5-lipoxygenase inhibitors reduce PC-3 cell proliferation and initiate nonnecrotic cell death

Prostate

Volumn 37, Issue 3, 1998, Pages 161-173

  Anderson, K M ^a   Seed, T ^b,e   Vos, M ^c   Mulshine, J ^c   Meng, J ^a   Alrefai, W ^a   Ou, D ^d   Harris, J E ^a  

^a RUSH MEDICAL COLLEGE   (United States)

^b TechMicro Services   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d West Side VA ^*  (United States)

^e ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE   (United States)

Author keywords

5 lipoxygenase inhibitors; PC 3 cells; Programmed cell death

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; LIPOXYGENASE INHIBITOR;

ARACHIDONIC ACID METABOLISM; ARTICLE; AUTOPHAGY; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELL ULTRASTRUCTURE; DNA SYNTHESIS INHIBITION; DRUG EFFECT; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

AMIDES; ARACHIDONATE 5-LIPOXYGENASE; CELL DEATH; CELL DIVISION; CELL SURVIVAL; HUMANS; INDOLES; LIPOXYGENASE INHIBITORS; MALE; MICROSCOPY, ELECTRON; POLYMERASE CHAIN REACTION; PROSTATIC NEOPLASMS; PYRIDINES; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0031737260     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0045(19981101)37:3<161::AID-PROS5>3.0.CO;2-D     Document Type: Article

References (38)

