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Volumn 13, Issue 3, 2004, Pages 125-138

The vulnerable atherosclerotic plaque: Pathogenesis and therapeutic approach

Author keywords

[No Author keywords available]

Indexed keywords

CERIVASTATIN; GELATINASE A; GELATINASE B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; LOW DENSITY LIPOPROTEIN; MACROPHAGE ACTIVATING FACTOR; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN DERIVATIVE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

EID: 1842662594     PISSN: 10548807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1054-8807(04)00004-3     Document Type: Article
Times cited : (207)

References (134)
  • 1
    • 0034941755 scopus 로고    scopus 로고
    • Vascular inflammation and activation: New targets for lipid lowering
    • Aikawa M., Libby P. Vascular inflammation and activation: new targets for lipid lowering. Eur Heart J Suppl. 3:2001;B3-B11.
    • (2001) Eur Heart J Suppl , vol.3
    • Aikawa, M.1    Libby, P.2
  • 2
    • 0036852699 scopus 로고    scopus 로고
    • Stabilization of atherosclerotic plaques: New mechanisms and clinical targets
    • Libby P., Aikawa M. Stabilization of atherosclerotic plaques: new mechanisms and clinical targets. Nat Med. 8:2002;1257-1262.
    • (2002) Nat Med , vol.8 , pp. 1257-1262
    • Libby, P.1    Aikawa, M.2
  • 3
    • 0024496991 scopus 로고
    • Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults
    • Stary H.C. Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis. 9:1989;I19-I32.
    • (1989) Arteriosclerosis , vol.9
    • Stary, H.C.1
  • 5
    • 0023976675 scopus 로고
    • The pathogenesis of atherosclerosis: Atherogenesis and inflammation
    • Munro J.M., Cotran R.S. The pathogenesis of atherosclerosis: atherogenesis and inflammation. Lab Invest. 58:1988;249-261.
    • (1988) Lab Invest , vol.58 , pp. 249-261
    • Munro, J.M.1    Cotran, R.S.2
  • 6
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature. 420:2002;868-874.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 7
    • 0034994888 scopus 로고    scopus 로고
    • Evolution and stabilization of vulnerable atherosclerotic plaques
    • Libby P., Aikawa M. Evolution and stabilization of vulnerable atherosclerotic plaques. Jpn Circ J. 65:2001;473-479.
    • (2001) Jpn Circ J , vol.65 , pp. 473-479
    • Libby, P.1    Aikawa, M.2
  • 8
    • 0023737363 scopus 로고
    • Dietary cholesterol and human coronary heart disease. The epidemiologic evidence
    • Stamler J., Shekelle R. Dietary cholesterol and human coronary heart disease. The epidemiologic evidence. Arch Pathol Lab Med. 112:1988;1032-1040.
    • (1988) Arch Pathol Lab Med , vol.112 , pp. 1032-1040
    • Stamler, J.1    Shekelle, R.2
  • 10
    • 0025216049 scopus 로고
    • The cholesterol facts. A summary of the evidence relating dietary fats, serum cholesterol, and coronary heart disease. A joint statement by the American Heart Association and the National Heart, Lung, and Blood Institute. The Task Force on Cholesterol Issues American Heart Association
    • LaRosa J.C., Hunninghake D., Bush D., Criqui M.H., Getz G.S., Gotto A.M., Grundy S.M., Rakita L., Robertson R.M., Weisfeldt MLet al. The cholesterol facts. A summary of the evidence relating dietary fats, serum cholesterol, and coronary heart disease. A joint statement by the American Heart Association and the National Heart, Lung, and Blood Institute. The Task Force on Cholesterol Issues American Heart Association. Circulation. 81:1990;1721-1733.
    • (1990) Circulation , vol.81 , pp. 1721-1733
    • Larosa, J.C.1    Hunninghake, D.2    Bush, D.3    Criqui, M.H.4    Getz, G.S.5    Gotto, A.M.6    Grundy, S.M.7    Rakita, L.8    Robertson, R.M.9    Weisfeldt, M.-A.10
  • 11
    • 0020633273 scopus 로고
    • On experimental cholesterin steatosis and its significance in the origin of some pathological processes (1913)
    • Reprint
    • Anitschkow N., Chalatow S. On experimental cholesterin steatosis and its significance in the origin of some pathological processes (1913). Arteriosclerosis. 3:1983;178-182. Reprint.
    • (1983) Arteriosclerosis , vol.3 , pp. 178-182
    • Anitschkow, N.1    Chalatow, S.2
  • 12
    • 0023743101 scopus 로고
    • Animal models and the study of atherosclerosis
    • Vesselinovitch D. Animal models and the study of atherosclerosis. Arch Pathol Lab Med. 112:1988;1011-1017.
    • (1988) Arch Pathol Lab Med , vol.112 , pp. 1011-1017
    • Vesselinovitch, D.1
  • 15
    • 0024603895 scopus 로고
    • Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity
    • Steinberg D., Parthasarathy S., Carew T.E., Khoo J.C., Witztum J.L. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 320:1989;915-924.
    • (1989) N Engl J Med , vol.320 , pp. 915-924
    • Steinberg, D.1    Parthasarathy, S.2    Carew, T.E.3    Khoo, J.C.4    Witztum, J.L.5
  • 18
    • 0142055950 scopus 로고    scopus 로고
    • Oxidative stress and cardiovascular injury
    • Griendling KK, FitzGerald GA. Oxidative stress and cardiovascular injury. Circulation 2003;108:1912-6, 2034-2040.
    • (2003) Circulation , vol.108 , pp. 1912-1916
    • Griendling, K.K.1    Fitzgerald, G.A.2
  • 19
    • 0023687897 scopus 로고
    • Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits
    • Haberland M.E., Fong D., Cheng L. Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits. Science. 241:1988;215-218.
