메뉴 건너뛰기




Volumn 20, Issue 3, 1998, Pages 589-602

Aberrant RNA processing in a neurodegenerative disease: The cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; GLUTAMIC ACID; PROTEIN EAAT 2; UNCLASSIFIED DRUG;

EID: 0032032013     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80997-6     Document Type: Article
Times cited : (599)

References (55)
  • 2
    • 0027991954 scopus 로고
    • Evidence for autoimmunity in amyotrophic lateral sclerosis
    • Appel, S.H., Smith, R.G., Engelhardt, J.I., and Stefani, E. (1994). Evidence for autoimmunity in amyotrophic lateral sclerosis. J. Neurol. Sci. 124 (suppl.), 14-19.
    • (1994) J. Neurol. Sci. , vol.124 , Issue.SUPPL. , pp. 14-19
    • Appel, S.H.1    Smith, R.G.2    Engelhardt, J.I.3    Stefani, E.4
  • 3
    • 0028031487 scopus 로고
    • Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex
    • Arriza, J.L., Fairman, W.A., Wadiche, J.I., Murdoch, G.H., Kavanaugh, M.P., and Amara, S.G. (1994). Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci. 14, 5559-5569.
    • (1994) J Neurosci. , vol.14 , pp. 5559-5569
    • Arriza, J.L.1    Fairman, W.A.2    Wadiche, J.I.3    Murdoch, G.H.4    Kavanaugh, M.P.5    Amara, S.G.6
  • 4
  • 5
    • 0028097839 scopus 로고
    • A controlled trial of riluzole in amyotrophic lateral sclerosis
    • ALS/Riluzole Study Group
    • Bensimon, G., Lacomblez, L., and Meininger, V. (1994). A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N. Engl. J. Med. 330, 585-591.
    • (1994) N. Engl. J. Med. , vol.330 , pp. 585-591
    • Bensimon, G.1    Lacomblez, L.2    Meininger, V.3
  • 6
    • 0027359334 scopus 로고
    • Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis
    • Bowling, A.C., Schulz, J.B., Brown, R.H., Jr., and Beal, M.F. (1993). Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J. Neurochem. 61, 2322-2325.
    • (1993) J. Neurochem. , vol.61 , pp. 2322-2325
    • Bowling, A.C.1    Schulz, J.B.2    Brown R.H., Jr.3    Beal, M.F.4
  • 8
    • 0029884012 scopus 로고    scopus 로고
    • Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex
    • Bristol, L.A., and Rothstein, J.D. (1996). Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex. Ann. Neurol. 39, 676-679.
    • (1996) Ann. Neurol. , vol.39 , pp. 676-679
    • Bristol, L.A.1    Rothstein, J.D.2
  • 9
    • 0028142392 scopus 로고
    • El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis
    • Subcommittee on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial "Clinical limits of amyotrophic lateral sclerosis" workshop contributors
    • Brooks, B.R. (1994). El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial "Clinical limits of amyotrophic lateral sclerosis" workshop contributors. J. Neurol. Sci. 124 (suppl.), 96-107.
    • (1994) J. Neurol. Sci. , vol.124 , Issue.SUPPL. , pp. 96-107
    • Brooks, B.R.1
  • 10
    • 0030026831 scopus 로고    scopus 로고
    • Superoxide dismutase and familial amyotrophic lateral sclerosis: New insights into mechanisms and treatments
    • Brown, R.H., Jr. (1996). Superoxide dismutase and familial amyotrophic lateral sclerosis: new insights into mechanisms and treatments. Ann. Neurol. 39, 145-146.
    • (1996) Ann. Neurol. , vol.39 , pp. 145-146
    • Brown R.H., Jr.1
  • 11
    • 0029969678 scopus 로고    scopus 로고
    • Mechanisms of selective motor neuron death in ALS: Insights from transgenic mouse models of motor neuron disease
    • Bruijn, L.I., and Cleveland, D.W. (1996). Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease. Neuropathol. Appl. Neurobiol. 22, 373-387.
