 23: 2919-33.
-
(2004)
Oncogene
, vol.23
, pp. 2919-2933
-
-
Shay, J.W.1
Roninson, I.B.2
-
4
-
-
0037148342
-
Telomeres, aging and cancer: In search of a happy ending
-
Kim SH, Kaminker P, Campisi J. Telomeres, aging and cancer: in search of a happy ending. Oncogene 2002; 21: 503-11.
-
(2002)
Oncogene
, vol.21
, pp. 503-511
-
-
Kim, S.H.1
Kaminker, P.2
Campisi, J.3
-
5
-
-
0035929353
-
Switching and signaling at the telomere
-
Blackburn EH. Switching and signaling at the telomere. Cell 2001; 106: 661-73.
-
(2001)
Cell
, vol.106
, pp. 661-673
-
-
Blackburn, E.H.1
-
6
-
-
0037148277
-
Protection of mammalian telomeres
-
De Lange T. Protection of mammalian telomeres. Oncogene 2002; 21: 532-40.
-
(2002)
Oncogene
, vol.21
, pp. 532-540
-
-
De Lange, T.1
-
7
-
-
0022402513
-
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
-
Greider CW, Blackburn EH. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 1985; 43: 405-13.
-
(1985)
Cell
, vol.43
, pp. 405-413
-
-
Greider, C.W.1
Blackburn, E.H.2
-
8
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345: 458-60.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
9
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349-52.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
-
10
-
-
0032924343
-
Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
-
Morales CP, Holt SE, Ouellette M, et al. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet 1999; 21: 115-8.
-
(1999)
Nat Genet
, vol.21
, pp. 115-118
-
-
Morales, C.P.1
Holt, S.E.2
Ouellette, M.3
-
11
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
Hahn WC, Counter CM, Lundberg AS, et al. Creation of human tumour cells with defined genetic elements. Nature 1999; 400: 464-8.
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
-
12
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011-5.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
-
13
-
-
84993876589
-
Correlating telomerase activity levels with human neuroblastoma outcomes
-
Hiyama E, Hiyama K, Yokoyama T, et al. Correlating telomerase activity levels with human neuroblastoma outcomes. Nat Med 1995; 1: 249-55.
-
(1995)
Nat Med
, vol.1
, pp. 249-255
-
-
Hiyama, E.1
Hiyama, K.2
Yokoyama, T.3
-
14
-
-
0028910530
-
Does telomere shortening drive selection for p53 mutation in human cancer?
-
Wynford-Thomas D, Bond JA, Wyllie FS, et al. Does telomere shortening drive selection for p53 mutation in human cancer? Mol Carcinog 1995; 12: 119-23.
-
(1995)
Mol Carcinog
, vol.12
, pp. 119-123
-
-
Wynford-Thomas, D.1
Bond, J.A.2
Wyllie, F.S.3
-
15
-
-
0031935827
-
Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies
-
Gire V, Wynford-Thomas D. Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Mol Cell Biol 1998; 18: 1611-21.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 1611-1621
-
-
Gire, V.1
Wynford-Thomas, D.2
-
16
-
-
0028342664
-
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
-
Noda A, Ning Y, Venable SF, et al. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 1994; 211: 90-8.
-
(1994)
Exp Cell Res
, vol.211
, pp. 90-98
-
-
Noda, A.1
Ning, Y.2
Venable, S.F.3
-
17
-
-
3342929538
-
DNA damage checkpoint kinase Chk2 triggers replicative senescence
-
Gire V, Roux P, Wynford-Thomas D, et al. DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO J 2004; 23: 2554-63.
-
(2004)
EMBO J
, vol.23
, pp. 2554-2563
-
-
Gire, V.1
Roux, P.2
Wynford-Thomas, D.3
-
18
-
-
0027970713
-
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
-
Di Leonardo A, Linke SP, Clarkin K, et al. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev 1994, 8: 2540-51.
-
(1994)
Genes Dev
, vol.8
, pp. 2540-2551
-
-
Di Leonardo, A.1
Linke, S.P.2
Clarkin, K.3
-
19
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
D'Adda di Fagagna F, Reaper PM, Clay-Farrace L, et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003; 426: 194-8.
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
D'Adda Di Fagagna, F.1
Reaper, P.M.2
Clay-Farrace, L.3
-
20
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003; 421: 499-506.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
21
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 2001; 15: 2177-96.
-
(2001)
Genes Dev
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
22
-
-
0026523228
-
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
-
Counter CM, Avilion AA, LeFeuvre CE, et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 1992; 11: 1921-9.
-
(1992)
EMBO J
, vol.11
, pp. 1921-1929
-
-
Counter, C.M.1
Avilion, A.A.2
LeFeuvre, C.E.3
-
23
-
-
0037192462
-
Senescence induced by altered telomere state, not telomere loss
-
Karlseder J, Smogorzewska A, de Lange T. Senescence induced by altered telomere state, not telomere loss. Science 2002; 295: 2446-9.
-
(2002)
Science
, vol.295
, pp. 2446-2449
-
-
Karlseder, J.1
Smogorzewska, A.2
De Lange, T.3
-
24
-
-
0033605145
-
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
-
Karlseder J, Broccoli D, Dai Y, et al. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 1999; 283: 1321-5.
-
(1999)
Science
, vol.283
, pp. 1321-1325
-
-
Karlseder, J.1
Broccoli, D.2
Dai, Y.3
-
25
-
-
0042420304
-
DNA damage foci at dysfunctional telomeres
-
Takai H, Smagarzewska A, de Lange T. DNA damage foci at dysfunctional telomeres. Curr Biol 2003; 13: 1549-56.
