메뉴 건너뛰기




Volumn 20, Issue 1, 2000, Pages 70-79

The ACAT inhibitor avasimibe reduces macrophages and matrix metalloproteinase expression in atherosclerotic lesions of hypercholesterolemic rabbits

Author keywords

ACAT; Atherosclerosis; Macrophages; Matrix metalloproteinases; Plaque rupture

Indexed keywords

AVASIMIBE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; MATRIX METALLOPROTEINASE; MESSENGER RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

EID: 0033972030     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.20.1.70     Document Type: Article
Times cited : (114)

References (34)
  • 1
    • 0023972981 scopus 로고
    • Progression and regression of atherosclerotic lesions: Insights from lipid physical biochemistry
    • Small D. Progression and regression of atherosclerotic lesions: insights from lipid physical biochemistry. Arteriosclerosis. 1988;8:103-129.
    • (1988) Arteriosclerosis , vol.8 , pp. 103-129
    • Small, D.1
  • 2
    • 0014068097 scopus 로고
    • Lipid in the aortic intima: The correlation of morphological and chemical characteristics
    • Smith EB, Evans PH, Downham MD. Lipid in the aortic intima: the correlation of morphological and chemical characteristics. J Atheroscler Res. 1967;7:171-186.
    • (1967) J Atheroscler Res , vol.7 , pp. 171-186
    • Smith, E.B.1    Evans, P.H.2    Downham, M.D.3
  • 3
    • 0020972414 scopus 로고
    • Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
    • Brown MS, Goldstein JL. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem. 1983;52:223-261.
    • (1983) Annu Rev Biochem , vol.52 , pp. 223-261
    • Brown, M.S.1    Goldstein, J.L.2
  • 4
    • 0013665462 scopus 로고
    • The natural history of human atherosclerotic lesions
    • Moore S, ed. New York, NY: Marcel Dekker
    • Haust MD. The natural history of human atherosclerotic lesions. In: Moore S, ed. Vascular Injury and Atherosclerosis. New York, NY: Marcel Dekker; 1981:1-23.
    • (1981) Vascular Injury and Atherosclerosis , pp. 1-23
    • Haust, M.D.1
  • 5
    • 0028836794 scopus 로고
    • Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases
    • Galis ZS, Sukhova GK, Kranzhoefer R, Clark S, Libby P. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases. Proc Natl Acad Sci U S A. 1995;92:402-406.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 402-406
    • Galis, Z.S.1    Sukhova, G.K.2    Kranzhoefer, R.3    Clark, S.4    Libby, P.5
  • 6
    • 0028063408 scopus 로고
    • Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
    • Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 1994;94: 2493-2503.
    • (1994) J Clin Invest , vol.94 , pp. 2493-2503
    • Galis, Z.S.1    Sukhova, G.K.2    Lark, M.W.3    Libby, P.4
  • 8
    • 0029817688 scopus 로고    scopus 로고
    • Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme
    • Halpert I, Sires UI, Roby JD, Potter-Perigo S, Wight TN, Shapiro SD, Welgus HG, Wickline SA, Parks WC. Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme. Proc Natl Acad Sci U S A. 1996;93: 9748-9753.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 9748-9753
    • Halpert, I.1    Sires, U.I.2    Roby, J.D.3    Potter-Perigo, S.4    Wight, T.N.5    Shapiro, S.D.6    Welgus, H.G.7    Wickline, S.A.8    Parks, W.C.9
  • 9
    • 0028906790 scopus 로고
    • Identification of 92-kD gelatinase in human coronary atherosclerotic lesions: Association of active enzyme synthesis with unstable angina
    • Brown DL, Hibbs MS, Kearney M, Loushin C, Isner JM. Identification of 92-kD gelatinase in human coronary atherosclerotic lesions: association of active enzyme synthesis with unstable angina. Circulation. 1995;91:2125-2131.
    • (1995) Circulation , vol.91 , pp. 2125-2131
    • Brown, D.L.1    Hibbs, M.S.2    Kearney, M.3    Loushin, C.4    Isner, J.M.5
  • 10
    • 0002776685 scopus 로고
    • ACAT inhibitors: Physiologic mechanisms for hypolipidemic and anti-atherosclerotic activities in experimental animals
    • Ruffolo RR, Hollinger MA, eds. Boca Raton, Fla: CRC Press
    • Krause BR, Bocan TMA. ACAT inhibitors: physiologic mechanisms for hypolipidemic and anti-atherosclerotic activities in experimental animals. In: Ruffolo RR, Hollinger MA, eds. Inflammation: Mediators and Pathways. Boca Raton, Fla: CRC Press; 1995:173-198.
    • (1995) Inflammation: Mediators and Pathways , pp. 173-198
    • Krause, B.R.1    Bocan, T.M.A.2
  • 12
    • 0031911857 scopus 로고    scopus 로고
    • ACAT inhibitors: Evolution from cholesterol-absorption inhibitors to antiatherosclerotic agents
    • Roth BD. ACAT inhibitors: evolution from cholesterol-absorption inhibitors to antiatherosclerotic agents. Drug Discovery Today. 1998; 3:19-25.
    • (1998) Drug Discovery Today , vol.3 , pp. 19-25
    • Roth, B.D.1
  • 13
    • 0031937705 scopus 로고    scopus 로고
    • Animal models of atherosclerosis and interpretation of drug intervention studies
    • Bocan TMA. Animal models of atherosclerosis and interpretation of drug intervention studies. Curr Pharm Des. 1998;4:39-53.
    • (1998) Curr Pharm Des , vol.4 , pp. 39-53
    • Bocan, T.M.A.1
  • 14
    • 0026347265 scopus 로고
    • Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions: A biochemical, morphological and morphometric evaluation