    • (1988) Science , vol.241 , pp. 215-218
    • Haberland, M.E.1    Fong, D.2    Cheng, L.3
  • 22
    • 0023192020 scopus 로고
    • Oxidatively modified low density lipoproteins: A potential role in recruitment and retention of monocyte/macrophages during atherogenesis
    • Quinn M.T., Parthasarathy S., Fong L.G., Steinberg D. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci USA. 84:1987;2995-2998.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 2995-2998
    • Quinn, M.T.1    Parthasarathy, S.2    Fong, L.G.3    Steinberg, D.4
  • 24
    • 0025063716 scopus 로고
    • Macrophage and smooth muscle cell proliferation in atherosclerotic lesions of WHHL and comparably hypercholesterolemic fat-fed rabbits
    • Rosenfeld M.E., Ross R. Macrophage and smooth muscle cell proliferation in atherosclerotic lesions of WHHL and comparably hypercholesterolemic fat-fed rabbits. Arteriosclerosis. 10:1990;680-687.
    • (1990) Arteriosclerosis , vol.10 , pp. 680-687
    • Rosenfeld, M.E.1    Ross, R.2
  • 26
    • 0035895319 scopus 로고    scopus 로고
    • An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro
    • Aikawa M., Rabkin E., Sugiyama S., Voglic S.J., Fukumoto Y., Furukawa Y., Shiomi M., Schoen F.J., Libby P. An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro. Circulation. 103:2001;276-283.
    • (2001) Circulation , vol.103 , pp. 276-283
    • Aikawa, M.1    Rabkin, E.2    Sugiyama, S.3    Voglic, S.J.4    Fukumoto, Y.5    Furukawa, Y.6    Shiomi, M.7    Schoen, F.J.8    Libby, P.9
  • 28
    • 0034746311 scopus 로고    scopus 로고
    • NF-kappaB: Pivotal mediator or innocent bystander in atherogenesis?
    • Collins T., Cybulsky M.I. NF-kappaB: pivotal mediator or innocent bystander in atherogenesis? J Clin Invest. 107:2001;255-264.
    • (2001) J Clin Invest , vol.107 , pp. 255-264
    • Collins, T.1    Cybulsky, M.I.2
  • 29
    • 0025177343 scopus 로고
    • Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils
    • Kodama T., Freeman M., Rohrer L., Zabrecky J., Matsudaira P., Krieger M. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature. 343:1990;531-535.
    • (1990) Nature , vol.343 , pp. 531-535
    • Kodama, T.1    Freeman, M.2    Rohrer, L.3    Zabrecky, J.4    Matsudaira, P.5    Krieger, M.6
  • 30
    • 0030775322 scopus 로고    scopus 로고
    • Oxidative stress and cardiovascular disease
    • Griendling K.K., Alexander R.W. Oxidative stress and cardiovascular disease. Circulation. 96:1997;3264-3265.
    • (1997) Circulation , vol.96 , pp. 3264-3265
    • Griendling, K.K.1    Alexander, R.W.2
  • 31
    • 0021847311 scopus 로고
    • Plaque fissuring - The cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina
    • Davies M.J., Thomas A.C. Plaque fissuring - the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. Br Heart J. 53:1985;363-373.
    • (1985) Br Heart J , vol.53 , pp. 363-373
    • Davies, M.J.1    Thomas, A.C.2
  • 32
    • 0024214548 scopus 로고
    • Pre-existing coronary stenoses in patients with first myocardial infarction are not necessarily severe
    • Hackett D., Davies G., Maseri A. Pre-existing coronary stenoses in patients with first myocardial infarction are not necessarily severe. Eur Heart J. 9:1988;1317-1323.
    • (1988) Eur Heart J , vol.9 , pp. 1317-1323
    • Hackett, D.1    Davies, G.2    Maseri, A.3
  • 34
    • 0027253887 scopus 로고
    • Risk of thrombosis in human atherosclerotic plaques: Role of extracellular lipid, macrophage, and smooth muscle cell content
    • Davies M.J., Richardson P.D., Woolf N., Katz D.R., Mann J. Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content. Br Heart J. 69:1993;377-381.
    • (1993) Br Heart J , vol.69 , pp. 377-381
    • Davies, M.J.1    Richardson, P.D.2    Woolf, N.3    Katz, D.R.4    Mann, J.5
  • 35
    • 0028085059 scopus 로고
    • Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology
    • van der Wal A.C., Becker A.E., van der Loos C.M., Das P.K. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation. 89:1994;36-44.
    • (1994) Circulation , vol.89 , pp. 36-44
    • Van Der Wal, A.C.1    Becker, A.E.2    Van Der Loos, C.M.3    Das, P.K.4
  • 36
    • 0028059056 scopus 로고
    • Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture
    • Moreno P.R., Falk E., Palacios I.F., Newell J.B., Fuster V., Fallon J.T. Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture. Circulation. 90:1994;775-778.
    • (1994) Circulation , vol.90 , pp. 775-778
    • Moreno, P.R.1    Falk, E.2    Palacios, I.F.3    Newell, J.B.4    Fuster, V.5    Fallon, J.T.6
  • 37
    • 0037693895 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry
    • Visse R., Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res. 92:2003;827-839.
    • (2003) Circ Res , vol.92 , pp. 827-839
    • Visse, R.1    Nagase, H.2
  • 38
    • 0141505052 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinase (matrixin) genes in blood vessels: A multi-step recruitment model for pathological remodelling
    • Chase A.J., Newby A.C. Regulation of matrix metalloproteinase (matrixin) genes in blood vessels: a multi-step recruitment model for pathological remodelling. J Vasc Res. 40:2003;329-343.
