NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells

Cancer Research

Volumn 58, Issue 19, 1998, Pages 4245-4249

  Liu, Xin Hua ^a   Yao, Shen ^a   Kirschenbaum, Alexander ^a   Levine, Alice C ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL NUCLEUS; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA DEGRADATION; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION;

APOPTOSIS; CELLS, CULTURED; CHROMATIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DNA FRAGMENTATION; FETUS; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-2; HUMANS; IN SITU NICK-END LABELING; ISOENZYMES; MALE; MEMBRANE PROTEINS; NITROBENZENES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTATE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; SULFONAMIDES; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0032188853     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Boring, C. C., Squires T. S., and Tong, T. Cancer statistics. CA Cancer J. Clin., 43: 7-26, 1993.
2. Steller, H. Mechanisms and genes of cellular suicide. Science (Washington DC), 267: 1445-1449, 1995.
3. Denmeade, S. R., Lin, X. S., and Isaacs, J. T. Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer. Prostate, 28: 251-265, 1996.
4. Berges, R. S., Vukanovic, J., Epstein, J. I., Carmichel, M., Cisek, L., Johnson, D. E., Veltri, R. W., Walsh, P. H., and Isaacs, J. T. Implication of cell kinetic changes during the progression of human prostatic cancer. Clin. Cancer Res., 1: 473-480, 1995.
5. Herschman, H. R. Primary response genes induced by growth factors and tumor promoters. Annu. Rev. Biochem., 60: 281-319, 1991.
6. Simmons, D. L., Levy, D. B., Yannoni, Y., and Erikson, R. L. Identification of a phorbol ester-repressible v-src-inducible gene. Proc. Natl. Acad. Sci. USA, 86: 1178-1182, 1989.
7. Kujubu, D. A., Flecher, B. S., Varnum, B. C., Lim, R. W., and Herschman, H. R. TIS110, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells encodes a novel prostaglandin synthase/cyclooxygenase homologue. J. Biol. Chem., 166: 12866-12872, 1991.
8. Tsujii, M., and DuBois, R. N. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell, 83: 493-501, 1995.
9. Sheng, H. M., Shao, J. Y., Morrow, J. D., Beauchamp, R. D., and DuBois, R. N. Modulation of apoptosis and bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res., 58: 362-366, 1998.
10. DuBois, R. N., Giardiello, F. M., and Smalley, W. E. Nonsteroidal anti-inflammatory drugs, eicosanoids and colorectal cancer prevention. Gastroenterol. Clin. N. Am., 25: 773-791, 1996.
11. Sheng, H., Shao, J., Kirkland, S. C., Isakson, P., Coffey, R., Morrow, J., Beauchamp, R. D., and DuBois, R. N. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J. Clin. Invest., 99: 2254-2259, 1997.
12. Kawamori, T., Rao, C. V., Seibert, K., and Reddy, B. S. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. Cancer Res., 58: 409-412, 1998.
13. Tjandrawinata, R. R., Dahiya, R., and Hughes-Fulford, M. Induction of cyclooxygenase-2 mRNA by prostaglandin E2 in human prostatic carcinoma cells. Br. J. Cancer, 75: 1111-1118, 1997.
14. Futaki, N., Takahashi, S., Yokoyama, M., Arai, I., Higuchi, S., and Otomo, S. NS398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/ cyclooxygenase (COX-2) activity in vitro. Prostaglandins, 47: 55-59, 1994.
15. Levine, A. C., Ren, M., Huber, G. K., and Kirschenbaum, A. The effect of androgen, estrogen, and growth factors on the proliferation of cultured fibroblasts derived from human fetal and adult prostates. Endocrinology, 130: 2413-2419, 1992.
16. Moore, K. J., and Matlashewski, G. Intracellular infection by Leishmania donovani inhibits macrophage apoptosis. J. Immunol., 152: 2930-2937, 1994.
17. 2+ concentration. Arch. Biochem. Biophys., 269: 365-370, 1989.
18. Liu, X. H., and Rose, D. P. Differential expression and regulation of cyclooxygenase-1 and-2 in two human breast cancer cell lines. Cancer Res., 56: 5125-5127, 1996.
19. Colombel, M., Symmans, F., Gil, S., O'Toole, K. M., Chopin, D., Benson, M., Olsson, C. A., Korsmeyer, S., and Buttyan, R. Detection of the apoptosis-suppressing oncoprotein bcl-2 in hormone-refractory human prostate cancers. Am. J. Pathol., 143: 390-400, 1993.
20. Haldar, S., Jena, N., and Croce, C. M. Inactivation of bcl-2 by phosphorylation. Proc. Nalt. Acad. Sci. USA, 92: 4507-4511, 1995.
21. Eberhart, C. E., Coffey, R. J., Radhika, A., Giardiello, F. M., Ferrenbach, S., and DuBois, R. N. Upregulation of cyclooxygenase-2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology, 107: 1183-1188, 1994.
22. Ristmaki, D. A., Jankala, H., Sipponen, P., and Harkonen, M. Expression of cyclooxygenase-2 in human gastric carcinomas. Cancer Res., 57: 1276-1280, 1997.
23. v-src-transformed 3T3 fibroblasts. Proc. Natl. Acad. Sci. USA, 87: 3373-3377, 1990.
24. Korsmeyer, S. J. Bcl-2 initiates a new category of oncogenes: regulation of cell death. Blood, 80: 879-886, 1992.
25. Susin, S. A., Zamzami, N., Castedo, M., Hirsch, T., Marchetti, P., Marho, A., Daugas, E., Geuskens, M., and Kroemer, G. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J. Exp. Med., 184: 1331-1341, 1996.
26. Yang, J., Liu, X. S., Bhalla, K., Kim, C. N., Ibrado, A. M., Cai, J. Y., Peng, T., Jones, D. P., and Wang, X. D. Prevention of apoptosis by bcl-2: release of cytochrome c from mitochondria blocked. Science (Washington DC), 275: 1129-1132, 1997.
27. Tsujii, M., Kawano, S., Tsujii, S., Sawaoka, H., Hori, M., and DuBois, R. N. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell, 93: 705-716, 1998.
28. Kalgutkar, A. S., Crews, B. C., Rowlinson, S. W., Garner, C., Seibert, K., Marnett, J. Aspirin-like molecules that covalently inactivate cyclooxygenase-2. Science (Washington DC), 280: 1268-1270, 1998.