Preferential pharmacological inhibition of macrophage ACAT increases plaque formation in mouse and rabbit models of atherogenesis

Atherosclerosis

Volumn 155, Issue 2, 2001, Pages 359-370

  Perrey, Stéphane ^a   Legendre, Christiane ^a   Matsuura, Akihiro ^b   Guffroy, Christian ^a   Binet, Jean ^a   Ohbayashi, Shigeo ^b   Tanaka, Toshiya ^b   Ortuno, Jean Claude ^a   Matsukura, Takeo ^b   Laugel, Thierry ^a   Padovani, Paul ^a   Bellamy, François ^a   Edgar, Alan D ^a  

^a Laboratoires Fournier SA   (France)

^b Grelan Research Center   (Japan)

Author keywords

ACAT; Atherosclerosis; Macrophage

Indexed keywords

2 [[(BUTYLAMINO)CARBONYL]AMINO] 5 DIMETHYLAMINO N [(DIPHENYLMETHYL 4 PIPERIDINYL)METHYL]BENZAMIDE; 2,2 DIMETHYL N (2,4,6 TRIMETHOXYPHENYL)DODECANAMIDE; 2,2 DIMETHYL N [2,4,6 TRIMETHOXYPHENYL]DODECANAMIDE; 5 [DIMETHYLAMINO] N [[1 (DIPHENYLMETHYL) 4 PIPERIDINYL]METHYL] 2 [[(HEPTYLAMINO)CARBONYL]AMINO]BENZAMIDE; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; CHOLESTEROL ESTER; GF 1 054; GF 1 086; GF 2 021; GF 2 025; N [[1 (DIPHENYLMETHYL) 4 PIPERIDINYL]METHYL] 2 [[(HEPTYLAMINO)CARBONYL]AMINO]BENZAMIDE; N [[1 (DIPHENYLMETHYL) 4 PIPERIDINYL]METHYL] 2 [[(PROPYLAMINO)CARBONYL]AMINO] 5 [MORPHOLINYL]BENZAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD ANALYSIS; CONTROLLED STUDY; CYTOTOXICITY; DISEASE COURSE; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; ESTERIFICATION; FEMALE; FOAM CELL; HUMAN; HUMAN CELL; LIPID DIET; MACROPHAGE; MACROPHAGE MIGRATION INHIBITION; MALE; MONOCYTE; MOUSE; NONHUMAN; ORGAN DISTRIBUTION; PRIORITY JOURNAL; RABBIT; RAT;

ANILIDES; ANIMAL FEED; ANIMALS; AORTA; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; CHOLESTEROL ESTERS; DIET, ATHEROGENIC; DIETARY FATS; ENZYME INHIBITORS; FEMALE; FOAM CELLS; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSOMES; MICROSOMES, LIVER; MONOCYTES; PIPERIDINES; RABBITS; RECEPTORS, LDL; STEROL O-ACYLTRANSFERASE; TUMOR CELLS, CULTURED;

EID: 0035096678     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(00)00599-2     Document Type: Article

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