1. Anderson KM, Wiederhold M, Ondrey F: Participation of lipoxygenase products in lymphohematopoietic and other cell proliferation and differentiation. In Harris JE, Braun D, Anderson KM (eds): "Prostaglandin Inhibitors in Tumor Immunology and Immunotherapy," Boca Raton: CRC Press, 1994:41-72.
2. Haliday EM, Ramesha CS, Ringold G: TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite. EMBO J 1991;10:109-115.
3. Anderson KM, Seed T, Plate JM, Jajeh A, Meng J, Harris JE: Selective inhibitors of 5-lipoxygenase reduce CML blast cell proliferation and induce limited differentiation and apoptosis. Leuk Res 1995;19:789-801.
4. Anderson KM, Seed T, Meng J, Harris JE: Searle SC41661A, a selective inhibitor of 5-lipoxygenase, induces apoptosis in androgen-independent human prostate (PC-3) cells [abstract]. Am Soc Clin Oncol 1995;14:22.
5. Avis IM, Jett M, Boyle T, Vos MD, Moody T, Treston AM, Martinez A, Mulshine JL: Growth control of lung cancer by the interruption of 5-lipoxygenase-mediated growth factor signaling. J Clin Invest 1996;97:806-813.
6. GIllard J, Ford-Hutchinson AW, Chan C, Charleson S, Denis D, Foster A, Fortin R, Leger S, McFarlane CS, Morton H, Piechute H, Riendeau D, Rouzer CA, Rokach J, Young R, MacIntyre DE, Peterson L, Bach T, Eiermann S, Hopple J, Hames L, Hupe S, Luell JM, Metzser J, Meurer D, Meller K, Opas E, Pacholok S: L-663,536 (MK886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol 1989;67:456-464.
7. Ford-Hutchinson AW, Cresser M, Young RN: 5-lipoxygenase. Annu Rev Biochem 1994;61:383-417.
8. Mancini JA, Abramovitz M, Cos ME, Wong E, Charleson S, Perrier H, Wang Z, Prasit P, Vickers PJ: 5-lipoxygenase activating protein is an arachidonate binding protein. FEBS Lett 1993; 318:277-281.
9. Anderson KM, Wygodny JB, Ondrey F, Harris J: Human PC-3 prostate cell line DNA synthesis is suppressed by eicosatetraynoic acid, an in vitro inhibitor of arachidonic acid metabolism. Prostate 1988;12:3-12.
10. Anderson KM, Seed T, Ondrey F, Harris JE: The selective 5-lipoxygenase inhibitor A63162 reduces PC-3 proliferation and initiates morphologic changes consistent with secretion. Anticancer Res 1994;14:1951-1960.
11. Ghosh J, Myers CE: Modulation of prostate cancer cell growth and invasion by arachidonic acid: Involvement of the metabolites of the 5-lipoxygenase pathway [abstract]. Proc Am Assoc Cancer Res 1996;37:4111.
12. Anderson KM, Seed T, Jajeh A, Dudeja P, Byun T, Meng J, Ou D, Harris JE: An in vivo inhibitor of 5-lipoxygenase, MK886, at micromolar concentration induces apoptosis in U937 and CML cells. Anticancer Res 1996;16:2589-2599.
13. Kyprianou N, Isaacs JT: Activation of programmed cell death in the rat ventral prostate after castration. Endocrinology 1988;122: 552-562.
14. Zakeri Z, Bursch W, Tenniswood M, Lockshin RA: Cell death, programmed, apoptosis, necrosis or other. Death Differ 1995;2: 87-96.
15. Kocan GP, Partis RA, Mueller RS, Smith WG, Nakao A: Contrasting effects of two arachidonate 5-lipoxygenase inhibitors on formyl-methionly-leucyl-phenylalanine (fMLP) and complement fragment 5a induced human neutrophil superoxide generation. Biochem Pharmacol 1994;47:1029-1037.
16. Kaighn ME, Narayan KS, Onuka Y, Lechner JF, Jones LW: Establishment and characterization of a human prostatic cancer cell line (PC-3). Invest Urol 1979;17:16-23.
17. Wu YB, Shen ML, Gu GG, Anderson KM, Ou DW: The effects of cocaine injections on mouse thymocyte population. Proc Soc Exp Biol Med 1997;214:173-179.
18. Anderson KM, Seed TM, WIlson DE, Harris JE: 5,8,11,14-eicosatatraynoic acid-induced destruction of mitochondria in human prostate cells (PC-3). In Vitro Cell Dev Biol 1992;28:410-414.
19. Ghosh J, Myers CE: Arachidonic acid stimulates prostate cancer cell growth: Critical role of 5-lipoxygenase. Biochem Biophys Res Commun 1997;235:418-423.
20. Clarke PGH: Developmental cell death: Morphological diversity and multiple mechanisms. Anat Embryol (Berl) 1990;181:195-213.
21. Gjertsen BT, Cressey LI, Ruchaud S, Houge G, Lanotte M, Doskeland SO: Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line. J Cell Sci 1994;107:3363-3377.
22. Asher E, Payne CM, Bernstein C: Evaluation of cell death in EBV-transformed lymphocytes using agarose gel electrophoresis, light microscopy and electron microscopy. II. Induction of non-classic apoptosis ("para-apoptosis") by tritiated thymidine. Leuk Lymphoma 1995;19:107-119.
23. Schwartz LM, Smith SW, Jones ME, Osborne BA: Do all programmed cell deaths occur via apoptosis? Proc Natl Acad Sci USA 1993;90:980-984.
24. Eguchi Y, Shimizu S, Tsujimoto Y: Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res 1997;57:1835-1840.
25. Kamens J, Paskind M, Hugunin M, Talanian RV, Allen H, Banach D, Bump N, Hackett M, Johnston CG, Li P, Mankavich JA, Terranova M, Ghayur T: Identification and characterization of ICH-2, a novel member of the interleukin-lbeta-converting enzyme famIly of cysteine proteases. J Biol Chem 1996;270:15250-15256.
26. Kroemer G, Zamzami N, Susin SA: Mitochondrial control of apoptosis. Immunol Today 1997;18:44-51.
27. Van den Eijnde SM, Boshart L, Reutelingsperger CPM, De Zeeuw CI, Vermeij-Keers C: Phosphatidylserine plasma membrane asymmetry in vivo: A pancellular phenomenon which alters during apoptosis. Cell Death Differ 1997;4:311-316.
28. Pandey S, Wang E: Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2 and RB phosphorylation, resembling events of early cell cycle traverse. J Cell Biochem 1995;58:135-150.
29. Buttke TM, Sandstrom PA: Oxidative stress as a mediator of apoptosis. Immunol Today 1994;15:7-10.
30. Sarafian TA, Bredesen DE: Invited commentary. Is apoptosis mediated by reactive oxygen species? Free Radic Res 1994;21: 1-8.
31. Hockenbery DM, Oltavi ZN, Yin XM, MIlliman CL, Korsmeyer SJ: Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993;75:241-251.
32. Kroemer G, Petit P, Zamzami N, Vayssiere JL, Mignotte B: The biochemistry of programmed cell death. FASEB J 1995;9:1277-1287.
33. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X: Prevention of apoptosis by Bcl-2: Release of cvtochrome C from mitochondria blocked. Science 1997;275: 1129-1132.
34. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD: The release of cvtochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science 1997;75:1132-1136.
35. Shimizu S, Eguchi Y, Kamiike W, Waguri S, Uchiyama Y, Matsuda H, Tsujimoto Y: Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: Possible involvement of common mediators in apoptotic and necrotic signal transductions. Oncogene 1996;12:2045-2050.
36. L. Cancer Res 1996;56:2161-2166.
37. Tang DG, Chen YQ, Honn KV: Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. Proc Natl Acad Sci USA 1996;93:5241-5246.
38. Swinscow TDV: Statistics at square one. Brit Med J 1976, pg 1-84.