-
(2003)
Curr Biol
, vol.13
, pp. 1549-1556
-
-
Takai, H.1
Smagarzewska, A.2
De Lange, T.3
-
26
-
-
0032489012
-
TRF2 protects human telomeres from end-to-end fusions
-
Van Steensel B, Smagorzewska A, de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 1998; 92: 401-13.
-
(1998)
Cell
, vol.92
, pp. 401-413
-
-
Van Steensel, B.1
Smagorzewska, A.2
De Lange, T.3
-
27
-
-
0037382414
-
Erosion of the telomeric single-strand overhang at replicative senescence
-
Stewart SA, Ben-Porath I, Carey VJ, et al. Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet 2003; 33: 492-6.
-
(2003)
Nat Genet
, vol.33
, pp. 492-496
-
-
Stewart, S.A.1
Ben-Porath, I.2
Carey, V.J.3
-
28
-
-
0027496456
-
The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen
-
Shay JW, Van Der Haegen BA, Ying Y, et al. The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen. Exp Cell Res 1993; 209: 45-52.
-
(1993)
Exp Cell Res
, vol.209
, pp. 45-52
-
-
Shay, J.W.1
Van Der Haegen, B.A.2
Ying, Y.3
-
29
-
-
0026680249
-
The two-stage mechanism controlling cellular senescence and immortalization
-
Wright WE, Shay JW. The two-stage mechanism controlling cellular senescence and immortalization. Exp Gerontol 1992; 27: 383-9.
-
(1992)
Exp Gerontol
, vol.27
, pp. 383-389
-
-
Wright, W.E.1
Shay, J.W.2
-
30
-
-
0029162563
-
Telomere elongation in immortal human cells without detectable telomerase activity
-
Bryan TM, Englezou A, Gupta J, et al. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 1995; 14: 4240-8.
-
(1995)
EMBO J
, vol.14
, pp. 4240-4248
-
-
Bryan, T.M.1
Englezou, A.2
Gupta, J.3
-
31
-
-
0036849595
-
Mouse models to study the role of telomeres in cancer, aging and DNA repair
-
Blasco MA. Mouse models to study the role of telomeres in cancer, aging and DNA repair. Eur J Cancer 2002; 38: 2222-8.
-
(2002)
Eur J Cancer
, vol.38
, pp. 2222-2228
-
-
Blasco, M.A.1
-
32
-
-
0343228751
-
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
-
Gonzalez-Suarez E, Samper E, Flores JM, et al. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat Genet 2000; 26: 114-7.
-
(2000)
Nat Genet
, vol.26
, pp. 114-117
-
-
Gonzalez-Suarez, E.1
Samper, E.2
Flores, J.M.3
-
33
-
-
0000146723
-
Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse
-
Greenberg RA, Chin L, Femino A, et al. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell 1999; 97: 515-25.
-
(1999)
Cell
, vol.97
, pp. 515-525
-
-
Greenberg, R.A.1
Chin, L.2
Femino, A.3
-
34
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M, Lin AW, McCurrach ME, et al. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997; 88: 593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
-
35
-
-
0036467483
-
Immortalisation and transformation revisited
-
Drayton S, Peters G. Immortalisation and transformation revisited. Curr Opin Genet Dev 2002; 12: 98-104.
-
(2002)
Curr Opin Genet Dev
, vol.12
, pp. 98-104
-
-
Drayton, S.1
Peters, G.2
-
36
-
-
0034813364
-
Role of p14(ARF) in replicative and induced senescence of human fibroblasts
-
Wei W, Hemmer RM, Sedivy JM. Role of p14(ARF) in replicative and induced senescence of human fibroblasts. Mol Cell Biol 2001; 21: 6748-57.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 6748-6757
-
-
Wei, W.1
Hemmer, R.M.2
Sedivy, J.M.3
-
37
-
-
0030477686
-
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
-
Alcorta DA, Xiong Y, Phelps D, et al. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci USA 1996; 93: 13742-7.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 13742-13747
-
-
Alcorta, D.A.1
Xiong, Y.2
Phelps, D.3
-
38
-
-
0041966056
-
Reversal of human cellular senescence: Roles of the p53 and p16 pathways
-
Beausejour CM, Krtolica A, Galimi F, et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 2003; 22: 4212-22.
-
(2003)
EMBO J
, vol.22
, pp. 4212-4222
-
-
Beausejour, C.M.1
Krtolica, A.2
Galimi, F.3
-
39
-
-
0032487675
-
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
-
Kiyano T, Foster SA, Koop JI, et al. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998; 396: 84-8.
-
(1998)
Nature
, vol.396
, pp. 84-88
-
-
Kiyano, T.1
Foster, S.A.2
Koop, J.I.3
-
40
-
-
0035114576
-
Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
-
Ramirez RD, Morales CP, Herbert BS, et al. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev 2001; 15: 398-403.
-
(2001)
Genes Dev
, vol.15
, pp. 398-403
-
-
Ramirez, R.D.1
Morales, C.P.2
Herbert, B.S.3
-
41
-
-
0030728468
-
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
-
Kamija T, Zindy F, Roussel MF, et al. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 1997; 91: 649-59.
-
(1997)
Cell
, vol.91
, pp. 649-659
-
-
Kamija, T.1
Zindy, F.2
Roussel, M.F.3
-
42
-
-
0035817688
-
Lass of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
-
Sharpless NE, Bardeesy N, Lee KH, et al. Lass of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 2001; 413: 86-91.
-
(2001)
Nature
, vol.413
, pp. 86-91
-
-
Sharpless, N.E.1
Bardeesy, N.2
Lee, K.H.3
|