    • (1996) Neuropathol. Appl. Neurobiol. , vol.22 , pp. 373-387
    • Bruijn, L.I.1    Cleveland, D.W.2
  • 12
    • 0029077393 scopus 로고
    • NMDA and kainate induce internucleosomal DNA cleavage associated with both apoptotic and necrotic cell death in the neonatal rat brain
    • Campagne, M.V., Lucassen, P.J., Vermeulen, J.P., and Balazs, R. (1995). NMDA and kainate induce internucleosomal DNA cleavage associated with both apoptotic and necrotic cell death in the neonatal rat brain. Eur. J. Neurosci. 7, 1627-1640.
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 1627-1640
    • Campagne, M.V.1    Lucassen, P.J.2    Vermeulen, J.P.3    Balazs, R.4
  • 14
    • 0027397195 scopus 로고
    • Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors
    • Couratier, P., Hugon, J., Sindou, P., Vallat, J.M., and Dumas, M. (1993). Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors. Lancet 341, 265-268.
    • (1993) Lancet , vol.341 , pp. 265-268
    • Couratier, P.1    Hugon, J.2    Sindou, P.3    Vallat, J.M.4    Dumas, M.5
  • 17
    • 15844386531 scopus 로고    scopus 로고
    • Intron retention generates a novel isoform of the murine vitamin D receptor that acts in a dominant negative way on the vitamin D signaling pathway
    • Ebihara, K., Masuhiro, Y., Kitamoto, T., Suzawa, M., Uematsu, Y., Yoshizawa, T., Ono, T., Harada, H., Matsuda, K., Hasegawa, T., et al. (1996). Intron retention generates a novel isoform of the murine vitamin D receptor that acts in a dominant negative way on the vitamin D signaling pathway. Mol. Cell. Biol. 16, 3393-3400.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3393-3400
    • Ebihara, K.1    Masuhiro, Y.2    Kitamoto, T.3    Suzawa, M.4    Uematsu, Y.5    Yoshizawa, T.6    Ono, T.7    Harada, H.8    Matsuda, K.9    Hasegawa, T.10
  • 18
    • 0029076899 scopus 로고
    • An excitatory amino-acid transporterwith properties of a ligand-gated chloride channel
    • Fairman, W.A., Vandenberg, R.J., Arriza, J.L., Kavanaugh, M.P., and Amara, S.G. (1995). An excitatory amino-acid transporterwith properties of a ligand-gated chloride channel. Nature 375, 599-603.
    • (1995) Nature , vol.375 , pp. 599-603
    • Fairman, W.A.1    Vandenberg, R.J.2    Arriza, J.L.3    Kavanaugh, M.P.4    Amara, S.G.5
  • 21
    • 0030928716 scopus 로고    scopus 로고
    • The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis
    • Fischer, U., Liu, Q., and Dreyfuss, G. (1997). The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis. Cell 90, 1023-1029.
    • (1997) Cell , vol.90 , pp. 1023-1029
    • Fischer, U.1    Liu, Q.2    Dreyfuss, G.3
  • 22
    • 0031563761 scopus 로고    scopus 로고
    • Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4
    • Furuta, A., Martin, L.J., Lin, C.L.G., Dykes-Hoberg, M., and Rothstein, J.D. (1997). Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4. Neuroscience 81, 1031-1042.
    • (1997) Neuroscience , vol.81 , pp. 1031-1042
    • Furuta, A.1    Martin, L.J.2    Lin, C.L.G.3    Dykes-Hoberg, M.4    Rothstein, J.D.5
  • 23
    • 0030050727 scopus 로고    scopus 로고
    • Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis
    • Gurney, M.E., Cuttings, F.B., Zhai, P., Doble, A., Taylor, C.P., Andrus, P.K., and Hall, E.D. (1996). Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann. Neurol. 39, 147-157.
    • (1996) Ann. Neurol. , vol.39 , pp. 147-157
    • Gurney, M.E.1    Cuttings, F.B.2    Zhai, P.3    Doble, A.4    Taylor, C.P.5    Andrus, P.K.6    Hall, E.D.7
  • 24
    • 0030014686 scopus 로고    scopus 로고
    • Genomic organization, promoter analysis, and chromosomal localization of the gene for the mouse glial high-affinity glutamate transporter Slc1a3
    • Hagiwara, T., Tanaka, K., Takai, S., Maeno-Hikichi, Y., Mukainaka, Y., and Wada, K. (1996). Genomic organization, promoter analysis, and chromosomal localization of the gene for the mouse glial high-affinity glutamate transporter Slc1a3. Genomics 33, 508-515.