    • (2003) J Vasc Res , vol.40 , pp. 329-343
    • Chase, A.J.1    Newby, A.C.2
  • 39
    • 0033932709 scopus 로고    scopus 로고
    • Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction
    • Ducharme A., Frantz S., Aikawa M., Rabkin E., Lindsey M., Rohde L.E., Schoen F.J., Kelly R.A., Werb Z., Libby P., Lee R.T. Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J Clin Invest. 106:2000;55-62.
    • (2000) J Clin Invest , vol.106 , pp. 55-62
    • Ducharme, A.1    Frantz, S.2    Aikawa, M.3    Rabkin, E.4    Lindsey, M.5    Rohde, L.E.6    Schoen, F.J.7    Kelly, R.A.8    Werb, Z.9    Libby, P.10    Lee, R.T.11
  • 40
    • 0035923477 scopus 로고    scopus 로고
    • Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves
    • Rabkin E., Aikawa M., Stone J.R., Fukumoto Y., Libby P., Schoen F.J. Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves. Circulation. 104:2001;2525-2532.
    • (2001) Circulation , vol.104 , pp. 2525-2532
    • Rabkin, E.1    Aikawa, M.2    Stone, J.R.3    Fukumoto, Y.4    Libby, P.5    Schoen, F.J.6
  • 41
    • 0036516460 scopus 로고    scopus 로고
    • Matrix metalloproteinases: A tail of a frog that became a prince
    • Brinckerhoff C.E., Matrisian L.M. Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol. 3:2002;207-214.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 207-214
    • Brinckerhoff, C.E.1    Matrisian, L.M.2
  • 42
    • 1642390201 scopus 로고    scopus 로고
    • Matrix metalloproteinases: A review of their structure and role in acute coronary syndrome
    • Jones C.B., Sane D.C., Herrington D.M. Matrix metalloproteinases: a review of their structure and role in acute coronary syndrome. Cardiovasc Res. 59:2003;812-823.
    • (2003) Cardiovasc Res , vol.59 , pp. 812-823
    • Jones, C.B.1    Sane, D.C.2    Herrington, D.M.3
  • 43
    • 0028063408 scopus 로고
    • Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
    • Galis Z.S., Sukhova G.K., Lark M.W., Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 94:1994;2493-2503.
    • (1994) J Clin Invest , vol.94 , pp. 2493-2503
    • Galis, Z.S.1    Sukhova, G.K.2    Lark, M.W.3    Libby, P.4
  • 44
    • 0345465669 scopus 로고    scopus 로고
    • Evidence of increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques
    • Sukhova G., Schoenbeck U., Rabkin E., Schoen F., Poole A., Billinghurst R., Libby P. Evidence of increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques. Circulation. 99:1999;2503-2509.
    • (1999) Circulation , vol.99 , pp. 2503-2509
    • Sukhova, G.1    Schoenbeck, U.2    Rabkin, E.3    Schoen, F.4    Poole, A.5    Billinghurst, R.6    Libby, P.7
  • 45
    • 0035899898 scopus 로고    scopus 로고
    • Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: A novel collagenolytic pathway suggested by transcriptional profiling
    • Herman M.P., Sukhova G.K., Libby P., Gerdes N., Tang N., Horton D.B., Kilbride M., Breitbart R.E., Chun M., Schonbeck U. Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling. Circulation. 104:2001;1899-1904.
    • (2001) Circulation , vol.104 , pp. 1899-1904
    • Herman, M.P.1    Sukhova, G.K.2    Libby, P.3    Gerdes, N.4    Tang, N.5    Horton, D.B.6    Kilbride, M.7    Breitbart, R.E.8    Chun, M.9    Schonbeck, U.10
  • 46
    • 0030961921 scopus 로고    scopus 로고
    • Coronary risk factors and plaque morphology in men with coronary disease who died suddenly
    • Burke A.P., Farb A., Malcom G.T., Liang Y.H., Smialek J., Virmani R. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med. 336:1997;1276-1282.
    • (1997) N Engl J Med , vol.336 , pp. 1276-1282
    • Burke, A.P.1    Farb, A.2    Malcom, G.T.3    Liang, Y.H.4    Smialek, J.5    Virmani, R.6
  • 49
    • 0026787340 scopus 로고
    • Effects of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels
    • Loree H.M., Kamm R.D., Stringfellow R.G., Lee R.T. Effects of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels. Circ Res. 71:1992;850-858.
    • (1992) Circ Res , vol.71 , pp. 850-858
    • Loree, H.M.1    Kamm, R.D.2    Stringfellow, R.G.3    Lee, R.T.4
  • 51
    • 0001495165 scopus 로고
    • Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque
    • Wilcox J.N., Smith K.M., Schwartz S.M., Gordon D. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Natl Acad Sci USA. 86:1989;2839-2843.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 2839-2843
    • Wilcox, J.N.1    Smith, K.M.2    Schwartz, S.M.3    Gordon, D.4
  • 53
    • 0036591854 scopus 로고    scopus 로고
    • Oxidized amino acids: Culprits in human atherosclerosis and indicators of oxidative stress
    • Heinecke J.W. Oxidized amino acids: culprits in human atherosclerosis and indicators of oxidative stress. Free Radic Biol Med. 32:2002;1090-1101.
    • (2002) Free Radic Biol Med , vol.32 , pp. 1090-1101
    • Heinecke, J.W.1
  • 54
    • 0035108136 scopus 로고    scopus 로고
    • Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes
    • Sugiyama S., Okada Y., Sukhova G.K., Virmani R., Heinecke J.W., Libby P. Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes. Am J Pathol. 158:2001;879-891.
