Alterations in glutamate transporter protein levels in kindling-induced epilepsy

Journal of Neurochemistry

Volumn 68, Issue 4, 1997, Pages 1564-1570

  Miller, Heather Prince ^a   Levey, Allan I ^a   Rothstein, Jeffrey D ^b   Tzingounis, Anastassios V ^a   Conn, P Jeffrey ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Epilepsy; Hippocampus; Piriform cortex; Seizure; Uptake

Indexed keywords

GLUTAMIC ACID;

AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; EPILEPSY; HIPPOCAMPUS; KINDLING; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; PROTEIN TRANSPORT; PYRIFORM CORTEX; RAT; SEIZURE; SYNAPTIC TRANSMISSION;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0030939042     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68041564.x     Document Type: Article

References (44)

1. Arriza J. L., Fairman W. A., Wadiche J. I., Murdoch G. H., Kavanaugh M. P., and Amara S. G. (1994) Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J. Neurosci. 14, 5559-5569.
2. Barbour B., Brew H., and Attwell D. (1991) Electrogenic uptake of glutamate and aspartate into glial cells isolated from the salamander (Ambystoma) retina. J. Physiol. (Lond.) 436, 169-193.
3. Chen S.-J., Desai M. A., Klann E., Winder D. G., Sweatt J. D., and Conn P. J. (1992) Amygdala kindling alters protein kinase C activity in dentate gyrus. J. Neurochem. 59, 1761-1769.
4. Clements J. D., Lester R. A. J., Tong G., Jahr C. E., and Westbrook G. C. (1992) The time course of glutamate in the synaptic cleft. Science 258, 1498-1501.
5. Croucher M. J., Bradford H. F., Sunter D. C., and Watkins J. C. (1988) Inhibition of the development of electrical kindling of the prepyriform cortex by daily focal injections of excitatory amino acid antagonists. Eur. J. Pharmacol. 152, 29-38.
6. Danbolt N. C. (1994) The high affinity uptake system for excitatory amino acids in the brain. Prog. Neurobiol. 44, 377-396.
7. +] coupled L-glutamate transporter purified from rat brain is localized to glial cell processes. Neuroscience 51, 295-310.
8. During N. C. and Spencer D. D. (1993) Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet 341, 1607-1610.
9. Eccles C. U., Dykes-Hoberg M., and Rothstein J. D. (1996) Inhibition of synthesis of EAAC-1 glutamate transporter alters γ-aminobutyric acid levels in discrete brain regions. Soc. Neurosci. Abstr. 22, 1570.
10. Fairman W. A., Vandenberg R. J., Arriza J. L., Kavanaugh M. P., and Amara S. G. (1995) An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature 375, 599-603.
11. Ginsberg S. D., Martin L. J., and Rothstein J. D. (1995) Regional deafferentation down-regulates subtypes of glutamate transporter proteins. J. Neurochem. 65, 2800-2803.
12. Goddard G. V., McIntyre D. C., and Leech C. K. (1969) A permanent change in brain function resulting from daily electrical stimulation. Exp. Neurol. 25, 295-330.
13. Hansen A., Jørgensen O. S., Bolwig T. G., and Barry D. I. (1990) Hippocampal kindling alters the concentration of glial fibrillary acidic protein and other marker proteins in rat brain. Brain Res. 531, 307-311.
14. Hansen A., Jørgensen O. S., Bolwig T. G., and Barry D. I. (1991) Hippocampal kindling in the rat is associated with time-dependent increases in the concentration of glial fibrillary acidic protein. J. Neurochem. 57, 1716-1720.
15. Janjua N. A., Itano T., Kugoh T., Hosokawa K., Nakano M., Matsui H., and Hatase O. (1992) Familial increase in plasma glutamic acid in epilepsy. Epilepsy Res. 11, 37-44.
16. Jonas P. and Burnashev N. (1995) Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptors. Neuron 15, 987-990.
17. Kanai Y. and Hediger M. A. (1992) Primary structure and functional characterization of a high-affinity glutamate transporter. Nature 360, 467-471.
18. Klockner U., Storck T., Conradt M., and Stoffel W. (1993) Electrogenic L-glutamate uptake in Xenopus laevis oocytes expressing a cloned rat brain L-glutamate-L-aspartate transporter (GLAST-1). J. Biol. Chem. 268, 14594-14596.
19. 3H]D-aspartate uptake and glutamate metabolism in rats. Epilepsy Res. 1, 145-148.
20. Lehre K. P., Levy L. M., Ottersen O. P., Storm-Mathisen J., and Danbolt N. C. (1995) Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations. J. Neurosci. 15, 1835-1853.