    • Bocan TMA, Bak Mueller S, Uhlendorf PD, Newton RS, Krause BR. Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions: a biochemical, morphological and morphometric evaluation. Arterioscler Thromb. 1991;11:1830-1843.
    • (1991) Arterioscler Thromb , vol.11 , pp. 1830-1843
    • Bocan, T.M.A.1    Bak Mueller, S.2    Uhlendorf, P.D.3    Newton, R.S.4    Krause, B.R.5
  • 15
    • 84965088851 scopus 로고
    • Production of advanced cholesterol atherosclerosis in the rabbit
    • Constantinides P, Booth J, Carlson G. Production of advanced cholesterol atherosclerosis in the rabbit. Arch Pathol. 1960;70:80-92.
    • (1960) Arch Pathol , vol.70 , pp. 80-92
    • Constantinides, P.1    Booth, J.2    Carlson, G.3
  • 16
    • 0004774387 scopus 로고
    • Production of experimental atherosclerosis in animals
    • Constantinides P. Production of experimental atherosclerosis in animals. J Atheroscler Res. 1961;1:374-385.
    • (1961) J Atheroscler Res , vol.1 , pp. 374-385
    • Constantinides, P.1
  • 17
    • 0030472785 scopus 로고    scopus 로고
    • Inhibitors of acyl-CoA:Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents: CI-1011: An acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets
    • Lee HT, Sliskovic DR, Picard JA, Roth BD, Wierenga W, Hicks JL, Bousley RF, Hamelehle KL, Homan R, Speyer C, Stanfield RL, Krause BR. Inhibitors of acyl-CoA:cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents: CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets. J Med Chem. 1996;39:5031-5034.
    • (1996) J Med Chem , vol.39 , pp. 5031-5034
    • Lee, H.T.1    Sliskovic, D.R.2    Picard, J.A.3    Roth, B.D.4    Wierenga, W.5    Hicks, J.L.6    Bousley, R.F.7    Hamelehle, K.L.8    Homan, R.9    Speyer, C.10    Stanfield, R.L.11    Krause, B.R.12
  • 19
    • 0015847114 scopus 로고
    • Quantitative determination of serum triglycerides by the use of enzymes
    • Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 1973;19:476-482.
    • (1973) Clin Chem , vol.19 , pp. 476-482
    • Bucolo, G.1    David, H.2
  • 21
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissue
    • Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissue. J Biol Chem. 1957;226:497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane-Stanley, G.H.3
  • 22
    • 0030795168 scopus 로고    scopus 로고
    • Polyribonucleotides induce nitric oxide production by human monocyte-derived macrophages
    • Snell JC, Chernyshev O, Gilbert DL, Colton CA. Polyribonucleotides induce nitric oxide production by human monocyte-derived macrophages. J Leukoc Biol. 1997;62:369-373.
    • (1997) J Leukoc Biol , vol.62 , pp. 369-373
    • Snell, J.C.1    Chernyshev, O.2    Gilbert, D.L.3    Colton, C.A.4
  • 23
    • 0032562458 scopus 로고    scopus 로고
    • Rapid separation and quantitation of combined neutral and polar lipid classes by high-performance liquid chromatography and evaporative light-scattering mass detection
    • Homan R, Anderson MK. Rapid separation and quantitation of combined neutral and polar lipid classes by high-performance liquid chromatography and evaporative light-scattering mass detection. J Chromatogr B. 1998;708:21-26.
    • (1998) J Chromatogr B , vol.708 , pp. 21-26
    • Homan, R.1    Anderson, M.K.2
  • 24
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.1
  • 25
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 27
    • 0022965954 scopus 로고
    • Immunocytochemical analysis of cellular components in atherosclerotic lesions: Use of monoclonal antibodies with the Watanabe and fat-fed rabbit
    • Tsukada T, Rosenfeld M, Ross R, Gown AM. Immunocytochemical analysis of cellular components in atherosclerotic lesions: use of monoclonal antibodies with the Watanabe and fat-fed rabbit. Arteriosclerosis. 1986;6:601-613.
    • (1986) Arteriosclerosis , vol.6 , pp. 601-613
    • Tsukada, T.1    Rosenfeld, M.2    Ross, R.3    Gown, A.M.4
  • 28
    • 0021943984 scopus 로고
    • A smooth muscle-specific monoclonal antibody recognizes smooth muscle actin isozymes
    • Gown AM, Vogel AM, Gordon D, Lu PL. A smooth muscle-specific monoclonal antibody recognizes smooth muscle actin isozymes. J Cell Biol. 1985;100:807-813.
    • (1985) J Cell Biol , vol.100 , pp. 807-813
    • Gown, A.M.1    Vogel, A.M.2    Gordon, D.3    Lu, P.L.4
  • 32
    • 0022551279 scopus 로고
    • Metabolism of very low density lipoproteins after cessation of cholesterol feeding in rabbits
    • Daugherty A, Schonfeld G, Sobel BE, Lange LG. Metabolism of very low density lipoproteins after cessation of cholesterol feeding in rabbits. J Clin Invest. 1986;77:1108-1115.
    • (1986) J Clin Invest , vol.77 , pp. 1108-1115
    • Daugherty, A.1    Schonfeld, G.2    Sobel, B.E.3    Lange, L.G.4
  • 33
    • 0016373896 scopus 로고
    • Mode of cholesterol accumulation in various tissues of rabbits with prolonged exposure to various serum cholesterol levels
    • Ho KJ, Pang LC, Taylor CB. Mode of cholesterol accumulation in various tissues of rabbits with prolonged exposure to various serum cholesterol levels. Atherosclerosis. 1974;19:561-566.
    • (1974) Atherosclerosis , vol.19 , pp. 561-566
    • Ho, K.J.1    Pang, L.C.2    Taylor, C.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.