    • (2001) Am J Pathol , vol.158 , pp. 879-891
    • Sugiyama, S.1    Okada, Y.2    Sukhova, G.K.3    Virmani, R.4    Heinecke, J.W.5    Libby, P.6
  • 55
    • 10544246489 scopus 로고    scopus 로고
    • Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability
    • Rajagopalan S., Meng X.P., Ramasamy S., Harrison D.G., Galis Z.S. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest. 98:1996;2572-2579.
    • (1996) J Clin Invest , vol.98 , pp. 2572-2579
    • Rajagopalan, S.1    Meng, X.P.2    Ramasamy, S.3    Harrison, D.G.4    Galis, Z.S.5
  • 57
    • 0026781978 scopus 로고
    • Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells
    • Kume N., Cybulsky M.I., Gimbrone M.A. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J Clin Invest. 90:1992;1138-1144.
    • (1992) J Clin Invest , vol.90 , pp. 1138-1144
    • Kume, N.1    Cybulsky, M.I.2    Gimbrone, M.A.3
  • 58
    • 0028945307 scopus 로고
    • Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells
    • Khan B.V., Parthasarathy S.S., Alexander R.W., Medford R.M. Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells. J Clin Invest. 95:1995;1262-1270.
    • (1995) J Clin Invest , vol.95 , pp. 1262-1270
    • Khan, B.V.1    Parthasarathy, S.S.2    Alexander, R.W.3    Medford, R.M.4
  • 59
    • 0027476229 scopus 로고
    • An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium
    • Li H., Cybulsky M.I., Gimbrone M.A., Libby P. An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb. 13:1993;197-204.
    • (1993) Arterioscler Thromb , vol.13 , pp. 197-204
    • Li, H.1    Cybulsky, M.I.2    Gimbrone, M.A.3    Libby, P.4
  • 61
    • 0032134003 scopus 로고    scopus 로고
    • Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
    • Gu L., Okada Y., Clinton S.K., Gerard C., Sukhova G.K., Libby P., Rollins B.J. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell. 2:1998;275-281.
    • (1998) Mol Cell , vol.2 , pp. 275-281
    • Gu, L.1    Okada, Y.2    Clinton, S.K.3    Gerard, C.4    Sukhova, G.K.5    Libby, P.6    Rollins, B.J.7
  • 62
    • 0032572719 scopus 로고    scopus 로고
    • Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
    • Boring L., Gosling J., Cleary M., Charo I.F. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature. 394:1998;894-897.
    • (1998) Nature , vol.394 , pp. 894-897
    • Boring, L.1    Gosling, J.2    Cleary, M.3    Charo, I.F.4
  • 63
    • 0028293434 scopus 로고
    • Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine
    • Tsao P.S., McEvoy L.M., Drexler H., Butcher E.C., Cooke J.P. Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. Circulation. 89:1994;2176-2182.
    • (1994) Circulation , vol.89 , pp. 2176-2182
    • Tsao, P.S.1    McEvoy, L.M.2    Drexler, H.3    Butcher, E.C.4    Cooke, J.P.5
  • 64
    • 0029159779 scopus 로고
    • Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines
    • De Caterina R., Libby P., Peng H.B., Thannickal V.J., Rajavashisth T.B., Gimbrone M.A., Shin W.S., Liao J.K. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest. 96:1995;60-68.
    • (1995) J Clin Invest , vol.96 , pp. 60-68
    • De Caterina, R.1    Libby, P.2    Peng, H.B.3    Thannickal, V.J.4    Rajavashisth, T.B.5    Gimbrone, M.A.6    Shin, W.S.7    Liao, J.K.8
  • 65
    • 0029786764 scopus 로고    scopus 로고
    • Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells
    • Khan B.V., Harrison D.G., Olbrych M.T., Alexander R.W., Medford R.M. Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Proc Natl Acad Sci USA. 93:1996;9114-9119.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9114-9119
    • Khan, B.V.1    Harrison, D.G.2    Olbrych, M.T.3    Alexander, R.W.4    Medford, R.M.5
  • 67
    • 0032580971 scopus 로고    scopus 로고
    • Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis
    • Oemar B.S., Tschudi M.R., Godoy N., Brovkovich V., Malinski T., Luscher T.F. Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis. Circulation. 97:1998;2494-2498.
    • (1998) Circulation , vol.97 , pp. 2494-2498
    • Oemar, B.S.1    Tschudi, M.R.2    Godoy, N.3    Brovkovich, V.4    Malinski, T.5    Luscher, T.F.6
  • 68
    • 0028821643 scopus 로고
    • Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase
    • Liao J.K., Shin W.S., Lee W.Y., Clark S.L. Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J Biol Chem. 270:1995;319-324.
    • (1995) J Biol Chem , vol.270 , pp. 319-324
    • Liao, J.K.1    Shin, W.S.2    Lee, W.Y.3    Clark, S.L.4
  • 69
    • 0029876139 scopus 로고    scopus 로고
    • Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death
    • Farb A., Burke A.P., Tang A.L., Liang T.Y., Mannan P., Smialek J., Virmani R. Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death. Circulation. 93:1996;1354-1363.
    • (1996) Circulation , vol.93 , pp. 1354-1363
    • Farb, A.1    Burke, A.P.2    Tang, A.L.3    Liang, T.Y.4    Mannan, P.5    Smialek, J.6    Virmani, R.7
  • 72
    • 0037456528 scopus 로고    scopus 로고
    • Mechanisms of plaque stabilization with statins
    • Libby P., Aikawa M. Mechanisms of plaque stabilization with statins. Am J Cardiol. 91:2003;4B-8B.
    • (2003) Am J Cardiol , vol.91
    • Libby, P.1    Aikawa, M.2
  • 73
    • 0027322448 scopus 로고
    • Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease
    • Brown B.G., Zhao X.Q., Sacco D.E., Albers J.J. Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease. Circulation. 87:1993;1781-1791.