    • (1996) Genomics , vol.33 , pp. 508-515
    • Hagiwara, T.1    Tanaka, K.2    Takai, S.3    Maeno-Hikichi, Y.4    Mukainaka, Y.5    Wada, K.6
  • 26
    • 13344261949 scopus 로고    scopus 로고
    • Motor neuron degeneration induced by excitotoxin agonists has features in common with those seen in the SOD-1 transgenic mouse model of amyotrophic lateral sclerosis
    • Ikonomidou, C., Qin, Y.Q., Labruyere, J., and Olney, J.W. (1996). Motor neuron degeneration induced by excitotoxin agonists has features in common with those seen in the SOD-1 transgenic mouse model of amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 55, 211-224.
    • (1996) J. Neuropathol. Exp. Neurol. , vol.55 , pp. 211-224
    • Ikonomidou, C.1    Qin, Y.Q.2    Labruyere, J.3    Olney, J.W.4
  • 28
    • 0030017367 scopus 로고    scopus 로고
    • An intronic mutation in a lariat branchpoint sequence is a direct cause of an inherited human disorder (fish-eye disease)
    • Kuivenhoven, J.A., Weibusch, H., Pritchard, P.H., Funke, H., Benne, R., Assmann, G., and Kastelein, J.J.P. (1996). An intronic mutation in a lariat branchpoint sequence is a direct cause of an inherited human disorder (fish-eye disease). J. Clin. Invest. 98, 358-364.
    • (1996) J. Clin. Invest. , vol.98 , pp. 358-364
    • Kuivenhoven, J.A.1    Weibusch, H.2    Pritchard, P.H.3    Funke, H.4    Benne, R.5    Assmann, G.6    Kastelein, J.J.P.7
  • 29
    • 0001363208 scopus 로고
    • Motor neuron diseases
    • A.K. Asbury, G.M. McKhann, and W.I. McDonald, eds. (Philadelphia: W.B. Saunders)
    • Kuncl, R.W., Crawford, T.O., Rothstein, J.D., and Drachman, D.B. (1992). Motor neuron diseases. In Diseases of the Nervous System, A.K. Asbury, G.M. McKhann, and W.I. McDonald, eds. (Philadelphia: W.B. Saunders), pp. 1179-1208.
    • (1992) Diseases of the Nervous System , pp. 1179-1208
    • Kuncl, R.W.1    Crawford, T.O.2    Rothstein, J.D.3    Drachman, D.B.4
  • 30
    • 0029977337 scopus 로고    scopus 로고
    • Dose-ranging study of riluzole in amyotrophic lateral sclerosis
    • Lacomblez, L., Bensimon, G., Leigh, P.M., Guillet, P., and Meininger, V. (1996). Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Lancet 347, 1425-1431.
    • (1996) Lancet , vol.347 , pp. 1425-1431
    • Lacomblez, L.1    Bensimon, G.2    Leigh, P.M.3    Guillet, P.4    Meininger, V.5
  • 31
    • 0028116467 scopus 로고
    • A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease
    • Lee, M.K., Marszalek, J.R., and Cleveland, D.W. (1994). A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron 13, 975-988.
    • (1994) Neuron , vol.13 , pp. 975-988
    • Lee, M.K.1    Marszalek, J.R.2    Cleveland, D.W.3
  • 32
    • 0028958939 scopus 로고
    • Differential expression of two glial glutamate transporters in the rat brain: Quantitative and immunocytochemical observations
    • Lehre, K.P., Levy, L.M., Ottersen, O.P., Storm-Mathisen, J., and Danbolt, N.C. (1995). Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations. J. Neurosci. 15, 1835-1853.