21. +] coupled L-glutamate transporter purified from rat brain confirms glial cell localization. FEBS Lett. 317, 79-84.
22. Levy L. M., Lehre K. P., Walaas S. I., Storm-Mathisen J., and Danbolt N. C. (1995) Down-regulation of glial glutamate transporters after glutamatergic denervation in the rat brain. Eur. J. Neurosci. 7, 2036-2041.
23. McIntyre D. C. and Wong R. K. S. (1986) Cellular and synaptic properties of amygdala-kindled pyriform cortex in vitro. J. Neurophysiol. 55, 1295-1307.
24. Meldrum B. S. (1993) Excitotoxicity and selective neuronal loss in epilepsy. Brain Pathol. 3, 405-412.
25. Minamoto Y., Itano T., Tokuda M., Matsui H., Janjua N. A., Hosokawa K., Okada Y., Murakami T. H., Negi T., and Hatase O. (1992) In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat. Brain Res. 573, 345-348.
26. Nicholls D. and Attwell D. (1990) The release and uptake of excitatory amino acids. Trends Pharmacol. Sci. 11, 462-468.
27. Paxinos G. and Watson C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
28. Perry T. L. and Hansen S. (1981) Amino acid abnormalities in epileptogenic foci. Neurology 31, 872-876.
29. Pines G., Danbolt N. C., Bjoras M., Zhang Y., Bendahan A., Eide L., Koepsell H., Storm-Mathisen J., Seeberg E., and Kanner B. I. (1992) Cloning and expression of a rat brain L-glutamate transporter. Nature 360, 464-467.
30. Piredda S. and Gale K. (1985) A crucial epileptogenic site in the deep prepyriform cortex. Nature 317, 623-625.
31. Prince H. K., Conn P. J., Blackstone C. D., Huganir R. J., and Levey A. I. (1995) Down-regulation of AMPA receptor subunit GluR2 in amygdaloid kindling. J. Neurochem. 64, 462-465.
32. Racine R. (1972) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32, 281-294.
33. Racine R. J., Mosher M., and Kairiss E. W. (1988) The role of the piriform cortex in the generation of inter-ictal spikes in the kindled preparation. Brain Res. 454, 251-263.
34. Racine R. J., Ivy G. O., and Milgram N. W. (1989) Kindling: clinical relevance and anatomical substrate, in The Clinical Relevance of Kindling (Bolwig T. G. and Trimble M. R., eds), pp. 15-34. John Wiley and Sons, New York.
35. Rogawski M. A. (1995) Excitatory amino acids and seizures, in CNS Neurotransmitters and Neuromodulators: Glutamate (Stone T. W., ed), pp. 219-237. CRC Press, Boca Raton, Florida.
36. Rothstein J. D., Martin L., Levey A. I., Dykes-Hoberg M., Jin L., Wu D., Nash N., and Kuncl R. W. (1994) Localization of neuronal and glial glutamate transporters. Neuron 13, 713-725.
37. Rothstein J. D., Van Kammen M., Levey A. I., Martin L. J., and Kuncl R. W. (1995) An analysis of glutamate transporter subtypes in amyotrophic lateral sclerosis: a selective loss of glial glutamate transporter GLT-1. Ann. Neurol. 38, 73-84.
38. Rothstein J. D., Dykes-Hoberg M., Pardo C. A., Bristol L. A., Lin L., Kuncl D. W., Kanai Y., Hediger M. A., Wang Y., Schielke J. P., and Welty D. F. (1996) Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16, 675-686.
39. Shashidharan P. and Plaitakis A. (1993) Cloning and characterization of a glutamate transporter cDNA from human cerebellum. Biochim. Biophys. Acta 1216, 161-164.
40. Shashidharan P., Huntley G. W., Meyer T., Morrison J. H., and Plaitakis A. (1994a) Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain. Brain Res. 662, 245-250.
41. Shashidharan P., Wittenberg I., and Plaitakis A. (1994b) Molecular cloning of human brain glutamate/aspartate transporter II. Biochim. Biophys. Acta 1191, 393-396.
42. Sherwin A., Robitaille Y., Quesney F., Olivier A., Villemure J., Leblanc R., Feindel W., Andermann E., Gotman J., Andermann F., Ethier R., and Kish S. (1988) Excitatory amino acids are elevated in human epileptic cerebral cortex. Neurology 38, 920-923.
43. +-dependent glutamate/aspartate transporter from rat brain. Proc. Natl. Acad. Sci. USA 89, 10955-10959.
44. Zhang W. Q., Hudson P. M., Sobotka T. J., Hong J. S., and Tilson H. A. (1991) Extracellular concentrations of amino acid transmitters in ventral hippocampus during and after the development of kindling. Brain Res. 540, 315-318.