    • (1993) Circulation , vol.87 , pp. 1781-1791
    • Brown, B.G.1    Zhao, X.Q.2    Sacco, D.E.3    Albers, J.J.4
  • 74
    • 0029054734 scopus 로고
    • Molecular bases of the acute coronary syndromes
    • Libby P. Molecular bases of the acute coronary syndromes. Circulation. 91:1995;2844-2850.
    • (1995) Circulation , vol.91 , pp. 2844-2850
    • Libby, P.1
  • 75
    • 0023972981 scopus 로고
    • George Lyman Duff memorial lecture. Progression and regression of atherosclerotic lesions. Insights from lipid physical biochemistry
    • Small D.M. George Lyman Duff memorial lecture. Progression and regression of atherosclerotic lesions. Insights from lipid physical biochemistry. Arteriosclerosis. 8:1988;103-129.
    • (1988) Arteriosclerosis , vol.8 , pp. 103-129
    • Small, D.M.1
  • 76
    • 0025276302 scopus 로고
    • Can atherosclerotic plaques regress? Anatomic and biochemical evidence from nonhuman animal models
    • Wissler R.W., Vesselinovitch D. Can atherosclerotic plaques regress? Anatomic and biochemical evidence from nonhuman animal models. Am J Cardiol. 65:1990;33F-40F.
    • (1990) Am J Cardiol , vol.65
    • Wissler, R.W.1    Vesselinovitch, D.2
  • 77
    • 0036322869 scopus 로고    scopus 로고
    • Isoprenoids as mediators of the biological effects of statins
    • Liao J.K. Isoprenoids as mediators of the biological effects of statins. J Clin Invest. 110:2002;285-288.
    • (2002) J Clin Invest , vol.110 , pp. 285-288
    • Liao, J.K.1
  • 78
    • 0032560637 scopus 로고    scopus 로고
    • Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: A potential mechanism of lesion stabilization
    • Aikawa M., Rabkin E., Okada Y., Voglic S.J., Clinton S.K., Brinckerhoff C.E., Sukhova G.K., Libby P. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization. Circulation. 97:1998;2433-2444.
    • (1998) Circulation , vol.97 , pp. 2433-2444
    • Aikawa, M.1    Rabkin, E.2    Okada, Y.3    Voglic, S.J.4    Clinton, S.K.5    Brinckerhoff, C.E.6    Sukhova, G.K.7    Libby, P.8
  • 80
    • 0032538870 scopus 로고    scopus 로고
    • Lipid lowering promotes accumulation of mature smooth muscle cells expressing smooth muscle myosin heavy chain isoforms in rabbit atheroma
    • Aikawa M., Rabkin E., Voglic S.J., Shing H., Nagai R., Schoen F.J., Libby P. Lipid lowering promotes accumulation of mature smooth muscle cells expressing smooth muscle myosin heavy chain isoforms in rabbit atheroma. Circ Res. 83:1998;1015-1026.
    • (1998) Circ Res , vol.83 , pp. 1015-1026
    • Aikawa, M.1    Rabkin, E.2    Voglic, S.J.3    Shing, H.4    Nagai, R.5    Schoen, F.J.6    Libby, P.7
  • 81
    • 0032563650 scopus 로고    scopus 로고
    • Cell composition, replication, and apoptosis in atherosclerotic plaques after 6 months of cholesterol withdrawal
    • Kockx M.M., De Meyer G.R., Buyssens N., Knaapen M.W., Bult H., Herman A.G. Cell composition, replication, and apoptosis in atherosclerotic plaques after 6 months of cholesterol withdrawal. Circ Res. 83:1998;378-387.
    • (1998) Circ Res , vol.83 , pp. 378-387
    • Kockx, M.M.1    De Meyer, G.R.2    Buyssens, N.3    Knaapen, M.W.4    Bult, H.5    Herman, A.G.6
  • 82
    • 0035916233 scopus 로고    scopus 로고
    • Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: Implications for plaque stabilization
    • Crisby M., Nordin-Fredriksson G., Shah P.K., Yano J., Zhu J., Nilsson J. Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization. Circulation. 103:2001;926-933.
    • (2001) Circulation , vol.103 , pp. 926-933
    • Crisby, M.1    Nordin-Fredriksson, G.2    Shah, P.K.3    Yano, J.4    Zhu, J.5    Nilsson, J.6
  • 83
    • 0035916305 scopus 로고    scopus 로고
    • Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits
    • Fukumoto Y., Libby P., Rabkin E., Hill C.C., Enomoto M., Hirouchi Y., Shiomi M., Aikawa M. Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits. Circulation. 103:2001;993-999.
    • (2001) Circulation , vol.103 , pp. 993-999
    • Fukumoto, Y.1    Libby, P.2    Rabkin, E.3    Hill, C.C.4    Enomoto, M.5    Hirouchi, Y.6    Shiomi, M.7    Aikawa, M.8
  • 84
    • 0029118174 scopus 로고
    • Dietary correction of hypercholesterolemia in the rabbit normalizes endothelial superoxide anion production
    • Ohara Y., Peterson T.E., Sayegh H.S., Subramanian R.R., Wilcox J.N., Harrison D.G. Dietary correction of hypercholesterolemia in the rabbit normalizes endothelial superoxide anion production. Circulation. 92:1995;898-903.