    • (1995) J. Neurosci. , vol.15 , pp. 1835-1853
    • Lehre, K.P.1    Levy, L.M.2    Ottersen, O.P.3    Storm-Mathisen, J.4    Danbolt, N.C.5
  • 33
    • 0030931727 scopus 로고    scopus 로고
    • The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins
    • Liu, Q., Fischer, U., Wang, F., and Dreyfuss, G. (1997). The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Cell 90, 1013-1021.
    • (1997) Cell , vol.90 , pp. 1013-1021
    • Liu, Q.1    Fischer, U.2    Wang, F.3    Dreyfuss, G.4
  • 34
    • 0030889711 scopus 로고    scopus 로고
    • Genomic organization of the human excitatory amino acid transporter gene GLT-1
    • Meyer, T., Ludolph, A.C., Morkel, M., Hagemeier, C., and Speer, A. (1997). Genomic organization of the human excitatory amino acid transporter gene GLT-1. Neuroreport 8, 775-777.
    • (1997) Neuroreport , vol.8 , pp. 775-777
    • Meyer, T.1    Ludolph, A.C.2    Morkel, M.3    Hagemeier, C.4    Speer, A.5
  • 36
    • 0030931561 scopus 로고    scopus 로고
    • smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans
    • Morrison, M., Harris, K.S., and Roth, M.B. (1997). smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 94, 9782-9785.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9782-9785
    • Morrison, M.1    Harris, K.S.2    Roth, M.B.3
  • 37
    • 0029847118 scopus 로고    scopus 로고
    • Excitotoxicity hypothesis
    • Rothstein, J.D. (1996). Excitotoxicity hypothesis. Neurology 47, S19-S26.
    • (1996) Neurology , vol.47
    • Rothstein, J.D.1
  • 39
    • 0026597010 scopus 로고
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    • Rothstein, J.D., Martin, L.J., and Kuncl, R.W. (1992). Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N. Engl. J. Med. 326, 1464-1468.
    • (1992) N. Engl. J. Med. , vol.326 , pp. 1464-1468
    • Rothstein, J.D.1    Martin, L.J.2    Kuncl, R.W.3
  • 40
    • 0027274623 scopus 로고
    • Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
    • Rothstein, J.D., Jin, L., Dykes-Hoberg, M., and Kuncl, R.W. (1993). Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc. Natl. Acad. Sci. USA 90, 6591-6595.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6591-6595
    • Rothstein, J.D.1    Jin, L.2    Dykes-Hoberg, M.3    Kuncl, R.W.4
  • 42
    • 0029030610 scopus 로고
    • Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
    • Rothstein, J.D., Van Kammen, M., Levey, A.I., Martin, L.J., and Kuncl, R.W. (1995). Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann. Neurol. 38, 73-84.
    • (1995) Ann. Neurol. , vol.38 , pp. 73-84
    • Rothstein, J.D.1    Van Kammen, M.2    Levey, A.I.3    Martin, L.J.4    Kuncl, R.W.5
  • 43
    • 13344286293 scopus 로고    scopus 로고
    • Antisense knockout of glutamate transporters reveals a predominant role for astroglial glutamate transport in excitotoxicity and clearance of extracellular glutamate
    • Rothstein, J.D., Dykes-Hoberg, M., Pardo, C.A., Bristol, L.A., Jin, L., Kuncl, R.W., Kanai, Y., Hediger, M.A., Wang, Y., Schielke, J., et al. (1996). Antisense knockout of glutamate transporters reveals a predominant role for astroglial glutamate transport in excitotoxicity and clearance of extracellular glutamate. Neuron 16, 675-686.
    • (1996) Neuron , vol.16 , pp. 675-686
    • Rothstein, J.D.1    Dykes-Hoberg, M.2    Pardo, C.A.3    Bristol, L.A.4    Jin, L.5    Kuncl, R.W.6    Kanai, Y.7    Hediger, M.A.8    Wang, Y.9    Schielke, J.10
  • 44
    • 0029859668 scopus 로고    scopus 로고
    • Exon 10 skipping caused by intron 10 splice donor site mutation in cholesteryl ester transfer protein gene results in abnormal downstream splice site selection
    • Sakai, N., Santamarina-Fojo, S., Yamashita, S., Matsuzawa, Y., and Brewer, H.B. (1996). Exon 10 skipping caused by intron 10 splice donor site mutation in cholesteryl ester transfer protein gene results in abnormal downstream splice site selection. J. Lipid. Res. 37, 2065-2073.
