MK-886, a leukotriene biosynthesis inhibitor, induces antiproliferative effects and apoptosis in HL-60 cells

Leukemia Research

Volumn 22, Issue 1, 1998, Pages 49-53

  Dittmann, Klaus H ^a   Mayer, Claus ^a   Rodemann, H Peter ^a   Petrides, Petro E ^b   Denzlinger, Claudio ^c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Apoptosis; Cell proliferation; Cell survival; Leukemia; Leukotrienes

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; DNA; LEUKOTRIENE; LEUKOTRIENE B4; LIPOXYGENASE INHIBITOR; PROSTAGLANDIN D2;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN HL 60; CONTROLLED STUDY; DNA REPLICATION; HUMAN; HUMAN CELL; ICOSANOID METABOLISM; PRIORITY JOURNAL;

APOPTOSIS; CELL DIVISION; DNA DAMAGE; DNA REPLICATION; HL-60 CELLS; HUMANS; INDOLES; LEUKOTRIENE ANTAGONISTS; LIPOXYGENASE INHIBITORS;

EID: 0031970485     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(97)00132-X     Document Type: Article

References (16)

1. 1. Denzlinger, C., Biology and pathophysiolgy of leukotrienes. Crit. Rev. Oncol. Hematol., 1996, 23, 167.
2. 2. Wickremasinghe, R. G., Khan, M. A. and Hoffbrand, A. V., Do leukotrienes play a role in the regulation of proliferation of normal and leukemic hemopoietic cells? Prostaglandin Leukotriene Essays, 1993, 48, 123.
3. 3. Breitman, T. R., Collins, S. J. and Keene, B. R., Replacement of serum by insulin and transferrin supports growth and differentiation of the human promyelocytic cell line HL-60. Exp. Cell Res., 1980, 126, 494.
4. 4. Dittmann, K. H. and Petrides, P. E., A 41 kDa transferrin related molecule acts as an autocrine growth factor for HL-60 cells. Biochem. Biophys. Res. Comm., 1991, 176, 473.
5. 5. Leist, M., Gantner, F., Bohlinger, I., Germann, P. G., Tiegs, G. and Wendel, A., Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-α requires transcriptional arrest. J. Immunol., 1994, 153, 1778.
6. 6. Duke, R. C. and Cohen, J. J., IL-2 addition: withdrawal of growth factor activates a suicide program in dependent T cells. Lymphokine Res., 1986, 5, 289.
7. 7. Bassam, B. J., Caetano-Anolles, G. and Gresshoff, P. M., Fast and sensitive silver staining of DNA in polyacrylamide gels. Analyt. Chem., 1991, 196, 80.
8. 8. Franson, R. C., Eisen, D., Jesse, R. and Lanni, C., Inhibition of highly purified mammalian phospholipase A2 by non-steroidal anti-inflammatory agents. Modulation by calcium ions. Biochem. J., 1980, 186, 633.
9. 9. Negishi, M., Koizumi, T. and Ichikawa, A., Biological actions of Delta(12)-prostaglandin J(2). J. Lipid Mediators Cell Signal., 1995, 12, 443.
10. 10. Hotter, G., Ramis, D., Closa, D., Rosello-Catafau, J. and Gelpi, E., Altered leukotriene B4 levels by HL-60 cells after monocytic/macrophage differentiation. Agents Actions, 1993, 40, 72.
11. 11. Khan, M. A., Tateson, J. E., Hoffbrand, A. V. and Wickremasinge, R. G., Evidence that endogenous generation of leukotrienes does not regulate proliferation of malignant hemopoietic cell lines. Leukemia Res., 1993, 17, 241.
12. 12. Bertrand, R., Solary, E., Jenkins, J. and Pommier, Y., Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors. Exp. Cell Res., 1993, 207, 388.
13. 13. Mattern, M. R., Mong, S., Mong, S. M., Bartus, J. O. L., Sarau, H. M., Clark, M. A., Foley, J. J. and Crooke, S. T., Transient activation of topoisomerase I in leukotriene D4 signal transduction in human cells. Biochem. J., 1990, 265, 101.
14. 14. Tang, D. G., Chen. Y. Q. and Honn, K. V., Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. Proc. Natl. Acad. Sci. USA, 1996, 93, 5241.
15. 15. Hebert, M. J., Takano, T., Holthofer, H. and Brady, H. R., Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids. J. Immunol., 1996, 157, 3105.
16. 16. Sorkness, C. A., The use of 5-lipoxygenase inhibitors and leukotriene receptor antgonists in the treatment of chronic asthma. Phamacotherapeutics, 1997, 17, 50S.