    • (1995) Circulation , vol.92 , pp. 898-903
    • Ohara, Y.1    Peterson, T.E.2    Sayegh, H.S.3    Subramanian, R.R.4    Wilcox, J.N.5    Harrison, D.G.6
  • 85
    • 0029097852 scopus 로고
    • Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis
    • Palinski W., Tangirala R.K., Miller E., Young S.G., Witztum J.L. Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis. Arterioscler Thromb Vasc Biol. 15:1995;1569-1576.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1569-1576
    • Palinski, W.1    Tangirala, R.K.2    Miller, E.3    Young, S.G.4    Witztum, J.L.5
  • 88
    • 0030825407 scopus 로고    scopus 로고
    • Chemokines
    • Rollins B.J. Chemokines. Blood. 90:1997;909-928.
    • (1997) Blood , vol.90 , pp. 909-928
    • Rollins, B.J.1
  • 90
    • 0027360010 scopus 로고
    • Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic FGF with plaque microvessels and macrophages
    • Brogi E., Winkles J.A., Underwood R., Clinton S.K., Alberts G.F., Libby P. Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic FGF with plaque microvessels and macrophages. J Clin Invest. 92:1993;2408-2418.
    • (1993) J Clin Invest , vol.92 , pp. 2408-2418
    • Brogi, E.1    Winkles, J.A.2    Underwood, R.3    Clinton, S.K.4    Alberts, G.F.5    Libby, P.6
  • 91
    • 0031882931 scopus 로고    scopus 로고
    • Neovascularization in atherectomy specimens from patients with unstable angina: Implications for pathogenesis of unstable angina
    • Tenaglia A.N., Peters K.G., Sketch M.H., Annex B.H. Neovascularization in atherectomy specimens from patients with unstable angina: implications for pathogenesis of unstable angina. Am Heart J. 135:1998;10-14.
    • (1998) Am Heart J , vol.135 , pp. 10-14
    • Tenaglia, A.N.1    Peters, K.G.2    Sketch, M.H.3    Annex, B.H.4
  • 93
    • 0033528660 scopus 로고    scopus 로고
    • Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice
    • Moulton K.S., Heller E., Konerding M.A., Flynn E., Palinski W., Folkman J. Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation. 99:1999;1726-1732.
    • (1999) Circulation , vol.99 , pp. 1726-1732
    • Moulton, K.S.1    Heller, E.2    Konerding, M.A.3    Flynn, E.4    Palinski, W.5    Folkman, J.6
  • 94
    • 0037022910 scopus 로고    scopus 로고
    • Inflammation and atherosclerosis
    • Libby P., Ridker P.M., Maseri A. Inflammation and atherosclerosis. Circulation. 105:2002;1135-1143.
    • (2002) Circulation , vol.105 , pp. 1135-1143
    • Libby, P.1    Ridker, P.M.2    Maseri, A.3
  • 95
    • 0037454043 scopus 로고    scopus 로고
    • C-reactive protein and other inflammatory risk markers in acute coronary syndromes
    • Blake G.J., Ridker P.M. C-reactive protein and other inflammatory risk markers in acute coronary syndromes. J Am Coll Cardiol. 41:2003;37S-42S.
    • (2003) J Am Coll Cardiol , vol.41
    • Blake, G.J.1    Ridker, P.M.2
  • 96
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein J.L., Brown M.S. Regulation of the mevalonate pathway. Nature. 343:1990;425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 97
    • 0031025656 scopus 로고    scopus 로고
    • Vastatins inhibit tissue factor in cultured human macrophages. A novel mechanism of protection against atherothrombosis
    • Colli S., Eligini S., Lalli M., Camera M., Paoletti R., Tremoli E. Vastatins inhibit tissue factor in cultured human macrophages. A novel mechanism of protection against atherothrombosis. Arterioscler Thromb Vasc Biol. 17:1997;265-272.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 265-272
    • Colli, S.1    Eligini, S.2    Lalli, M.3    Camera, M.4    Paoletti, R.5    Tremoli, E.6
  • 99
    • 0032494101 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture
    • Guijarro C., Blanco-Colio L.M., Ortego M., Alonso C., Ortiz A., Plaza J.J., Diaz C., Hernandez G., Edigo J. 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. Circ Res. 83:1998;490-500.
    • (1998) Circ Res , vol.83 , pp. 490-500
    • Guijarro, C.1    Blanco-Colio, L.M.2    Ortego, M.3    Alonso, C.4    Ortiz, A.5    Plaza, J.J.6    Diaz, C.7    Hernandez, G.8    Edigo, J.9
  • 100
    • 0033966049 scopus 로고    scopus 로고
    • HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells
    • Bourcier T., Libby P. HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells. Arterioscler Thromb Vasc Biol. 20:2000;556-562.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 556-562
    • Bourcier, T.1    Libby, P.2
  • 102
    • 0031582209 scopus 로고    scopus 로고
    • Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors; Comparison with other human cell types
    • Negre-Aminou P., van Vliet A.K., van Erck M., van Thiel G.C., van Leeuwen R.E., Cohen L.H. Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors; comparison with other human cell types. Biochim Biophys Acta. 1345:1997;259-268.
    • (1997) Biochim Biophys Acta , vol.1345 , pp. 259-268
    • Negre-Aminou, P.1    Van Vliet, A.K.2    Van Erck, M.3    Van Thiel, G.C.4    Van Leeuwen, R.E.5    Cohen, L.H.6
  • 103
    • 0032508533 scopus 로고    scopus 로고
    • Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
    • Laufs U., Liao J.K. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem. 273:1998;24266-24271.
    • (1998) J Biol Chem , vol.273 , pp. 24266-24271
    • Laufs, U.1    Liao, J.K.2
  • 104
    • 0034730781 scopus 로고    scopus 로고
    • Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells
    • Hernandez-Perera O., Perez-Sala D., Soria E., Lamas S. Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells. Circ Res. 87:2000;616-622.