    • (1996) J. Lipid. Res. , vol.37 , pp. 2065-2073
    • Sakai, N.1    Santamarina-Fojo, S.2    Yamashita, S.3    Matsuzawa, Y.4    Brewer, H.B.5
  • 45
    • 0028048374 scopus 로고
    • Excitotoxicity and motor neuron disease: A review of the evidence
    • Shaw, P.J. (1994). Excitotoxicity and motor neuron disease: a review of the evidence. J. Neurol. Sci. 124, 6-13.
    • (1994) J. Neurol. Sci. , vol.124 , pp. 6-13
    • Shaw, P.J.1
  • 46
    • 0028168346 scopus 로고
    • 3H]D-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: A quantitative autoradiographic study
    • 3H]D-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study. Brain Res. 655, 195-201.
    • (1994) Brain Res. , vol.655 , pp. 195-201
    • Shaw, P.J.1    Chinnery, R.M.2    Ince, P.G.3
  • 47
    • 0029067210 scopus 로고
    • CSF and plasma amino acid levels in motor neuron disease: Elevation of CSF glutamate in a subset of patients
    • Shaw, P.J., Forrest, V., Ince, P.G., Richardson, J.P., and Wastell, H.J. (1995). CSF and plasma amino acid levels in motor neuron disease: elevation of CSF glutamate in a subset of patients. Neurodegeneration 4, 209-216.
    • (1995) Neurodegeneration , vol.4 , pp. 209-216
    • Shaw, P.J.1    Forrest, V.2    Ince, P.G.3    Richardson, J.P.4    Wastell, H.J.5
  • 48
    • 0029810307 scopus 로고    scopus 로고
    • Genetics of amyotrophic lateral sclerosis
    • Siddique, T., and Deng, H.X. (1996). Genetics of amyotrophic lateral sclerosis. Hum. Mol. Genet. 5, 1465-1470.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1465-1470
    • Siddique, T.1    Deng, H.X.2
  • 50
    • 0030011331 scopus 로고    scopus 로고
    • + -dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): Gene structure and localization to chromosome 5p11-p12
    • + -dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): gene structure and localization to chromosome 5p11-p12. FEBS Lett. 386, 189-193.
    • (1996) FEBS Lett. , vol.386 , pp. 189-193
    • Stoffel, W.1    Sasse, J.2    Duker, M.3    Hofmann, K.4    Fink, T.5    Lichter, P.6
  • 53
    • 0027944554 scopus 로고
    • Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms
    • Volterra, A., Trotti, D., and Racagni, G. (1994). Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms. Mol. Pharmacol. 46, 986-992.
    • (1994) Mol. Pharmacol. , vol.46 , pp. 986-992
    • Volterra, A.1    Trotti, D.2    Racagni, G.3
  • 54
    • 0029946458 scopus 로고    scopus 로고
    • Alternative splicing in COL1A1 mRNA leads to a partial null allele and two in-frame forms with structural defects in non-lethal osteogenesis imperfecta
    • Wang, Q., Forlino, A., and Marini, J.C. (1996). Alternative splicing in COL1A1 mRNA leads to a partial null allele and two in-frame forms with structural defects in non-lethal osteogenesis imperfecta. J. Biol. Chem. 271, 28617-28623.
    • (1996) J. Biol. Chem. , vol.271 , pp. 28617-28623
    • Wang, Q.1    Forlino, A.2    Marini, J.C.3
  • 55
    • 0029053881 scopus 로고
    • An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
    • Wong, P.C., Pardo, C.A., Borchelt, D.R., Lee, M.K., Copeland, N.G., Jenkins, N.A., Sisodia, S.S., Cleveland, D.W., and Price, D.L. (1995). An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14, 1105-1116.
    • (1995) Neuron , vol.14 , pp. 1105-1116
    • Wong, P.C.1    Pardo, C.A.2    Borchelt, D.R.3    Lee, M.K.4    Copeland, N.G.5    Jenkins, N.A.6    Sisodia, S.S.7    Cleveland, D.W.8    Price, D.L.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.