Expression of the glutamate transporters in human temporal lobe epilepsy

Neuroscience

Volumn 88, Issue 4, 1999, Pages 1083-1091

  Tessler, S ^a   Danbolt, N C ^b   Faull, R L M ^c   Storm Mathisen, J ^b   Emson, P C ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Epilepsy; Excitatory amino acids; Human; Transporter

Indexed keywords

CARRIER PROTEIN;

ARTICLE; BRAIN BIOPSY; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; MACROGLIA; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TEMPORAL LOBE EPILEPSY; TISSUE DISTRIBUTION;

AGED; AMINO ACID TRANSPORT SYSTEM X-AG; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, WESTERN; EPILEPSY, TEMPORAL LOBE; EXCITATORY AMINO ACID TRANSPORTER 2; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MIDDLE AGED; RECEPTORS, NEUROTRANSMITTER; RNA, MESSENGER;

EID: 0032890096     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00301-7     Document Type: Article

References (33)

1. Akbar M. T., Torp R., Danbolt N. C., Levy L. M., Meldrum B. S., Ottersen O. P. Expression of glial glutamate transporters GLT-1 and GLAST is unchanged in the hippocampus in fully kindled rats. Neuroscience. 78:1997;351-359.
2. Arriza J. L., Eliasof S., Kavanaugh M. P., Amara S. G. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. natn. Acad. Sci. U.S.A. 94:1997;4155-4160.
3. Arriza J. L., Fairman W. A., Wadiche J. I., Murdoch G. F., Kavanaugh M. P., Amara S. G. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J. Neurosci. 14:1994;5559-5569.
4. Augood S. J., Faull R. L. M., Love D. R., Emson P. C. reduction in enkephalin and substance P mRNA in the striatum of early grade Huntington's disease: a detailed cellular in situ hybridization study. Neuroscience. 72:1996;1023-1036.
5. Balandini F., Porter R. H. P., Greenamyre J. T. Glutamate and Parkinson's disease. Molec. Neurobiol. 12:1996;73-94.
6. Beal M. F., Kowall N. W., Ellison D. W., Mazurek M. F., Swartz K. J., Martin J. B. Replication of the neurochemical characteristics of Huntingtons disease by quinolinic acid. Nature. 321:1986;168-171.
7. Carlson H., Rönne-Engström E. E., Ungerstedt U., Hillered L. Seizure-related elevations of extracellular amino acids in human focal epilepsy. Neurosci. Lett. 140:1992;30-32.
8. +] coupled L-glutamate transporter purified from rat is located in glial cell processes. Neuroscience. 51:1992;295-310.
9. During M. J., Spencer D. D. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet. 341:1993;1607-1610.
10. Fairman W. A., Vandenberg R. J., Arriza J. L., Kavanaugh M. P., Amara S. G. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature. 375:1995;599-603.
11. Flavin H. J., Wieraszko A., Seyfried T. N. Enhanced aspertate release from hippocampal slices of epileptic (EL) mice. J. Neurochem. 56:1991;1007-1011.
12. Hansson E., Rönnbäck L., Persson L. I., Löwenthal A., Noppe M., Alling C., Karlsson B. Cellular composition of primary cultures from cerebral cortex, striatum, hippocampus, brain-stem and cerebellum. Brain Res. 300:1994;9-18.
13. Haugeto O., Ullensvang K., Levy L. M., Chaudry F. A., Honore T., Nielsen M., Lehre K. P., Danbolt N. C. Brain glutamate transporter protein form homomultimers. J. biol. Chem. 271:1996;27715-27722.
14. Janjua N. A., Kabuto H., Mori A. Increased plasma glutamic acid in a genetic model of epilepsy. Neurochem. Res. 17:1992;293-296.
15. Kanai Y., Hediger M. A. Primary structure and functional analysis of a high affinity glutamate transporter. Nature. 360:1992;467-471.
16. Kawakami H., Tanaka K., Nakayama T., Inoue K., Nakamura S. Cloning and expression of a human glutamate transporter. Biochem. biophys. Res. Commun. 199:1994;171-176.
17. King J. T., LaMotte C. C. EL mouse as a model of focal epilepsy: a review. Epilepsia. 30:1989;257-265.
18. Lehre K. P., Levy L. M., Ottersen O. P., Storm-Mathisen J., Danbolt N. C. Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations. J. Neurosci. 15:1995;1835-1853.
19. Masliah E., Alford M., DeTeresa R., Mallory M., Hansen L. Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease. Ann. Neurol. 40:1996;759-766.
20. McDonald J. W., Garofalo E. A., Hood T., Sackellares J. C., Gilman S., McKeever P. E., Troncoso J. C., Johnston M. V. Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy. Ann. Neurol. 29:1991;529-541.
21. Meldrum B. S. The role of glutamate in epilepsy and other CNS disorders. Neurology. 44:1994;S14-S23.
22. Miller H. P., Levey A. I., Rothstein J. D., Tzingounis A. V., Conn P. J. Alterations in glutamate transporter protein levels in kindling-induced epilepsy. J. Neurochem. 68:1997;1564-1570.
23. Nicholls D., Attwell D. The release and uptake of excitatory amino acids. Trends pharmac. Sci. 11:1990;462-468.
24. Obrenovitch T. M., Urenjak J. Altered glutamergic transmission in neurological disorders: from high extracellular glutamate to excessive synaptic efficacy. Prog. Neurobiol. 51:1997;39-87.
25. Pines G., Danbolt N. C., Bjoras M., Zhang Y., Bendaham A., Eide L., Koepsell H., Storm-Mathisen J., Seeberg E., Kanner B. I. Cloning and expression of a rat brain L-glutamate transporter. Nature. 360:1992;464-467.
26. Rothstein J. D., Dykes-Hoberg M., Pardo C. A., Bristol L. A., Jin L., Kuncl R. P., Kanai Y., Hediger M. A., Wang Y., Schielke J. P., welty D. F. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 16:1996;675-686.
27. Rothstein J. D., Van Kammen M., Levey A. I., Martin L. J., Kuncl R. W. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann. Neurol. 38:1995;73-84.
28. Schindler M., Sellers L. A., Humphrey P. P. A., Emson P. C. Immunohistochemicel localization of the somatostatin SST2a receptor in the rat brain and spinal cord. Neuroscience. 76:1997;225-240.
29. Shashidharan P., Huntley G. W., Meyer T., Morrison J. H., Plaitakis A. Neuron-specific human glutamate transporter-molecular-cloning, characterization and expression in human brain. Brain Res. 662:1994;245-250.
30. Stein C. A. Does antisense exist? Nature Med. 1:1995;1119-1121.
31. Storck T., Schulte S., Hofmann K., Stoffel W. Structure, expression, and function analysis of a Na dependent glutamate/aspartate transporter from rat brain. Proc. natn. Acad. Sci. U.S.A. 89:1992;10955-10959.
32. Tanaka K., Watase K., Manabe T., Yamada K., Watanabe M., Takahashi K., Iwama H., Nishikawa T., Ichihara N., Kikuchi T., Okuyama S., Kawashima N., Hori S., Takimoto M., Wada K. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science. 276:1997;1699-1702.
33. Yamada K., Watanabe M., Shibata T., Tanaka K., Wada K., Inoue Y. EAAT4 is post-synaptic glutamate transporter at Purkinje cell synapses. NeuroReport. 7:1996;2013-2017.