    • (2000) Circ Res , vol.87 , pp. 616-622
    • Hernandez-Perera, O.1    Perez-Sala, D.2    Soria, E.3    Lamas, S.4
  • 105
    • 0035830412 scopus 로고    scopus 로고
    • Hydroxy-methylglutaryl-coenzyme a reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance
    • Feron O., Dessy C., Desager J.P., Balligand J.L. Hydroxy-methylglutaryl- coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance. Circulation. 103:2001;113-118.
    • (2001) Circulation , vol.103 , pp. 113-118
    • Feron, O.1    Dessy, C.2    Desager, J.P.3    Balligand, J.L.4
  • 106
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y., Luo Z., Shiojima I., Bialik A., Fulton D., Lefer D.J., Sessa W.C., Walsh K. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med. 6:2000;1004-1010.
    • (2000) Nat Med , vol.6 , pp. 1004-1010
    • Kureishi, Y.1    Luo, Z.2    Shiojima, I.3    Bialik, A.4    Fulton, D.5    Lefer, D.J.6    Sessa, W.C.7    Walsh, K.8
  • 107
    • 0035723275 scopus 로고    scopus 로고
    • Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: Involvement of Rho GTPase-dependent mechanism
    • Yoshida M., Sawada T., Ishii H., Gerszten R.E., Rosenzweig A., Gimbrone M.A., Yasukochi Y., Numano F. Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism. Arterioscler Thromb Vasc Biol. 21:2001;1165-1171.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1165-1171
    • Yoshida, M.1    Sawada, T.2    Ishii, H.3    Gerszten, R.E.4    Rosenzweig, A.5    Gimbrone, M.A.6    Yasukochi, Y.7    Numano, F.8
  • 108
    • 0037117639 scopus 로고    scopus 로고
    • Statin prevents tissue factor expression in human endothelial cells: Role of Rho/Rho-kinase and Akt pathways
    • Eto M., Kozai T., Cosentino F., Joch H., Luscher T.F. Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways. Circulation. 105:2002;1756-1759.
    • (2002) Circulation , vol.105 , pp. 1756-1759
    • Eto, M.1    Kozai, T.2    Cosentino, F.3    Joch, H.4    Luscher, T.F.5
  • 109
    • 0032487342 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl coenzyme a reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins
    • Essig M., Nguyen G., Prie D., Escoubet B., Sraer J.D., Friedlander G. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins. Circ Res. 83:1998;683-690.
    • (1998) Circ Res , vol.83 , pp. 683-690
    • Essig, M.1    Nguyen, G.2    Prie, D.3    Escoubet, B.4    Sraer, J.D.5    Friedlander, G.6
  • 111
    • 0037023634 scopus 로고    scopus 로고
    • Double-edged role of statins in angiogenesis signaling
    • Urbich C., Dernbach E., Zeiher A.M., Dimmeler S. Double-edged role of statins in angiogenesis signaling. Circ Res. 90:2002;737-744.
    • (2002) Circ Res , vol.90 , pp. 737-744
    • Urbich, C.1    Dernbach, E.2    Zeiher, A.M.3    Dimmeler, S.4
  • 112
    • 0037173080 scopus 로고    scopus 로고
    • Statin therapy accelerates reendothelialization: A novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells
    • Walter D.H., Rittig K., Bahlmann F.H., Kirchmair R., Silver M., Murayama T., Nishimura H., Losordo D.W., Asahara T., Isner J.M. Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation. 105:2002;3017-3024.
    • (2002) Circulation , vol.105 , pp. 3017-3024
    • Walter, D.H.1    Rittig, K.2    Bahlmann, F.H.3    Kirchmair, R.4    Silver, M.5    Murayama, T.6    Nishimura, H.7    Losordo, D.W.8    Asahara, T.9    Isner, J.M.10
  • 113
    • 0028283817 scopus 로고
    • Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia
    • Egashira K., Hirooka Y., Kai H., Sugimachi M., Suzuki S., Inou T., Takeshita A. Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia. Circulation. 89:1994;2519-2524.
    • (1994) Circulation , vol.89 , pp. 2519-2524
    • Egashira, K.1    Hirooka, Y.2    Kai, H.3    Sugimachi, M.4    Suzuki, S.5    Inou, T.6    Takeshita, A.7
  • 115
    • 0028939363 scopus 로고
    • The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion
    • Anderson T.J., Meredith I.T., Yeung A.C., Frei B., Selwyn A.P., Ganz P. The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med. 332:1995;488-493.
    • (1995) N Engl J Med , vol.332 , pp. 488-493
    • Anderson, T.J.1    Meredith, I.T.2    Yeung, A.C.3    Frei, B.4    Selwyn, A.P.5    Ganz, P.6
  • 117
    • 0035943091 scopus 로고    scopus 로고
    • Cerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days
    • Tsunekawa T., Hayashi T., Kano H., Sumi D., Matsui-Hirai H., Thakur N.K., Egashira K., Iguchi A. Cerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days. Circulation. 104:2001;376-379.
    • (2001) Circulation , vol.104 , pp. 376-379
    • Tsunekawa, T.1    Hayashi, T.2    Kano, H.3    Sumi, D.4    Matsui-Hirai, H.5    Thakur, N.K.6    Egashira, K.7    Iguchi, A.8
  • 118
    • 18844476446 scopus 로고    scopus 로고
    • Rapid effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition on coronary endothelial function
    • Wassmann S., Faul A., Hennen B., Scheller B., Bohm M., Nickenig G. Rapid effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition on coronary endothelial function. Circ Res. 93:2003;e98-103.
    • (2003) Circ Res , vol.93 , pp. 98-103
    • Wassmann, S.1    Faul, A.2    Hennen, B.3    Scheller, B.4    Bohm, M.5    Nickenig, G.6
  • 119
    • 0031014389 scopus 로고    scopus 로고
    • Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans
    • Tamai O., Matsuoka H., Itabe H., Wada Y., Kohno K., Imaizumi T. Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans. Circulation. 95:1997;76-82.
