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Volumn 277, Issue 35, 2002, Pages 31789-31795

Mitochondria are direct targets of the lipoxygenase inhibitor MK886: A strategy for cell killing by combined treatment with MK886 and cyclooxygenase inhibitors

(10) Gugliucci, Arianna a,b,c,d Ranzato, Laura a,b,c,d Scorrano, Luca a,b,c,d Colonna, Raffaele a,b,c,d Petronilli, Valeria a,b,c,d Cusan, Claudia a,b,c,d Prato, Maurizio a,b,c,d Mancini, Mariangela a,b,c,d Pagano, Francesco a,b,c,d Bernardi, Paolo a,b,c,d

a VENETIAN INSTITUTE OF MOLECULAR MEDICINE (Italy)

b UNIVERSITY OF PADOVA (Italy)

c UNIVERSITY OF TRIESTE (Italy)

d DANA FARBER CANCER INSTITUTE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RESPIRATION;

CELLS; ENZYME INHIBITION; ENZYMES; METABOLITES; TUMORS;

BIOCHEMISTRY;

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ARACHIDONIC ACID; CYTOCHROME C; INDOMETACIN; LIPOXYGENASE INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR;

ARACHIDONIC ACID METABOLISM; ARTICLE; CANCER CELL CULTURE; CELL DEATH; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIVER MITOCHONDRION; MITOCHONDRION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROSTATE CANCER;

ANIMALS; ARACHIDONIC ACID; CELL DEATH; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDOLES; INDOMETHACIN; INTRACELLULAR MEMBRANES; LIPOXYGENASE INHIBITORS; LIVER; MALE; MITOCHONDRIA, LIVER; OXYGEN CONSUMPTION; PERMEABILITY; PROSTATIC NEOPLASMS; RATS; RATS, WISTAR; TUMOR CELLS, CULTURED;

EID: 18544363407 PISSN: 00219258 EISSN: None Source Type: Journal
DOI: 10.1074/jbc.M204450200 Document Type: Article

Times cited : (60)

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