    • (1997) Circulation , vol.95 , pp. 76-82
    • Tamai, O.1    Matsuoka, H.2    Itabe, H.3    Wada, Y.4    Kohno, K.5    Imaizumi, T.6
  • 120
    • 0242349750 scopus 로고    scopus 로고
    • Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins
    • Shimizu K., Aikawa M., Takayama K., Libby P., Mitchell R.N. Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins. Circulation. 108:2003;2113-2120.
    • (2003) Circulation , vol.108 , pp. 2113-2120
    • Shimizu, K.1    Aikawa, M.2    Takayama, K.3    Libby, P.4    Mitchell, R.N.5
  • 121
    • 0032169240 scopus 로고    scopus 로고
    • Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators
    • Ridker P.M., Rifai N., Pfeffer M.A., Sacks F.M., Moye L.A., Goldman S., Flaker G.C., Braunwald E. Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators. Circulation. 98:1998;839-844.
    • (1998) Circulation , vol.98 , pp. 839-844
    • Ridker, P.M.1    Rifai, N.2    Pfeffer, M.A.3    Sacks, F.M.4    Moye, L.A.5    Goldman, S.6    Flaker, G.C.7    Braunwald, E.8
  • 122
    • 0035814945 scopus 로고    scopus 로고
    • Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia
    • Ridker P.M., Rifai N., Lowenthal S.P. Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia. Circulation. 103:2001;1191-1193.
    • (2001) Circulation , vol.103 , pp. 1191-1193
    • Ridker, P.M.1    Rifai, N.2    Lowenthal, S.P.3
  • 123
    • 0037490080 scopus 로고    scopus 로고
    • Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: Systematic review and meta-analysis
    • Law M.R., Wald N.J., Rudnicka A.R. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ. 326:2003;1423.
    • (2003) BMJ , vol.326 , pp. 1423
    • Law, M.R.1    Wald, N.J.2    Rudnicka, A.R.3
  • 125
    • 0037109137 scopus 로고    scopus 로고
    • ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: A randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness
    • Taylor A.J., Kent S.M., Flaherty P.J., Coyle L.C., Markwood T.T., Vernalis M.N. ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: a randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness. Circulation. 106:2002;2055-2060.
    • (2002) Circulation , vol.106 , pp. 2055-2060
    • Taylor, A.J.1    Kent, S.M.2    Flaherty, P.J.3    Coyle, L.C.4    Markwood, T.T.5    Vernalis, M.N.6
  • 126
    • 0037212882 scopus 로고    scopus 로고
    • Strong decrease of high sensitivity C-reactive protein with high-dose atorvastatin in patients with type 2 diabetes mellitus
    • van de Ree M.A., Huisman M.V., Princen H.M., Meinders A.E., Kluft C. Strong decrease of high sensitivity C-reactive protein with high-dose atorvastatin in patients with type 2 diabetes mellitus. Atherosclerosis. 166:2003;129-135.
    • (2003) Atherosclerosis , vol.166 , pp. 129-135
    • Van De Ree, M.A.1    Huisman, M.V.2    Princen, H.M.3    Meinders, A.E.4    Kluft, C.5
  • 127
    • 0141841612 scopus 로고    scopus 로고
    • High-dose atorvastatin enhances the decline in inflammatory markers in patients with acute coronary syndromes in the MIRACL study
    • Kinlay S., Schwartz G.G., Olsson A.G., Rifai N., Leslie S.J., Sasiela W.J., Szarek M., Libby P., Ganz P. High-dose atorvastatin enhances the decline in inflammatory markers in patients with acute coronary syndromes in the MIRACL study. Circulation. 108:2003;1560-1566.
    • (2003) Circulation , vol.108 , pp. 1560-1566
    • Kinlay, S.1    Schwartz, G.G.2    Olsson, A.G.3    Rifai, N.4    Leslie, S.J.5    Sasiela, W.J.6    Szarek, M.7    Libby, P.8    Ganz, P.9
  • 129
    • 0033972030 scopus 로고    scopus 로고
    • The ACAT inhibitor avasimibe reduces macrophages and matrix metalloproteinase expression in atherosclerotic lesions of hypercholesterolemic rabbits
    • Bocan T.M., Krause B.R., Rosebury W.S., Mueller S.B., Lu X., Dagle C., Major T., Lathia C., Lee H. The ACAT inhibitor avasimibe reduces macrophages and matrix metalloproteinase expression in atherosclerotic lesions of hypercholesterolemic rabbits. Arterioscler Thromb Vasc Biol. 20:2000;70-79.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 70-79
    • Bocan, T.M.1    Krause, B.R.2    Rosebury, W.S.3    Mueller, S.B.4    Lu, X.5    Dagle, C.6    Major, T.7    Lathia, C.8    Lee, H.9
  • 133
    • 0035903242 scopus 로고    scopus 로고
    • Clinical imaging of the high-risk or vulnerable atherosclerotic plaque
    • Fayad Z.A., Fuster V. Clinical imaging of the high-risk or vulnerable atherosclerotic plaque. Circ Res. 89:2001;305-316.
    • (2001) Circ Res , vol.89 , pp. 305-316
    • Fayad, Z.A.1    Fuster, V.2
  • 134
    • 0037236238 scopus 로고    scopus 로고
    • Shedding light onto live molecular targets
    • Weissleder R., Ntziachristos V. Shedding light onto live molecular targets. Nat Med. 9:2003;123-128.
    • (2003) Nat Med , vol.9 , pp. 123-128
    • Weissleder, R.1    Ntziachristos, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.